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The map label for this gene is acpA [H]

Identifier: 94313731

GI number: 94313731

Start: 1456463

End: 1458592

Strand: Direct

Name: acpA [H]

Synonym: Rmet_4809

Alternate gene names: 94313731

Gene position: 1456463-1458592 (Clockwise)

Preceding gene: 94313729

Following gene: 94313732

Centisome position: 56.45

GC content: 65.4

Gene sequence:

>2130_bases
ATGAGCCGTCTCACTCGTCTGTGGCCATTGGCCGCAATCGCCGCCGCATCGCTGACCGCCTGCGGTGGCAGCGATTCCGG
CACCGCCAGCACCCCCGCCGCCACCACCTCCGGCGTTGTGACTGGCAGCTACTTCGAGCACGCGAAAGTCTGTATCGACG
CCAACGCCAACGCCCAGTGCGATAGCGGCGAAGCATCGACCTATACCGATGCCAAGGGCGCTTTCACGCTGACGGGCCAG
GGCGCCGTGGTGGCCGAGATCGGCACGGATGCCTTCCGCAACGACGACACGGGCGCCCACAACGCCGTGACGCGCAAGCT
CGTGTTCCGCGCCCCGGCCGGCGCCAATGCCGTGGTGAGCGCAATCTCGACCGAACTGGCCGCGCTGATGGACAGCAACG
GCGGCAAGCTCGACGACGCACGCAATCAACTGGCTACCCGCCTGGGCGTCACCGCCGACAAACTGCTGGAAGACCACAAT
AAGGAAACCGACAGCAACATCAAGGCCACGCTGCAGGCCGAGATCGAGCAGGCGATCGACCTGATCGCCACGGCCGTGGC
ATCGGGCGGCGACATCGGCACCGCGATCCGTGATGGCGTGACCAAGCGCGTCGCGCTGCAGAACATCAAGAACGTCGTGG
TGATCTACGCCGAGAACCGCGGCTTCGACAACCTCTACGGCCTGTTCCCCGGCGCCAACGGCATTCCAGGCGTGAACCCG
ACGGCCGTGGGTACCGTGGAACCGCAGAAGGACTTTGACGGCTCGACGCTGGCCTCGCTGCCCCCGACCTGGGGCGGCTT
CACCGCCAGCGGCCAGACTGTCACGCTCCCGCAGGCCAGCACCGTGGGCTGGGCCAACAAGCCGTTCCGTATCGACGACC
CGGCCGGCGTGAACGGCACGGGCGTGGTGGTGGGCCAGAACGTGATCACGCGTGACCTGGTGCACCGCTTCTATAACAAC
CAGATGCAGATCAACGGCGGCAAGAACGACAAGTTCACGGCGTTCTCCGACGCCGGCGGCCTGGTCATGGGCTACTACGA
CGGCAGCGCCATGTCGATGTGGAAGCTCGCCCAGCAGTACACGCTGGCCGACAACTTCTTCATGGGCGCGTTCGGCGGCT
CGTTCCTGAACCACCAGTACCTGGTCTGCGCCTGCGCGCCGGTCTACCCGAATGCCGAAACCTCGGTGGCCTCGGGTTCG
ATTTCGGTCGTCGACACGGACGCCAACGGCAACTTCAAGAGCCTGTCGCTCAAGCCCACGAGCCCCGCCAGCATCCAGAC
CGGCACCGCCCAGTACGTGAACGACAGCACGCTGACCGCCAAGGACGGCACCGGCGTCTACTACGCGGTCAACACGATGC
AGCCGCCGTACCAGCCGAGCGGCAACGCACCTGCGTCGACGGACTCGACCAAGCTGCTGGCCGACCCGACCAAGGCCACC
ACGCTGCCTGCCCAGACCCAGGACACGATCGCCTCGCTGCTGGACCGCCGCGGCATCAGCTGGGCCTGGTACTCGGGCGC
ATGGAGCGCCGTGACCGCCAATAGCGCGCTGATTTACAACAACACCACGCCGAACTTCCAGCCGCACCACCAGCCGTTCA
ACTACTACTCGGCCTTCAGCCCGATCGATCACGCAGACTATCGCGCGGCTCACCTGAAGGACTACGACTCGTCGTTCCTG
GCTGATGCGGCAGCGGGCAAGCTGCCGGCCGTCTCGTTCTACAAGCCGCAAGGCAACCTGAACCAGCACGCCGGCTATGC
CAACGTGACCGACGGCGATGCCCACATCGCCAACGTGATCGCCCAGCTTCAGAAGAGCCCGCAGTGGAACAACATGCTGA
TCGTGGTGACGTACGACGAGAACGGTGGCTTCTATGACCACGCACCGGTGCCTAAGGCCGACCGCTGGGGCCCGGGTACC
CGTATCCCTGCCATCGTGATCTCGCCGTTCGCCAAGCGCGGCTTCGTCGATCACACGCAATACGACACCGCTTCGGTGCT
GCGTTTCATCACGCACCGCTTCGCGCTGCCGACGCTGCCTGGCCTGAAGCTGCGTGACGATTCGCTGATCGCAAACGGCA
AGCCGGCGATGGGCGACCTGACCAATGCGCTGACATTCCCGGCGCAGTAA

Upstream 100 bases:

>100_bases
CATCAACTTGACACATACCGCATACACACTCGCGGCGCACCCAGTAGTACCCCTCTGCTTTCCAAGCATTGAATACCCAC
ACATAAGAAAGAGGAAAACC

Downstream 100 bases:

>100_bases
GCAGGGCGCGAAGGCATTGCCTTCGCGCTGAAAAGGGGGCGGCTCCACGAGGGGCCGCCCCCTTGTCTATTGGATGGTCG
AAAGTCCGGTCGCGCCCCTT

Product: putative acid phosphatase protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 709; Mature: 708

Protein sequence:

>709_residues
MSRLTRLWPLAAIAAASLTACGGSDSGTASTPAATTSGVVTGSYFEHAKVCIDANANAQCDSGEASTYTDAKGAFTLTGQ
GAVVAEIGTDAFRNDDTGAHNAVTRKLVFRAPAGANAVVSAISTELAALMDSNGGKLDDARNQLATRLGVTADKLLEDHN
KETDSNIKATLQAEIEQAIDLIATAVASGGDIGTAIRDGVTKRVALQNIKNVVVIYAENRGFDNLYGLFPGANGIPGVNP
TAVGTVEPQKDFDGSTLASLPPTWGGFTASGQTVTLPQASTVGWANKPFRIDDPAGVNGTGVVVGQNVITRDLVHRFYNN
QMQINGGKNDKFTAFSDAGGLVMGYYDGSAMSMWKLAQQYTLADNFFMGAFGGSFLNHQYLVCACAPVYPNAETSVASGS
ISVVDTDANGNFKSLSLKPTSPASIQTGTAQYVNDSTLTAKDGTGVYYAVNTMQPPYQPSGNAPASTDSTKLLADPTKAT
TLPAQTQDTIASLLDRRGISWAWYSGAWSAVTANSALIYNNTTPNFQPHHQPFNYYSAFSPIDHADYRAAHLKDYDSSFL
ADAAAGKLPAVSFYKPQGNLNQHAGYANVTDGDAHIANVIAQLQKSPQWNNMLIVVTYDENGGFYDHAPVPKADRWGPGT
RIPAIVISPFAKRGFVDHTQYDTASVLRFITHRFALPTLPGLKLRDDSLIANGKPAMGDLTNALTFPAQ

Sequences:

>Translated_709_residues
MSRLTRLWPLAAIAAASLTACGGSDSGTASTPAATTSGVVTGSYFEHAKVCIDANANAQCDSGEASTYTDAKGAFTLTGQ
GAVVAEIGTDAFRNDDTGAHNAVTRKLVFRAPAGANAVVSAISTELAALMDSNGGKLDDARNQLATRLGVTADKLLEDHN
KETDSNIKATLQAEIEQAIDLIATAVASGGDIGTAIRDGVTKRVALQNIKNVVVIYAENRGFDNLYGLFPGANGIPGVNP
TAVGTVEPQKDFDGSTLASLPPTWGGFTASGQTVTLPQASTVGWANKPFRIDDPAGVNGTGVVVGQNVITRDLVHRFYNN
QMQINGGKNDKFTAFSDAGGLVMGYYDGSAMSMWKLAQQYTLADNFFMGAFGGSFLNHQYLVCACAPVYPNAETSVASGS
ISVVDTDANGNFKSLSLKPTSPASIQTGTAQYVNDSTLTAKDGTGVYYAVNTMQPPYQPSGNAPASTDSTKLLADPTKAT
TLPAQTQDTIASLLDRRGISWAWYSGAWSAVTANSALIYNNTTPNFQPHHQPFNYYSAFSPIDHADYRAAHLKDYDSSFL
ADAAAGKLPAVSFYKPQGNLNQHAGYANVTDGDAHIANVIAQLQKSPQWNNMLIVVTYDENGGFYDHAPVPKADRWGPGT
RIPAIVISPFAKRGFVDHTQYDTASVLRFITHRFALPTLPGLKLRDDSLIANGKPAMGDLTNALTFPAQ
>Mature_708_residues
SRLTRLWPLAAIAAASLTACGGSDSGTASTPAATTSGVVTGSYFEHAKVCIDANANAQCDSGEASTYTDAKGAFTLTGQG
AVVAEIGTDAFRNDDTGAHNAVTRKLVFRAPAGANAVVSAISTELAALMDSNGGKLDDARNQLATRLGVTADKLLEDHNK
ETDSNIKATLQAEIEQAIDLIATAVASGGDIGTAIRDGVTKRVALQNIKNVVVIYAENRGFDNLYGLFPGANGIPGVNPT
AVGTVEPQKDFDGSTLASLPPTWGGFTASGQTVTLPQASTVGWANKPFRIDDPAGVNGTGVVVGQNVITRDLVHRFYNNQ
MQINGGKNDKFTAFSDAGGLVMGYYDGSAMSMWKLAQQYTLADNFFMGAFGGSFLNHQYLVCACAPVYPNAETSVASGSI
SVVDTDANGNFKSLSLKPTSPASIQTGTAQYVNDSTLTAKDGTGVYYAVNTMQPPYQPSGNAPASTDSTKLLADPTKATT
LPAQTQDTIASLLDRRGISWAWYSGAWSAVTANSALIYNNTTPNFQPHHQPFNYYSAFSPIDHADYRAAHLKDYDSSFLA
DAAAGKLPAVSFYKPQGNLNQHAGYANVTDGDAHIANVIAQLQKSPQWNNMLIVVTYDENGGFYDHAPVPKADRWGPGTR
IPAIVISPFAKRGFVDHTQYDTASVLRFITHRFALPTLPGLKLRDDSLIANGKPAMGDLTNALTFPAQ

Specific function: Hydrolyzes sphingomyelin in addition to phosphatidylcholine. Probable virulence factor implicated in the pathogenesis of M.tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity [H]

COG id: COG3511

COG function: function code M; Phospholipase C

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Extracellular side [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial phospholipase C family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007312
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04185 Phosphoesterase [H]

EC number: =3.1.4.3 [H]

