BacMap

Definition	Cupriavidus metallidurans CH34 megaplasmid, complete sequence.
Accession	NC_007974
Length	2,580,084

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The map label for this gene is vdlC [H]

Identifier: 94313214

GI number: 94313214

Start: 879346

End: 880209

Strand: Reverse

Name: vdlC [H]

Synonym: Rmet_4288

Alternate gene names: 94313214

Gene position: 880209-879346 (Counterclockwise)

Preceding gene: 94313215

Following gene: 94313213

Centisome position: 34.12

GC content: 62.96

Gene sequence:

>864_bases
ATGCATTCCAAAGTTGCTCTCGTGACGGGCGCTTCTTCCGGTATTGGCGAAGCCACCGCACTCAAGCTTCTCGCCCAGGG
CTACACGGTCTACGCGGCCGCGCGTCGCGTGGAGCGGATGCGCAGCCAGGCCGACGCCGGTGTCCACGTGCTAGCGATGG
ACGTGACGGACGACGCCGTGATGCGGGCAGGCATAGAGGAGATCATCGCCAAGTCGGGCCGCCTCGACGTGTTGGTCAAT
AACGCCGGCTATGGTGCCTATGGTGCGATCGAGGACGTGCCGCTGGACGAAGCGCGCGCCCAGTTCGATGTCAACGTGTT
CGGTGCCGTGCGCTTGATCCAGTTGGCGCTGCCACATATGCGCGCGCAGCGATCTGGCACCATCGTCAACATCACCTCGA
TGGGCGGCAAGATCCACACGCCTATGGGTGCCTGGTACCACGGCACCAAGTTCGCGCTGGAGGCGATCAGTGACTGCCTG
CGCATGGAAGTGGAGCCCTTCGGCATTGACGTGGTGGTGATTGAGCCGGGCGGGATCAAGACGGAGTGGGCCGGCATTGC
AGCGGAAAACCTGCTGAAGGTATCCGGCACGGGCTCGTATGCGCCCCAGGCCAGCGCGATGGCAAAGTTGATGATCAACG
AGGCCAACGGCAATCGTCAGTCGCCACCCCAACTGATTGCAGAGACTATCGCAAAGGCTGTCAATGCCGCTCGTCCAAAG
ACACGTTACGCCGTCGGCTTCGGTGCCCGGCCCATGATTCTCATGCGACGCCTGCTGTCAGATCGCGCGTTCGATAGTCT
CATGCGCATGGCTGCCAGAATGCCCCGCAGTGCGCAGCGGCGCTCGTGCGGCGCAGCCAGTTGA

Upstream 100 bases:

>100_bases
CGCTAGAGGCCCAACGCCGCTCGATGCGTACAGTCAATGGCAAGGAAGGCGAACCGAATCCGGGCCGCCTTCCACCTCAA
CCCCATCAGGAAAAGTCACC

Downstream 100 bases:

>100_bases
GTGAGGACAGACACGATTACGCCAAGGCGTTGAAACACGCGCAGCAGTTGCCGGCTCGACCGATTCCACGAACCCGCGTA
TATGGCGCTAGTGCGCCTGC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MHSKVALVTGASSGIGEATALKLLAQGYTVYAAARRVERMRSQADAGVHVLAMDVTDDAVMRAGIEEIIAKSGRLDVLVN
NAGYGAYGAIEDVPLDEARAQFDVNVFGAVRLIQLALPHMRAQRSGTIVNITSMGGKIHTPMGAWYHGTKFALEAISDCL
RMEVEPFGIDVVVIEPGGIKTEWAGIAAENLLKVSGTGSYAPQASAMAKLMINEANGNRQSPPQLIAETIAKAVNAARPK
TRYAVGFGARPMILMRRLLSDRAFDSLMRMAARMPRSAQRRSCGAAS

Sequences:

>Translated_287_residues
MHSKVALVTGASSGIGEATALKLLAQGYTVYAAARRVERMRSQADAGVHVLAMDVTDDAVMRAGIEEIIAKSGRLDVLVN
NAGYGAYGAIEDVPLDEARAQFDVNVFGAVRLIQLALPHMRAQRSGTIVNITSMGGKIHTPMGAWYHGTKFALEAISDCL
RMEVEPFGIDVVVIEPGGIKTEWAGIAAENLLKVSGTGSYAPQASAMAKLMINEANGNRQSPPQLIAETIAKAVNAARPK
TRYAVGFGARPMILMRRLLSDRAFDSLMRMAARMPRSAQRRSCGAAS
>Mature_287_residues
MHSKVALVTGASSGIGEATALKLLAQGYTVYAAARRVERMRSQADAGVHVLAMDVTDDAVMRAGIEEIIAKSGRLDVLVN
NAGYGAYGAIEDVPLDEARAQFDVNVFGAVRLIQLALPHMRAQRSGTIVNITSMGGKIHTPMGAWYHGTKFALEAISDCL
RMEVEPFGIDVVVIEPGGIKTEWAGIAAENLLKVSGTGSYAPQASAMAKLMINEANGNRQSPPQLIAETIAKAVNAARPK
TRYAVGFGARPMILMRRLLSDRAFDSLMRMAARMPRSAQRRSCGAAS

