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The map label for this gene is mdtD [H]

Identifier: 94313748

GI number: 94313748

Start: 1478366

End: 1479820

Strand: Reverse

Name: mdtD [H]

Synonym: Rmet_4826

Alternate gene names: 94313748

Gene position: 1479820-1478366 (Counterclockwise)

Preceding gene: 94313749

Following gene: 94313744

Centisome position: 57.36

GC content: 63.57

Gene sequence:

>1455_bases
ATGTCCACAGCCACGCCTGCCGACCACCCGTCCACGATGCCCATCGACCGCCGCCTGCGCTTCATGCTGTGGGTGGTGGC
GGTGGGCTTCTTCATGCAGACGCTCGACTCGACGATCGTCAACACCGCCTTGCCGTCGATGGCGCACAGCCTTGGCGAGA
GCCCGTTGCGGATGCAATCGGTGATCATCGCCTACTCGCTGACCATGGCGGTCATCATTCCTGCTTCGGGCTGGCTGGCG
GACAAATTCGGCACAAGAACCATCTTCCAGATCGCGATCGTGTTGTTCGTGGCCGGATCCCTGCTTTGCGCCGCGGCGCC
TTCGCTGCCGTTCCTGACCGCGGCCCGCGTGGTGCAGGGGGCGGGCGGGGCGATGCTGCTGCCCGTGGGGCGACTCTCCG
TACTGCGTACGTTTCCGCGCGAGCAGTATCTGCAGGCGCTGAGTTTCGTGGCCATCCCAGGCATGATCGGTCCGCTCATC
GGCCCGACGCTGGGCGGTTGGATTACCCAGACCTTCTCCTGGCACTGGATCTTCCTGATCAACGTGCCGGTCGGCCTGCT
GGGCGTGCTGGCCACCATCCGCTATATGCCGAACTCGCGCTTGCCCGGCATCGGCACGTTCGATGCGGTTGGCTATGCGT
TCCTGGCAATTGCCATGGTGACGTTGTCGTTCTCGCTCGACGGACTCGCGGAGATGGGCTTTCAGCACGCCACGGTGCTG
ATGCTGCTGATCGCCAGCATGGCCGCGCTCAGCGCGTACGTGCTCCACGCCAACAAGCGCAAGCAGCCGCTGTTCCCGCT
GAGGCTGTTCCGCATTCATTCGTTCAGCGTGGGCCTGCTTGGCAACCTGTTCGCGCGTATCGGCAATGGCGCCATGCCGT
TCCTGATTCCACTGACCCTGCAGGTCAGCCTCGGCTATTCCCCGTTCGATGCCGGCCTGATGATGCTGCCTGTCACGGCC
GCCGGCATGGCGTCGAAGCGCCTGGCCACGTGGCTGATCGAACGGCACGGCTATCGCCGCGTGCTGGTGACGAACACATT
CGTGGTCGGACTGGTCATGGCGTCGTTCGCGCTGATCACGCCGACGCGCCCATTGGCGCTCATCGTGGTGCTACTGGCGA
TTTTTGGCGCGGTTAATTCGATCCAGTTCACCGCGATGAATACCGTGACGCTCAAGGATCTGAGTGGTACCCGGGCGAGC
AGCGGCAACAGCATGTTGTCGATGGTGCAGATGTTGTCGATGAGTCTGGCGGTGACATCCGCCGGCGCATTGCTGGCGAC
GTTCCAGGAGGGCATCGGCGAGCATCACCTGGACGTCCTGCCTGCGTTTCACGCGACGTTCGTCTGCGTCGGGCTCATTA
CGTCGGCATCGGCGTGGATCTTCATGCAGCTTTCGCCCGAGAAGGCGGAGCGGCACAAGGCCAGGGAAGACGTGAAGCAG
GGTGGGGAGGTTTGA

Upstream 100 bases:

>100_bases
CGCGCACCCGCACGGCTTGTGGACTTGCCAGCGCGGCCGTGCGAGCCTATGGTTGCGGTTCGTCCCGTGCGCAGTAGGGC
GCACGCACCGCCTCCAGCCC

Downstream 100 bases:

>100_bases
AGCAGGCCGGGGATGCGATTCCCGGCCCGAGTGCCTGACGTTCGGTTTGATGCGCGGAAGGATCAGGCTGACAGCAGCGA
GCAGAATCGCTCCAGGTCGA

Product: multidrug efflux system protein; drug resistance MFS transporter EmrB/QacA subfamily

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSTATPADHPSTMPIDRRLRFMLWVVAVGFFMQTLDSTIVNTALPSMAHSLGESPLRMQSVIIAYSLTMAVIIPASGWLA
DKFGTRTIFQIAIVLFVAGSLLCAAAPSLPFLTAARVVQGAGGAMLLPVGRLSVLRTFPREQYLQALSFVAIPGMIGPLI
GPTLGGWITQTFSWHWIFLINVPVGLLGVLATIRYMPNSRLPGIGTFDAVGYAFLAIAMVTLSFSLDGLAEMGFQHATVL
MLLIASMAALSAYVLHANKRKQPLFPLRLFRIHSFSVGLLGNLFARIGNGAMPFLIPLTLQVSLGYSPFDAGLMMLPVTA
AGMASKRLATWLIERHGYRRVLVTNTFVVGLVMASFALITPTRPLALIVVLLAIFGAVNSIQFTAMNTVTLKDLSGTRAS
SGNSMLSMVQMLSMSLAVTSAGALLATFQEGIGEHHLDVLPAFHATFVCVGLITSASAWIFMQLSPEKAERHKAREDVKQ
GGEV