Molecular weight: Translated: 74833; Mature: 74702

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLTRLWPLAAIAAASLTACGGSDSGTASTPAATTSGVVTGSYFEHAKVCIDANANAQC
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEECCCCCCC
DSGEASTYTDAKGAFTLTGQGAVVAEIGTDAFRNDDTGAHNAVTRKLVFRAPAGANAVVS
CCCCCCCEECCCCCEEEECCCEEEEECCCHHHCCCCCCCHHHHHHEEEEECCCCCHHHHH
AISTELAALMDSNGGKLDDARNQLATRLGVTADKLLEDHNKETDSNIKATLQAEIEQAID
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEHHHHHHHHHHH
LIATAVASGGDIGTAIRDGVTKRVALQNIKNVVVIYAENRGFDNLYGLFPGANGIPGVNP
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHEECCCCCCCCCCCC
TAVGTVEPQKDFDGSTLASLPPTWGGFTASGQTVTLPQASTVGWANKPFRIDDPAGVNGT
CEEECCCCCCCCCCCEECCCCCCCCCEECCCCEEECCCCCCCCCCCCCEECCCCCCCCCC
GVVVGQNVITRDLVHRFYNNQMQINGGKNDKFTAFSDAGGLVMGYYDGSAMSMWKLAQQY
EEEECCHHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHH
TLADNFFMGAFGGSFLNHQYLVCACAPVYPNAETSVASGSISVVDTDANGNFKSLSLKPT
HHHCCCEEECCCCHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCC
SPASIQTGTAQYVNDSTLTAKDGTGVYYAVNTMQPPYQPSGNAPASTDSTKLLADPTKAT
CCCCEECCCHHEECCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCC
TLPAQTQDTIASLLDRRGISWAWYSGAWSAVTANSALIYNNTTPNFQPHHQPFNYYSAFS
CCCCCCHHHHHHHHHHCCCCEEEECCCEEEEECCCEEEECCCCCCCCCCCCCCCHHHCCC
PIDHADYRAAHLKDYDSSFLADAAAGKLPAVSFYKPQGNLNQHAGYANVTDGDAHIANVI
CCCCCCCCHHHHCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
AQLQKSPQWNNMLIVVTYDENGGFYDHAPVPKADRWGPGTRIPAIVISPFAKRGFVDHTQ
HHHHCCCCCCCEEEEEEECCCCCEECCCCCCCCCCCCCCCCCCEEEECCHHHCCCCCCCC
YDTASVLRFITHRFALPTLPGLKLRDDSLIANGKPAMGDLTNALTFPAQ
CCHHHHHHHHHHHHCCCCCCCCEECCCCEEECCCCCCCHHHHCCCCCCC
>Mature Secondary Structure 
SRLTRLWPLAAIAAASLTACGGSDSGTASTPAATTSGVVTGSYFEHAKVCIDANANAQC
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEECCCCCCC
DSGEASTYTDAKGAFTLTGQGAVVAEIGTDAFRNDDTGAHNAVTRKLVFRAPAGANAVVS
CCCCCCCEECCCCCEEEECCCEEEEECCCHHHCCCCCCCHHHHHHEEEEECCCCCHHHHH
AISTELAALMDSNGGKLDDARNQLATRLGVTADKLLEDHNKETDSNIKATLQAEIEQAID
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEHHHHHHHHHHH
LIATAVASGGDIGTAIRDGVTKRVALQNIKNVVVIYAENRGFDNLYGLFPGANGIPGVNP
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHEECCCCCCCCCCCC
TAVGTVEPQKDFDGSTLASLPPTWGGFTASGQTVTLPQASTVGWANKPFRIDDPAGVNGT
CEEECCCCCCCCCCCEECCCCCCCCCEECCCCEEECCCCCCCCCCCCCEECCCCCCCCCC
GVVVGQNVITRDLVHRFYNNQMQINGGKNDKFTAFSDAGGLVMGYYDGSAMSMWKLAQQY
EEEECCHHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHH
TLADNFFMGAFGGSFLNHQYLVCACAPVYPNAETSVASGSISVVDTDANGNFKSLSLKPT
HHHCCCEEECCCCHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCC
SPASIQTGTAQYVNDSTLTAKDGTGVYYAVNTMQPPYQPSGNAPASTDSTKLLADPTKAT
CCCCEECCCHHEECCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCC
TLPAQTQDTIASLLDRRGISWAWYSGAWSAVTANSALIYNNTTPNFQPHHQPFNYYSAFS
CCCCCCHHHHHHHHHHCCCCEEEECCCEEEEECCCEEEECCCCCCCCCCCCCCCHHHCCC
PIDHADYRAAHLKDYDSSFLADAAAGKLPAVSFYKPQGNLNQHAGYANVTDGDAHIANVI
CCCCCCCCHHHHCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
AQLQKSPQWNNMLIVVTYDENGGFYDHAPVPKADRWGPGTRIPAIVISPFAKRGFVDHTQ
HHHHCCCCCCCEEEEEEECCCCCEECCCCCCCCCCCCCCCCCCEEEECCHHHCCCCCCCC
YDTASVLRFITHRFALPTLPGLKLRDDSLIANGKPAMGDLTNALTFPAQ
CCHHHHHHHHHHHHCCCCCCCCEECCCCEEECCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8757862; 9634230; 12218036 [H]