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The map label for this gene is 94314131

Identifier: 94314131

GI number: 94314131

Start: 1905771

End: 1906772

Strand: Direct

Name: 94314131

Synonym: Rmet_5212

Alternate gene names: NA

Gene position: 1905771-1906772 (Clockwise)

Preceding gene: 94314130

Following gene: 94314133

Centisome position: 73.86

GC content: 63.27

Gene sequence:

>1002_bases
ATGAAGAAAATCGATATGCATGCCCACTTCTTTCCGCGCATCACGCGGGAAGAAGCCGCCGCGCTGGACGCGGACAACGC
GCCATGGCTCGCCGTCGACAGCGATGGCGAATCGGGCCACATCATGGCCGGCGACAGACGTTTCCGGCCCGTCTATCGCG
CGCTATGGGACCCCGCGCTGCGCATCGAGGAAATGGACCGCAACGGACTGGACATGCAGATCGTCTGCGCCACGCCGATC
ATGTTCGGTTATGGATACGACGCCAGCGCCGCAGCCACGTGGGCGCGCCGGATGAACGACCTCGCGCTCGAGCATTGCGC
CTATCGCCCGCAGCGCCTGAAGGCGCTGGCACAGGTGCCGCTGCAGGACCTGGACCTGGCGTGCATCGAAGCCTCACGCG
CCAGGGAGTCCGGCCACGTTGGCGTGCAAATCGGCAATCACCTGGGTCCGCACGACCTGGATGACGAGCGCCTGGTCAGG
TTCCTGGTGCATTGCGCGAACAACGATATTCCGGTGCTGGTGCATCCATGGGACATGATGACCGACGGGCGCATGAAAAA
ATGGATGCTGCCGTGGCTGGTATCGATGCCGGCGGAAACGCAACTCGGCATCCTCTCGTTGATCCTGTCCGGCGCGTTTG
AGCGGATTCCGGAAACGCTGAAGCTCTGCTTCGCCCACGGCGGTGGTGGTTTTGCCTTCCTGCTGGGTCGCGCGGAGAAC
GCCTGGCATTGCCGGGACATCGTGCGGCAGGACTGTCCCCAGCCGCCCTCCCACTATCTGAAGCGGTTCTCCGTGGACAG
CGCGGTATTCGACGATCGTTCGCTACGTCTGCTGGTGGAAGTCATGGGTGCCGACCACGTGATGCTGGGCTCGGACTACC
CGTTTCCGCTCGGTGAACAGGAAATCGGCAAGCTGGTCGCCAACAGCCCCAACCTCGATGAAACGGACCGGGCGCGGATT
CTGGCAGGCAATGCCATGCGCTTCTTCGGTCTGACAGGCTGA

Upstream 100 bases:

>100_bases
GACCGACCCGCACGACCGTGGCCGTGCACCAGCTTCCGCATCCCCACCTGCGCATCGAGATCAAAGCGATCGCCTACCGT
CCGCTCACGTCCCAGGCAAC

Downstream 100 bases:

>100_bases
GGACCCCGCTGCACATCGGTGCTCCGCCGCTGTATCGGACAGCGGCGGACTTGGATGCCGCCTCGCCCGGTATCAGCCCG
CGCTTTTCGCGCCGCCGCCC

Product: Aminocarboxymuconate-semialdehyde decarboxylase

Products: 2-aminomuconate semialdehyde; CO2

Alternate protein names: Amidohydrolase; 2-Amino-3-Carboxylmuconate-6-Semialdehyde Decarboxylase; 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase; 2-Amino-3-Carboxymuconate-6- Semialdehyde Decarboxylase; Tryptophan 2 3-Dioxygenase; Amidohydrolase Family; 2-Amino-3-Carboxymuconate 6-Semialdehyde Decarboxylase; Amidase; Metal-Dependent Hydrolase; O-Pyrocatechuate Decarboxylase; Decarboxylase; 5-Carboxy-2-Hydroxymuconate-6-Semialdehyde Decarboxylase

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MKKIDMHAHFFPRITREEAAALDADNAPWLAVDSDGESGHIMAGDRRFRPVYRALWDPALRIEEMDRNGLDMQIVCATPI
MFGYGYDASAAATWARRMNDLALEHCAYRPQRLKALAQVPLQDLDLACIEASRARESGHVGVQIGNHLGPHDLDDERLVR
FLVHCANNDIPVLVHPWDMMTDGRMKKWMLPWLVSMPAETQLGILSLILSGAFERIPETLKLCFAHGGGGFAFLLGRAEN
AWHCRDIVRQDCPQPPSHYLKRFSVDSAVFDDRSLRLLVEVMGADHVMLGSDYPFPLGEQEIGKLVANSPNLDETDRARI
LAGNAMRFFGLTG

Sequences:

>Translated_333_residues
MKKIDMHAHFFPRITREEAAALDADNAPWLAVDSDGESGHIMAGDRRFRPVYRALWDPALRIEEMDRNGLDMQIVCATPI
MFGYGYDASAAATWARRMNDLALEHCAYRPQRLKALAQVPLQDLDLACIEASRARESGHVGVQIGNHLGPHDLDDERLVR
FLVHCANNDIPVLVHPWDMMTDGRMKKWMLPWLVSMPAETQLGILSLILSGAFERIPETLKLCFAHGGGGFAFLLGRAEN
AWHCRDIVRQDCPQPPSHYLKRFSVDSAVFDDRSLRLLVEVMGADHVMLGSDYPFPLGEQEIGKLVANSPNLDETDRARI
LAGNAMRFFGLTG
>Mature_333_residues
MKKIDMHAHFFPRITREEAAALDADNAPWLAVDSDGESGHIMAGDRRFRPVYRALWDPALRIEEMDRNGLDMQIVCATPI
MFGYGYDASAAATWARRMNDLALEHCAYRPQRLKALAQVPLQDLDLACIEASRARESGHVGVQIGNHLGPHDLDDERLVR
FLVHCANNDIPVLVHPWDMMTDGRMKKWMLPWLVSMPAETQLGILSLILSGAFERIPETLKLCFAHGGGGFAFLLGRAEN
AWHCRDIVRQDCPQPPSHYLKRFSVDSAVFDDRSLRLLVEVMGADHVMLGSDYPFPLGEQEIGKLVANSPNLDETDRARI
LAGNAMRFFGLTG

Specific function: Unknown

COG id: COG2159

COG function: function code R; Predicted metal-dependent hydrolase of the TIM-barrel fold

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI109715856, Length=332, Percent_Identity=41.2650602409639, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71995651, Length=332, Percent_Identity=33.7349397590361, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI71995655, Length=381, Percent_Identity=29.6587926509186, Blast_Score=175, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.45

Molecular weight: Translated: 37315; Mature: 37315

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIDMHAHFFPRITREEAAALDADNAPWLAVDSDGESGHIMAGDRRFRPVYRALWDPAL
CCCCCCCHHHCCCHHHHHHHHCCCCCCCEEEEECCCCCCCEEECCCHHHHHHHHHCCHHH
RIEEMDRNGLDMQIVCATPIMFGYGYDASAAATWARRMNDLALEHCAYRPQRLKALAQVP
HHHHCCCCCCCEEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
LQDLDLACIEASRARESGHVGVQIGNHLGPHDLDDERLVRFLVHCANNDIPVLVHPWDMM
HHHCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCC
TDGRMKKWMLPWLVSMPAETQLGILSLILSGAFERIPETLKLCFAHGGGGFAFLLGRAEN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
AWHCRDIVRQDCPQPPSHYLKRFSVDSAVFDDRSLRLLVEVMGADHVMLGSDYPFPLGEQ
CHHHHHHHHHHCCCCHHHHHHHHCCCHHHCCCCHHHHHHHHHCCCEEEECCCCCCCCCHH
EIGKLVANSPNLDETDRARILAGNAMRFFGLTG
HHHHHHCCCCCCCCCCCCEEEECCCEEEEECCC
>Mature Secondary Structure
MKKIDMHAHFFPRITREEAAALDADNAPWLAVDSDGESGHIMAGDRRFRPVYRALWDPAL
CCCCCCCHHHCCCHHHHHHHHCCCCCCCEEEEECCCCCCCEEECCCHHHHHHHHHCCHHH
RIEEMDRNGLDMQIVCATPIMFGYGYDASAAATWARRMNDLALEHCAYRPQRLKALAQVP
HHHHCCCCCCCEEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
LQDLDLACIEASRARESGHVGVQIGNHLGPHDLDDERLVRFLVHCANNDIPVLVHPWDMM
HHHCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCC
TDGRMKKWMLPWLVSMPAETQLGILSLILSGAFERIPETLKLCFAHGGGGFAFLLGRAEN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
AWHCRDIVRQDCPQPPSHYLKRFSVDSAVFDDRSLRLLVEVMGADHVMLGSDYPFPLGEQ
CHHHHHHHHHHCCCCHHHHHHHHCCCHHHCCCCHHHHHHHHHCCCEEEECCCCCCCCCHH
EIGKLVANSPNLDETDRARILAGNAMRFFGLTG
HHHHHHCCCCCCCCCCCCEEEECCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate

Specific reaction: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate = 2-aminomuconate semialdehyde + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA