Click here to switch to the map view.

The map label for this gene is argH1 [H]

Identifier: 94313267

GI number: 94313267

Start: 937734

End: 939236

Strand: Reverse

Name: argH1 [H]

Synonym: Rmet_4342

Alternate gene names: 94313267

Gene position: 939236-937734 (Counterclockwise)

Preceding gene: 94313268

Following gene: 94313266

Centisome position: 36.4

GC content: 61.94

Gene sequence:

>1503_bases
ATGACATCGACTCCCCACGAAACACTACTTGCCGAGGCTCGCCTGAGTTCGCCTCCTGCCTCCCGGTTGACGAAGCACTA
CGCACTGCCAGGGCTCGAGCGCGAACGCAGGCAGTTTCACGAGTTCGTCGCCGTTGATCTTGCCCATACGACCATGCTCG
TGGAACAGGGCATTCTTTCGGCGGAGACCGGTCGGGCCATCCTGGAGCAATTGCTGATCATTCGGAGAATGCAGCCCTCC
GCGTTTCCCGTGGATGTGCGCAAGGGCAGCCTTCTGCTGCAGATCGAGTCGTATCTCTTCGGCGCCATCGGCGAGGACGT
GGGCGGCCAGATGCACACCGGCCGCAGCCGCATCGATCAGGGCGCCACGGTACGCCGCCTGTACAAGCGCAACCGCATGC
TGGATGTGATGGACCAGTTGAACGTATTCCAGGAGGCGATTGCCGAACAAGCGCGCCACCACGCGCACACGATCATGCCC
GGCTACACCCATATGCAGCAGGCCCAGCCATGGGTGTTCGGACACTATCTGCTCAGCTTCAGCTCCCGATTGCATGACAG
CTTCGAGCGTCTGGCGCAGGCGTACGGACGCGTCAACCGCAATCCACTGGGAACCGTGGGTCTTGCCGGCACGTCATGGC
CGCTTAATCGCGAGCGAACCACGGAACTGCTCGGATTCGACGGCCAAATCGAGAACTCCAAGCTTGGCCGCGAAGCTTTC
GATGCAGCGGATGCGATCTGCGCACTGTCGTTCATCATGGCCGATTTGAACGATCTGGCTACCGACCTGCATATCTGGTC
CAGTGCCGAGTTCGGATTGGTTGAATCCGATGACAGCTACTGTGGTACGAGCAGCATCTTCCCGCAGAAGAAGAACCCGG
TCGCACTGGAGACCATCAGGAAGGCCGCCGGTCCTGCCGTGACGTGGCTGAGCGCGGCGCTGGCCACGTTCCGCGCGGAA
GGGACCGGCGACCAGGCCATGCGTAGCGTCTCACATATCGACGAGGCCTTGGCAACGACAGAAAGCATGCTCGATCTGTT
CACTGGCGTCATGGAAACGCTGATCGTGCATCAGGACCACATGGCCGAATCGCTCAAGGGAAGCTGGTGCACCGCGAGCA
ATCTGGCGGACGTCGTCGTGCGTGAACGACGTCTGTCCTTCCGCCAGGTGCACCACATCGTCGCCCGTGCGGTGCGCAAC
TGCGTGGCGCAAGGACTGCGTCCCGATCAGTTGACCAGCAGCCGTCTCGATGAGGCAGCTCTCGAAACGGTGGGTATCGC
GCTGAATCTGGGCGACGCGGCGGTACGTGATGCGCTCGATCCGGTTCGCTTTGTCGAAACCCGGATTACGGAAGGCAGCG
TCGGGCCGCAGCAGGTTGCGCGACTGCTCGAACGCGCGGCGCAAGAACGCGCTGCGGATCGCCAATGGGTCAGCGAGGCG
CGCGGCCGACTGAGTCGATCGCAACTGGCACTCAATGAAGCCGTGAGCAAGCTGGTTGCCTGA

Upstream 100 bases:

>100_bases
GCTTGCAGCGCGCGGGGCGAGGCCCCCGTCTGAACCGCATTATTGCTGGGTAGAGAAGCGCCGTCCGCATGGCCAGGCGC
CGATTGCCTCGCTTGTTACC

Downstream 100 bases:

>100_bases
GAACCAGCGTGACGCTTACGAAAAAATACCGAAGGAGACGCTGGTTATGTTGAAGTCGAAGTCCTTTGCCTTGTTTATGT
CCCTCGCGGCACTCTCCCTG

Product: fumarate lyase

Products: NA

Alternate protein names: ASAL 1; Arginosuccinase 1 [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MTSTPHETLLAEARLSSPPASRLTKHYALPGLERERRQFHEFVAVDLAHTTMLVEQGILSAETGRAILEQLLIIRRMQPS
AFPVDVRKGSLLLQIESYLFGAIGEDVGGQMHTGRSRIDQGATVRRLYKRNRMLDVMDQLNVFQEAIAEQARHHAHTIMP
GYTHMQQAQPWVFGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGTVGLAGTSWPLNRERTTELLGFDGQIENSKLGREAF
DAADAICALSFIMADLNDLATDLHIWSSAEFGLVESDDSYCGTSSIFPQKKNPVALETIRKAAGPAVTWLSAALATFRAE
GTGDQAMRSVSHIDEALATTESMLDLFTGVMETLIVHQDHMAESLKGSWCTASNLADVVVRERRLSFRQVHHIVARAVRN
CVAQGLRPDQLTSSRLDEAALETVGIALNLGDAAVRDALDPVRFVETRITEGSVGPQQVARLLERAAQERAADRQWVSEA
RGRLSRSQLALNEAVSKLVA

