Click here to switch to the map view.

The map label for this gene is copA [H]

Identifier: 94972026

GI number: 94972026

Start: 494058

End: 495431

Strand: Direct

Name: copA [H]

Synonym: Dgeo_2558

Alternate gene names: 94972026

Gene position: 494058-495431 (Clockwise)

Preceding gene: 94972027

Following gene: 94972025

Centisome position: 86.05

GC content: 65.72

Gene sequence:

>1374_bases
ATGAACGACCATAACGGCTCACAGCAGCCTTCCTCACCGCACGGCGAGATGGACATGACGCCGAAGGTGTCGCGTCCCCA
GATCGCCGCCGTGACCATCCTCAGTGTGCTGGCGCTGGCGGCGGGCGTCGGCCTGGCGGCCCAGTTTGGCGACCTGAGCA
TGAGCGCCCGCAACACGCAGGCGCAGGGCGGGCAGAACATGTCCGGGATGGATATGAACAGCAACGCGTCTTCCGACACG
ATGTCCGGGATGGCGATGGGCGGCGGGGCGCCCTCCGGCGGCACGGGGAACCAAAGCATGCCGGGCATGAACATGGGCAC
GTCCGCCAGCAGCCCCACCCCGGTCAGCCAGTTGCCCGAAACCCCCCTTCAGACCCCCACACGGATGGGGAACCTGGTGA
TGCCGCCCGGGATGATCATGACCCGGGGGATGCCGATGGAAGCGATGCAGGACATGGCGGCCGTGGAGCTCTCGCAGGTC
CGCTTCACCGCGCCCGCCGCGGCGCGGGGTGACCAGCCGCTCGCGCCGCAGGTGGTGAATGGCGTCAAGGTCTTCAACTT
CGAGACCTCGGTGATCCGCTGGAATATCCTGCCGGACGTGCAGGTGGCGGCCTACGCGGTGAACCGCCAGGTGCCGGGAC
CCCGGCTGGAACTCACCCAGGGTGACCGGGTGCGCATCAACGTGAAGAACAGCCTGCCTGAACCCACCACCATCCACTGG
CACGGCCTGATCGTGCCGAACGGCATGGACGGCGCCGCGGACGTCACCCAGAAGCCGATCGCTCCCGGTCAGACCTTCAC
GTACGAGTTCACGGTGCAGCAGGCGGGCACGTACTTCTACCACTCCCACAAGAACCCTGACCGCCAGCAGGGCCTGGGCC
TGTACGGCGCGCTGCTGGTGAAGCCGAAGGACCCCGCCCGCGAACCCAAAGCGGACCTCGACTACACCGTGCAGTTGCAG
GAGTGGTTGCAGCGGGACGGCTACACCTTCCCAGCGATGATCATGGAGGGCGCGCTGCCCAACTTCTTCACCATCAACGG
CAAGGCTTACCCCGCGACAGACACCATCCGCATGAAGATCGGGCAGACGGTAAAGCTGCGCTTCATCGGCAGCAACAACA
ACTTCGTACACCCGATGCATGTCCACGGTGGCCCCTTCGAGGTGGTCGCACGCGACGGCGAGACGCTCAAGGAAAGCGCG
CGCTTCCTGGCCGACACGGTGAATGTCGGTCCGGGGCAGCGCTACGACGTGATCTGGAAGGCGCGCGAGAAGGGCACCTG
GCTGATTCACTGCCACATCCCGCACCACATCACCAACGACAACGTGGAAGTTGAGGGCGGTGGTGGGCTGACGATGCTGA
TCCAGGTGAGCTGA

Upstream 100 bases:

>100_bases
CACAGCCTCGCCGCAGAGGAACGGCTGATCGAGCACACCACCGGCGAAGTCCCTGCGCCGAACGCCTCCACCGCCCACCA
CACCATGAAAGGAATGTGAC

Downstream 100 bases:

>100_bases
AGGTGCTCGCACGCCCTTTGCGCGGAAAGGATCAAGCCTGCCCCCGCTGTTGAGAAGCGTCGCGGGCAAGCCCGAAGACC
CAGCCCGCAAAGCAGCGCAT

Product: multicopper oxidase, type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MNDHNGSQQPSSPHGEMDMTPKVSRPQIAAVTILSVLALAAGVGLAAQFGDLSMSARNTQAQGGQNMSGMDMNSNASSDT
MSGMAMGGGAPSGGTGNQSMPGMNMGTSASSPTPVSQLPETPLQTPTRMGNLVMPPGMIMTRGMPMEAMQDMAAVELSQV
RFTAPAAARGDQPLAPQVVNGVKVFNFETSVIRWNILPDVQVAAYAVNRQVPGPRLELTQGDRVRINVKNSLPEPTTIHW
HGLIVPNGMDGAADVTQKPIAPGQTFTYEFTVQQAGTYFYHSHKNPDRQQGLGLYGALLVKPKDPAREPKADLDYTVQLQ
EWLQRDGYTFPAMIMEGALPNFFTINGKAYPATDTIRMKIGQTVKLRFIGSNNNFVHPMHVHGGPFEVVARDGETLKESA
RFLADTVNVGPGQRYDVIWKAREKGTWLIHCHIPHHITNDNVEVEGGGGLTMLIQVS

Sequences:

>Translated_457_residues
MNDHNGSQQPSSPHGEMDMTPKVSRPQIAAVTILSVLALAAGVGLAAQFGDLSMSARNTQAQGGQNMSGMDMNSNASSDT
MSGMAMGGGAPSGGTGNQSMPGMNMGTSASSPTPVSQLPETPLQTPTRMGNLVMPPGMIMTRGMPMEAMQDMAAVELSQV
RFTAPAAARGDQPLAPQVVNGVKVFNFETSVIRWNILPDVQVAAYAVNRQVPGPRLELTQGDRVRINVKNSLPEPTTIHW
HGLIVPNGMDGAADVTQKPIAPGQTFTYEFTVQQAGTYFYHSHKNPDRQQGLGLYGALLVKPKDPAREPKADLDYTVQLQ
EWLQRDGYTFPAMIMEGALPNFFTINGKAYPATDTIRMKIGQTVKLRFIGSNNNFVHPMHVHGGPFEVVARDGETLKESA
RFLADTVNVGPGQRYDVIWKAREKGTWLIHCHIPHHITNDNVEVEGGGGLTMLIQVS
>Mature_457_residues
MNDHNGSQQPSSPHGEMDMTPKVSRPQIAAVTILSVLALAAGVGLAAQFGDLSMSARNTQAQGGQNMSGMDMNSNASSDT
MSGMAMGGGAPSGGTGNQSMPGMNMGTSASSPTPVSQLPETPLQTPTRMGNLVMPPGMIMTRGMPMEAMQDMAAVELSQV
RFTAPAAARGDQPLAPQVVNGVKVFNFETSVIRWNILPDVQVAAYAVNRQVPGPRLELTQGDRVRINVKNSLPEPTTIHW
HGLIVPNGMDGAADVTQKPIAPGQTFTYEFTVQQAGTYFYHSHKNPDRQQGLGLYGALLVKPKDPAREPKADLDYTVQLQ
EWLQRDGYTFPAMIMEGALPNFFTINGKAYPATDTIRMKIGQTVKLRFIGSNNNFVHPMHVHGGPFEVVARDGETLKESA
RFLADTVNVGPGQRYDVIWKAREKGTWLIHCHIPHHITNDNVEVEGGGGLTMLIQVS

