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The map label for this gene is macA [H]

Identifier: 94313985

GI number: 94313985

Start: 1752880

End: 1753947

Strand: Reverse

Name: macA [H]

Synonym: Rmet_5063

Alternate gene names: 94313985

Gene position: 1753947-1752880 (Counterclockwise)

Preceding gene: 94313986

Following gene: 94313984

Centisome position: 67.98

GC content: 69.66

Gene sequence:

>1068_bases
ATGGAACCGTTCGTTTATCAGGCCACGCCGTCGCGGGTGGTCTTCGGCGCGGGCCGGTTGGAGGCGTTGCCCGAGGAGGT
GCTGCGGCTAGGCGCGCGGCGGGCTCTGGTGCTGACCACGCCCGGGCATCGGGCACTCGGCGAGCGGGTGGCCGCGTTGC
TGGGGGAGTGCTCCGCGGGCGTTTACAGCGAGGCGGTGATGCATGTGCCGGTGGAGGTGGCTCACGCCGCACGCGATGAG
GCCGCGCGGCTGGGTGCTGACTGCTACGTGGCGGTTGGCGGTGGGTCCACCATCGGGCTTGGCAAGGCCATCGCCCTCGT
TTCGGGGCAACCCATCATCGCGGTACCGACCACCTACGCGGGATCGGAGGTAACACCGATCTACGGCCTGACCGAAGGAC
GCCTGAAACAGACCGGCCGCGACCCGCGCGTGCTGCCGCGCACGGTCCTCTACGATCCCGAACTGACGCTGACGTTGCCG
GTGGAGATTTCCGCCGCCTCTGGCATGAATGCGATGGCGCACGCGGTGGAGGCGATATACGCCGAGGACGCGAACCCGAT
CATCAGCCTGATGGCCGAGGCGTCGATCCGCGCGCTGGCCGGGGCCTTGCCCACCGTGGTGCGGCGGCCGGACGATATCG
ACGCCCGTGGCGACGCGCTGTACGGCGCGTGGCTGGCGGGTGCCTGCCTTGGCTCGGTTGGCATGGCGATCCATCACAAG
CTATGCCACACGCTGGGCGGGACCTTCAACCTGCCCCATGCGCAGACCCATGCCATCTTGCTACCGCATACCGCGCACTA
CAACCACGCCGCCGCGCCACTTGCGCTGGCACGCGTGGCGCGGGCGCTGGGTGGCGAACGCGCGCAGGATACCGGCCCGC
TGCTGTTCCGGCTGAACCAGACGCTGGGTATCGCCACGGCGTTGTCGGCCATCGGTATGCCCGAGGATGGGTTGGACGAG
GCGGCCACGCTGGCCTGCGCCAATCCCTACTACAACCCGAGGCTGGTCGAGCGCGAGCCGATCCGGGCGTTGCTGGAACG
CGCCTGGCGCGGCGAGAGCCCGGCCTGA

Upstream 100 bases:

>100_bases
TGAACCGGGCGATTCGGTCGCCCGCTCGCCCGGCATGTGCGTCATGCGAAGCAGGACTACACTGAAGCGCATTCGGTGGG
TTGATGCCTTGGGAGAGGGG

Downstream 100 bases:

>100_bases
GAGCGATCGGCGCACGGCAACCATCACAAAGGAGAGACACCATGGAGGCAACGCCCCACGCAGCCGCCGAAGCCGCGCTG
ACCGAGCAGGTCGTCGCGCG

Product: maleylacetate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MEPFVYQATPSRVVFGAGRLEALPEEVLRLGARRALVLTTPGHRALGERVAALLGECSAGVYSEAVMHVPVEVAHAARDE
AARLGADCYVAVGGGSTIGLGKAIALVSGQPIIAVPTTYAGSEVTPIYGLTEGRLKQTGRDPRVLPRTVLYDPELTLTLP
VEISAASGMNAMAHAVEAIYAEDANPIISLMAEASIRALAGALPTVVRRPDDIDARGDALYGAWLAGACLGSVGMAIHHK
LCHTLGGTFNLPHAQTHAILLPHTAHYNHAAAPLALARVARALGGERAQDTGPLLFRLNQTLGIATALSAIGMPEDGLDE
AATLACANPYYNPRLVEREPIRALLERAWRGESPA

Sequences:

>Translated_355_residues
MEPFVYQATPSRVVFGAGRLEALPEEVLRLGARRALVLTTPGHRALGERVAALLGECSAGVYSEAVMHVPVEVAHAARDE
AARLGADCYVAVGGGSTIGLGKAIALVSGQPIIAVPTTYAGSEVTPIYGLTEGRLKQTGRDPRVLPRTVLYDPELTLTLP
VEISAASGMNAMAHAVEAIYAEDANPIISLMAEASIRALAGALPTVVRRPDDIDARGDALYGAWLAGACLGSVGMAIHHK
LCHTLGGTFNLPHAQTHAILLPHTAHYNHAAAPLALARVARALGGERAQDTGPLLFRLNQTLGIATALSAIGMPEDGLDE
AATLACANPYYNPRLVEREPIRALLERAWRGESPA
>Mature_355_residues
MEPFVYQATPSRVVFGAGRLEALPEEVLRLGARRALVLTTPGHRALGERVAALLGECSAGVYSEAVMHVPVEVAHAARDE
AARLGADCYVAVGGGSTIGLGKAIALVSGQPIIAVPTTYAGSEVTPIYGLTEGRLKQTGRDPRVLPRTVLYDPELTLTLP
VEISAASGMNAMAHAVEAIYAEDANPIISLMAEASIRALAGALPTVVRRPDDIDARGDALYGAWLAGACLGSVGMAIHHK
LCHTLGGTFNLPHAQTHAILLPHTAHYNHAAAPLALARVARALGGERAQDTGPLLFRLNQTLGIATALSAIGMPEDGLDE
AATLACANPYYNPRLVEREPIRALLERAWRGESPA

Specific function: Fucose metabolism; fourth step. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=314, Percent_Identity=24.8407643312102, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1789163, Length=374, Percent_Identity=29.6791443850267, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI48994951, Length=221, Percent_Identity=32.1266968325792, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI87082107, Length=228, Percent_Identity=29.8245614035088, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1787493, Length=311, Percent_Identity=23.7942122186495, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17537053, Length=420, Percent_Identity=22.8571428571429, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321181, Length=372, Percent_Identity=27.4193548387097, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.3.1.32 [H]

Molecular weight: Translated: 37234; Mature: 37234

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPFVYQATPSRVVFGAGRLEALPEEVLRLGARRALVLTTPGHRALGERVAALLGECSAG
CCCEEEECCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCC
VYSEAVMHVPVEVAHAARDEAARLGADCYVAVGGGSTIGLGKAIALVSGQPIIAVPTTYA
HHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCEEEEECCCCEEEECCCCC
GSEVTPIYGLTEGRLKQTGRDPRVLPRTVLYDPELTLTLPVEISAASGMNAMAHAVEAIY
CCCCCEEECCCCCHHHHCCCCCCCCCCEEEECCCEEEEEEEEEECCCCCHHHHHHHHHHH
AEDANPIISLMAEASIRALAGALPTVVRRPDDIDARGDALYGAWLAGACLGSVGMAIHHK
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LCHTLGGTFNLPHAQTHAILLPHTAHYNHAAAPLALARVARALGGERAQDTGPLLFRLNQ
HHHHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
TLGIATALSAIGMPEDGLDEAATLACANPYYNPRLVEREPIRALLERAWRGESPA
HHHHHHHHHHCCCCCCCCHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEPFVYQATPSRVVFGAGRLEALPEEVLRLGARRALVLTTPGHRALGERVAALLGECSAG
CCCEEEECCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCC
VYSEAVMHVPVEVAHAARDEAARLGADCYVAVGGGSTIGLGKAIALVSGQPIIAVPTTYA
HHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCEEEEECCCCEEEECCCCC
GSEVTPIYGLTEGRLKQTGRDPRVLPRTVLYDPELTLTLPVEISAASGMNAMAHAVEAIY
CCCCCEEECCCCCHHHHCCCCCCCCCCEEEECCCEEEEEEEEEECCCCCHHHHHHHHHHH
AEDANPIISLMAEASIRALAGALPTVVRRPDDIDARGDALYGAWLAGACLGSVGMAIHHK
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LCHTLGGTFNLPHAQTHAILLPHTAHYNHAAAPLALARVARALGGERAQDTGPLLFRLNQ
HHHHCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
TLGIATALSAIGMPEDGLDEAATLACANPYYNPRLVEREPIRALLERAWRGESPA
HHHHHHHHHHCCCCCCCCHHHHHEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]