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The map label for this gene is nrdD [C]

Identifier: 94314058

GI number: 94314058

Start: 1835505

End: 1837229

Strand: Reverse

Name: nrdD [C]

Synonym: Rmet_5139

Alternate gene names: 94314058

Gene position: 1837229-1835505 (Counterclockwise)

Preceding gene: 94314059

Following gene: 94314057

Centisome position: 71.21

GC content: 62.49

Gene sequence:

>1725_bases
ATGCAACAGAACATCCGGGGCGCGACGACTGTCGACGTCGAGTCGTCTATCAATGAATACCTGGACCGCAAGGACTGGCG
GATTCACGCCAACGCCAACCAGGGGTATTCGCTGGGCGGACTGATCCTCAATGTGGCCGGCAAGGTCACCGCCAACTACT
GGCTTTCGCATGTCTACGCGCCCGAGGCTGGCGCCGCGCACCGGGAAGGCGACCTCCATATCCACGATCTCGACATGCTG
TCCGGCTATTGCGCCGGCTGGTCGTTGCGCACTCTGCTGCATGAAGGCCTCAACGGCGTGCCGGGCAAGGTGGAAGCCGC
GCCGCCGCGGCATATGTCGAGCGCGGTCGGGCAGATCGTGAATTTCCTGGGGACGATGCAGAACGAATGGGCCGGCGCGC
AGGCCTTCTCGTCGTTCGACACCTATATGGCGCCTTTCATCCGCAAGGACGCGATGACGTACCCCGAGGTCAGGCAGCAC
ATCCAGGAGCTGATCTATAACCTCAACGTGCCGTCGCGCTGGGGCACGCAGACGCCATTCACAAACCTGACGTTCGACTG
GACATGTCCCGACGATCTCAAGGAACAGGTGCCCGTCATCGGCGGCGAGGAAATGCCGTTCCGCTATGGCGACCTGCAAG
CGGAGATGGACATGATCAACCGTGCGTACATCGAGGTGATGACGCAGGGCGATGCCAAAGGGCGCGTCTTCACGTTCCCG
ATCCCCACCTACAACATCACGCCGGATTTCCCGTGGGAAAGCGAGAACGCCGCGCGGCTGTTCGAGATGACGGCGAAGTA
CGGCCTGCCGTACTTCCAGAACTTCGTGAATTCGGACCTGACGCCCAATATGGTCCGGTCCATGTGCTGCCGGTTGCAAC
TGGATCTGCGTGAATTGCTCAAGCGCGGCAACGGCTTGTTCGGCAGTGCGGAGCAGACCGGGTCCCTGGGTGTGGTCACC
ATCAACTGCGCGCGACTCGGTTACCTGTATCAAGGCGACGAAGCCGCACTGCTGAACCGGCTCGACTCACTGCTGGACAT
GGGCCGCGACACGCTGGAGGCCAAGCGCGAGCGTATCCAGCAACTGATGGACGAAGGGCTGTTCCCCTACACGAAGCGCT
ACCTGGGCACACTGCGCAATCATTTCTCGACGCTTGGCGTGAACGGCATCAACGAGATGATCCGCAATTTCTCGGGCGAT
GCGTACGACATCACTACGGAAGCCGGGCACGCGATGGCGATGCGTCTGCTGGACCATGTACGCGGGCGGATCGTCGAATT
CCAGGAAGCCACGGGCCACATGTACAACCTGGAGGCAACGCCAGCGGAAGGCACCACGTATCGCTTCGCGCGTGAAGACC
GCAAGCGCTGGCCCGACATCCTGCAGGCCGGCACGGCCGATCAGCCCTACTACACGAACTCGTCGCAGTTGCCCGTCGGC
TTTACCGACGATCCATTCGAGGCGCTGGCGCGTCAGGAATCCCTGCAATCGAAGTACACCGGGGGCACGGTCCTGCATCT
CTACATGGGCGAGCGCCTGTCGAGCGGGGAGGCCTGCAAGCGGATGGTGCGTCGCGCGCTGGAGTCGTTCCGGCTGCCTT
ACATCACGATCACGCCGACGTTCTCCGTCTGCCCCAAGCACGGCTATCTGGCCGGCGAACACCGCTTCTGCCCGAAGTGC
GACGAGGACATTCTCGCGCGCAAACGCGCCGCGCTGGCGGCGTGA

Upstream 100 bases:

>100_bases
CCCCGCAGCGGTGTCGCCGTTTGATCTGTCGCAACACCACCTATGGTATCGATATAGATAATCCACCCCATATTTTGTGC
GTAAGCACGGGAGGGGTGCG

Downstream 100 bases:

>100_bases
GGTTTCCCGATTTTCAACCCGACGTTTCGCACATGAGGAGCAACGCCATGACTGATCTCGCTGTCGCCCGCCATTTCTCG
ATCGAACCCGCACTGGCACT

Product: anaerobic ribonucleoside triphosphate reductase

Products: ribonucleoside triphosphate; thioredoxin

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MQQNIRGATTVDVESSINEYLDRKDWRIHANANQGYSLGGLILNVAGKVTANYWLSHVYAPEAGAAHREGDLHIHDLDML
SGYCAGWSLRTLLHEGLNGVPGKVEAAPPRHMSSAVGQIVNFLGTMQNEWAGAQAFSSFDTYMAPFIRKDAMTYPEVRQH
IQELIYNLNVPSRWGTQTPFTNLTFDWTCPDDLKEQVPVIGGEEMPFRYGDLQAEMDMINRAYIEVMTQGDAKGRVFTFP
IPTYNITPDFPWESENAARLFEMTAKYGLPYFQNFVNSDLTPNMVRSMCCRLQLDLRELLKRGNGLFGSAEQTGSLGVVT
INCARLGYLYQGDEAALLNRLDSLLDMGRDTLEAKRERIQQLMDEGLFPYTKRYLGTLRNHFSTLGVNGINEMIRNFSGD
AYDITTEAGHAMAMRLLDHVRGRIVEFQEATGHMYNLEATPAEGTTYRFAREDRKRWPDILQAGTADQPYYTNSSQLPVG
FTDDPFEALARQESLQSKYTGGTVLHLYMGERLSSGEACKRMVRRALESFRLPYITITPTFSVCPKHGYLAGEHRFCPKC
DEDILARKRAALAA

Sequences:

>Translated_574_residues
MQQNIRGATTVDVESSINEYLDRKDWRIHANANQGYSLGGLILNVAGKVTANYWLSHVYAPEAGAAHREGDLHIHDLDML
SGYCAGWSLRTLLHEGLNGVPGKVEAAPPRHMSSAVGQIVNFLGTMQNEWAGAQAFSSFDTYMAPFIRKDAMTYPEVRQH
IQELIYNLNVPSRWGTQTPFTNLTFDWTCPDDLKEQVPVIGGEEMPFRYGDLQAEMDMINRAYIEVMTQGDAKGRVFTFP
IPTYNITPDFPWESENAARLFEMTAKYGLPYFQNFVNSDLTPNMVRSMCCRLQLDLRELLKRGNGLFGSAEQTGSLGVVT
INCARLGYLYQGDEAALLNRLDSLLDMGRDTLEAKRERIQQLMDEGLFPYTKRYLGTLRNHFSTLGVNGINEMIRNFSGD
AYDITTEAGHAMAMRLLDHVRGRIVEFQEATGHMYNLEATPAEGTTYRFAREDRKRWPDILQAGTADQPYYTNSSQLPVG
FTDDPFEALARQESLQSKYTGGTVLHLYMGERLSSGEACKRMVRRALESFRLPYITITPTFSVCPKHGYLAGEHRFCPKC
DEDILARKRAALAA
>Mature_574_residues
MQQNIRGATTVDVESSINEYLDRKDWRIHANANQGYSLGGLILNVAGKVTANYWLSHVYAPEAGAAHREGDLHIHDLDML
SGYCAGWSLRTLLHEGLNGVPGKVEAAPPRHMSSAVGQIVNFLGTMQNEWAGAQAFSSFDTYMAPFIRKDAMTYPEVRQH
IQELIYNLNVPSRWGTQTPFTNLTFDWTCPDDLKEQVPVIGGEEMPFRYGDLQAEMDMINRAYIEVMTQGDAKGRVFTFP
IPTYNITPDFPWESENAARLFEMTAKYGLPYFQNFVNSDLTPNMVRSMCCRLQLDLRELLKRGNGLFGSAEQTGSLGVVT
INCARLGYLYQGDEAALLNRLDSLLDMGRDTLEAKRERIQQLMDEGLFPYTKRYLGTLRNHFSTLGVNGINEMIRNFSGD
AYDITTEAGHAMAMRLLDHVRGRIVEFQEATGHMYNLEATPAEGTTYRFAREDRKRWPDILQAGTADQPYYTNSSQLPVG
FTDDPFEALARQESLQSKYTGGTVLHLYMGERLSSGEACKRMVRRALESFRLPYITITPTFSVCPKHGYLAGEHRFCPKC
DEDILARKRAALAA

Specific function: Unknown

COG id: COG1328

COG function: function code F; Oxygen-sensitive ribonucleoside-triphosphate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 DOD-type homing endonuclease domains [H]

Homologues:

Organism=Escherichia coli, GI1790686, Length=560, Percent_Identity=22.6785714285714, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR003586
- InterPro:   IPR003587
- InterPro:   IPR007869
- InterPro:   IPR006142
- InterPro:   IPR004042
- InterPro:   IPR006141
- InterPro:   IPR012833 [H]

Pfam domain/function: PF03477 ATP-cone; PF05204 Hom_end [H]

EC number: 1.17.4.2

Molecular weight: Translated: 64704; Mature: 64704

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQNIRGATTVDVESSINEYLDRKDWRIHANANQGYSLGGLILNVAGKVTANYWLSHVYA
CCCCCCCCEEEEHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PEAGAAHREGDLHIHDLDMLSGYCAGWSLRTLLHEGLNGVPGKVEAAPPRHMSSAVGQIV
CCCCCCCCCCCEEEEEHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
NFLGTMQNEWAGAQAFSSFDTYMAPFIRKDAMTYPEVRQHIQELIYNLNVPSRWGTQTPF
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
TNLTFDWTCPDDLKEQVPVIGGEEMPFRYGDLQAEMDMINRAYIEVMTQGDAKGRVFTFP
CCCEEECCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCCEEEEC
IPTYNITPDFPWESENAARLFEMTAKYGLPYFQNFVNSDLTPNMVRSMCCRLQLDLRELL
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KRGNGLFGSAEQTGSLGVVTINCARLGYLYQGDEAALLNRLDSLLDMGRDTLEAKRERIQ
HHCCCCCCCCCCCCCEEEEEEEHHHCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHH
QLMDEGLFPYTKRYLGTLRNHFSTLGVNGINEMIRNFSGDAYDITTEAGHAMAMRLLDHV
HHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
RGRIVEFQEATGHMYNLEATPAEGTTYRFAREDRKRWPDILQAGTADQPYYTNSSQLPVG
HHHEEEEHHHCCCEEEEECCCCCCCEEHHHHHHHHHCHHHHHCCCCCCCEECCCCCCCCC
FTDDPFEALARQESLQSKYTGGTVLHLYMGERLSSGEACKRMVRRALESFRLPYITITPT
CCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECCC
FSVCPKHGYLAGEHRFCPKCDEDILARKRAALAA
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQQNIRGATTVDVESSINEYLDRKDWRIHANANQGYSLGGLILNVAGKVTANYWLSHVYA
CCCCCCCCEEEEHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PEAGAAHREGDLHIHDLDMLSGYCAGWSLRTLLHEGLNGVPGKVEAAPPRHMSSAVGQIV
CCCCCCCCCCCEEEEEHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
NFLGTMQNEWAGAQAFSSFDTYMAPFIRKDAMTYPEVRQHIQELIYNLNVPSRWGTQTPF
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
TNLTFDWTCPDDLKEQVPVIGGEEMPFRYGDLQAEMDMINRAYIEVMTQGDAKGRVFTFP
CCCEEECCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEECCCCCCCEEEEC
IPTYNITPDFPWESENAARLFEMTAKYGLPYFQNFVNSDLTPNMVRSMCCRLQLDLRELL
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KRGNGLFGSAEQTGSLGVVTINCARLGYLYQGDEAALLNRLDSLLDMGRDTLEAKRERIQ
HHCCCCCCCCCCCCCEEEEEEEHHHCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHH
QLMDEGLFPYTKRYLGTLRNHFSTLGVNGINEMIRNFSGDAYDITTEAGHAMAMRLLDHV
HHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHH
RGRIVEFQEATGHMYNLEATPAEGTTYRFAREDRKRWPDILQAGTADQPYYTNSSQLPVG
HHHEEEEHHHCCCEEEEECCCCCCCEEHHHHHHHHHCHHHHHCCCCCCCEECCCCCCCCC
FTDDPFEALARQESLQSKYTGGTVLHLYMGERLSSGEACKRMVRRALESFRLPYITITPT
CCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECCC
FSVCPKHGYLAGEHRFCPKCDEDILARKRAALAA
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2'-deoxyribonucleoside triphosphate; thioredoxin disulfide; H2O

Specific reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]