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The map label for this gene is pncB [H]

Identifier: 94985426

GI number: 94985426

Start: 1408540

End: 1410000

Strand: Reverse

Name: pncB [H]

Synonym: Dgeo_1325

Alternate gene names: 94985426

Gene position: 1410000-1408540 (Counterclockwise)

Preceding gene: 94985427

Following gene: 94985425

Centisome position: 57.15

GC content: 69.95

Gene sequence:

>1461_bases
ATGACCGGACCTTCCTCGCCCCCCACCTCCTCGGCCCTCTTCACCGATCTCTATCAGCTCACGATGATGCAGGGCTACTA
CGCCCACGGTCTACACACCGAGGAGGCGGTCTTTGATCTGTACTTCCGCAAGCAGCCCTTCGGCGGCGGCTTCGCGGTGT
GGGCGGGGCTAGAACCGGCGCTGGAGCTGCTCGAAACCCTGCGCTTCAGCGAAACGGACCTCGCCTACCTGGACTCGCTG
GGCCTCTTTCAGCCCGAGTTCCTTACGGCGCTGCGCGGCTGGAAGTTCAGCGGGCGCGTCACGGCCTTCCGCGAGGGCAG
CGTGGTGTTCGCGCACGAGCCGCTGCTGACTGTCACCGCGCCGCTGTGGGAGGCGCAGCTTGTCGAGACGGCGCTGCTCA
ACACCCTGAACTTCCAGACCCTGGTGGCGACCAAGGCGGCCCGCTGCGTCCTGGCGGCAGAGGCCAGTCCCTACGGCGGG
CAGATCATCGAGTTTGGTGCGCGGCGAGCGCAGGGGCCGGACGGGGCACTCAGCGCCGCGCGTGCCGCCTTTGTGGGGGG
AGCAGTCGGCACCAGCAACGTGGAGGCGGGGCGTATCTTCGGCCTGCCACTGACCGGCACGCACGCCCACGCCTGGGTGG
AGAGCTTTCCCGACGAATTGACGGCCTTCCGCGCCTATGCCGCCCTGTACCCCGACAACACCACCCTGCTGCTCGATACG
GTGGACACGCTGCGCAGCGGTTTGCCCAATGCGCTCATTGTGGCGCGGGAACTGCGCGCGGCGGGGCATGAGCTGCGCGG
TGTGCGGCTTGACAGCGGTGACCTCGCGTACCTGTCGAGCCGGATTCGTGCGGCGCTCGACGCGGCGGGCTTCCCGGACG
TGAAGATTGTCGCCAGCAATGACCTGTCCGAATCGGTGATCGCTTCGGTCATCGCAGAGGGCGGGCGGGTGGACGTGTAC
GGCGTCGGCACCCAGCTGGCCACGGCGGGCGGGGAGGGCGGCGGCGCGCTGGGGGGCGTCTTTAAACTCGCGCAGCTCGG
CGGCGTGCCCAAGATGAAGCTGACGGGCGACCCCGCCAAATCCAGCCTGCCCGGGGTGAAGTATGTGTGGCGGGGCGTGG
GCGAGGACGGACAGTACGCCCTCGACGTGCTGACGCTGGGCGAGGTGCCCTGCCCAGGCCAGCGCGTCAGCGACCCTACC
AACCCGCTGCGCTTCGCGCGGCTGCCCGACGGCCTCGCCTGGCGGGATGCCCGCGAGGTGGTGCTCGAGGGCGGGCGGCG
CACCGGTCCGCCCGAGACGCTGGGGCAGGCCCAGGCCCGCGCCCGCGCTGACCTCGCCCGGCTCCCAGCGGGTACGCGCC
GTCCCCTCAATCCCCATATCTACCGCGTCAGCCTGGGAGATGACGTGGCCGGATTGCGCGACCGTGTGGCAGAGGAGCTG
CGTGCGCACGTGGGGAGATGA

Upstream 100 bases:

>100_bases
TTGCCGCCTGCTTTGCGCTGGCTGCCCTATGCGGCTGGGCCATCGGGATCGAGACACGTGGGCGCAAGCTGCCGGAGACG
CTGCTGCCGGAGAATGGGGC

Downstream 100 bases:

>100_bases
GCGCGCCGCCTGCACCCGCCGCTGTCTTCGTGGGCCGCTTTCAGCCGCCACACGCGGCGCACGTGGCGACGGTGCAGCAC
GCGCTGGTCCACGCCTCCCG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTGPSSPPTSSALFTDLYQLTMMQGYYAHGLHTEEAVFDLYFRKQPFGGGFAVWAGLEPALELLETLRFSETDLAYLDSL
GLFQPEFLTALRGWKFSGRVTAFREGSVVFAHEPLLTVTAPLWEAQLVETALLNTLNFQTLVATKAARCVLAAEASPYGG
QIIEFGARRAQGPDGALSAARAAFVGGAVGTSNVEAGRIFGLPLTGTHAHAWVESFPDELTAFRAYAALYPDNTTLLLDT
VDTLRSGLPNALIVARELRAAGHELRGVRLDSGDLAYLSSRIRAALDAAGFPDVKIVASNDLSESVIASVIAEGGRVDVY
GVGTQLATAGGEGGGALGGVFKLAQLGGVPKMKLTGDPAKSSLPGVKYVWRGVGEDGQYALDVLTLGEVPCPGQRVSDPT
NPLRFARLPDGLAWRDAREVVLEGGRRTGPPETLGQAQARARADLARLPAGTRRPLNPHIYRVSLGDDVAGLRDRVAEEL
RAHVGR

Sequences:

>Translated_486_residues
MTGPSSPPTSSALFTDLYQLTMMQGYYAHGLHTEEAVFDLYFRKQPFGGGFAVWAGLEPALELLETLRFSETDLAYLDSL
GLFQPEFLTALRGWKFSGRVTAFREGSVVFAHEPLLTVTAPLWEAQLVETALLNTLNFQTLVATKAARCVLAAEASPYGG
QIIEFGARRAQGPDGALSAARAAFVGGAVGTSNVEAGRIFGLPLTGTHAHAWVESFPDELTAFRAYAALYPDNTTLLLDT
VDTLRSGLPNALIVARELRAAGHELRGVRLDSGDLAYLSSRIRAALDAAGFPDVKIVASNDLSESVIASVIAEGGRVDVY
GVGTQLATAGGEGGGALGGVFKLAQLGGVPKMKLTGDPAKSSLPGVKYVWRGVGEDGQYALDVLTLGEVPCPGQRVSDPT
NPLRFARLPDGLAWRDAREVVLEGGRRTGPPETLGQAQARARADLARLPAGTRRPLNPHIYRVSLGDDVAGLRDRVAEEL
RAHVGR
>Mature_485_residues
TGPSSPPTSSALFTDLYQLTMMQGYYAHGLHTEEAVFDLYFRKQPFGGGFAVWAGLEPALELLETLRFSETDLAYLDSLG
LFQPEFLTALRGWKFSGRVTAFREGSVVFAHEPLLTVTAPLWEAQLVETALLNTLNFQTLVATKAARCVLAAEASPYGGQ
IIEFGARRAQGPDGALSAARAAFVGGAVGTSNVEAGRIFGLPLTGTHAHAWVESFPDELTAFRAYAALYPDNTTLLLDTV
DTLRSGLPNALIVARELRAAGHELRGVRLDSGDLAYLSSRIRAALDAAGFPDVKIVASNDLSESVIASVIAEGGRVDVYG
VGTQLATAGGEGGGALGGVFKLAQLGGVPKMKLTGDPAKSSLPGVKYVWRGVGEDGQYALDVLTLGEVPCPGQRVSDPTN
PLRFARLPDGLAWRDAREVVLEGGRRTGPPETLGQAQARARADLARLPAGTRRPLNPHIYRVSLGDDVAGLRDRVAEELR
AHVGR