Sequences:

>Translated_500_residues
MTSTPHETLLAEARLSSPPASRLTKHYALPGLERERRQFHEFVAVDLAHTTMLVEQGILSAETGRAILEQLLIIRRMQPS
AFPVDVRKGSLLLQIESYLFGAIGEDVGGQMHTGRSRIDQGATVRRLYKRNRMLDVMDQLNVFQEAIAEQARHHAHTIMP
GYTHMQQAQPWVFGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGTVGLAGTSWPLNRERTTELLGFDGQIENSKLGREAF
DAADAICALSFIMADLNDLATDLHIWSSAEFGLVESDDSYCGTSSIFPQKKNPVALETIRKAAGPAVTWLSAALATFRAE
GTGDQAMRSVSHIDEALATTESMLDLFTGVMETLIVHQDHMAESLKGSWCTASNLADVVVRERRLSFRQVHHIVARAVRN
CVAQGLRPDQLTSSRLDEAALETVGIALNLGDAAVRDALDPVRFVETRITEGSVGPQQVARLLERAAQERAADRQWVSEA
RGRLSRSQLALNEAVSKLVA
>Mature_499_residues
TSTPHETLLAEARLSSPPASRLTKHYALPGLERERRQFHEFVAVDLAHTTMLVEQGILSAETGRAILEQLLIIRRMQPSA
FPVDVRKGSLLLQIESYLFGAIGEDVGGQMHTGRSRIDQGATVRRLYKRNRMLDVMDQLNVFQEAIAEQARHHAHTIMPG
YTHMQQAQPWVFGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGTVGLAGTSWPLNRERTTELLGFDGQIENSKLGREAFD
AADAICALSFIMADLNDLATDLHIWSSAEFGLVESDDSYCGTSSIFPQKKNPVALETIRKAAGPAVTWLSAALATFRAEG
TGDQAMRSVSHIDEALATTESMLDLFTGVMETLIVHQDHMAESLKGSWCTASNLADVVVRERRLSFRQVHHIVARAVRNC
VAQGLRPDQLTSSRLDEAALETVGIALNLGDAAVRDALDPVRFVETRITEGSVGPQQVARLLERAAQERAADRQWVSEAR
GRLSRSQLALNEAVSKLVA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=311, Percent_Identity=32.475884244373, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI68303542, Length=311, Percent_Identity=32.475884244373, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI68303547, Length=309, Percent_Identity=32.6860841423948, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI68303549, Length=311, Percent_Identity=30.5466237942122, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1790398, Length=421, Percent_Identity=30.4038004750594, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6321806, Length=327, Percent_Identity=35.474006116208, Blast_Score=170, Evalue=5e-43,
Organism=Drosophila melanogaster, GI221473854, Length=318, Percent_Identity=32.7044025157233, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI78706858, Length=318, Percent_Identity=32.7044025157233, Blast_Score=151, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 55250; Mature: 55119

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTPHETLLAEARLSSPPASRLTKHYALPGLERERRQFHEFVAVDLAHTTMLVEQGILS
CCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AETGRAILEQLLIIRRMQPSAFPVDVRKGSLLLQIESYLFGAIGEDVGGQMHTGRSRIDQ
HHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHHC
GATVRRLYKRNRMLDVMDQLNVFQEAIAEQARHHAHTIMPGYTHMQQAQPWVFGHYLLSF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHH
SSRLHDSFERLAQAYGRVNRNPLGTVGLAGTSWPLNRERTTELLGFDGQIENSKLGREAF
HHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHH
DAADAICALSFIMADLNDLATDLHIWSSAEFGLVESDDSYCGTSSIFPQKKNPVALETIR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHH
KAAGPAVTWLSAALATFRAEGTGDQAMRSVSHIDEALATTESMLDLFTGVMETLIVHQDH
HHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAESLKGSWCTASNLADVVVRERRLSFRQVHHIVARAVRNCVAQGLRPDQLTSSRLDEAA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LETVGIALNLGDAAVRDALDPVRFVETRITEGSVGPQQVARLLERAAQERAADRQWVSEA
HHHHHHHEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RGRLSRSQLALNEAVSKLVA
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSTPHETLLAEARLSSPPASRLTKHYALPGLERERRQFHEFVAVDLAHTTMLVEQGILS
CCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AETGRAILEQLLIIRRMQPSAFPVDVRKGSLLLQIESYLFGAIGEDVGGQMHTGRSRIDQ
HHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHHC
GATVRRLYKRNRMLDVMDQLNVFQEAIAEQARHHAHTIMPGYTHMQQAQPWVFGHYLLSF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHH
SSRLHDSFERLAQAYGRVNRNPLGTVGLAGTSWPLNRERTTELLGFDGQIENSKLGREAF
HHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHH
DAADAICALSFIMADLNDLATDLHIWSSAEFGLVESDDSYCGTSSIFPQKKNPVALETIR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHH
KAAGPAVTWLSAALATFRAEGTGDQAMRSVSHIDEALATTESMLDLFTGVMETLIVHQDH
HHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAESLKGSWCTASNLADVVVRERRLSFRQVHHIVARAVRNCVAQGLRPDQLTSSRLDEAA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LETVGIALNLGDAAVRDALDPVRFVETRITEGSVGPQQVARLLERAAQERAADRQWVSEA
HHHHHHHEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RGRLSRSQLALNEAVSKLVA
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA