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The map label for this gene is moaE [H]

Identifier: 94984437

GI number: 94984437

Start: 324989

End: 325663

Strand: Reverse

Name: moaE [H]

Synonym: Dgeo_0329

Alternate gene names: 94984437

Gene position: 325663-324989 (Counterclockwise)

Preceding gene: 94984443

Following gene: 94984430

Centisome position: 13.2

GC content: 63.11

Gene sequence:

>675_bases
ATGCAGGTCAACGTGGTGTTTTTTGCGCGTCTAAAGCATGAAACTGGTCTGGAAGCCGCGACGATTGAGGCACCGGCGGG
AGCGACGGTGCGGGAGCTGGCGGCCCAGGTGGAGCAGACCTATGGCCTGAGCCTGCGCGGCTGCATGGTTGCAGTGAATG
AGACGTACGCGCAGCCGGAACAGGTGCTGCGGGACGGGGACGAGGTGGCCTTTCTGCCGCCCGTAGCGGGAGGGGCAGAA
GAGGACACCTGCTGCGAAGTGGTGACCTCTCCCCTGCTGCTGACAGAGGCGGAGACCTTCTTGGTCCGGCCCCAGTACGG
GGCACAGGCCTATTTTGTGGGGACGGTACGTTCTCCAAATCAGGGCAAACGAGTGGAGTACATCGAGTACGAAGGCTATA
CACCGATGGCCGAGAAGGTGATGCGTGAGGCTGCCGAACAGGCGCGTGTCCAGTACGGTGAGCTGCGGGTACTGGTGCGG
CACCGCGTGGGCCGCCTGCATCCTGGCGAGGCCAGCATTCTGATCGGCGTTGCCACTCCTCATCGCCGTGCGGCCCTCGA
AGCGTGCGAGTTCCTGATTGAATACCTCAAAGTGCACCTGCCCGTCTGGAAGCACGAGGCCAATGAGGACGGGCAACACT
GGGTGGAGGGGCAGACTGGGAACCCCACCCTCTAG

Upstream 100 bases:

>100_bases
TGAGGCTCAGAAAAGATACAGGCTCCCCCCACGCCTGTCAACCCCCAGCCTCAACGGGTCCCTTGAGAGAGCGCAGACGC
CCACATGGTACGCTCGCCCC

Downstream 100 bases:

>100_bases
CTCTAGGGCGAACGGGGATGGTCGCGGGCATGGGTCTCGAAATGCAGATAGTACCTACCTGCCAGAATGACCATCAGCAG
CACCACCGCTCCCAACGCGA

Product: molybdopterin converting factor, subunit 1

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MQVNVVFFARLKHETGLEAATIEAPAGATVRELAAQVEQTYGLSLRGCMVAVNETYAQPEQVLRDGDEVAFLPPVAGGAE
EDTCCEVVTSPLLLTEAETFLVRPQYGAQAYFVGTVRSPNQGKRVEYIEYEGYTPMAEKVMREAAEQARVQYGELRVLVR
HRVGRLHPGEASILIGVATPHRRAALEACEFLIEYLKVHLPVWKHEANEDGQHWVEGQTGNPTL

Sequences:

>Translated_224_residues
MQVNVVFFARLKHETGLEAATIEAPAGATVRELAAQVEQTYGLSLRGCMVAVNETYAQPEQVLRDGDEVAFLPPVAGGAE
EDTCCEVVTSPLLLTEAETFLVRPQYGAQAYFVGTVRSPNQGKRVEYIEYEGYTPMAEKVMREAAEQARVQYGELRVLVR
HRVGRLHPGEASILIGVATPHRRAALEACEFLIEYLKVHLPVWKHEANEDGQHWVEGQTGNPTL
>Mature_224_residues
MQVNVVFFARLKHETGLEAATIEAPAGATVRELAAQVEQTYGLSLRGCMVAVNETYAQPEQVLRDGDEVAFLPPVAGGAE
EDTCCEVVTSPLLLTEAETFLVRPQYGAQAYFVGTVRSPNQGKRVEYIEYEGYTPMAEKVMREAAEQARVQYGELRVLVR
HRVGRLHPGEASILIGVATPHRRAALEACEFLIEYLKVHLPVWKHEANEDGQHWVEGQTGNPTL

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=123, Percent_Identity=39.0243902439024, Blast_Score=99, Evalue=3e-21,
Organism=Escherichia coli, GI1787003, Length=141, Percent_Identity=36.8794326241135, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17509279, Length=110, Percent_Identity=32.7272727272727, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356259, Length=136, Percent_Identity=33.8235294117647, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 24789; Mature: 24789

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVNVVFFARLKHETGLEAATIEAPAGATVRELAAQVEQTYGLSLRGCMVAVNETYAQPE
CEEEEEEEEEEHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEECCEEEEECHHHCCHH
QVLRDGDEVAFLPPVAGGAEEDTCCEVVTSPLLLTEAETFLVRPQYGAQAYFVGTVRSPN
HHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCEEECCCEEEECCCCCCEEEEEEEECCCC
QGKRVEYIEYEGYTPMAEKVMREAAEQARVQYGELRVLVRHRVGRLHPGEASILIGVATP
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCC
HRRAALEACEFLIEYLKVHLPVWKHEANEDGQHWVEGQTGNPTL
CHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEECCCCCCCCC
>Mature Secondary Structure
MQVNVVFFARLKHETGLEAATIEAPAGATVRELAAQVEQTYGLSLRGCMVAVNETYAQPE
CEEEEEEEEEEHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEECCEEEEECHHHCCHH
QVLRDGDEVAFLPPVAGGAEEDTCCEVVTSPLLLTEAETFLVRPQYGAQAYFVGTVRSPN
HHHHCCCCEEEECCCCCCCCCHHHHHHHHCCCEEECCCEEEECCCCCCEEEEEEEECCCC
QGKRVEYIEYEGYTPMAEKVMREAAEQARVQYGELRVLVRHRVGRLHPGEASILIGVATP
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCC
HRRAALEACEFLIEYLKVHLPVWKHEANEDGQHWVEGQTGNPTL
CHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]