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The map label for this gene is phoP [H]

Identifier: 94972066

GI number: 94972066

Start: 456961

End: 457365

Strand: Direct

Name: phoP [H]

Synonym: Dgeo_2598

Alternate gene names: 94972066

Gene position: 456961-457365 (Clockwise)

Preceding gene: 94972076

Following gene: 94972065

Centisome position: 79.59

GC content: 62.22

Gene sequence:

>405_bases
ATGTACCTGGACTTTGGCGTGGACGACTATGTGGTCAAGCCCTTCAGTCCGCGTGAAGTTGTGGCGCGGGTGCGGGCCTT
ACTGCGGCGCGTGGGCGTACAGGAAGAAATCGCCGTGGGTGATCTCCGCATTGACCTGCGGGGCCACTCCGCCAGCCTCA
GCGGTGAACGACTGGAACTCTCCAAACTCGAATTCGATCTGCTCAGCGCCCTGGCCCAGCACCCCGGCATGGCCTGGCCG
CGTGAACGCCTGCTGGAACGGGTCTGGGGTAGTGACTTTCCCGGCACCGAGCGCGTGGTGGACGTGCATATTACGGGGCT
TCGCAAGAAACTGGGGGACACCAGCGACACACCGCGTTTTATTGAGACAGTACGCGGTGTGGGCTACCGCTTCCGGGAAG
AATAG

Upstream 100 bases:

>100_bases
CCTCCCCACTCGGACAGCGTGGCTTTGGCACACGTCAGAGAACCCACGCCAGAGAAACGGTGCGGCCAGCGCCGCCCACA
GCCTAACTATTTCGACATCT

Downstream 100 bases:

>100_bases
GTCATGCGTTTCTTCCCAAGGCTGCTGCTCTCACACTTGCTGGTGATCCTGCTGGCGGTACTGGGCATGTTTCTCTCTGC
GGAACTGGTTGCCCCGAACT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MYLDFGVDDYVVKPFSPREVVARVRALLRRVGVQEEIAVGDLRIDLRGHSASLSGERLELSKLEFDLLSALAQHPGMAWP
RERLLERVWGSDFPGTERVVDVHITGLRKKLGDTSDTPRFIETVRGVGYRFREE

Sequences:

>Translated_134_residues
MYLDFGVDDYVVKPFSPREVVARVRALLRRVGVQEEIAVGDLRIDLRGHSASLSGERLELSKLEFDLLSALAQHPGMAWP
RERLLERVWGSDFPGTERVVDVHITGLRKKLGDTSDTPRFIETVRGVGYRFREE
>Mature_134_residues
MYLDFGVDDYVVKPFSPREVVARVRALLRRVGVQEEIAVGDLRIDLRGHSASLSGERLELSKLEFDLLSALAQHPGMAWP
RERLLERVWGSDFPGTERVVDVHITGLRKKLGDTSDTPRFIETVRGVGYRFREE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=132, Percent_Identity=43.9393939393939, Blast_Score=107, Evalue=3e-25,
Organism=Escherichia coli, GI1788394, Length=133, Percent_Identity=43.609022556391, Blast_Score=101, Evalue=2e-23,
Organism=Escherichia coli, GI1786784, Length=130, Percent_Identity=41.5384615384615, Blast_Score=99, Evalue=1e-22,
Organism=Escherichia coli, GI2367329, Length=137, Percent_Identity=40.8759124087591, Blast_Score=94, Evalue=3e-21,
Organism=Escherichia coli, GI1790860, Length=134, Percent_Identity=41.7910447761194, Blast_Score=94, Evalue=3e-21,
Organism=Escherichia coli, GI1789809, Length=138, Percent_Identity=38.4057971014493, Blast_Score=94, Evalue=3e-21,
Organism=Escherichia coli, GI87082012, Length=130, Percent_Identity=40, Blast_Score=87, Evalue=4e-19,
Organism=Escherichia coli, GI1790863, Length=140, Percent_Identity=36.4285714285714, Blast_Score=82, Evalue=1e-17,
Organism=Escherichia coli, GI1789402, Length=134, Percent_Identity=40.2985074626866, Blast_Score=81, Evalue=2e-17,
Organism=Escherichia coli, GI1790552, Length=131, Percent_Identity=39.6946564885496, Blast_Score=81, Evalue=3e-17,
Organism=Escherichia coli, GI1786911, Length=133, Percent_Identity=33.0827067669173, Blast_Score=72, Evalue=1e-14,
Organism=Escherichia coli, GI145693140, Length=146, Percent_Identity=33.5616438356164, Blast_Score=67, Evalue=3e-13,
Organism=Escherichia coli, GI1787375, Length=132, Percent_Identity=31.8181818181818, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1787229, Length=141, Percent_Identity=34.7517730496454, Blast_Score=59, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 15279; Mature: 15279

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLDFGVDDYVVKPFSPREVVARVRALLRRVGVQEEIAVGDLRIDLRGHSASLSGERLEL
CEECCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCEEECEEEEEECCCCCCCCCCCHHH
SKLEFDLLSALAQHPGMAWPRERLLERVWGSDFPGTERVVDVHITGLRKKLGDTSDTPRF
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHCCCCCCCHHH
IETVRGVGYRFREE
HHHHHHCCCCCCCC
>Mature Secondary Structure
MYLDFGVDDYVVKPFSPREVVARVRALLRRVGVQEEIAVGDLRIDLRGHSASLSGERLEL
CEECCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCEEECEEEEEECCCCCCCCCCCHHH
SKLEFDLLSALAQHPGMAWPRERLLERVWGSDFPGTERVVDVHITGLRKKLGDTSDTPRF
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHCCCCCCCHHH
IETVRGVGYRFREE
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]