Sequences:

>Translated_484_residues
MSTATPADHPSTMPIDRRLRFMLWVVAVGFFMQTLDSTIVNTALPSMAHSLGESPLRMQSVIIAYSLTMAVIIPASGWLA
DKFGTRTIFQIAIVLFVAGSLLCAAAPSLPFLTAARVVQGAGGAMLLPVGRLSVLRTFPREQYLQALSFVAIPGMIGPLI
GPTLGGWITQTFSWHWIFLINVPVGLLGVLATIRYMPNSRLPGIGTFDAVGYAFLAIAMVTLSFSLDGLAEMGFQHATVL
MLLIASMAALSAYVLHANKRKQPLFPLRLFRIHSFSVGLLGNLFARIGNGAMPFLIPLTLQVSLGYSPFDAGLMMLPVTA
AGMASKRLATWLIERHGYRRVLVTNTFVVGLVMASFALITPTRPLALIVVLLAIFGAVNSIQFTAMNTVTLKDLSGTRAS
SGNSMLSMVQMLSMSLAVTSAGALLATFQEGIGEHHLDVLPAFHATFVCVGLITSASAWIFMQLSPEKAERHKAREDVKQ
GGEV
>Mature_483_residues
STATPADHPSTMPIDRRLRFMLWVVAVGFFMQTLDSTIVNTALPSMAHSLGESPLRMQSVIIAYSLTMAVIIPASGWLAD
KFGTRTIFQIAIVLFVAGSLLCAAAPSLPFLTAARVVQGAGGAMLLPVGRLSVLRTFPREQYLQALSFVAIPGMIGPLIG
PTLGGWITQTFSWHWIFLINVPVGLLGVLATIRYMPNSRLPGIGTFDAVGYAFLAIAMVTLSFSLDGLAEMGFQHATVLM
LLIASMAALSAYVLHANKRKQPLFPLRLFRIHSFSVGLLGNLFARIGNGAMPFLIPLTLQVSLGYSPFDAGLMMLPVTAA
GMASKRLATWLIERHGYRRVLVTNTFVVGLVMASFALITPTRPLALIVVLLAIFGAVNSIQFTAMNTVTLKDLSGTRASS
GNSMLSMVQMLSMSLAVTSAGALLATFQEGIGEHHLDVLPAFHATFVCVGLITSASAWIFMQLSPEKAERHKAREDVKQG
GEV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=472, Percent_Identity=44.0677966101695, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1788392, Length=469, Percent_Identity=47.9744136460554, Blast_Score=387, Evalue=1e-108,
Organism=Escherichia coli, GI1789042, Length=413, Percent_Identity=29.7820823244552, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1788710, Length=409, Percent_Identity=29.5843520782396, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI87081983, Length=335, Percent_Identity=30.7462686567164, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6325455, Length=129, Percent_Identity=34.8837209302326, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322958, Length=177, Percent_Identity=28.2485875706215, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51982; Mature: 51850

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTATPADHPSTMPIDRRLRFMLWVVAVGFFMQTLDSTIVNTALPSMAHSLGESPLRMQS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VIIAYSLTMAVIIPASGWLADKFGTRTIFQIAIVLFVAGSLLCAAAPSLPFLTAARVVQG
HHHHHHHHHHEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
AGGAMLLPVGRLSVLRTFPREQYLQALSFVAIPGMIGPLIGPTLGGWITQTFSWHWIFLI
CCCEEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEE
NVPVGLLGVLATIRYMPNSRLPGIGTFDAVGYAFLAIAMVTLSFSLDGLAEMGFQHATVL
ECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCHHHHHHH
MLLIASMAALSAYVLHANKRKQPLFPLRLFRIHSFSVGLLGNLFARIGNGAMPFLIPLTL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEE
QVSLGYSPFDAGLMMLPVTAAGMASKRLATWLIERHGYRRVLVTNTFVVGLVMASFALIT
EEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHC
PTRPLALIVVLLAIFGAVNSIQFTAMNTVTLKDLSGTRASSGNSMLSMVQMLSMSLAVTS
CCCHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
AGALLATFQEGIGEHHLDVLPAFHATFVCVGLITSASAWIFMQLSPEKAERHKAREDVKQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHC
GGEV
CCCC
>Mature Secondary Structure 
STATPADHPSTMPIDRRLRFMLWVVAVGFFMQTLDSTIVNTALPSMAHSLGESPLRMQS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VIIAYSLTMAVIIPASGWLADKFGTRTIFQIAIVLFVAGSLLCAAAPSLPFLTAARVVQG
HHHHHHHHHHEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
AGGAMLLPVGRLSVLRTFPREQYLQALSFVAIPGMIGPLIGPTLGGWITQTFSWHWIFLI
CCCEEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEE
NVPVGLLGVLATIRYMPNSRLPGIGTFDAVGYAFLAIAMVTLSFSLDGLAEMGFQHATVL
ECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCHHHHHHH
MLLIASMAALSAYVLHANKRKQPLFPLRLFRIHSFSVGLLGNLFARIGNGAMPFLIPLTL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEE
QVSLGYSPFDAGLMMLPVTAAGMASKRLATWLIERHGYRRVLVTNTFVVGLVMASFALIT
EEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHC
PTRPLALIVVLLAIFGAVNSIQFTAMNTVTLKDLSGTRASSGNSMLSMVQMLSMSLAVTS
CCCHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
AGALLATFQEGIGEHHLDVLPAFHATFVCVGLITSASAWIFMQLSPEKAERHKAREDVKQ
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHC
GGEV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA