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The map label for this gene is ilvA [H]

Identifier: 94314521

GI number: 94314521

Start: 2356033

End: 2357124

Strand: Reverse

Name: ilvA [H]

Synonym: Rmet_5602

Alternate gene names: 94314521

Gene position: 2357124-2356033 (Counterclockwise)

Preceding gene: 94314524

Following gene: 94314520

Centisome position: 91.36

GC content: 67.22

Gene sequence:

>1092_bases
ATGCCGTTAACCCATCCCCTTGCCGTGCCCCAAGCCGTTGCGCCGGGCCAGTCGTTCGATGCCGAGCCGTTTGAAGCGGC
ACACGACGCCTGGAGCGACGCCGACGATTACCTGAGGCGCATCCTGACCGCGCGCGTCTACGACGTGGCACGGGAGACCG
CGCTGGAGGCGGCGCCGACCTTGTCCGCGCATCTCGGCCACCGCGTCTGGCTCAAGCGCGAGGATCACCAGCCCGTGTTT
TCGTTCAAGGTGCGCGGCGCCTACAACAAGATGGCCAGCCTGCCGGCCGATGCGCTTGCCCGTGGCGTGATCACGGCCTC
AGCCGGCAATCACGCGCAAGGCGTGGCGCTGGCCGCGGCCCGGCTTGGTGTGCGGGCGATCATCGTCGTGCCGCAATCCG
CGCCGCAGGTGAAGGTGGATGCGGTGCGTGCCCACGGTAGCGGGATGGTGGAAGTCGTGCTGGCCGGCGAGTCCTATTCC
GATGCCTTCGACCATGCGCTATCCCTGCAGCAACAACACGGACTGACGTTCATCCCGGCGTTCGACGATCCCGACGTCAT
CGCCGGGCAAGGAACCGTGGGCATGGAGATCCTGCGGCAGCATCGCGGTCCGCTTGATGCCGTGTTCGTGCCGATCGGCG
GTGGCAGCCTGGCAGCAGGCGTGGCGGCATATGTCAAGGCGGTCCGGCCGGAAGTCCAGGTCATCGGCGTGCAAACGGAG
GATTCCTGCGCCATGGCGCGTTCGCTGGCCGCTGGCGAGCGGGTCACGCTCGATACCGTGGGATTGTTCTCGGATGGCAC
GGCGGTCAAGCGCGTCGGGGAAGAGACGTTTCGGCTTTGCCAGAAGTACCTTGATGGCGTGCTGACGGTGGATACCGATG
CGCTCTGCGCGGCGATCAAGGACATCTTCCAGGACACGCGCAGCCTGGTGGAGCCGGCCGGCGCGCTGGCCGTGGCGGGG
CTCAAGCAGTATGCGGCGACGGCGGGCAACGCCTCGCTGGCGCTGGTCGCGATCACATCGGGCGCCAATATGAACTTTGA
CCGCTTGCGCATCGTGGCGGAGCGGGCGGAAGTGGTTGGCGCCGCACGATGA

Upstream 100 bases:

>100_bases
GCGTCCGAAACAGACATCAATAACCCGCCCAACGAGGCGGGTTTTTTTATGGCCGCCTCCAGGGATTTCCAGAGATTTCC
CCCTCAAGAATGGAGTCGCC

Downstream 100 bases:

>100_bases
TGGAAGGGGAGGCCGATGATCGCCCAGAAGTTGTCGTACAACTGTGGTTCTTTCGGGCAGAATCAGGGGTGGCACTCTTC
CCAGCCACAAGACATTGGAG

Product: putative threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MPLTHPLAVPQAVAPGQSFDAEPFEAAHDAWSDADDYLRRILTARVYDVARETALEAAPTLSAHLGHRVWLKREDHQPVF
SFKVRGAYNKMASLPADALARGVITASAGNHAQGVALAAARLGVRAIIVVPQSAPQVKVDAVRAHGSGMVEVVLAGESYS
DAFDHALSLQQQHGLTFIPAFDDPDVIAGQGTVGMEILRQHRGPLDAVFVPIGGGSLAAGVAAYVKAVRPEVQVIGVQTE
DSCAMARSLAAGERVTLDTVGLFSDGTAVKRVGEETFRLCQKYLDGVLTVDTDALCAAIKDIFQDTRSLVEPAGALAVAG
LKQYAATAGNASLALVAITSGANMNFDRLRIVAERAEVVGAAR

Sequences:

>Translated_363_residues
MPLTHPLAVPQAVAPGQSFDAEPFEAAHDAWSDADDYLRRILTARVYDVARETALEAAPTLSAHLGHRVWLKREDHQPVF
SFKVRGAYNKMASLPADALARGVITASAGNHAQGVALAAARLGVRAIIVVPQSAPQVKVDAVRAHGSGMVEVVLAGESYS
DAFDHALSLQQQHGLTFIPAFDDPDVIAGQGTVGMEILRQHRGPLDAVFVPIGGGSLAAGVAAYVKAVRPEVQVIGVQTE
DSCAMARSLAAGERVTLDTVGLFSDGTAVKRVGEETFRLCQKYLDGVLTVDTDALCAAIKDIFQDTRSLVEPAGALAVAG
LKQYAATAGNASLALVAITSGANMNFDRLRIVAERAEVVGAAR
>Mature_362_residues
PLTHPLAVPQAVAPGQSFDAEPFEAAHDAWSDADDYLRRILTARVYDVARETALEAAPTLSAHLGHRVWLKREDHQPVFS
FKVRGAYNKMASLPADALARGVITASAGNHAQGVALAAARLGVRAIIVVPQSAPQVKVDAVRAHGSGMVEVVLAGESYSD
AFDHALSLQQQHGLTFIPAFDDPDVIAGQGTVGMEILRQHRGPLDAVFVPIGGGSLAAGVAAYVKAVRPEVQVIGVQTED
SCAMARSLAAGERVTLDTVGLFSDGTAVKRVGEETFRLCQKYLDGVLTVDTDALCAAIKDIFQDTRSLVEPAGALAVAGL
KQYAATAGNASLALVAITSGANMNFDRLRIVAERAEVVGAAR

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=320, Percent_Identity=31.875, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI33469958, Length=314, Percent_Identity=29.6178343949045, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI19923959, Length=310, Percent_Identity=29.0322580645161, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790207, Length=339, Percent_Identity=51.9174041297935, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1789505, Length=308, Percent_Identity=37.6623376623377, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI2367138, Length=188, Percent_Identity=27.6595744680851, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=295, Percent_Identity=32.2033898305085, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17508781, Length=257, Percent_Identity=31.1284046692607, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17537387, Length=267, Percent_Identity=34.8314606741573, Blast_Score=121, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6320930, Length=337, Percent_Identity=50.7418397626113, Blast_Score=302, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6322631, Length=308, Percent_Identity=33.4415584415584, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319788, Length=274, Percent_Identity=25.9124087591241, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21355833, Length=252, Percent_Identity=32.9365079365079, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24645328, Length=182, Percent_Identity=31.3186813186813, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 38120; Mature: 37989

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTHPLAVPQAVAPGQSFDAEPFEAAHDAWSDADDYLRRILTARVYDVARETALEAAPT
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LSAHLGHRVWLKREDHQPVFSFKVRGAYNKMASLPADALARGVITASAGNHAQGVALAAA
HHHHCCCEEEEEECCCCCEEEEEECCHHHHHHCCCHHHHHCCEEEECCCCCCCHHHHHHH
RLGVRAIIVVPQSAPQVKVDAVRAHGSGMVEVVLAGESYSDAFDHALSLQQQHGLTFIPA
HCCEEEEEEECCCCCCEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEC
FDDPDVIAGQGTVGMEILRQHRGPLDAVFVPIGGGSLAAGVAAYVKAVRPEVQVIGVQTE
CCCCCEEECCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCC
DSCAMARSLAAGERVTLDTVGLFSDGTAVKRVGEETFRLCQKYLDGVLTVDTDALCAAIK
HHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHH
DIFQDTRSLVEPAGALAVAGLKQYAATAGNASLALVAITSGANMNFDRLRIVAERAEVVG
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHC
AAR
CCC
>Mature Secondary Structure 
PLTHPLAVPQAVAPGQSFDAEPFEAAHDAWSDADDYLRRILTARVYDVARETALEAAPT
CCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LSAHLGHRVWLKREDHQPVFSFKVRGAYNKMASLPADALARGVITASAGNHAQGVALAAA
HHHHCCCEEEEEECCCCCEEEEEECCHHHHHHCCCHHHHHCCEEEECCCCCCCHHHHHHH
RLGVRAIIVVPQSAPQVKVDAVRAHGSGMVEVVLAGESYSDAFDHALSLQQQHGLTFIPA
HCCEEEEEEECCCCCCEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEC
FDDPDVIAGQGTVGMEILRQHRGPLDAVFVPIGGGSLAAGVAAYVKAVRPEVQVIGVQTE
CCCCCEEECCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCC
DSCAMARSLAAGERVTLDTVGLFSDGTAVKRVGEETFRLCQKYLDGVLTVDTDALCAAIK
HHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHH
DIFQDTRSLVEPAGALAVAGLKQYAATAGNASLALVAITSGANMNFDRLRIVAERAEVVG
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHC
AAR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA