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The map label for this gene is fdh [H]

Identifier: 94984149

GI number: 94984149

Start: 37477

End: 38694

Strand: Reverse

Name: fdh [H]

Synonym: Dgeo_0041

Alternate gene names: 94984149

Gene position: 38694-37477 (Counterclockwise)

Preceding gene: 94984150

Following gene: 94984148

Centisome position: 1.57

GC content: 66.34

Gene sequence:

>1218_bases
ATGAAGGCGCTGGTGTGGCAGGGCATCAACCGGGTGGGAGTGGAGCGCGTTCCCGATCCCACGATTCTCCAACCCACCGA
CGCCATCGTGCGCGTGACCGCGACCGCGATCTGCGGCTCGGACCTGCACCTGCTCGACGGCTACATCCCGAGCATGGTGA
AGGGCGACATCCTCGGGCACGAGTTCATGGGCGAGGTGGTGGAGGTCGGCTCCGCAGTCCGGCGCATCCGGGTCGGGGAC
CGGGTGATTGTGCCCTTTCCGATCGCCTGCGGCAAATGCTGGTACTGCCAGCACGGCCTGACCTCGCTGTGTGACAACTC
CAACCCCAACCCCAAGCTTGCGGAGACGCTGTGGGGCTACGCCGGCGCCGGCATCTACGGCTACTCGCACATCACAGGGG
GATACGCGGGCGGCCAAGCGCAGTTTGCCCGCACCGTCTACGCCGACGCCAACCTCTATCCGGTGCCCGAGGGCCTGACC
GACGAGCAGGTGCTCTTCCTGACCGACATCCTCCCCACCGGCTACATGGCCGCCGAACACAGCAACATCCAGCCGGGCGA
CGTGGTGACGGTATTTGGGGCAGGGCCAGTTGGCCTCTTCACGGTCATGAGCGCCTTCCTGCTGGGAGCAGGACGGGTGA
TCTCGATTGACCGCTTCGACGACCGCTTGAAGCTCGCGCGCCAGCTGGGCGCCGAGACGATCAACTACGAGGCGGACAAT
GTCTTTGAGCGCCTGAAGGAACTGACCGGCGGGCGTGGCCCCGACAGCGTAGTGGACGCGGTGGGCATGGAGTCGCACGG
CACCGGCCTAGGCGGCATCTACGACGCCGTCAAGCAGACCACCCGCGTGCTGGAAACAGAGCGCCCCCACGCCCTGCGCG
CCGCGATCATGGCCTGCCGCAAGGGAGGCACCGTCAGCGTGCCGGGAGTATACGGCGGCCTAGCGGACAAGATCCCAGTG
GGCGCCTTGATGAACAAGGGCCTTACCCTGCGCACCGGGCAAACCCACGTTCACCGCTATCTTGATACCCTGACCCAACA
CATCCTGCGCGGCGACATCGACCCCACCGTGATCATCACCCACCGCCTGAGCCTGGACGAGGCGCCGCGGGGCTACCAGC
TGTTCAAGCACAAGCACGACGGCTGCATCAAGTGTGTGCTCGACCCCTGGGCCGATCCCAAGGAGCACGCGCCGACGTCG
CCTCAGCCGGAGACCTGA

Upstream 100 bases:

>100_bases
TGGAGGTGGGGGAGCTGCCCACCACCGAGGGGCAGTCCAGCGGGCGCCAGACGCCGCTGGGCAAACTGGAGGCGAAGATG
TACGACAACGCGAGGACCTC

Downstream 100 bases:

>100_bases
GCTGATCCGGCCTGCTCCATGGCTCCGTGCCCGCCCGCAGCCCGCGCCCGCGCTACGCTGCCTGCATGACGGCGCTCCCC
TCTCCCGATCGGCCCCGCAT

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKALVWQGINRVGVERVPDPTILQPTDAIVRVTATAICGSDLHLLDGYIPSMVKGDILGHEFMGEVVEVGSAVRRIRVGD
RVIVPFPIACGKCWYCQHGLTSLCDNSNPNPKLAETLWGYAGAGIYGYSHITGGYAGGQAQFARTVYADANLYPVPEGLT
DEQVLFLTDILPTGYMAAEHSNIQPGDVVTVFGAGPVGLFTVMSAFLLGAGRVISIDRFDDRLKLARQLGAETINYEADN
VFERLKELTGGRGPDSVVDAVGMESHGTGLGGIYDAVKQTTRVLETERPHALRAAIMACRKGGTVSVPGVYGGLADKIPV
GALMNKGLTLRTGQTHVHRYLDTLTQHILRGDIDPTVIITHRLSLDEAPRGYQLFKHKHDGCIKCVLDPWADPKEHAPTS
PQPET

Sequences:

>Translated_405_residues
MKALVWQGINRVGVERVPDPTILQPTDAIVRVTATAICGSDLHLLDGYIPSMVKGDILGHEFMGEVVEVGSAVRRIRVGD
RVIVPFPIACGKCWYCQHGLTSLCDNSNPNPKLAETLWGYAGAGIYGYSHITGGYAGGQAQFARTVYADANLYPVPEGLT
DEQVLFLTDILPTGYMAAEHSNIQPGDVVTVFGAGPVGLFTVMSAFLLGAGRVISIDRFDDRLKLARQLGAETINYEADN
VFERLKELTGGRGPDSVVDAVGMESHGTGLGGIYDAVKQTTRVLETERPHALRAAIMACRKGGTVSVPGVYGGLADKIPV
GALMNKGLTLRTGQTHVHRYLDTLTQHILRGDIDPTVIITHRLSLDEAPRGYQLFKHKHDGCIKCVLDPWADPKEHAPTS
PQPET
>Mature_405_residues
MKALVWQGINRVGVERVPDPTILQPTDAIVRVTATAICGSDLHLLDGYIPSMVKGDILGHEFMGEVVEVGSAVRRIRVGD
RVIVPFPIACGKCWYCQHGLTSLCDNSNPNPKLAETLWGYAGAGIYGYSHITGGYAGGQAQFARTVYADANLYPVPEGLT
DEQVLFLTDILPTGYMAAEHSNIQPGDVVTVFGAGPVGLFTVMSAFLLGAGRVISIDRFDDRLKLARQLGAETINYEADN
VFERLKELTGGRGPDSVVDAVGMESHGTGLGGIYDAVKQTTRVLETERPHALRAAIMACRKGGTVSVPGVYGGLADKIPV
GALMNKGLTLRTGQTHVHRYLDTLTQHILRGDIDPTVIITHRLSLDEAPRGYQLFKHKHDGCIKCVLDPWADPKEHAPTS
PQPET

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=394, Percent_Identity=26.6497461928934, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI156523966, Length=372, Percent_Identity=25.8064516129032, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI34577061, Length=350, Percent_Identity=29.4285714285714, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4501933, Length=270, Percent_Identity=30.7407407407407, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI71565152, Length=274, Percent_Identity=29.5620437956204, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI4501929, Length=271, Percent_Identity=30.9963099630996, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=25.4847645429363, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI71743840, Length=257, Percent_Identity=27.2373540856031, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI262073058, Length=257, Percent_Identity=27.2373540856031, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786825, Length=401, Percent_Identity=44.139650872818, Blast_Score=325, Evalue=2e-90,
Organism=Escherichia coli, GI1788073, Length=366, Percent_Identity=25.9562841530055, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1787863, Length=393, Percent_Identity=24.4274809160305, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790045, Length=381, Percent_Identity=25.4593175853018, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082125, Length=256, Percent_Identity=29.6875, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788075, Length=251, Percent_Identity=29.4820717131474, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786552, Length=368, Percent_Identity=28.2608695652174, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87081918, Length=231, Percent_Identity=32.9004329004329, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI226510992, Length=373, Percent_Identity=23.8605898123324, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790718, Length=349, Percent_Identity=22.9226361031519, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788407, Length=244, Percent_Identity=28.2786885245902, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=268, Percent_Identity=32.089552238806, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=268, Percent_Identity=30.5970149253731, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI25146526, Length=369, Percent_Identity=26.8292682926829, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=397, Percent_Identity=25.6926952141058, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=378, Percent_Identity=25.9259259259259, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322619, Length=382, Percent_Identity=26.7015706806283, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=382, Percent_Identity=26.7015706806283, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=396, Percent_Identity=25.7575757575758, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=380, Percent_Identity=27.8947368421053, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=277, Percent_Identity=28.5198555956679, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=295, Percent_Identity=25.0847457627119, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=341, Percent_Identity=27.8592375366569, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=249, Percent_Identity=29.718875502008, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17137530, Length=268, Percent_Identity=31.7164179104478, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17737897, Length=268, Percent_Identity=28.7313432835821, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17737895, Length=366, Percent_Identity=27.8688524590164, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 43691; Mature: 43691

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVWQGINRVGVERVPDPTILQPTDAIVRVTATAICGSDLHLLDGYIPSMVKGDILGH
CCCHHHCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
EFMGEVVEVGSAVRRIRVGDRVIVPFPIACGKCWYCQHGLTSLCDNSNPNPKLAETLWGY
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
AGAGIYGYSHITGGYAGGQAQFARTVYADANLYPVPEGLTDEQVLFLTDILPTGYMAAEH
HCCCCCCHHHCCCCCCCCHHHHHHEEEECCCEEECCCCCCCCCEEEEEHHCCCCCEECCC
SNIQPGDVVTVFGAGPVGLFTVMSAFLLGAGRVISIDRFDDRLKLARQLGAETINYEADN
CCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCCCCHHH
VFERLKELTGGRGPDSVVDAVGMESHGTGLGGIYDAVKQTTRVLETERPHALRAAIMACR
HHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
KGGTVSVPGVYGGLADKIPVGALMNKGLTLRTGQTHVHRYLDTLTQHILRGDIDPTVIIT
CCCCEECCCHHCCCHHCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEE
HRLSLDEAPRGYQLFKHKHDGCIKCVLDPWADPKEHAPTSPQPET
EECCCCCCCCCHHHHHHCCCCEEEEEECCCCCCHHCCCCCCCCCC
>Mature Secondary Structure
MKALVWQGINRVGVERVPDPTILQPTDAIVRVTATAICGSDLHLLDGYIPSMVKGDILGH
CCCHHHCCHHHHCCCCCCCCCEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
EFMGEVVEVGSAVRRIRVGDRVIVPFPIACGKCWYCQHGLTSLCDNSNPNPKLAETLWGY
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
AGAGIYGYSHITGGYAGGQAQFARTVYADANLYPVPEGLTDEQVLFLTDILPTGYMAAEH
HCCCCCCHHHCCCCCCCCHHHHHHEEEECCCEEECCCCCCCCCEEEEEHHCCCCCEECCC
SNIQPGDVVTVFGAGPVGLFTVMSAFLLGAGRVISIDRFDDRLKLARQLGAETINYEADN
CCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCCCCHHH
VFERLKELTGGRGPDSVVDAVGMESHGTGLGGIYDAVKQTTRVLETERPHALRAAIMACR
HHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
KGGTVSVPGVYGGLADKIPVGALMNKGLTLRTGQTHVHRYLDTLTQHILRGDIDPTVIIT
CCCCEECCCHHCCCHHCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEE
HRLSLDEAPRGYQLFKHKHDGCIKCVLDPWADPKEHAPTSPQPET
EECCCCCCCCCHHHHHHCCCCEEEEEECCCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]