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The map label for this gene is aceA [C]

Identifier: 94313659

GI number: 94313659

Start: 1381643

End: 1383223

Strand: Reverse

Name: aceA [C]

Synonym: Rmet_4737

Alternate gene names: 94313659

Gene position: 1383223-1381643 (Counterclockwise)

Preceding gene: 94313661

Following gene: 94313657

Centisome position: 53.61

GC content: 61.67

Gene sequence:

>1581_bases
ATGGCTCAGTATCAAGACGACATCAAGGCAGTTGCTGGTTTGAAAGAGCAACACGGCAGCGCGTGGAATGCCATCAACCC
CGAGTATGCCGCTCGCATGCGTGCCCAGAACAAGTTCAAGACGGGTCTGGACATCGCCAAGTACACCGCCAAGATCATGC
GCGCCGACATGGCCGCCTATGATGCGAATCCTTCCAAGTACACCCAGTCGCTCGGTTGCTGGCACGGTTTCATCGGCCAG
CAGAAGATGATTTCCATCAAGAAGCACTTCAAGAGCACCGAGCGTCGCTACCTCTACCTGTCGGGCTGGATGGTCGCTGC
GCTGCGCTCCGAGTTCGGCCCGCTGCCGGACCAGTCGATGCACGAAAAGACCTCGGTCAGCGCGCTGATCCGCGAGCTGT
ACACGTTCCTGCGCCAGGCTGACGCACGGGAACTGGGCGGCCTGTTCCGCGAACTGGATGCCGCCACCGGTGCCGCCAAA
GCCGCCATCCAGGAAAAGATCGACAACCACGTCACCCACGTGGTGCCCATCATCGCCGACATCGACGCTGGTTTCGGCAA
TGCCGAGGCGACGTACCTGCTGGCCAAGCAGTTCATCGAAGCCGGTGCATGCTGCATCCAGATCGAGAACCAGGTGTCCG
ACGAGAAGCAGTGCGGCCACCAGGATGGCAAGGTCACCGTGCCGCACGAGGACTTCCTGGCCAAGATCCGCGCGATCCGC
TACGCCTTCCTCGAACTGGGCGTGGACGACGGCGTCATTGTGGCCCGTACCGATTCGCTGGGCGCAGGCCTGACCAAGCA
GATCGCCGTGACCGCCACCCCGGGCGACCTGGGCGACCAGTACAACTCGTTCCTGGATTGCGAGGAACTGTCGGCTGACC
AACTGGGCAACGGTGATGTCATCATCAAGCGCGACGGCAAGCTGCTGCGTCCGAAGCGTCTGCCGAGCAACCTGTTCCAG
TTCCGTGCCGGCACGGGCGAAGCACGTTGCGTCCTGGATTGCGTCACCGCGCTGCAAAACGGCGCCGACCTGCTGTGGAT
CGAAACCGAAAAGCCGCATATCGCCCAGATCGGTGGCATGGTCAGCGAAATCCGCAAGGTCATCCCGAACGCCAAGCTGG
TGTACAACAACAGCCCGTCGTTCAACTGGACCCTGAACTTCCGCCAGCAGGCCTACGACGCGATGAAGGCCGCGGGCAAG
GACGTGTCGGCATACGAGCGCACCCAGCTGATGAGCGTGGAATACGACGACAGCGAACTCGCCAAGATCGCTGACGAGAA
GATCCGCACGTTCCAGGCCGATGCATCGCGTGAAGCCGGTATCTTCCACCACCTGATCACGCTGCCGACGTACCACACCG
CCGCGCTGTCGACCGACAACCTGGCCAAGGAATACTTCGGCGACCAGGGCATGCTGGGCTACGTGGCCGGCGTGCAGCGC
AAGGAAATCCGTCAGGGCATCGCCTGCGTCAAGCACCAGAACATGTCCGGCTCGGACATCGGTGACGACCACAAGGAATA
CTTCAGCGGCGAAGCTGCCCTGAAGGCGGCTGGCAAGGACAACACGATGAACCAGTTCTGA

Upstream 100 bases:

>100_bases
TCAAAAACCCCCTACAATTATTTCCACGCTGCTTGCTTCGACACCCGTAGCGGCACAGGCAAACACTTCTTCAAACACGC
TTCACTCTTAGGAAACTCGT

Downstream 100 bases:

>100_bases
TCTGGGTCGTACTCCTAAGCAAGCTTCAGGCAGAACGCCAACCCTTCGCGGGTTGGCGTTTTTTTTTTAATTTGGCGACG
CGCAAAAAAAAGAGCCGACG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MAQYQDDIKAVAGLKEQHGSAWNAINPEYAARMRAQNKFKTGLDIAKYTAKIMRADMAAYDANPSKYTQSLGCWHGFIGQ
QKMISIKKHFKSTERRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVSALIRELYTFLRQADARELGGLFRELDAATGAAK
AAIQEKIDNHVTHVVPIIADIDAGFGNAEATYLLAKQFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIRAIR
YAFLELGVDDGVIVARTDSLGAGLTKQIAVTATPGDLGDQYNSFLDCEELSADQLGNGDVIIKRDGKLLRPKRLPSNLFQ
FRAGTGEARCVLDCVTALQNGADLLWIETEKPHIAQIGGMVSEIRKVIPNAKLVYNNSPSFNWTLNFRQQAYDAMKAAGK
DVSAYERTQLMSVEYDDSELAKIADEKIRTFQADASREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVAGVQR
KEIRQGIACVKHQNMSGSDIGDDHKEYFSGEAALKAAGKDNTMNQF

Sequences:

>Translated_526_residues
MAQYQDDIKAVAGLKEQHGSAWNAINPEYAARMRAQNKFKTGLDIAKYTAKIMRADMAAYDANPSKYTQSLGCWHGFIGQ
QKMISIKKHFKSTERRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVSALIRELYTFLRQADARELGGLFRELDAATGAAK
AAIQEKIDNHVTHVVPIIADIDAGFGNAEATYLLAKQFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIRAIR
YAFLELGVDDGVIVARTDSLGAGLTKQIAVTATPGDLGDQYNSFLDCEELSADQLGNGDVIIKRDGKLLRPKRLPSNLFQ
FRAGTGEARCVLDCVTALQNGADLLWIETEKPHIAQIGGMVSEIRKVIPNAKLVYNNSPSFNWTLNFRQQAYDAMKAAGK
DVSAYERTQLMSVEYDDSELAKIADEKIRTFQADASREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVAGVQR
KEIRQGIACVKHQNMSGSDIGDDHKEYFSGEAALKAAGKDNTMNQF
>Mature_525_residues
AQYQDDIKAVAGLKEQHGSAWNAINPEYAARMRAQNKFKTGLDIAKYTAKIMRADMAAYDANPSKYTQSLGCWHGFIGQQ
KMISIKKHFKSTERRYLYLSGWMVAALRSEFGPLPDQSMHEKTSVSALIRELYTFLRQADARELGGLFRELDAATGAAKA
AIQEKIDNHVTHVVPIIADIDAGFGNAEATYLLAKQFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIRAIRY
AFLELGVDDGVIVARTDSLGAGLTKQIAVTATPGDLGDQYNSFLDCEELSADQLGNGDVIIKRDGKLLRPKRLPSNLFQF
RAGTGEARCVLDCVTALQNGADLLWIETEKPHIAQIGGMVSEIRKVIPNAKLVYNNSPSFNWTLNFRQQAYDAMKAAGKD
VSAYERTQLMSVEYDDSELAKIADEKIRTFQADASREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVAGVQRK
EIRQGIACVKHQNMSGSDIGDDHKEYFSGEAALKAAGKDNTMNQF

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=409, Percent_Identity=27.8728606356968, Blast_Score=129, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71982926, Length=409, Percent_Identity=27.3838630806846, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17561814, Length=409, Percent_Identity=27.3838630806846, Blast_Score=123, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320908, Length=497, Percent_Identity=25.5533199195171, Blast_Score=128, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6325263, Length=106, Percent_Identity=34.9056603773585, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 58085; Mature: 57954

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQYQDDIKAVAGLKEQHGSAWNAINPEYAARMRAQNKFKTGLDIAKYTAKIMRADMAAY
CCCHHHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DANPSKYTQSLGCWHGFIGQQKMISIKKHFKSTERRYLYLSGWMVAALRSEFGPLPDQSM
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCCHH
HEKTSVSALIRELYTFLRQADARELGGLFRELDAATGAAKAAIQEKIDNHVTHVVPIIAD
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IDAGFGNAEATYLLAKQFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIRAIR
CCCCCCCCHHHHHHHHHHHHCCCEEEEECHHCCHHHHCCCCCCEEECCHHHHHHHHHHHH
YAFLELGVDDGVIVARTDSLGAGLTKQIAVTATPGDLGDQYNSFLDCEELSADQLGNGDV
HHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHCCCHHHHCCCCCCCCCE
IIKRDGKLLRPKRLPSNLFQFRAGTGEARCVLDCVTALQNGADLLWIETEKPHIAQIGGM
EEECCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
VSEIRKVIPNAKLVYNNSPSFNWTLNFRQQAYDAMKAAGKDVSAYERTQLMSVEYDDSEL
HHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHEEEEECCHHHH
AKIADEKIRTFQADASREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVAGVQR
HHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCCCHHHHCCCH
KEIRQGIACVKHQNMSGSDIGDDHKEYFSGEAALKAAGKDNTMNQF
HHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHEECCCCCCCCCC
>Mature Secondary Structure 
AQYQDDIKAVAGLKEQHGSAWNAINPEYAARMRAQNKFKTGLDIAKYTAKIMRADMAAY
CCHHHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DANPSKYTQSLGCWHGFIGQQKMISIKKHFKSTERRYLYLSGWMVAALRSEFGPLPDQSM
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCCHH
HEKTSVSALIRELYTFLRQADARELGGLFRELDAATGAAKAAIQEKIDNHVTHVVPIIAD
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IDAGFGNAEATYLLAKQFIEAGACCIQIENQVSDEKQCGHQDGKVTVPHEDFLAKIRAIR
CCCCCCCCHHHHHHHHHHHHCCCEEEEECHHCCHHHHCCCCCCEEECCHHHHHHHHHHHH
YAFLELGVDDGVIVARTDSLGAGLTKQIAVTATPGDLGDQYNSFLDCEELSADQLGNGDV
HHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHCCCHHHHCCCCCCCCCE
IIKRDGKLLRPKRLPSNLFQFRAGTGEARCVLDCVTALQNGADLLWIETEKPHIAQIGGM
EEECCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
VSEIRKVIPNAKLVYNNSPSFNWTLNFRQQAYDAMKAAGKDVSAYERTQLMSVEYDDSEL
HHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHEEEEECCHHHH
AKIADEKIRTFQADASREAGIFHHLITLPTYHTAALSTDNLAKEYFGDQGMLGYVAGVQR
HHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCCCHHHHCCCH
KEIRQGIACVKHQNMSGSDIGDDHKEYFSGEAALKAAGKDNTMNQF
HHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]