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The map label for this gene is pyrH

Identifier: 94985151

GI number: 94985151

Start: 1118902

End: 1119675

Strand: Reverse

Name: pyrH

Synonym: Dgeo_1047

Alternate gene names: 94985151

Gene position: 1119675-1118902 (Counterclockwise)

Preceding gene: 94985152

Following gene: 94985150

Centisome position: 45.38

GC content: 65.63

Gene sequence:

>774_bases
ATGTTCAAACGCGTTCTGCTCAAGCTCTCCGGTGAGTTTCTCTCCGGTCCAGCGCCCGACGGCTCAGCGGGCTTTGGCAT
CAGTCCCGACACGACCGCCCAGCTCGCGCGCCTGATCACGGACGCACTGACGGGCACGAACGTCGAGCTGGCTATCGTGA
TCGGGGGCGGAAACCTGTGGCGCGGCGCGCGCAACGGCAAGGGCATGGATGCCGCGACCGCCGACTACATCGGGATGCTG
GGCACGGTGATGAACGCGATGGCCCTTCAGGACGCGATGGAGGCAGCGGGCCAGCCCACACGCGTCATGACAGCCATCCA
GATGGCGGCGGTGGCTGAGCCGTACATCCGCCGCCGGGCCATTCGCCACCTGGAAAAGGGCCGGGTGGTGATTTTCGGCG
GGGGAAACGGTGCTCCCTTTTTCACCACGGATACCACGGCCACCCTGCGCGCGCTGGAAATCGGGGCCGACGTGGTGCTG
ATGGCGAAGAACAAGGTGGACGGCGTATACGACAGCGATCCGCGCAAGAATCCAGACGCGCGGCGGCTTGACAGCCTCAC
ACACATCGAGGTCGTCGAGCGCCGCTTGGAAGTGATGGACGCCACCGCGCTGACCCTCTGCATGGACAAGGGACTCCCCA
TCGTGGTGTTTGACCTCTTCCAGCCGGGCAATCTGCGCCGCCTCCTAGAGGGCGAACGGGTCGGGACGCTGATCGAGAGC
GAGCGGCGGCCAGAACGGCTTTCCCACGACCCATCTTCCCACGTTCCCCGCTAG

Upstream 100 bases:

>100_bases
CAGGGAAGCCGCCCCTTTCCTGGGCCGCTGCCCCTCTCTCCCTCGCCCGGCGGCCTCTTGGCGCCGGGTCTTTTCTTGCC
GCTCTCTCCCGAGGTGATTC

Downstream 100 bases:

>100_bases
AATCCCCCCAAGGAGAAACCCGCATGCCAGACATCAAAGCCATTCAGGCGGACGCGCGCGAGCGCATGGGCAAGGCCATT
GAGGCGCTGGAAAACAATCT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MFKRVLLKLSGEFLSGPAPDGSAGFGISPDTTAQLARLITDALTGTNVELAIVIGGGNLWRGARNGKGMDAATADYIGML
GTVMNAMALQDAMEAAGQPTRVMTAIQMAAVAEPYIRRRAIRHLEKGRVVIFGGGNGAPFFTTDTTATLRALEIGADVVL
MAKNKVDGVYDSDPRKNPDARRLDSLTHIEVVERRLEVMDATALTLCMDKGLPIVVFDLFQPGNLRRLLEGERVGTLIES
ERRPERLSHDPSSHVPR

Sequences:

>Translated_257_residues
MFKRVLLKLSGEFLSGPAPDGSAGFGISPDTTAQLARLITDALTGTNVELAIVIGGGNLWRGARNGKGMDAATADYIGML
GTVMNAMALQDAMEAAGQPTRVMTAIQMAAVAEPYIRRRAIRHLEKGRVVIFGGGNGAPFFTTDTTATLRALEIGADVVL
MAKNKVDGVYDSDPRKNPDARRLDSLTHIEVVERRLEVMDATALTLCMDKGLPIVVFDLFQPGNLRRLLEGERVGTLIES
ERRPERLSHDPSSHVPR
>Mature_257_residues
MFKRVLLKLSGEFLSGPAPDGSAGFGISPDTTAQLARLITDALTGTNVELAIVIGGGNLWRGARNGKGMDAATADYIGML
GTVMNAMALQDAMEAAGQPTRVMTAIQMAAVAEPYIRRRAIRHLEKGRVVIFGGGNGAPFFTTDTTATLRALEIGADVVL
MAKNKVDGVYDSDPRKNPDARRLDSLTHIEVVERRLEVMDATALTLCMDKGLPIVVFDLFQPGNLRRLLEGERVGTLIES
ERRPERLSHDPSSHVPR

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=239, Percent_Identity=47.6987447698745, Blast_Score=200, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_DEIGD (Q1IZI8)

Other databases:

- EMBL:   CP000359
- RefSeq:   YP_604515.1
- ProteinModelPortal:   Q1IZI8
- STRING:   Q1IZI8
- GeneID:   4057832
- GenomeReviews:   CP000359_GR
- KEGG:   dge:Dgeo_1047
- NMPDR:   fig|68909.1.peg.523
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   DGEO319795:DGEO_1047-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 27738; Mature: 27738

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: NA

Important sites: BINDING 56-56 BINDING 57-57 BINDING 61-61 BINDING 75-75 BINDING 164-164 BINDING 170-170 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKRVLLKLSGEFLSGPAPDGSAGFGISPDTTAQLARLITDALTGTNVELAIVIGGGNLW
CHHHHHHHHCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
RGARNGKGMDAATADYIGMLGTVMNAMALQDAMEAAGQPTRVMTAIQMAAVAEPYIRRRA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
IRHLEKGRVVIFGGGNGAPFFTTDTTATLRALEIGADVVLMAKNKVDGVYDSDPRKNPDA
HHHHHCCCEEEEECCCCCCEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCH
RRLDSLTHIEVVERRLEVMDATALTLCMDKGLPIVVFDLFQPGNLRRLLEGERVGTLIES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCHHHHHHHH
ERRPERLSHDPSSHVPR
CCCCHHHCCCCCCCCCC
>Mature Secondary Structure
MFKRVLLKLSGEFLSGPAPDGSAGFGISPDTTAQLARLITDALTGTNVELAIVIGGGNLW
CHHHHHHHHCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
RGARNGKGMDAATADYIGMLGTVMNAMALQDAMEAAGQPTRVMTAIQMAAVAEPYIRRRA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
IRHLEKGRVVIFGGGNGAPFFTTDTTATLRALEIGADVVLMAKNKVDGVYDSDPRKNPDA
HHHHHCCCEEEEECCCCCCEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCH
RRLDSLTHIEVVERRLEVMDATALTLCMDKGLPIVVFDLFQPGNLRRLLEGERVGTLIES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHCCCHHHHHHHH
ERRPERLSHDPSSHVPR
CCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA