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The map label for this gene is prpR [H]

Identifier: 94313218

GI number: 94313218

Start: 883485

End: 885422

Strand: Direct

Name: prpR [H]

Synonym: Rmet_4292

Alternate gene names: 94313218

Gene position: 883485-885422 (Clockwise)

Preceding gene: 94313212

Following gene: 291481525

Centisome position: 34.24

GC content: 60.94

Gene sequence:

>1938_bases
ATGTCAACGCTCATTTCACATCCAAACCAGCTCCGCCCGGGCATCGCGCTGGTCAGCATCAGCCGGATGAGTACGCTGTG
TGAGACCGTCGCGCCTCGCTACAACGAGCTGGCGCGTTTCTTCTCGATTCGCGCGGGCTACGGGGCTGCCGTGACCGCCC
TCCAGGCGTACGTCGATGCAGGCACGGTTGACGTCGTGCTGGCGGCCGGCTCGAACGGCGCGTATCTGCGTGACAATCTC
AGTGTGCCCGTGGTGATGGTAAAGGTGAATGGCTTCGACGTGCTGAACGCTATCACGCAGGCCATCACAGCGTGGCCGGG
TGAGGCCATCGGTTTGGTGCTGCACGATTCGGTGTCGAGGGAACTGGCCAACCTCAGCGGCTGGCTGAATGTTGCATTGA
AACAGCGCGCATACCGTTCGATCGACGAGGTGCGTGCGGCCGTGGATACGCTTGCGGCAGAAGGCTGCACCGTCATCATT
GGTCCTGGCATGGCATGCGATCTGGCGCTGCAGGCGGGATTGCAATGCGTATTTCTCTATTCCATTGGCGCTGTGGAGGA
AGCGTTCGAGCGCTCCATTGAGTTGGCACGCATGAGTCGCCAGAAGGAATCAAAGCGCGTGCGACTCAACACCATCGTCG
CGCATTTGCGCGACGGCGTTGCGGCATTCGACGAGGGTGGGCAGCTTGAGGTGGTGAATCCTGCGATGTTGGATCTGCTC
GGCATGGACCGCTCCCGCGATGTGGCGTCACAGCTCCTGGGGGCGGTCGGCCCGCACCTACGCGAAACACTCGATGCCAA
TTCGCCAAGCAACGAGCGCATCGAACAGATCGGCGGTCGCTCGCTGATTGTCAACTGCGTGCCAATCGTTGAGCATGGCT
CACGCTCGGGAGCGGTGGTCACTGTACAGGACACACTAATCGCACAGCGCATTGACCGCTCGTTGCGAACCAATCAGCGG
CCGAAGCATCTGGTGGCGCGGCATAACCTGGCTGATCTGATCGGCGGCTCTCCGGAGCTTGAACGCGTGCGGTGGCTAGC
GCGAGCCAGCGCCGCGCACGACGCTACCGTGCTGCTCACAGGCGAAAGCGGCACTGGCAAGGAACTGGTTGCTCAAGGTA
TTCACAATGCCAGCCGTCGGCGTGGCAACCCATTCGTCGCGTTCAATTGTGCGGCACTGCCGGAAGGTTTGATAGAAAGC
GAACTGTTTGGCCACGAAGAGGGCGCCTTCACCGGCGCACGGCGTGGTGGAAAGCCGGGCCTCTTCGAGGTCGCGCATAC
GGGGACCATTTTTCTCGATGAGATCGGTGAGATGCCGGCCGCGTTGCAGAGCCGCCTGCTACGTGTATTGCAGGAACGCG
AAGTGATGAAGCTCGGCTCTGGGCGCGCAACGCCAATCGATGTCCGTGTCATCGCCGCGACGCATCGTAATCTGCGCGAG
TTGGTCAAGCGCGGCACATTTCGCGCCGACCTGTATTTCCGGCTCAATCTGCTACAGATCGAACTGCCGCCCTTGCGTGA
GCGGCGCAGTGATATACCCGGCCTAGCGCAGCATCTGCTCGCACGGAGTGCAGCAAAGTACCACCTGCCAGCCACCGTCA
CGAAGCACATTCTGGAGTTCCTCTCGCCGCTCTTCGAGCTTTACACATGGCCCGGAAACGTACGGGAGCTTGAAAACCTC
GTAGCGCGCGCGGCGATCTATCTGAGCGATGGTTCAGGCAGTGCGCGGGAAGACCTGCGGGCCATGTTTCCCGAGTTTGG
AGAGATGCAATCGCTGCCTGTTGCAGCGGACAGGCACAAGGTTACCGATGCGCCGACTGGGACCGTGACTCGGGACGACA
TCATGCGAGTCCTGCAGAAAAACGGTGGCAATCGCGCCGCTGCGAGTCGTACCTTGGGGATCGGACGAACGACGCTTTGG
AGGTTAATGAAGGAGTAA

Upstream 100 bases:

>100_bases
CAATGGCTTACGAGATTTCATACCGGAAGCACGCTCATGCGACAATGTTCCACATGTTTCTCGGGGCGTTCCAAAAGCGT
TCCACTCAGGAGCCTCCAAG

Downstream 100 bases:

>100_bases
GAAAGAAGCTGCGAATGGCCGCTTCAGGAGCCAGGCAACGCAGTTTTCCGCGTACCAGCGGTCGAGGCTCGTGGCAAGCC
GCCACCATTCTCGACTTCAG

Product: transcriptional regulator PrpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 645; Mature: 644

Protein sequence:

>645_residues
MSTLISHPNQLRPGIALVSISRMSTLCETVAPRYNELARFFSIRAGYGAAVTALQAYVDAGTVDVVLAAGSNGAYLRDNL
SVPVVMVKVNGFDVLNAITQAITAWPGEAIGLVLHDSVSRELANLSGWLNVALKQRAYRSIDEVRAAVDTLAAEGCTVII
GPGMACDLALQAGLQCVFLYSIGAVEEAFERSIELARMSRQKESKRVRLNTIVAHLRDGVAAFDEGGQLEVVNPAMLDLL
GMDRSRDVASQLLGAVGPHLRETLDANSPSNERIEQIGGRSLIVNCVPIVEHGSRSGAVVTVQDTLIAQRIDRSLRTNQR
PKHLVARHNLADLIGGSPELERVRWLARASAAHDATVLLTGESGTGKELVAQGIHNASRRRGNPFVAFNCAALPEGLIES
ELFGHEEGAFTGARRGGKPGLFEVAHTGTIFLDEIGEMPAALQSRLLRVLQEREVMKLGSGRATPIDVRVIAATHRNLRE
LVKRGTFRADLYFRLNLLQIELPPLRERRSDIPGLAQHLLARSAAKYHLPATVTKHILEFLSPLFELYTWPGNVRELENL
VARAAIYLSDGSGSAREDLRAMFPEFGEMQSLPVAADRHKVTDAPTGTVTRDDIMRVLQKNGGNRAAASRTLGIGRTTLW
RLMKE

Sequences:

>Translated_645_residues
MSTLISHPNQLRPGIALVSISRMSTLCETVAPRYNELARFFSIRAGYGAAVTALQAYVDAGTVDVVLAAGSNGAYLRDNL
SVPVVMVKVNGFDVLNAITQAITAWPGEAIGLVLHDSVSRELANLSGWLNVALKQRAYRSIDEVRAAVDTLAAEGCTVII
GPGMACDLALQAGLQCVFLYSIGAVEEAFERSIELARMSRQKESKRVRLNTIVAHLRDGVAAFDEGGQLEVVNPAMLDLL
GMDRSRDVASQLLGAVGPHLRETLDANSPSNERIEQIGGRSLIVNCVPIVEHGSRSGAVVTVQDTLIAQRIDRSLRTNQR
PKHLVARHNLADLIGGSPELERVRWLARASAAHDATVLLTGESGTGKELVAQGIHNASRRRGNPFVAFNCAALPEGLIES
ELFGHEEGAFTGARRGGKPGLFEVAHTGTIFLDEIGEMPAALQSRLLRVLQEREVMKLGSGRATPIDVRVIAATHRNLRE
LVKRGTFRADLYFRLNLLQIELPPLRERRSDIPGLAQHLLARSAAKYHLPATVTKHILEFLSPLFELYTWPGNVRELENL
VARAAIYLSDGSGSAREDLRAMFPEFGEMQSLPVAADRHKVTDAPTGTVTRDDIMRVLQKNGGNRAAASRTLGIGRTTLW
RLMKE
>Mature_644_residues
STLISHPNQLRPGIALVSISRMSTLCETVAPRYNELARFFSIRAGYGAAVTALQAYVDAGTVDVVLAAGSNGAYLRDNLS
VPVVMVKVNGFDVLNAITQAITAWPGEAIGLVLHDSVSRELANLSGWLNVALKQRAYRSIDEVRAAVDTLAAEGCTVIIG
PGMACDLALQAGLQCVFLYSIGAVEEAFERSIELARMSRQKESKRVRLNTIVAHLRDGVAAFDEGGQLEVVNPAMLDLLG
MDRSRDVASQLLGAVGPHLRETLDANSPSNERIEQIGGRSLIVNCVPIVEHGSRSGAVVTVQDTLIAQRIDRSLRTNQRP
KHLVARHNLADLIGGSPELERVRWLARASAAHDATVLLTGESGTGKELVAQGIHNASRRRGNPFVAFNCAALPEGLIESE
LFGHEEGAFTGARRGGKPGLFEVAHTGTIFLDEIGEMPAALQSRLLRVLQEREVMKLGSGRATPIDVRVIAATHRNLREL
VKRGTFRADLYFRLNLLQIELPPLRERRSDIPGLAQHLLARSAAKYHLPATVTKHILEFLSPLFELYTWPGNVRELENLV
ARAAIYLSDGSGSAREDLRAMFPEFGEMQSLPVAADRHKVTDAPTGTVTRDDIMRVLQKNGGNRAAASRTLGIGRTTLWR
LMKE

Specific function: Involved in the transcriptional regulation of the propionate catabolism operon [H]

COG id: COG3829

COG function: function code KT; Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1786524, Length=330, Percent_Identity=46.0606060606061, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1788550, Length=303, Percent_Identity=45.5445544554455, Blast_Score=248, Evalue=6e-67,
Organism=Escherichia coli, GI1790437, Length=310, Percent_Identity=46.1290322580645, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI87082117, Length=338, Percent_Identity=42.8994082840237, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI1788905, Length=314, Percent_Identity=44.5859872611465, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1790299, Length=411, Percent_Identity=37.4695863746959, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1789087, Length=320, Percent_Identity=43.75, Blast_Score=221, Evalue=2e-58,
Organism=Escherichia coli, GI1789233, Length=327, Percent_Identity=37.9204892966361, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI87082152, Length=321, Percent_Identity=43.3021806853583, Blast_Score=218, Evalue=1e-57,
Organism=Escherichia coli, GI1787583, Length=435, Percent_Identity=33.5632183908046, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI87081872, Length=231, Percent_Identity=44.1558441558442, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI87081858, Length=447, Percent_Identity=31.0961968680089, Blast_Score=170, Evalue=3e-43,
Organism=Escherichia coli, GI1789828, Length=225, Percent_Identity=39.5555555555556, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR012704
- InterPro:   IPR010524 [H]

Pfam domain/function: PF02954 HTH_8; PF06506 PrpR_N; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 70133; Mature: 70002

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLISHPNQLRPGIALVSISRMSTLCETVAPRYNELARFFSIRAGYGAAVTALQAYVDA
CCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCC
GTVDVVLAAGSNGAYLRDNLSVPVVMVKVNGFDVLNAITQAITAWPGEAIGLVLHDSVSR
CCEEEEEEECCCCCEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEEHHHHHH
ELANLSGWLNVALKQRAYRSIDEVRAAVDTLAAEGCTVIIGPGMACDLALQAGLQCVFLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCCEEEEH
SIGAVEEAFERSIELARMSRQKESKRVRLNTIVAHLRDGVAAFDEGGQLEVVNPAMLDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEECHHHHHHH
GMDRSRDVASQLLGAVGPHLRETLDANSPSNERIEQIGGRSLIVNCVPIVEHGSRSGAVV
CCCCCHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHCCCCEEEEEEEEHHCCCCCCCCEE
TVQDTLIAQRIDRSLRTNQRPKHLVARHNLADLIGGSPELERVRWLARASAAHDATVLLT
EEHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEE
GESGTGKELVAQGIHNASRRRGNPFVAFNCAALPEGLIESELFGHEEGAFTGARRGGKPG
CCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCC
LFEVAHTGTIFLDEIGEMPAALQSRLLRVLQEREVMKLGSGRATPIDVRVIAATHRNLRE
CEEEECCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHH
LVKRGTFRADLYFRLNLLQIELPPLRERRSDIPGLAQHLLARSAAKYHLPATVTKHILEF
HHHCCCCEEEEEEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LSPLFELYTWPGNVRELENLVARAAIYLSDGSGSAREDLRAMFPEFGEMQSLPVAADRHK
HHHHHHHHCCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCC
VTDAPTGTVTRDDIMRVLQKNGGNRAAASRTLGIGRTTLWRLMKE
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
STLISHPNQLRPGIALVSISRMSTLCETVAPRYNELARFFSIRAGYGAAVTALQAYVDA
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCC
GTVDVVLAAGSNGAYLRDNLSVPVVMVKVNGFDVLNAITQAITAWPGEAIGLVLHDSVSR
CCEEEEEEECCCCCEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEEHHHHHH
ELANLSGWLNVALKQRAYRSIDEVRAAVDTLAAEGCTVIIGPGMACDLALQAGLQCVFLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCCEEEEH
SIGAVEEAFERSIELARMSRQKESKRVRLNTIVAHLRDGVAAFDEGGQLEVVNPAMLDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEECHHHHHHH
GMDRSRDVASQLLGAVGPHLRETLDANSPSNERIEQIGGRSLIVNCVPIVEHGSRSGAVV
CCCCCHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHCCCCEEEEEEEEHHCCCCCCCCEE
TVQDTLIAQRIDRSLRTNQRPKHLVARHNLADLIGGSPELERVRWLARASAAHDATVLLT
EEHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEE
GESGTGKELVAQGIHNASRRRGNPFVAFNCAALPEGLIESELFGHEEGAFTGARRGGKPG
CCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCC
LFEVAHTGTIFLDEIGEMPAALQSRLLRVLQEREVMKLGSGRATPIDVRVIAATHRNLRE
CEEEECCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHH
LVKRGTFRADLYFRLNLLQIELPPLRERRSDIPGLAQHLLARSAAKYHLPATVTKHILEF
HHHCCCCEEEEEEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LSPLFELYTWPGNVRELENLVARAAIYLSDGSGSAREDLRAMFPEFGEMQSLPVAADRHK
HHHHHHHHCCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCC
VTDAPTGTVTRDDIMRVLQKNGGNRAAASRTLGIGRTTLWRLMKE
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9006051; 11677609 [H]