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=530, Percent_Identity=36.4150943396226, Blast_Score=264, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI71997947, Length=529, Percent_Identity=35.1606805293006, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71997952, Length=529, Percent_Identity=35.1606805293006, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI71997955, Length=231, Percent_Identity=43.7229437229437, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24581587, Length=520, Percent_Identity=35, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI161076680, Length=209, Percent_Identity=44.0191387559809, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24581595, Length=209, Percent_Identity=44.0191387559809, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI28574709, Length=209, Percent_Identity=44.0191387559809, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24581593, Length=209, Percent_Identity=44.0191387559809, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24581591, Length=209, Percent_Identity=44.0191387559809, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 51663; Mature: 51532

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPSSPPTSSALFTDLYQLTMMQGYYAHGLHTEEAVFDLYFRKQPFGGGFAVWAGLEPA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEECCCHHH
LELLETLRFSETDLAYLDSLGLFQPEFLTALRGWKFSGRVTAFREGSVVFAHEPLLTVTA
HHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEECCCEEEEECCCEEEEC
PLWEAQLVETALLNTLNFQTLVATKAARCVLAAEASPYGGQIIEFGARRAQGPDGALSAA
CHHHHHHHHHHHHHHCCHHHHHHHHHHHEEEEECCCCCCCHHHHHCCHHCCCCCHHHHHH
RAAFVGGAVGTSNVEAGRIFGLPLTGTHAHAWVESFPDELTAFRAYAALYPDNTTLLLDT
HHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCHHHHHHHHHHHEECCCCCEEEEEC
VDTLRSGLPNALIVARELRAAGHELRGVRLDSGDLAYLSSRIRAALDAAGFPDVKIVASN
HHHHHCCCCCHHHHHHHHHHCCHHHCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECC
DLSESVIASVIAEGGRVDVYGVGTQLATAGGEGGGALGGVFKLAQLGGVPKMKLTGDPAK
CCHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCCC
SSLPGVKYVWRGVGEDGQYALDVLTLGEVPCPGQRVSDPTNPLRFARLPDGLAWRDAREV
CCCCCHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHH
VLEGGRRTGPPETLGQAQARARADLARLPAGTRRPLNPHIYRVSLGDDVAGLRDRVAEEL
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
RAHVGR
HHHHCC
>Mature Secondary Structure 
TGPSSPPTSSALFTDLYQLTMMQGYYAHGLHTEEAVFDLYFRKQPFGGGFAVWAGLEPA
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEECCCHHH
LELLETLRFSETDLAYLDSLGLFQPEFLTALRGWKFSGRVTAFREGSVVFAHEPLLTVTA
HHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEECCCEEEEECCCEEEEC
PLWEAQLVETALLNTLNFQTLVATKAARCVLAAEASPYGGQIIEFGARRAQGPDGALSAA
CHHHHHHHHHHHHHHCCHHHHHHHHHHHEEEEECCCCCCCHHHHHCCHHCCCCCHHHHHH
RAAFVGGAVGTSNVEAGRIFGLPLTGTHAHAWVESFPDELTAFRAYAALYPDNTTLLLDT
HHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCHHHHHHHHHHHEECCCCCEEEEEC
VDTLRSGLPNALIVARELRAAGHELRGVRLDSGDLAYLSSRIRAALDAAGFPDVKIVASN
HHHHHCCCCCHHHHHHHHHHCCHHHCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECC
DLSESVIASVIAEGGRVDVYGVGTQLATAGGEGGGALGGVFKLAQLGGVPKMKLTGDPAK
CCHHHHHHHHHHCCCCEEEEECCCEEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCCC
SSLPGVKYVWRGVGEDGQYALDVLTLGEVPCPGQRVSDPTNPLRFARLPDGLAWRDAREV
CCCCCHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHH
VLEGGRRTGPPETLGQAQARARADLARLPAGTRRPLNPHIYRVSLGDDVAGLRDRVAEEL
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
RAHVGR
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]