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=227, Percent_Identity=27.3127753303965, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6321067, Length=233, Percent_Identity=28.3261802575107, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323703, Length=124, Percent_Identity=39.5161290322581, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24650186, Length=242, Percent_Identity=30.5785123966942, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574104, Length=156, Percent_Identity=37.1794871794872, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI18859919, Length=144, Percent_Identity=38.8888888888889, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281360167, Length=249, Percent_Identity=30.9236947791165, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24585842, Length=249, Percent_Identity=30.9236947791165, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221330000, Length=249, Percent_Identity=30.9236947791165, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221329998, Length=249, Percent_Identity=30.9236947791165, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 49269; Mature: 49269

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDHNGSQQPSSPHGEMDMTPKVSRPQIAAVTILSVLALAAGVGLAAQFGDLSMSARNTQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCEECCCCCC
AQGGQNMSGMDMNSNASSDTMSGMAMGGGAPSGGTGNQSMPGMNMGTSASSPTPVSQLPE
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCC
TPLQTPTRMGNLVMPPGMIMTRGMPMEAMQDMAAVELSQVRFTAPAAARGDQPLAPQVVN
CCCCCCHHCCCEECCCCCEEECCCCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHC
GVKVFNFETSVIRWNILPDVQVAAYAVNRQVPGPRLELTQGDRVRINVKNSLPEPTTIHW
CEEEEEEEEEEEEEECCCCCEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCEEEE
HGLIVPNGMDGAADVTQKPIAPGQTFTYEFTVQQAGTYFYHSHKNPDRQQGLGLYGALLV
EEEEEECCCCCCCHHHCCCCCCCCEEEEEEEEECCCEEEEECCCCCCHHHCCCEEEEEEE
KPKDPAREPKADLDYTVQLQEWLQRDGYTFPAMIMEGALPNFFTINGKAYPATDTIRMKI
CCCCCCCCCCCCCCEEEEHHHHHHHCCCCCHHHHHHCCCCCEEEECCEEECCCCEEEEEE
GQTVKLRFIGSNNNFVHPMHVHGGPFEVVARDGETLKESARFLADTVNVGPGQRYDVIWK
CCEEEEEEEECCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEE
AREKGTWLIHCHIPHHITNDNVEVEGGGGLTMLIQVS
ECCCCEEEEEEECCCCCCCCCEEEECCCCEEEEEEEC
>Mature Secondary Structure
MNDHNGSQQPSSPHGEMDMTPKVSRPQIAAVTILSVLALAAGVGLAAQFGDLSMSARNTQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCEECCCCCC
AQGGQNMSGMDMNSNASSDTMSGMAMGGGAPSGGTGNQSMPGMNMGTSASSPTPVSQLPE
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCC
TPLQTPTRMGNLVMPPGMIMTRGMPMEAMQDMAAVELSQVRFTAPAAARGDQPLAPQVVN
CCCCCCHHCCCEECCCCCEEECCCCHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHC
GVKVFNFETSVIRWNILPDVQVAAYAVNRQVPGPRLELTQGDRVRINVKNSLPEPTTIHW
CEEEEEEEEEEEEEECCCCCEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCEEEE
HGLIVPNGMDGAADVTQKPIAPGQTFTYEFTVQQAGTYFYHSHKNPDRQQGLGLYGALLV
EEEEEECCCCCCCHHHCCCCCCCCEEEEEEEEECCCEEEEECCCCCCHHHCCCEEEEEEE
KPKDPAREPKADLDYTVQLQEWLQRDGYTFPAMIMEGALPNFFTINGKAYPATDTIRMKI
CCCCCCCCCCCCCCEEEEHHHHHHHCCCCCHHHHHHCCCCCEEEECCEEECCCCEEEEEE
GQTVKLRFIGSNNNFVHPMHVHGGPFEVVARDGETLKESARFLADTVNVGPGQRYDVIWK
CCEEEEEEEECCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEE
AREKGTWLIHCHIPHHITNDNVEVEGGGGLTMLIQVS
ECCCCEEEEEEECCCCCCCCCEEEECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]