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The map label for this gene is betA3 [H]

Identifier: 94313937

GI number: 94313937

Start: 1694792

End: 1696465

Strand: Direct

Name: betA3 [H]

Synonym: Rmet_5015

Alternate gene names: 94313937

Gene position: 1694792-1696465 (Clockwise)

Preceding gene: 94313936

Following gene: 94313938

Centisome position: 65.69

GC content: 68.04

Gene sequence:

>1674_bases
GTGACCCAAAATGAAAAACTCGCCGGCGATACGCCAGCGGTGGCGGCCTTCGACTACATCGTCGTCGGCGCAGGATCAGC
CGGGTGCGCCGTCGCGGCGCGGCTGGCAGAGGATGCCGGCGTGACCGTGGCCCTGCTTGAAGCTGGCCCGAGCGACCATC
ACTTCAGCGTCTGGACGCCGGTGGCCCTCGCCGCGGTCGTCCCGAAAGCCGGTCCGCGCAACTACGCCTATCGCTCCGTG
CCGCAGCCGGGGCTCAACGGCCGGCGCTCCTACCAGCCGCGCGGGCGCGGTTTGGGCGGCAGCTCGTCGATCAATGGCAT
GGTCTATATCCGTGGCCACCGCAAGGACTACGACACCTGGGCGCAACTGGGCTGCCAGGGCTGGGGCTATGAGGATGTGC
TCCCCTACTTCCGTCGCAGCGAAACCAACCATGCGCTCGATGACCGGCACCACGGCAAGGACGGCCCGCTGCACGTCAAC
GAGCTGCGCACGCCCAACCCGTTTTCCGCGCGCTTCATCGAGGCCGCGATGCAGGCCGGCATCCCGTTCAACCGCGACTT
CAACGGCGCCGAACAGGACGGCGCCGGCTATTACCAGGTAACACAGCGCAACGGCGAGCGCTGGAACAGCGCGCGCGCCT
ACCTGCACCATGGCGATGCCAACGATGGCACCTTCAGCGGCGGCCGCCGCAACCTGACGGTCTGGACGGACACGCAGGTG
CAGCGCATCGTGTTCGAGGGTCGCCGCGCGGTCGGCGTCAGCATCACGCGCGCCGGCGTCACACAGGTGCTACGCGCGCG
CCGCGAAGTGATCGTCAGCGGCGGCGCCTTCAACTCGCCGCAGCTTCTGCTCGCGTCCGGTATCGGCCCTGCTGCCCATC
TGCGCGATCTCGGCATCGACGTCGTACACGACCTGCCCGGCGTGGGCGAAAACCTGCAGGACCACCTTGACATCGCTGTG
TGCCATCAGGTGCCGTCGCCGCAGCTTTTCGGATACTCGCTGCGCGGCGCGGCCAAGATGCTGGGCCAGTGGCGCCAGTA
TCGACGCGACCGCACCGGCATGTTCAGCTCCAATCTTGCCGAAGCAGGCGCCTTCCTGCGCAGCCGGCGGGAACTGGCCG
AGCCCGACCTGCAGTTCCACTTCGTGCCGGGGCTTTCCTCGACGCATACCGGCATGCGACGCCGCGACCTCAAGCATGGC
TTCACCGGCCTGGCCTGCCTGCTGCGCCCCGAAAGCCGCGGCCACGTGCGGCTGAACAGTGCCGATACCCGCGACGCGCC
GCTGATCGATCCGCGCTTCCTTTCCGCCGAATCGGACATGGCAGGCATGGTCGCCTGCTTCCGCCTGATGCGCCGCATCC
TGGCGCAGCCGGCACTGGCTTCCGCGCAAGGCCGTGAACTGCTCACCGAGGAGATCGGCCCCGGCGACGGCGACGAAGCC
GCCATCCGCGCCTATGTGCGCCGTCATGCGGATTCGGTCTTCCACGCTATCGGAACTTGCAAGATGGGCGTGGATGCAAT
GGCCGTGGTCGACCCGTCCCTGCGTGTGCACGGCGTGGAAGGCTTGCGCGTGGTCGACGCCTCGATCATGCCGACGCTGA
TCGGCGGCAACACCAACGCACCTGCCATGATGATCGGCGAGAAGGCCGCGGACCTGATCCGCTCGGGCGCCTGA

Upstream 100 bases:

>100_bases
GTTCTCTTGAACGCAATTTGATGTACTGCGCTCCGGCCATGAGCTTTTCGCGCGTGCGCGCCGGCTCGGCGACCCAACAA
GCCGCATACAGGAGACAGAT

Downstream 100 bases:

>100_bases
TGACCACCACCTCTTCCCACCTGGAGCATTTGATGCGCTGTTCCACCCGCTTCGCACTGACCGCCATCGCGGCCAGCCTG
ATTGCCACGACCGCCTGCGC

Product: choline dehydrogenase, a flavoprotein

Products: Betaine Aldehyde; Reduced Acceptor. [C]

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MTQNEKLAGDTPAVAAFDYIVVGAGSAGCAVAARLAEDAGVTVALLEAGPSDHHFSVWTPVALAAVVPKAGPRNYAYRSV
PQPGLNGRRSYQPRGRGLGGSSSINGMVYIRGHRKDYDTWAQLGCQGWGYEDVLPYFRRSETNHALDDRHHGKDGPLHVN
ELRTPNPFSARFIEAAMQAGIPFNRDFNGAEQDGAGYYQVTQRNGERWNSARAYLHHGDANDGTFSGGRRNLTVWTDTQV
QRIVFEGRRAVGVSITRAGVTQVLRARREVIVSGGAFNSPQLLLASGIGPAAHLRDLGIDVVHDLPGVGENLQDHLDIAV
CHQVPSPQLFGYSLRGAAKMLGQWRQYRRDRTGMFSSNLAEAGAFLRSRRELAEPDLQFHFVPGLSSTHTGMRRRDLKHG
FTGLACLLRPESRGHVRLNSADTRDAPLIDPRFLSAESDMAGMVACFRLMRRILAQPALASAQGRELLTEEIGPGDGDEA
AIRAYVRRHADSVFHAIGTCKMGVDAMAVVDPSLRVHGVEGLRVVDASIMPTLIGGNTNAPAMMIGEKAADLIRSGA

Sequences:

>Translated_557_residues
MTQNEKLAGDTPAVAAFDYIVVGAGSAGCAVAARLAEDAGVTVALLEAGPSDHHFSVWTPVALAAVVPKAGPRNYAYRSV
PQPGLNGRRSYQPRGRGLGGSSSINGMVYIRGHRKDYDTWAQLGCQGWGYEDVLPYFRRSETNHALDDRHHGKDGPLHVN
ELRTPNPFSARFIEAAMQAGIPFNRDFNGAEQDGAGYYQVTQRNGERWNSARAYLHHGDANDGTFSGGRRNLTVWTDTQV
QRIVFEGRRAVGVSITRAGVTQVLRARREVIVSGGAFNSPQLLLASGIGPAAHLRDLGIDVVHDLPGVGENLQDHLDIAV
CHQVPSPQLFGYSLRGAAKMLGQWRQYRRDRTGMFSSNLAEAGAFLRSRRELAEPDLQFHFVPGLSSTHTGMRRRDLKHG
FTGLACLLRPESRGHVRLNSADTRDAPLIDPRFLSAESDMAGMVACFRLMRRILAQPALASAQGRELLTEEIGPGDGDEA
AIRAYVRRHADSVFHAIGTCKMGVDAMAVVDPSLRVHGVEGLRVVDASIMPTLIGGNTNAPAMMIGEKAADLIRSGA
>Mature_556_residues
TQNEKLAGDTPAVAAFDYIVVGAGSAGCAVAARLAEDAGVTVALLEAGPSDHHFSVWTPVALAAVVPKAGPRNYAYRSVP
QPGLNGRRSYQPRGRGLGGSSSINGMVYIRGHRKDYDTWAQLGCQGWGYEDVLPYFRRSETNHALDDRHHGKDGPLHVNE
LRTPNPFSARFIEAAMQAGIPFNRDFNGAEQDGAGYYQVTQRNGERWNSARAYLHHGDANDGTFSGGRRNLTVWTDTQVQ
RIVFEGRRAVGVSITRAGVTQVLRARREVIVSGGAFNSPQLLLASGIGPAAHLRDLGIDVVHDLPGVGENLQDHLDIAVC
HQVPSPQLFGYSLRGAAKMLGQWRQYRRDRTGMFSSNLAEAGAFLRSRRELAEPDLQFHFVPGLSSTHTGMRRRDLKHGF
TGLACLLRPESRGHVRLNSADTRDAPLIDPRFLSAESDMAGMVACFRLMRRILAQPALASAQGRELLTEEIGPGDGDEAA
IRAYVRRHADSVFHAIGTCKMGVDAMAVVDPSLRVHGVEGLRVVDASIMPTLIGGNTNAPAMMIGEKAADLIRSGA

Specific function: Converts aliphatic medium-chain-length alcohols into aldehydes. May be linked to the electron transfer chain [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=547, Percent_Identity=43.5100548446069, Blast_Score=413, Evalue=1e-115,
Organism=Escherichia coli, GI1786503, Length=550, Percent_Identity=44, Blast_Score=398, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17532301, Length=557, Percent_Identity=37.8815080789946, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24642042, Length=574, Percent_Identity=37.8048780487805, Blast_Score=324, Evalue=9e-89,
Organism=Drosophila melanogaster, GI24642039, Length=574, Percent_Identity=36.0627177700348, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI45551458, Length=575, Percent_Identity=36, Blast_Score=305, Evalue=6e-83,
Organism=Drosophila melanogaster, GI45549471, Length=575, Percent_Identity=36, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI18859995, Length=574, Percent_Identity=36.2369337979094, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24642035, Length=586, Percent_Identity=36.0068259385666, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24642055, Length=578, Percent_Identity=35.2941176470588, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24642037, Length=581, Percent_Identity=34.7676419965577, Blast_Score=293, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24650267, Length=590, Percent_Identity=34.4067796610169, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24642059, Length=576, Percent_Identity=34.0277777777778, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24642048, Length=589, Percent_Identity=33.446519524618, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI17137792, Length=561, Percent_Identity=34.7593582887701, Blast_Score=282, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24642051, Length=581, Percent_Identity=32.013769363167, Blast_Score=265, Evalue=6e-71,
Organism=Drosophila melanogaster, GI18859993, Length=580, Percent_Identity=32.5862068965517, Blast_Score=262, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24642057, Length=603, Percent_Identity=31.5091210613599, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24645930, Length=592, Percent_Identity=28.2094594594595, Blast_Score=166, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.99.1 [C]

Molecular weight: Translated: 60322; Mature: 60191

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNEKLAGDTPAVAAFDYIVVGAGSAGCAVAARLAEDAGVTVALLEAGPSDHHFSVWTP
CCCCCCCCCCCCHHHEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEHHHH
VALAAVVPKAGPRNYAYRSVPQPGLNGRRSYQPRGRGLGGSSSINGMVYIRGHRKDYDTW
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHH
AQLGCQGWGYEDVLPYFRRSETNHALDDRHHGKDGPLHVNELRTPNPFSARFIEAAMQAG
HHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHCCCCCCCHHHHHHHHHHHHC
IPFNRDFNGAEQDGAGYYQVTQRNGERWNSARAYLHHGDANDGTFSGGRRNLTVWTDTQV
CCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHEEECCCCCCCCCCCCCEEEEEEECCHH
QRIVFEGRRAVGVSITRAGVTQVLRARREVIVSGGAFNSPQLLLASGIGPAAHLRDLGID
HHHHHCCCCEEEEEEHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCHHHHHHHCCCH
VVHDLPGVGENLQDHLDIAVCHQVPSPQLFGYSLRGAAKMLGQWRQYRRDRTGMFSSNLA
HHHCCCCCCCCHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EAGAFLRSRRELAEPDLQFHFVPGLSSTHTGMRRRDLKHGFTGLACLLRPESRGHVRLNS
HHHHHHHHHHHHCCCCCEEEEECCCCCHHCHHHHHHHHCCCCCEEEEECCCCCCCEEECC
ADTRDAPLIDPRFLSAESDMAGMVACFRLMRRILAQPALASAQGRELLTEEIGPGDGDEA
CCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHCCCCCCHHH
AIRAYVRRHADSVFHAIGTCKMGVDAMAVVDPSLRVHGVEGLRVVDASIMPTLIGGNTNA
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCEEEECCHHCCEEECCCCCC
PAMMIGEKAADLIRSGA
CEEEECHHHHHHHHCCC
>Mature Secondary Structure 
TQNEKLAGDTPAVAAFDYIVVGAGSAGCAVAARLAEDAGVTVALLEAGPSDHHFSVWTP
CCCCCCCCCCCHHHEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEHHHH
VALAAVVPKAGPRNYAYRSVPQPGLNGRRSYQPRGRGLGGSSSINGMVYIRGHRKDYDTW
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHH
AQLGCQGWGYEDVLPYFRRSETNHALDDRHHGKDGPLHVNELRTPNPFSARFIEAAMQAG
HHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHCCCCCCCHHHHHHHHHHHHC
IPFNRDFNGAEQDGAGYYQVTQRNGERWNSARAYLHHGDANDGTFSGGRRNLTVWTDTQV
CCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHEEECCCCCCCCCCCCCEEEEEEECCHH
QRIVFEGRRAVGVSITRAGVTQVLRARREVIVSGGAFNSPQLLLASGIGPAAHLRDLGID
HHHHHCCCCEEEEEEHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCHHHHHHHCCCH
VVHDLPGVGENLQDHLDIAVCHQVPSPQLFGYSLRGAAKMLGQWRQYRRDRTGMFSSNLA
HHHCCCCCCCCHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EAGAFLRSRRELAEPDLQFHFVPGLSSTHTGMRRRDLKHGFTGLACLLRPESRGHVRLNS
HHHHHHHHHHHHCCCCCEEEEECCCCCHHCHHHHHHHHCCCCCEEEEECCCCCCCEEECC
ADTRDAPLIDPRFLSAESDMAGMVACFRLMRRILAQPALASAQGRELLTEEIGPGDGDEA
CCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHCCCCCCHHH
AIRAYVRRHADSVFHAIGTCKMGVDAMAVVDPSLRVHGVEGLRVVDASIMPTLIGGNTNA
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCEEEECCHHCCEEECCCCCC
PAMMIGEKAADLIRSGA
CEEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Coenzyme Q [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 7 {choline}} 1.1 {phenazine}} [C]

Substrates: Choline; Acceptor [C]

Specific reaction: Choline + Acceptor = Betaine Aldehyde + Reduced Acceptor. [C]

General reaction: Redox reaction [C]

Inhibitor: 2-Dimethylaminoethanol; Betaine aldehyde; Monoethanolamine; Semicarbazide [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11390693 [H]