Click here to switch to the map view.

The map label for this gene is norM [H]

Identifier: 94972010

GI number: 94972010

Start: 505665

End: 507044

Strand: Direct

Name: norM [H]

Synonym: Dgeo_2542

Alternate gene names: 94972010

Gene position: 505665-507044 (Clockwise)

Preceding gene: 94972011

Following gene: 94972009

Centisome position: 88.08

GC content: 69.42

Gene sequence:

>1380_bases
ATGAGGAACGAACTGGAGCGCAACGAGGCGGGCCGGGTGAACAGCCCTCAGGAGGCTGCGCGCTCCGTTTCCGTGACGCG
GGACCTGCTGCTCCTCGCCTGGCCTGCCATCACGGAGAACTTGCTCCAGAGCGCGATGGGCTTCGCGGACAGCTTCTTCG
TGTCCCGGCTGGGCCTGGAAGCCGTCGCTGCTGTGGGCGTCTCCAACGCGCTGCTTCAGGTGTTCTTCGCGGTCTTCCTT
GCCGTTGCCACCGCCTCCGGCACGTTCAGCGCCCGCGCGACCGGCGCCAAGGATGCCGCCGCGGTCCAGCGGGCGACGGT
GCAGGCGTTGTGGCTGGCCGCCCTCGTCGGGCTGATCTGTGGCCTCCTCGCCCTGGTGCTGGCGGGGCCACTGCTCACCG
TGATGGGGGCCGCGCCGGAAGTCCGCGCTGCTGGGGAAACCTACTTCCGCATCGTGGCCGTGCCCTCAGTGGTCATCGCC
GTGATGTCTACCGCAGGCGCGGTGTTGCGGGGGGCCGGGGATACGCGGGCGGCCTTGAGGGCGGGCCTGTGGATGAATGC
CGCCCATGTCGTGCTGGACCCGCTCCTGATCTTTGGCCTGGGGTTTAGCGGCCTGGGCCTCGTGGGCGCGGGCGTGGCGA
CGGTCCTCGCGCGGTTGCTGGGGGCAGGACTGCTGCTGGCACGGCTCCGACGGGCCGGGACGCTGCCGTCCTCGTGGCGT
GGGGCCGGGCCGGACTGGGGCCTCATGCGCCGCATGTCGCGTCTGAGTGTTCCAACTGCCCTGGAACGGTTGGCGATGCG
CTTCGGGCAGATCGTGTATTTCGGGCTGATCCTGCGGCTGGGTACCGAGGTCTACGCCGCCCATACCCTGACCGGGAACT
TCACGCTGTTCGCCTCGGTGGCGGGAACCGGCCTCGCGGCAGCCATCAGCGCGCGGGTCGGGCAGCGGCTCGGCGCGGGC
GACGAGGGCGAGGCACGGCGCTATGCCCTGTCCGGCATCTGGGTGTCGTCCGTCTTGATGACGGCCCTCGCCCTGCTCGC
CTGGGTGGCGTCGTTCTGGGGCGCGAGTCTCTTCACAAGTGACGCGCGAGTCGTGGCCTTGATCGTGCTGGCCCTGGGCA
TCGACGTCCTGACGCAACCGGCAACGGGAGTGGTCACAGCCTTGACAGCGACCCTGCAAGCCGGTGGCGATACCCGCTTT
CCCATGTGGACCACGCTGGTCGGCATCTGGGGCGTGAGGACGGTCGGCGTGTATTTGCTGGGAGTCCGCTGGGGACTTGG
CCTCGCCGGGGTCTGGCTGGCCATTCTGCTGGACAACTCCCTTCGGGCATTCGCGCTCTGGCTCCGTTACCGCTCGGGGC
GCTGGATTCAGGGTCTCTGA

Upstream 100 bases:

>100_bases
AGCGTCGTTGGGGCCGTGGTGATCGTCCTGCTGTGGCTGGTCGTGGTTGGGCTGGTCGGCAGATACGTCTGGTGGAGACT
CCGGCCTTGACGGTCCAAGT

Downstream 100 bases:

>100_bases
TGTTATACCCCAACACTACCTTTGGAAGGGACAATCACCGCTTATGACGCTTCTTCGCTCGCTCGTTGCCCGCTTCCCGT
GGTTGATCGCGCTGCTGCTG

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MRNELERNEAGRVNSPQEAARSVSVTRDLLLLAWPAITENLLQSAMGFADSFFVSRLGLEAVAAVGVSNALLQVFFAVFL
AVATASGTFSARATGAKDAAAVQRATVQALWLAALVGLICGLLALVLAGPLLTVMGAAPEVRAAGETYFRIVAVPSVVIA
VMSTAGAVLRGAGDTRAALRAGLWMNAAHVVLDPLLIFGLGFSGLGLVGAGVATVLARLLGAGLLLARLRRAGTLPSSWR
GAGPDWGLMRRMSRLSVPTALERLAMRFGQIVYFGLILRLGTEVYAAHTLTGNFTLFASVAGTGLAAAISARVGQRLGAG
DEGEARRYALSGIWVSSVLMTALALLAWVASFWGASLFTSDARVVALIVLALGIDVLTQPATGVVTALTATLQAGGDTRF
PMWTTLVGIWGVRTVGVYLLGVRWGLGLAGVWLAILLDNSLRAFALWLRYRSGRWIQGL

Sequences:

>Translated_459_residues
MRNELERNEAGRVNSPQEAARSVSVTRDLLLLAWPAITENLLQSAMGFADSFFVSRLGLEAVAAVGVSNALLQVFFAVFL
AVATASGTFSARATGAKDAAAVQRATVQALWLAALVGLICGLLALVLAGPLLTVMGAAPEVRAAGETYFRIVAVPSVVIA
VMSTAGAVLRGAGDTRAALRAGLWMNAAHVVLDPLLIFGLGFSGLGLVGAGVATVLARLLGAGLLLARLRRAGTLPSSWR
GAGPDWGLMRRMSRLSVPTALERLAMRFGQIVYFGLILRLGTEVYAAHTLTGNFTLFASVAGTGLAAAISARVGQRLGAG
DEGEARRYALSGIWVSSVLMTALALLAWVASFWGASLFTSDARVVALIVLALGIDVLTQPATGVVTALTATLQAGGDTRF
PMWTTLVGIWGVRTVGVYLLGVRWGLGLAGVWLAILLDNSLRAFALWLRYRSGRWIQGL
>Mature_459_residues
MRNELERNEAGRVNSPQEAARSVSVTRDLLLLAWPAITENLLQSAMGFADSFFVSRLGLEAVAAVGVSNALLQVFFAVFL
AVATASGTFSARATGAKDAAAVQRATVQALWLAALVGLICGLLALVLAGPLLTVMGAAPEVRAAGETYFRIVAVPSVVIA
VMSTAGAVLRGAGDTRAALRAGLWMNAAHVVLDPLLIFGLGFSGLGLVGAGVATVLARLLGAGLLLARLRRAGTLPSSWR
GAGPDWGLMRRMSRLSVPTALERLAMRFGQIVYFGLILRLGTEVYAAHTLTGNFTLFASVAGTGLAAAISARVGQRLGAG
DEGEARRYALSGIWVSSVLMTALALLAWVASFWGASLFTSDARVVALIVLALGIDVLTQPATGVVTALTATLQAGGDTRF
PMWTTLVGIWGVRTVGVYLLGVRWGLGLAGVWLAILLDNSLRAFALWLRYRSGRWIQGL

Specific function: Multidrug efflux pump [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=451, Percent_Identity=27.0509977827051, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI48994890, Length=448, Percent_Identity=25.8928571428571, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48025; Mature: 48025

Theoretical pI: Translated: 11.73; Mature: 11.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNELERNEAGRVNSPQEAARSVSVTRDLLLLAWPAITENLLQSAMGFADSFFVSRLGLE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVAAVGVSNALLQVFFAVFLAVATASGTFSARATGAKDAAAVQRATVQALWLAALVGLIC
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GLLALVLAGPLLTVMGAAPEVRAAGETYFRIVAVPSVVIAVMSTAGAVLRGAGDTRAALR
HHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AGLWMNAAHVVLDPLLIFGLGFSGLGLVGAGVATVLARLLGAGLLLARLRRAGTLPSSWR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GAGPDWGLMRRMSRLSVPTALERLAMRFGQIVYFGLILRLGTEVYAAHTLTGNFTLFASV
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEHH
AGTGLAAAISARVGQRLGAGDEGEARRYALSGIWVSSVLMTALALLAWVASFWGASLFTS
HCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCC
DARVVALIVLALGIDVLTQPATGVVTALTATLQAGGDTRFPMWTTLVGIWGVRTVGVYLL
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
GVRWGLGLAGVWLAILLDNSLRAFALWLRYRSGRWIQGL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRNELERNEAGRVNSPQEAARSVSVTRDLLLLAWPAITENLLQSAMGFADSFFVSRLGLE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVAAVGVSNALLQVFFAVFLAVATASGTFSARATGAKDAAAVQRATVQALWLAALVGLIC
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GLLALVLAGPLLTVMGAAPEVRAAGETYFRIVAVPSVVIAVMSTAGAVLRGAGDTRAALR
HHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AGLWMNAAHVVLDPLLIFGLGFSGLGLVGAGVATVLARLLGAGLLLARLRRAGTLPSSWR
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GAGPDWGLMRRMSRLSVPTALERLAMRFGQIVYFGLILRLGTEVYAAHTLTGNFTLFASV
CCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEHH
AGTGLAAAISARVGQRLGAGDEGEARRYALSGIWVSSVLMTALALLAWVASFWGASLFTS
HCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCC
DARVVALIVLALGIDVLTQPATGVVTALTATLQAGGDTRFPMWTTLVGIWGVRTVGVYLL
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
GVRWGLGLAGVWLAILLDNSLRAFALWLRYRSGRWIQGL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]