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The map label for this gene is oprM [H]

Identifier: 94314509

GI number: 94314509

Start: 2343427

End: 2344884

Strand: Reverse

Name: oprM [H]

Synonym: Rmet_5590

Alternate gene names: 94314509

Gene position: 2344884-2343427 (Counterclockwise)

Preceding gene: 94314510

Following gene: 94314508

Centisome position: 90.88

GC content: 67.08

Gene sequence:

>1458_bases
ATGTCTGTTTCCTTTCGTGCCACCTTGCTGACGCTTGCGGCGGCGATGTTCGCCGCGGGCTGCACCGTTGGCCCCGACTA
TCGCGGCGCGCCGCAGGTGGCTGGCAACGCGATCGACACCGGAAAATTTCCCCGCGCCGGGGAAGGCACCGACAGCCAGA
CGCCACGTGTAGCCGACTGGTGGCACGCGCTGGGCGACACGCAACTCGATGGACTGATCGAATCGGCGTTGAAGCAAAGC
CCCGATATCCGCGTGGCGCGCGCGCGCGTGCGACAGGCACGTGCCGGACTGGCCGGAAACAAGGCCAACCTGTTCCCGAC
GGTTGCCGTCGATGCGGCCACGTTGCGCACGCGCTCGCCGAACCTGTCCGCGCTGTCGGGCCAGGGCTCGTCGAATGCCG
GGCGCGGGCCGTTGTCGCTCTATATCGCAGCCTTCGACGCAAGCTGGGAGATCGACCTGTTCGGTGGCACGCGTCGTTCG
ATCGAAGCTGCGTCGGCCGAAGCCGATGCCGCCGATGCGCAACTGGCCGATGCCCACGTGCAATTGGCTGCCGAAGTGGC
ACAGGCCTACATCACACTGCGCGAGCAGCAGGAAAGCCTTGCGCACCTGACGTCGTCCGAGCAACTCGAAGCGGAGATGT
TCGAGCTGACGCAGCAGCGTCGCGCACGCGGCGTGGCATCGCAGCTTGAGGTGGAGCGGCTGATGACGCAACTCGACAAC
ACGCGCGCGCAGATGTCGCCGGTGCAAGCCAGCATCGCCGAATCGCTGGACCAGCTTGCGATGCTGACTGGCCGCTCGCC
GGGGACGCTCGACGCGGAGCTATCGGCGCCGAAGCCGTTGCCCGGCGTGCCGGAAACCGTCGCCGTTGGCGATCCGGGCG
CGCTGCTGAAATCACGTCCCGATATCCGTGCCGCCGAACGGCGTCTGGCATCGAGCACGGCGCAGATCGGCGTGCGCAAG
GCGGACTGGTTTCCGAAGCTGTCGCTGCTCGGCTCGCTGGGCTTCGCGGCGACGGACCCCAGTCACCTCGCGCGCAAGGA
AAATGGCACGTGGATGACGCTGCCGCGCCTGCAATGGAATATCCTCGATTTCGGCCGTGTGGCCGCAGGAGTCGAGGGCG
CCGAGGGCGGGCGCGACGAAGCGGAGGCCAGCTACGAGAGCGTGGTGCTGAAGGCACTGCGCGATGCCGATGTCGCATTG
TCGCGCTACGGCCATCAGCGCGAGCACGTGGTTGTGCTGCGTCGCGTGGAAGCATCCGCGGAACGCGCCTCGACGTTGCA
GCAGCAGCGCTACCGCGCCGGCACGGCAAGCATGCTCGAATGGCTCGATGTCGAACGCACGCGAGTGGTGGCCCAACAGA
GCCGCATCTCGGGCGATGCGGATCTGCTCAAGGATTTCGTCTCGCTGCAGAAGTCGCTGGGCCTCGGCTGGCAATCTTCC
GCGGCGCCAGCCTCCTGA

Upstream 100 bases:

>100_bases
CCTTCTTCGCGCTCGGCGTGGCCCTGCTGTTCTGTGTGCCGCTGGCCCTGCTGCTGAAACCGCCCCGTCCGGGCGCACCT
ATTTCCACCGGTCACTGATC

Downstream 100 bases:

>100_bases
CCCGGCGCGCTTACTGCGGCGCGTTTACCAGCGACGGGTAGGCTTCAACATCATCTCGATCCTTGTGAATGGCACCGCGC
AGCGGCGGCAGGCGCGGGCG

Product: NodT family RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSVSFRATLLTLAAAMFAAGCTVGPDYRGAPQVAGNAIDTGKFPRAGEGTDSQTPRVADWWHALGDTQLDGLIESALKQS
PDIRVARARVRQARAGLAGNKANLFPTVAVDAATLRTRSPNLSALSGQGSSNAGRGPLSLYIAAFDASWEIDLFGGTRRS
IEAASAEADAADAQLADAHVQLAAEVAQAYITLREQQESLAHLTSSEQLEAEMFELTQQRRARGVASQLEVERLMTQLDN
TRAQMSPVQASIAESLDQLAMLTGRSPGTLDAELSAPKPLPGVPETVAVGDPGALLKSRPDIRAAERRLASSTAQIGVRK
ADWFPKLSLLGSLGFAATDPSHLARKENGTWMTLPRLQWNILDFGRVAAGVEGAEGGRDEAEASYESVVLKALRDADVAL
SRYGHQREHVVVLRRVEASAERASTLQQQRYRAGTASMLEWLDVERTRVVAQQSRISGDADLLKDFVSLQKSLGLGWQSS
AAPAS

Sequences:

>Translated_485_residues
MSVSFRATLLTLAAAMFAAGCTVGPDYRGAPQVAGNAIDTGKFPRAGEGTDSQTPRVADWWHALGDTQLDGLIESALKQS
PDIRVARARVRQARAGLAGNKANLFPTVAVDAATLRTRSPNLSALSGQGSSNAGRGPLSLYIAAFDASWEIDLFGGTRRS
IEAASAEADAADAQLADAHVQLAAEVAQAYITLREQQESLAHLTSSEQLEAEMFELTQQRRARGVASQLEVERLMTQLDN
TRAQMSPVQASIAESLDQLAMLTGRSPGTLDAELSAPKPLPGVPETVAVGDPGALLKSRPDIRAAERRLASSTAQIGVRK
ADWFPKLSLLGSLGFAATDPSHLARKENGTWMTLPRLQWNILDFGRVAAGVEGAEGGRDEAEASYESVVLKALRDADVAL
SRYGHQREHVVVLRRVEASAERASTLQQQRYRAGTASMLEWLDVERTRVVAQQSRISGDADLLKDFVSLQKSLGLGWQSS
AAPAS
>Mature_484_residues
SVSFRATLLTLAAAMFAAGCTVGPDYRGAPQVAGNAIDTGKFPRAGEGTDSQTPRVADWWHALGDTQLDGLIESALKQSP
DIRVARARVRQARAGLAGNKANLFPTVAVDAATLRTRSPNLSALSGQGSSNAGRGPLSLYIAAFDASWEIDLFGGTRRSI
EAASAEADAADAQLADAHVQLAAEVAQAYITLREQQESLAHLTSSEQLEAEMFELTQQRRARGVASQLEVERLMTQLDNT
RAQMSPVQASIAESLDQLAMLTGRSPGTLDAELSAPKPLPGVPETVAVGDPGALLKSRPDIRAAERRLASSTAQIGVRKA
DWFPKLSLLGSLGFAATDPSHLARKENGTWMTLPRLQWNILDFGRVAAGVEGAEGGRDEAEASYESVVLKALRDADVALS
RYGHQREHVVVLRRVEASAERASTLQQQRYRAGTASMLEWLDVERTRVVAQQSRISGDADLLKDFVSLQKSLGLGWQSSA
APAS

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor. Note=Attached to the outer membrane by a lipid anchor and via the transmembrane beta-barrel. The membrane anchor is not necessary for antibiotic efflux. In one report (PubMed:10889211) the Cys-18- Gly mutant is reported

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=483, Percent_Identity=25.2587991718427, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI2367348, Length=439, Percent_Identity=26.6514806378132, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51817; Mature: 51685

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSFRATLLTLAAAMFAAGCTVGPDYRGAPQVAGNAIDTGKFPRAGEGTDSQTPRVADW
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
WHALGDTQLDGLIESALKQSPDIRVARARVRQARAGLAGNKANLFPTVAVDAATLRTRSP
HHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCCC
NLSALSGQGSSNAGRGPLSLYIAAFDASWEIDLFGGTRRSIEAASAEADAADAQLADAHV
CCCEECCCCCCCCCCCCEEEEEEEECCCEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHH
QLAAEVAQAYITLREQQESLAHLTSSEQLEAEMFELTQQRRARGVASQLEVERLMTQLDN
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRAQMSPVQASIAESLDQLAMLTGRSPGTLDAELSAPKPLPGVPETVAVGDPGALLKSRP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHCCCC
DIRAAERRLASSTAQIGVRKADWFPKLSLLGSLGFAATDPSHLARKENGTWMTLPRLQWN
CHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHCCCCCCCCHHHHHHCCCCCEEEECCCEEC
ILDFGRVAAGVEGAEGGRDEAEASYESVVLKALRDADVALSRYGHQREHVVVLRRVEASA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
ERASTLQQQRYRAGTASMLEWLDVERTRVVAQQSRISGDADLLKDFVSLQKSLGLGWQSS
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
AAPAS
CCCCC
>Mature Secondary Structure 
SVSFRATLLTLAAAMFAAGCTVGPDYRGAPQVAGNAIDTGKFPRAGEGTDSQTPRVADW
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
WHALGDTQLDGLIESALKQSPDIRVARARVRQARAGLAGNKANLFPTVAVDAATLRTRSP
HHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCCC
NLSALSGQGSSNAGRGPLSLYIAAFDASWEIDLFGGTRRSIEAASAEADAADAQLADAHV
CCCEECCCCCCCCCCCCEEEEEEEECCCEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHH
QLAAEVAQAYITLREQQESLAHLTSSEQLEAEMFELTQQRRARGVASQLEVERLMTQLDN
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRAQMSPVQASIAESLDQLAMLTGRSPGTLDAELSAPKPLPGVPETVAVGDPGALLKSRP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHCCCC
DIRAAERRLASSTAQIGVRKADWFPKLSLLGSLGFAATDPSHLARKENGTWMTLPRLQWN
CHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHCCCCCCCCHHHHHHCCCCCEEEECCCEEC
ILDFGRVAAGVEGAEGGRDEAEASYESVVLKALRDADVALSRYGHQREHVVVLRRVEASA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
ERASTLQQQRYRAGTASMLEWLDVERTRVVAQQSRISGDADLLKDFVSLQKSLGLGWQSS
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
AAPAS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8226684; 10889211; 10984043; 7968531; 8540696; 9401051; 9603892; 10952562 [H]