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The map label for this gene is bhbA [H]

Identifier: 94984969

GI number: 94984969

Start: 919494

End: 921140

Strand: Reverse

Name: bhbA [H]

Synonym: Dgeo_0862

Alternate gene names: 94984969

Gene position: 921140-919494 (Counterclockwise)

Preceding gene: 94984974

Following gene: 94984966

Centisome position: 37.34

GC content: 63.21

Gene sequence:

>1647_bases
ATGAAGAGCAAGAACGAGTGGCTGCACAGCGTCTATCAGCCGGCCACGCAGAAGTTTCCTGAGCGCAAGTACAACTTCAA
GAACCTGTCGGATATGGACCCCGACCCGATCTACACGACGGACGACCTGAAAGACTGGGACGCGGGGCGCGACCTAGGGT
ACCCCGGCGAGTTCCCGTATACGCGCGGCGTGCAGCCCTCGGTGTACCGCGGCAAGCTCTGGACGATGCGGATGTTTGCG
GGCTTTGGCAGCGCCGAACAGACAAACGAACGCTTTCACGCGCTGCTGCGCGCCGGGCAGACCGGCCTCAGCACGGCCTT
TGACCTTCCCACCCTGATGGGCTACGACTCCGACCACCCCTTCAGCAAAGGCGAGGTCGGCAAGTGTGGCGTGGCGGTGA
GCAGCCTGGCGGATATGGAGATTCTCTTTCGGGGCATCGACCCCGAAGCGGTCACCACCTCCATGACCATCAACAGCCCC
GCAAACGCAATCTGGGCGATGTACATCGCCAACGCCCAAAAGCAGGGCAAGGACCTCACAAAGATCGGCGGAACCATTCA
GAACGACATCCTCAAGGAGTTCATCGCACAGAAAGAGTTCATCTTCCCGCCTGCTCCCAGCGTCAAACTCGTGATCGATA
CCTTTGAGTGGGGGCCGCGCGTTGTTCCCAAGTGGAACTTCATCTCGGTGAGCGGCTACCACATCCGCGAGGCGGGGGCG
ACGGGGGTGCAGGAACTGGCCTTTACGCTCGCGGACGGCTTCCATTACGTTGAAAAGGCGCTGGAACGCGGGCTGGACAT
CGACGAGTTCGCGCCGCGCATCTCGTTCTTCTGGGACATCCACAACGACTTTTTCGAGGAGATCGCCAAGCTGCGCGCCG
CCCGCCGGATCTGGGCGCGGCAGATGCGGGACCGCTACGGGGCCAAGAATCCCCGCTCGTGGATGCTCCGCACACACTCG
CAGACCGCTGGCGTCAGCCTGCCCGCGCAGCAGCCACTCAACAACATCGCCCGCGTGGCGATTCAGGCCCTCGCCGCCGT
GCTGGGCGGCACCCAGAGCCTCCACACCGACGCCTTTGACGAGGCGCTGGCCCTGCCCACCGAGGAGGCGGCCACCATCG
CCCTGCGCACGCAGCAGATCATCGCCTATGAAACGGGCGTGGCCGGGGTCATCGATCCGCTGGCGGGCAGCTATTACGTT
GAGAAGCTGACGAACGATATCGAGGCCGCTGCGATGGGCTACATCGAGCAGATTCGCGCGATGGGCGGCGTAGAGGCGGG
CATCGAGAACGGCTTCTTCCAGCTGGAGATGGCCGAGGCCGCCTACCGTTACCAGCAGGAGGTTGAGAACAAGGAACGAA
TCATCGTTGGCGTGAATGAGTTCGTGCAGGATGCGGTGGAGGTGCCCATCCAACTGATTGATCCTGAGGTCGAGCGCGTG
CAGGCAGCTCGGCTGGCTCAGGTGCGCCGCGAACGCGATCCCAAGCGTGTGGAGGCCGCGCTCAACGCCCTGCGCGACGC
TGCTGTCACCGGGGCCAACACCATGCCCGCCTTCCTGGAGTGCGCCCACGCCTATGCCACGCTGGGTGAACAGATGGACA
CGCTGAAAAAGGTCTACGGGGAATACGTGGAGCCGGTGTTGGTGTAG

Upstream 100 bases:

>100_bases
AAGATCAACCCGGCGCACGAAGAGCCTGTCCCAAACCGGCCTTTCTGCTACCCTATCTCTACCTAACGAGCGTTTGTTTC
TGTCCCCAGGGAGGCCGAAC

Downstream 100 bases:

>100_bases
GGGGCAGCAGCAGGAGCTGCCAAGACAGCTGGCTTGGGCCTGAGAGCGTCCACCGCAACACCGTCATTCGGTGGTTCACG
CGGTGGACCACCCGGCAAGG

Product: methylmalonyl-CoA mutase, alpha subunit

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MKSKNEWLHSVYQPATQKFPERKYNFKNLSDMDPDPIYTTDDLKDWDAGRDLGYPGEFPYTRGVQPSVYRGKLWTMRMFA
GFGSAEQTNERFHALLRAGQTGLSTAFDLPTLMGYDSDHPFSKGEVGKCGVAVSSLADMEILFRGIDPEAVTTSMTINSP
ANAIWAMYIANAQKQGKDLTKIGGTIQNDILKEFIAQKEFIFPPAPSVKLVIDTFEWGPRVVPKWNFISVSGYHIREAGA
TGVQELAFTLADGFHYVEKALERGLDIDEFAPRISFFWDIHNDFFEEIAKLRAARRIWARQMRDRYGAKNPRSWMLRTHS
QTAGVSLPAQQPLNNIARVAIQALAAVLGGTQSLHTDAFDEALALPTEEAATIALRTQQIIAYETGVAGVIDPLAGSYYV
EKLTNDIEAAAMGYIEQIRAMGGVEAGIENGFFQLEMAEAAYRYQQEVENKERIIVGVNEFVQDAVEVPIQLIDPEVERV
QAARLAQVRRERDPKRVEAALNALRDAAVTGANTMPAFLECAHAYATLGEQMDTLKKVYGEYVEPVLV

Sequences:

>Translated_548_residues
MKSKNEWLHSVYQPATQKFPERKYNFKNLSDMDPDPIYTTDDLKDWDAGRDLGYPGEFPYTRGVQPSVYRGKLWTMRMFA
GFGSAEQTNERFHALLRAGQTGLSTAFDLPTLMGYDSDHPFSKGEVGKCGVAVSSLADMEILFRGIDPEAVTTSMTINSP
ANAIWAMYIANAQKQGKDLTKIGGTIQNDILKEFIAQKEFIFPPAPSVKLVIDTFEWGPRVVPKWNFISVSGYHIREAGA
TGVQELAFTLADGFHYVEKALERGLDIDEFAPRISFFWDIHNDFFEEIAKLRAARRIWARQMRDRYGAKNPRSWMLRTHS
QTAGVSLPAQQPLNNIARVAIQALAAVLGGTQSLHTDAFDEALALPTEEAATIALRTQQIIAYETGVAGVIDPLAGSYYV
EKLTNDIEAAAMGYIEQIRAMGGVEAGIENGFFQLEMAEAAYRYQQEVENKERIIVGVNEFVQDAVEVPIQLIDPEVERV
QAARLAQVRRERDPKRVEAALNALRDAAVTGANTMPAFLECAHAYATLGEQMDTLKKVYGEYVEPVLV
>Mature_548_residues
MKSKNEWLHSVYQPATQKFPERKYNFKNLSDMDPDPIYTTDDLKDWDAGRDLGYPGEFPYTRGVQPSVYRGKLWTMRMFA
GFGSAEQTNERFHALLRAGQTGLSTAFDLPTLMGYDSDHPFSKGEVGKCGVAVSSLADMEILFRGIDPEAVTTSMTINSP
ANAIWAMYIANAQKQGKDLTKIGGTIQNDILKEFIAQKEFIFPPAPSVKLVIDTFEWGPRVVPKWNFISVSGYHIREAGA
TGVQELAFTLADGFHYVEKALERGLDIDEFAPRISFFWDIHNDFFEEIAKLRAARRIWARQMRDRYGAKNPRSWMLRTHS
QTAGVSLPAQQPLNNIARVAIQALAAVLGGTQSLHTDAFDEALALPTEEAATIALRTQQIIAYETGVAGVIDPLAGSYYV
EKLTNDIEAAAMGYIEQIRAMGGVEAGIENGFFQLEMAEAAYRYQQEVENKERIIVGVNEFVQDAVEVPIQLIDPEVERV
QAARLAQVRRERDPKRVEAALNALRDAAVTGANTMPAFLECAHAYATLGEQMDTLKKVYGEYVEPVLV

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=511, Percent_Identity=45.5968688845401, Blast_Score=454, Evalue=1e-127,
Organism=Escherichia coli, GI1789284, Length=553, Percent_Identity=43.3996383363472, Blast_Score=428, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI25144500, Length=510, Percent_Identity=45.8823529411765, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 61115; Mature: 61115

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKNEWLHSVYQPATQKFPERKYNFKNLSDMDPDPIYTTDDLKDWDAGRDLGYPGEFPY
CCCHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TRGVQPSVYRGKLWTMRMFAGFGSAEQTNERFHALLRAGQTGLSTAFDLPTLMGYDSDHP
CCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHCCCCCCC
FSKGEVGKCGVAVSSLADMEILFRGIDPEAVTTSMTINSPANAIWAMYIANAQKQGKDLT
CCCCCCCCCHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCHHHHHHHHHHHHHHCCCHHH
KIGGTIQNDILKEFIAQKEFIFPPAPSVKLVIDTFEWGPRVVPKWNFISVSGYHIREAGA
HHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCCEECCCCC
TGVQELAFTLADGFHYVEKALERGLDIDEFAPRISFFWDIHNDFFEEIAKLRAARRIWAR
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMRDRYGAKNPRSWMLRTHSQTAGVSLPAQQPLNNIARVAIQALAAVLGGTQSLHTDAFD
HHHHHHCCCCCHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EALALPTEEAATIALRTQQIIAYETGVAGVIDPLAGSYYVEKLTNDIEAAAMGYIEQIRA
HHHCCCCHHHHEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGGVEAGIENGFFQLEMAEAAYRYQQEVENKERIIVGVNEFVQDAVEVPIQLIDPEVERV
HCCHHHHHCCCEEEEEHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCHHHCCCHHHHH
QAARLAQVRRERDPKRVEAALNALRDAAVTGANTMPAFLECAHAYATLGEQMDTLKKVYG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EYVEPVLV
HHHCHHCC
>Mature Secondary Structure
MKSKNEWLHSVYQPATQKFPERKYNFKNLSDMDPDPIYTTDDLKDWDAGRDLGYPGEFPY
CCCHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TRGVQPSVYRGKLWTMRMFAGFGSAEQTNERFHALLRAGQTGLSTAFDLPTLMGYDSDHP
CCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHCCCCCCC
FSKGEVGKCGVAVSSLADMEILFRGIDPEAVTTSMTINSPANAIWAMYIANAQKQGKDLT
CCCCCCCCCHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCHHHHHHHHHHHHHHCCCHHH
KIGGTIQNDILKEFIAQKEFIFPPAPSVKLVIDTFEWGPRVVPKWNFISVSGYHIREAGA
HHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCCEECCCCC
TGVQELAFTLADGFHYVEKALERGLDIDEFAPRISFFWDIHNDFFEEIAKLRAARRIWAR
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMRDRYGAKNPRSWMLRTHSQTAGVSLPAQQPLNNIARVAIQALAAVLGGTQSLHTDAFD
HHHHHHCCCCCHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
EALALPTEEAATIALRTQQIIAYETGVAGVIDPLAGSYYVEKLTNDIEAAAMGYIEQIRA
HHHCCCCHHHHEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGGVEAGIENGFFQLEMAEAAYRYQQEVENKERIIVGVNEFVQDAVEVPIQLIDPEVERV
HCCHHHHHCCCEEEEEHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCHHHCCCHHHHH
QAARLAQVRRERDPKRVEAALNALRDAAVTGANTMPAFLECAHAYATLGEQMDTLKKVYG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EYVEPVLV
HHHCHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]