BacMap

Definition	Cupriavidus metallidurans CH34 megaplasmid, complete sequence.
Accession	NC_007974
Length	2,580,084

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The map label for this gene is fabG [H]

Identifier: 94314744

GI number: 94314744

Start: 12014

End: 12910

Strand: Reverse

Name: fabG [H]

Synonym: Rmet_5825

Alternate gene names: 94314744

Gene position: 12910-12014 (Counterclockwise)

Preceding gene: 94314745

Following gene: 94314743

Centisome position: 0.5

GC content: 62.76

Gene sequence:

>897_bases
GTGAAGGCCCGCCGAGTATCGACACACAGCACTGAAAACAAGACGACTAGAACGAAGGAGACACGAAGCATGAGCAAACT
GACCAACAAGGTAGCGATCGTATCGGGCTCCGGCCGGGGCATCGGCCGCGAGATCGCGCTGAAGCTGGCAAGCGAAGGGG
CGGCGGTTGTCGTCAACGATCTTGACGCGGAACCGGCCGAGGCCGTGGTCCGCGAGATCACCACGATGGGCGGCCGGGCC
GTAGCCTGCGTGGGCAGCGTGACCGAGGCCGACTTCGGCACGCGCTTCGTGGGTACCGCATTGCAGACTTTTGGCGGGCT
CGACATCATCGTCAACAACGCCGGCTATACGTGGGACAACGTGATCCAGAAAATGACCGACGACCAGTGGTCGGCCATCA
TGGATGTGCACGTCACTGCGCCGTTCCGCATTCTGCGCGCTGCGGCGGACTACTTCCGCGAGACCTCGAAGCAGGAAGCC
GAGCAAGGCCGCGAAGTATTCCGCAAGGTGGTGAACATCTCCTCGGCCTCGGGCGTGATAGGCAATGCCGGCCAAGCCAA
CTATTCGGCGGGCAAGGCTGCCATCAACGGCCTGACCAAGGCGCTGGCCAAGGAGTGGGGACGCTACAAGGTCAACGTCA
ACAGCGTCGCGTTCGGCCTGATCAAGACGCGCCTGACCGAGGCCGTAGCAGGCGAAGGCCATGCCACCATCGACATCGCT
GGCAATGAAATCAAGGTGGGCGTGAATCCGCAGCTCATGAAGAACATCGAGGCCACGATTCCGCTGGGCCGTGGCGGCAC
GCCCGCCGAAGCCGCCGGCTCCGTCTACCTGCTTTGCATTCCGGAATCCAACTACATCACGGGTCAGGTGCTTGTGGTGG
GTGGCGGCCGTCCCTGA

Upstream 100 bases:

>100_bases
GCGGCGAAGCAGGCGACCGGCAGGTAGCCGGCGCGCGCCTGGCACTGCAGCACAACCTGGGTCTGGGCGGCGCGTGCGTG
GTCACGCTGTACCAGCGCCA

Downstream 100 bases:

>100_bases
ACGGAAGGAGACCGAGATGGATAACGCAAGACGCCGCGCGCTGCGCCGGCTAGGCTGGGGCATGGCGGGCGTGGCCGGCA
TGCAGATTGCGCTGCCCAGC

Product: 3-oxoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MKARRVSTHSTENKTTRTKETRSMSKLTNKVAIVSGSGRGIGREIALKLASEGAAVVVNDLDAEPAEAVVREITTMGGRA
VACVGSVTEADFGTRFVGTALQTFGGLDIIVNNAGYTWDNVIQKMTDDQWSAIMDVHVTAPFRILRAAADYFRETSKQEA
EQGREVFRKVVNISSASGVIGNAGQANYSAGKAAINGLTKALAKEWGRYKVNVNSVAFGLIKTRLTEAVAGEGHATIDIA
GNEIKVGVNPQLMKNIEATIPLGRGGTPAEAAGSVYLLCIPESNYITGQVLVVGGGRP

Sequences:

>Translated_298_residues
MKARRVSTHSTENKTTRTKETRSMSKLTNKVAIVSGSGRGIGREIALKLASEGAAVVVNDLDAEPAEAVVREITTMGGRA
VACVGSVTEADFGTRFVGTALQTFGGLDIIVNNAGYTWDNVIQKMTDDQWSAIMDVHVTAPFRILRAAADYFRETSKQEA
EQGREVFRKVVNISSASGVIGNAGQANYSAGKAAINGLTKALAKEWGRYKVNVNSVAFGLIKTRLTEAVAGEGHATIDIA
GNEIKVGVNPQLMKNIEATIPLGRGGTPAEAAGSVYLLCIPESNYITGQVLVVGGGRP
>Mature_298_residues
MKARRVSTHSTENKTTRTKETRSMSKLTNKVAIVSGSGRGIGREIALKLASEGAAVVVNDLDAEPAEAVVREITTMGGRA
VACVGSVTEADFGTRFVGTALQTFGGLDIIVNNAGYTWDNVIQKMTDDQWSAIMDVHVTAPFRILRAAADYFRETSKQEA
EQGREVFRKVVNISSASGVIGNAGQANYSAGKAAINGLTKALAKEWGRYKVNVNSVAFGLIKTRLTEAVAGEGHATIDIA
GNEIKVGVNPQLMKNIEATIPLGRGGTPAEAAGSVYLLCIPESNYITGQVLVVGGGRP

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=216, Percent_Identity=37.037037037037, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI15277342, Length=281, Percent_Identity=31.6725978647687, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI32483357, Length=276, Percent_Identity=31.8840579710145, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI40254992, Length=271, Percent_Identity=32.1033210332103, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI5031737, Length=270, Percent_Identity=29.2592592592593, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI59889578, Length=257, Percent_Identity=31.9066147859922, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI126723750, Length=282, Percent_Identity=27.6595744680851, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI10190704, Length=272, Percent_Identity=28.6764705882353, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI19923817, Length=277, Percent_Identity=24.9097472924188, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI126723191, Length=232, Percent_Identity=29.3103448275862, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI33667109, Length=204, Percent_Identity=30.3921568627451, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI32455239, Length=214, Percent_Identity=28.9719626168224, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI5031765, Length=214, Percent_Identity=28.9719626168224, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4758504, Length=276, Percent_Identity=28.2608695652174, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI20149619, Length=219, Percent_Identity=26.9406392694064, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4503301, Length=256, Percent_Identity=25.390625, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=267, Percent_Identity=34.0823970037453, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1789208, Length=274, Percent_Identity=28.1021897810219, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788459, Length=273, Percent_Identity=32.967032967033, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082160, Length=271, Percent_Identity=29.1512915129151, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790717, Length=274, Percent_Identity=28.1021897810219, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1787905, Length=275, Percent_Identity=29.0909090909091, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082100, Length=275, Percent_Identity=27.6363636363636, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI2367175, Length=270, Percent_Identity=28.8888888888889, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789378, Length=275, Percent_Identity=28.7272727272727, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1789057, Length=273, Percent_Identity=26.7399267399267, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI2367365, Length=273, Percent_Identity=25.6410256410256, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=216, Percent_Identity=40.2777777777778, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25147288, Length=271, Percent_Identity=33.9483394833948, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17555706, Length=270, Percent_Identity=31.1111111111111, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17562910, Length=279, Percent_Identity=31.1827956989247, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17561402, Length=274, Percent_Identity=28.1021897810219, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17544670, Length=286, Percent_Identity=27.6223776223776, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562906, Length=282, Percent_Identity=31.2056737588652, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=273, Percent_Identity=27.8388278388278, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562908, Length=281, Percent_Identity=30.2491103202847, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=281, Percent_Identity=27.7580071174377, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI72000259, Length=287, Percent_Identity=31.0104529616725, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=286, Percent_Identity=29.3706293706294, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=282, Percent_Identity=28.3687943262411, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=287, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=279, Percent_Identity=28.673835125448, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=279, Percent_Identity=29.3906810035842, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=278, Percent_Identity=28.0575539568345, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=271, Percent_Identity=27.6752767527675, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=280, Percent_Identity=26.4285714285714, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=289, Percent_Identity=27.3356401384083, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=282, Percent_Identity=28.7234042553192, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=271, Percent_Identity=27.6752767527675, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=271, Percent_Identity=25.830258302583, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=280, Percent_Identity=26.0714285714286, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=277, Percent_Identity=27.0758122743682, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=280, Percent_Identity=26.0714285714286, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=268, Percent_Identity=26.865671641791, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=205, Percent_Identity=31.219512195122, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=262, Percent_Identity=25.9541984732824, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=275, Percent_Identity=25.8181818181818, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=212, Percent_Identity=39.622641509434, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI18859837, Length=240, Percent_Identity=35.4166666666667, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24639444, Length=276, Percent_Identity=31.5217391304348, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21355319, Length=276, Percent_Identity=29.7101449275362, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI23397609, Length=272, Percent_Identity=29.7794117647059, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24644339, Length=269, Percent_Identity=26.3940520446097, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17737361, Length=280, Percent_Identity=27.1428571428571, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28571526, Length=277, Percent_Identity=26.3537906137184, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357041, Length=275, Percent_Identity=25.0909090909091, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640492, Length=182, Percent_Identity=25.8241758241758, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281364892, Length=177, Percent_Identity=25.9887005649718, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 31455; Mature: 31455

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKARRVSTHSTENKTTRTKETRSMSKLTNKVAIVSGSGRGIGREIALKLASEGAAVVVND
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHEECCCCCEEEEEC
LDAEPAEAVVREITTMGGRAVACVGSVTEADFGTRFVGTALQTFGGLDIIVNNAGYTWDN
CCCCHHHHHHHHHHHCCCCEEEEECCCHHCCCCHHHHHHHHHHCCCEEEEECCCCCCHHH
VIQKMTDDQWSAIMDVHVTAPFRILRAAADYFRETSKQEAEQGREVFRKVVNISSASGVI
HHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GNAGQANYSAGKAAINGLTKALAKEWGRYKVNVNSVAFGLIKTRLTEAVAGEGHATIDIA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GNEIKVGVNPQLMKNIEATIPLGRGGTPAEAAGSVYLLCIPESNYITGQVLVVGGGRP
CCEEEECCCHHHHHCCHHEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEECCCC
>Mature Secondary Structure
MKARRVSTHSTENKTTRTKETRSMSKLTNKVAIVSGSGRGIGREIALKLASEGAAVVVND
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHEECCCCCEEEEEC
LDAEPAEAVVREITTMGGRAVACVGSVTEADFGTRFVGTALQTFGGLDIIVNNAGYTWDN
CCCCHHHHHHHHHHHCCCCEEEEECCCHHCCCCHHHHHHHHHHCCCEEEEECCCCCCHHH
VIQKMTDDQWSAIMDVHVTAPFRILRAAADYFRETSKQEAEQGREVFRKVVNISSASGVI
HHHHHCCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GNAGQANYSAGKAAINGLTKALAKEWGRYKVNVNSVAFGLIKTRLTEAVAGEGHATIDIA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GNEIKVGVNPQLMKNIEATIPLGRGGTPAEAAGSVYLLCIPESNYITGQVLVVGGGRP
CCEEEECCCHHHHHCCHHEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9384377; 9534248; 8654983 [H]