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The map label for this gene is pphA [H]

Identifier: 94984325

GI number: 94984325

Start: 201327

End: 202148

Strand: Reverse

Name: pphA [H]

Synonym: Dgeo_0217

Alternate gene names: 94984325

Gene position: 202148-201327 (Counterclockwise)

Preceding gene: 94984326

Following gene: 94984324

Centisome position: 8.19

GC content: 70.56

Gene sequence:

>822_bases
ATGACCCGTCCGGTCGTGGTCGTGCCCGATCTGCACGGGCGCGCGGACCTGCTGGCGGAGGCGGTGGCGTACGTGGAGGC
CACGCATGGCCCCGACGCGCACCTGTTGAGTCTAGGGGACGCGATCGACCGGGGACCGCAGAGCCTGGCCTGTGCGGCGC
TGCTGCTGGACCTGCACCGGCAGGGCCGCGCAACCCTGCTGATGGGCAACCACGAGCGCATGGCGCAGGAGGGGCTGCAG
TGGTACCGCCAGTACCTCAGCTCGCGCGACCTGGCCGACTATCGCCGCGCCATGGAGGGCCTGAGCTGGTGGATAAGCAA
CGGTGGCGAGAGCGTCCGCCGCGAGGCGGGTGGCCTGACGCTGGAGGCGTTTCCGCCCGCGCTGGCCGAGTATCTCGACA
CACTGGAGCGGGTGGTATACGTGACGGCGGACGGCGAGCTGCACCAAACGCCCCCTCAGGAACCCAGCGTGCTCGTCGCC
CACGCCAGCCCCCCGGTCCAACACCGCCAGTACCCCAATCCGGAGTCGGCGGCGCTGTGGTTGCGGCCTTTTGAAGGCCC
CTTTCCGCTGCCTGAGGGCGTGACATACAGCGTGCACGGGCACACCCCCGTCTGTAACCCGGTGCGGCTGGGCCGCCACG
TGTACCTCGACCTGGGGGCCTACGAGACGGGCCGCCTCGCGCTGCTGACGGTCAACGTGACTGGGCGGCCTGAGGTGACC
GTACTGGAGGGGCGCGGCAATCCGGGTGCCGCACGCCGCTACCCCAACTTCGGTGAACCGCTCCCCACCCGGACCGTCAG
CCTGACCGGGAGGCGACCATGA

Upstream 100 bases:

>100_bases
CACGCCTGCTGCGCGAGCGGAGCAAACAGACCCTCCTCGACTTTGCCGATGAACCGGGGGAGGCGGACGCTGGAGCGGAC
CCGTCCGGGCAGGCCCGGCC

Downstream 100 bases:

>100_bases
GCCGACGCAGCCGTGCAGCAGAACGCCTCAAGCCCCTGTGGGATGCCCTGCGCGCGGGCGACCCACAGGCCGTCCACGCG
GCGCGCAAGCTGACGCGGCG

Product: metallophosphoesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MTRPVVVVPDLHGRADLLAEAVAYVEATHGPDAHLLSLGDAIDRGPQSLACAALLLDLHRQGRATLLMGNHERMAQEGLQ
WYRQYLSSRDLADYRRAMEGLSWWISNGGESVRREAGGLTLEAFPPALAEYLDTLERVVYVTADGELHQTPPQEPSVLVA
HASPPVQHRQYPNPESAALWLRPFEGPFPLPEGVTYSVHGHTPVCNPVRLGRHVYLDLGAYETGRLALLTVNVTGRPEVT
VLEGRGNPGAARRYPNFGEPLPTRTVSLTGRRP

Sequences:

>Translated_273_residues
MTRPVVVVPDLHGRADLLAEAVAYVEATHGPDAHLLSLGDAIDRGPQSLACAALLLDLHRQGRATLLMGNHERMAQEGLQ
WYRQYLSSRDLADYRRAMEGLSWWISNGGESVRREAGGLTLEAFPPALAEYLDTLERVVYVTADGELHQTPPQEPSVLVA
HASPPVQHRQYPNPESAALWLRPFEGPFPLPEGVTYSVHGHTPVCNPVRLGRHVYLDLGAYETGRLALLTVNVTGRPEVT
VLEGRGNPGAARRYPNFGEPLPTRTVSLTGRRP
>Mature_272_residues
TRPVVVVPDLHGRADLLAEAVAYVEATHGPDAHLLSLGDAIDRGPQSLACAALLLDLHRQGRATLLMGNHERMAQEGLQW
YRQYLSSRDLADYRRAMEGLSWWISNGGESVRREAGGLTLEAFPPALAEYLDTLERVVYVTADGELHQTPPQEPSVLVAH
ASPPVQHRQYPNPESAALWLRPFEGPFPLPEGVTYSVHGHTPVCNPVRLGRHVYLDLGAYETGRLALLTVNVTGRPEVTV
LEGRGNPGAARRYPNFGEPLPTRTVSLTGRRP

Specific function: Plays a key role in signaling protein misfolding via the CpxR/CPXA transducing system. It also modulates the phosphorylated status of many phosphoproteins in E.coli, some of which acting as major chaperones. Has been shown, in vitro, to act on Ser, Thr an

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081988, Length=235, Percent_Identity=28.5106382978723, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR006186 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 29978; Mature: 29847

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPVVVVPDLHGRADLLAEAVAYVEATHGPDAHLLSLGDAIDRGPQSLACAALLLDLHR
CCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHEEEHHHHHHCCHHHHHHHHHHHHHHC
QGRATLLMGNHERMAQEGLQWYRQYLSSRDLADYRRAMEGLSWWISNGGESVRREAGGLT
CCCEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCEE
LEAFPPALAEYLDTLERVVYVTADGELHQTPPQEPSVLVAHASPPVQHRQYPNPESAALW
EECCCHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCEEE
LRPFEGPFPLPEGVTYSVHGHTPVCNPVRLGRHVYLDLGAYETGRLALLTVNVTGRPEVT
EEECCCCCCCCCCCEEEEECCCCCCCHHHCCCEEEEEECCCCCCCEEEEEEEECCCCCEE
VLEGRGNPGAARRYPNFGEPLPTRTVSLTGRRP
EEECCCCCCHHCCCCCCCCCCCCCEEEECCCCC
>Mature Secondary Structure 
TRPVVVVPDLHGRADLLAEAVAYVEATHGPDAHLLSLGDAIDRGPQSLACAALLLDLHR
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHEEEHHHHHHCCHHHHHHHHHHHHHHC
QGRATLLMGNHERMAQEGLQWYRQYLSSRDLADYRRAMEGLSWWISNGGESVRREAGGLT
CCCEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCEE
LEAFPPALAEYLDTLERVVYVTADGELHQTPPQEPSVLVAHASPPVQHRQYPNPESAALW
EECCCHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCEEE
LRPFEGPFPLPEGVTYSVHGHTPVCNPVRLGRHVYLDLGAYETGRLALLTVNVTGRPEVT
EEECCCCCCCCCCCEEEEECCCCCCCHHHCCCEEEEEECCCCCCCEEEEEEEECCCCCEE
VLEGRGNPGAARRYPNFGEPLPTRTVSLTGRRP
EEECCCCCCHHCCCCCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9130712; 9097040; 9278503 [H]