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The map label for this gene is acdA [H]

Identifier: 94313383

GI number: 94313383

Start: 1054217

End: 1055389

Strand: Direct

Name: acdA [H]

Synonym: Rmet_4458

Alternate gene names: 94313383

Gene position: 1054217-1055389 (Clockwise)

Preceding gene: 94313382

Following gene: 94313385

Centisome position: 40.86

GC content: 65.9

Gene sequence:

>1173_bases
ATGAACTTCGAAAGGACACCTGAGCAGAACGCGATCGTCGAGGCCGTGACGCAGCTTTGCAGCGATTTTGGAGCCGAGTA
CTGGGCTGAACTCGACCGCGAGCACAAGTTTCCCGAGGCTTTCCATCGGGCGATGGCCGACGCGGGTTGGCTGGGCATCG
CCATGCCCGAACGGTTCGGCGGCGCGGGGCTGGGGATCACCGAAGCGGCGCTGATCATGCAGACGGTCTCGGCGTCGGGT
GCAGGCTTCTCCGGGGCATCGTCGATCCATATGAACGTGTTCGGCCTGAATCCGGTGGTGGTGTTCGGCACCGAGGCCCA
GCAGGCCGCCGCGTTGCCGCCGCTGATCGCGGGGCGCGACAAGGCATGTTTTGCCGTGACCGAGCCTGACGCCGGGCTGG
ATACCACGCACCTGAAGACGCAGGCCGTGCGCACCGCCGACGGCAGCGCCTATCGCGTGGACGGCCGCAAGATCTGGATT
TCGACGGCGCAGGTGGCATCGCGCATGCTGCTGCTGGCGCGTACCACGCCGCTAGATGCGGTGGCCAAGCCGACCCAGGG
TTTGAGCCTGTTCTACACGACGCTGGACCGGAACCACATCGAGGTACGCGAGATCGACAAGATGGGGCGGGGCGCGGTCG
ATTCGAACATGCTGTTCATCGACGGCCTGATGGTGCCCGCGGAGGATCGTATCGGCGAGGAGGGCCGTGGCTTTGAGTAC
ATCCTGCATGGCCTGAACCCCGAACGCATTCTGATCGCCGCGGAATCGGTAGGCCTTGGCCGCGCCGCGCTGGAGGCGGC
CACGCGCTACGCGCGCGAGCGCACGGTGTTCGGGCGGCCGATCGGCCAGAACCAGGGGATTCAGCATCCGCTGGCCCAGG
CGTGGATGGCGCTGGAAGCGGCCGACATGATGGTGTGGAAGGCCGCCTGGCTCTACGACAATGGAAAGCCGTGCGGCGCC
GAGGCGAATGCGGCGAAGTATCTGGCCGCCGAGGCCGCGCACCAGGCCTGTCAGACCGCCGTGCTGACGCTGGGTGGCAT
GGGCTATGCCCGGGAATACCACGTCGAGCGCTATCTGCGCGAATCCTATATCCCGCGTATCGCACCGGTCAGCGCACAGC
TGATCATGTGCCATATCGCCGAGCGGGTGCTGGGATTGCCGAAGTCCTACTGA

Upstream 100 bases:

>100_bases
GACGCCACAGCAGTTCGCGGGCTTTGTGGGCAGCGAACTGGTGAAGTGGAACAAGCTGGTGAAGGACGCCGGCATCCAGC
CGGAATAAGAGGACACATAG

Downstream 100 bases:

>100_bases
GCTTGAGACCAAGGCCGAAAATCAGGCGGACGTAGAAATGAAGAAGCCCTGGTGCGCGACGCACCAGGGCTTGGCGATGG
TGTGACTCCCACGTACCGCA

Product: acyl-CoA dehydrogenase-like protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MNFERTPEQNAIVEAVTQLCSDFGAEYWAELDREHKFPEAFHRAMADAGWLGIAMPERFGGAGLGITEAALIMQTVSASG
AGFSGASSIHMNVFGLNPVVVFGTEAQQAAALPPLIAGRDKACFAVTEPDAGLDTTHLKTQAVRTADGSAYRVDGRKIWI
STAQVASRMLLLARTTPLDAVAKPTQGLSLFYTTLDRNHIEVREIDKMGRGAVDSNMLFIDGLMVPAEDRIGEEGRGFEY
ILHGLNPERILIAAESVGLGRAALEAATRYARERTVFGRPIGQNQGIQHPLAQAWMALEAADMMVWKAAWLYDNGKPCGA
EANAAKYLAAEAAHQACQTAVLTLGGMGYAREYHVERYLRESYIPRIAPVSAQLIMCHIAERVLGLPKSY

Sequences:

>Translated_390_residues
MNFERTPEQNAIVEAVTQLCSDFGAEYWAELDREHKFPEAFHRAMADAGWLGIAMPERFGGAGLGITEAALIMQTVSASG
AGFSGASSIHMNVFGLNPVVVFGTEAQQAAALPPLIAGRDKACFAVTEPDAGLDTTHLKTQAVRTADGSAYRVDGRKIWI
STAQVASRMLLLARTTPLDAVAKPTQGLSLFYTTLDRNHIEVREIDKMGRGAVDSNMLFIDGLMVPAEDRIGEEGRGFEY
ILHGLNPERILIAAESVGLGRAALEAATRYARERTVFGRPIGQNQGIQHPLAQAWMALEAADMMVWKAAWLYDNGKPCGA
EANAAKYLAAEAAHQACQTAVLTLGGMGYAREYHVERYLRESYIPRIAPVSAQLIMCHIAERVLGLPKSY
>Mature_390_residues
MNFERTPEQNAIVEAVTQLCSDFGAEYWAELDREHKFPEAFHRAMADAGWLGIAMPERFGGAGLGITEAALIMQTVSASG
AGFSGASSIHMNVFGLNPVVVFGTEAQQAAALPPLIAGRDKACFAVTEPDAGLDTTHLKTQAVRTADGSAYRVDGRKIWI
STAQVASRMLLLARTTPLDAVAKPTQGLSLFYTTLDRNHIEVREIDKMGRGAVDSNMLFIDGLMVPAEDRIGEEGRGFEY
ILHGLNPERILIAAESVGLGRAALEAATRYARERTVFGRPIGQNQGIQHPLAQAWMALEAADMMVWKAAWLYDNGKPCGA
EANAAKYLAAEAAHQACQTAVLTLGGMGYAREYHVERYLRESYIPRIAPVSAQLIMCHIAERVLGLPKSY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=33.9522546419098, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=30.4, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=30.4, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4501859, Length=382, Percent_Identity=29.5811518324607, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI226958412, Length=374, Percent_Identity=28.0748663101604, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI76496475, Length=383, Percent_Identity=29.5039164490862, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI4557235, Length=383, Percent_Identity=29.5039164490862, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI226958414, Length=339, Percent_Identity=28.9085545722714, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI21361497, Length=354, Percent_Identity=27.683615819209, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4501857, Length=370, Percent_Identity=28.1081081081081, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI7656849, Length=365, Percent_Identity=29.3150684931507, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI7669494, Length=330, Percent_Identity=27.5757575757576, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4503943, Length=330, Percent_Identity=27.5757575757576, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI48976061, Length=317, Percent_Identity=27.1293375394322, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI211971008, Length=317, Percent_Identity=27.1293375394322, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI38505218, Length=279, Percent_Identity=27.5985663082437, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=31.4432989690722, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1786223, Length=385, Percent_Identity=28.3116883116883, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI87082384, Length=273, Percent_Identity=28.9377289377289, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=28.0323450134771, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=29.9212598425197, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17569725, Length=390, Percent_Identity=29.7435897435897, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17508101, Length=382, Percent_Identity=29.0575916230367, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17538396, Length=375, Percent_Identity=26.9333333333333, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=28.9405684754522, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=30.3116147308782, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI71990804, Length=301, Percent_Identity=29.9003322259136, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17533517, Length=385, Percent_Identity=26.4935064935065, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71985192, Length=287, Percent_Identity=28.5714285714286, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17505929, Length=350, Percent_Identity=27.7142857142857, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17534353, Length=355, Percent_Identity=24.5070422535211, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=350, Percent_Identity=25.7142857142857, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=28.2608695652174, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=26.6423357664234, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562446, Length=285, Percent_Identity=27.719298245614, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=262, Percent_Identity=29.7709923664122, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=262, Percent_Identity=29.7709923664122, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=33.8624338624339, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24666513, Length=379, Percent_Identity=32.7176781002639, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24646207, Length=354, Percent_Identity=31.9209039548023, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI281363737, Length=382, Percent_Identity=29.3193717277487, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24660351, Length=347, Percent_Identity=28.8184438040346, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21355753, Length=349, Percent_Identity=29.2263610315186, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI19920834, Length=364, Percent_Identity=24.4505494505494, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42310; Mature: 42310

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFERTPEQNAIVEAVTQLCSDFGAEYWAELDREHKFPEAFHRAMADAGWLGIAMPERFG
CCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCHHCC
GAGLGITEAALIMQTVSASGAGFSGASSIHMNVFGLNPVVVFGTEAQQAAALPPLIAGRD
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEECCCHHHHHCCCCCCCCCC
KACFAVTEPDAGLDTTHLKTQAVRTADGSAYRVDGRKIWISTAQVASRMLLLARTTPLDA
CEEEEEECCCCCCCCHHHHHHHHEECCCCEEEECCEEEEEEHHHHHHHHHHHHCCCCHHH
VAKPTQGLSLFYTTLDRNHIEVREIDKMGRGAVDSNMLFIDGLMVPAEDRIGEEGRGFEY
HCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEECEEECCHHHCCCCCCCHHH
ILHGLNPERILIAAESVGLGRAALEAATRYARERTVFGRPIGQNQGIQHPLAQAWMALEA
HEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
ADMMVWKAAWLYDNGKPCGAEANAAKYLAAEAAHQACQTAVLTLGGMGYAREYHVERYLR
HHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ESYIPRIAPVSAQLIMCHIAERVLGLPKSY
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNFERTPEQNAIVEAVTQLCSDFGAEYWAELDREHKFPEAFHRAMADAGWLGIAMPERFG
CCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEECCHHCC
GAGLGITEAALIMQTVSASGAGFSGASSIHMNVFGLNPVVVFGTEAQQAAALPPLIAGRD
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCEEEEECCCHHHHHCCCCCCCCCC
KACFAVTEPDAGLDTTHLKTQAVRTADGSAYRVDGRKIWISTAQVASRMLLLARTTPLDA
CEEEEEECCCCCCCCHHHHHHHHEECCCCEEEECCEEEEEEHHHHHHHHHHHHCCCCHHH
VAKPTQGLSLFYTTLDRNHIEVREIDKMGRGAVDSNMLFIDGLMVPAEDRIGEEGRGFEY
HCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEECEEECCHHHCCCCCCCHHH
ILHGLNPERILIAAESVGLGRAALEAATRYARERTVFGRPIGQNQGIQHPLAQAWMALEA
HEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
ADMMVWKAAWLYDNGKPCGAEANAAKYLAAEAAHQACQTAVLTLGGMGYAREYHVERYLR
HHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ESYIPRIAPVSAQLIMCHIAERVLGLPKSY
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]