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI223718074, Length=273, Percent_Identity=32.2344322344322, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI7657478, Length=309, Percent_Identity=29.7734627831715, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI20149619, Length=196, Percent_Identity=33.6734693877551, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI7706318, Length=188, Percent_Identity=35.1063829787234, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI44680136, Length=284, Percent_Identity=29.9295774647887, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI44680133, Length=284, Percent_Identity=29.9295774647887, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI17738292, Length=284, Percent_Identity=29.9295774647887, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI19743808, Length=295, Percent_Identity=26.4406779661017, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI150247226, Length=295, Percent_Identity=28.135593220339, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI119392083, Length=297, Percent_Identity=28.956228956229, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI50726952, Length=288, Percent_Identity=29.1666666666667, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI157739938, Length=192, Percent_Identity=27.0833333333333, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI22507405, Length=197, Percent_Identity=32.48730964467, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI40548397, Length=264, Percent_Identity=26.5151515151515, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI214010158, Length=264, Percent_Identity=26.5151515151515, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI214010156, Length=264, Percent_Identity=26.5151515151515, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI22758144, Length=264, Percent_Identity=26.5151515151515, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI4504503, Length=307, Percent_Identity=27.6872964169381, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4503817, Length=235, Percent_Identity=26.8085106382979, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI59889578, Length=152, Percent_Identity=32.8947368421053, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI40254992, Length=193, Percent_Identity=30.0518134715026, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI32483357, Length=193, Percent_Identity=29.5336787564767, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI7705855, Length=206, Percent_Identity=27.1844660194175, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI109715829, Length=195, Percent_Identity=28.2051282051282, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI32455239, Length=198, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI5031765, Length=198, Percent_Identity=30.3030303030303, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786701, Length=271, Percent_Identity=34.6863468634686, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI87082100, Length=190, Percent_Identity=31.5789473684211, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786812, Length=235, Percent_Identity=31.063829787234, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788459, Length=192, Percent_Identity=31.7708333333333, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787820, Length=181, Percent_Identity=31.4917127071823, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787335, Length=185, Percent_Identity=34.0540540540541, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI2367175, Length=191, Percent_Identity=32.9842931937173, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787905, Length=140, Percent_Identity=32.8571428571429, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082160, Length=187, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI2367365, Length=183, Percent_Identity=29.5081967213115, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17557780, Length=275, Percent_Identity=29.0909090909091, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115534660, Length=292, Percent_Identity=25, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=201, Percent_Identity=32.3383084577114, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71994600, Length=188, Percent_Identity=30.3191489361702, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=201, Percent_Identity=31.3432835820896, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562908, Length=198, Percent_Identity=34.8484848484849, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71997402, Length=229, Percent_Identity=28.3842794759825, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32563809, Length=272, Percent_Identity=25.7352941176471, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17507613, Length=274, Percent_Identity=25.5474452554745, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=194, Percent_Identity=32.9896907216495, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17570069, Length=229, Percent_Identity=28.82096069869, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=195, Percent_Identity=31.7948717948718, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=198, Percent_Identity=32.3232323232323, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538486, Length=212, Percent_Identity=29.7169811320755, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=196, Percent_Identity=27.5510204081633, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=198, Percent_Identity=34.3434343434343, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=194, Percent_Identity=30.4123711340206, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=194, Percent_Identity=27.319587628866, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559552, Length=227, Percent_Identity=27.3127753303965, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=211, Percent_Identity=32.7014218009479, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=268, Percent_Identity=27.9850746268657, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=190, Percent_Identity=29.4736842105263, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=197, Percent_Identity=27.4111675126904, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=194, Percent_Identity=30.4123711340206, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=195, Percent_Identity=29.7435897435897, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17557668, Length=229, Percent_Identity=27.9475982532751, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=257, Percent_Identity=25.6809338521401, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=146, Percent_Identity=27.3972602739726, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=198, Percent_Identity=29.2929292929293, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=196, Percent_Identity=29.0816326530612, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=184, Percent_Identity=26.6304347826087, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=194, Percent_Identity=29.8969072164948, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=197, Percent_Identity=35.0253807106599, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322067, Length=187, Percent_Identity=32.620320855615, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322861, Length=190, Percent_Identity=27.8947368421053, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322226, Length=185, Percent_Identity=24.8648648648649, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI23397609, Length=187, Percent_Identity=35.2941176470588, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21358495, Length=246, Percent_Identity=30.4878048780488, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI28571526, Length=186, Percent_Identity=34.4086021505376, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357041, Length=187, Percent_Identity=32.0855614973262, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI116007236, Length=207, Percent_Identity=32.3671497584541, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI116007238, Length=187, Percent_Identity=32.620320855615, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644339, Length=181, Percent_Identity=32.0441988950276, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24580925, Length=197, Percent_Identity=31.9796954314721, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24651139, Length=191, Percent_Identity=29.8429319371728, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355319, Length=194, Percent_Identity=30.9278350515464, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648944, Length=199, Percent_Identity=30.6532663316583, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24643142, Length=182, Percent_Identity=33.5164835164835, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24641232, Length=200, Percent_Identity=33, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28571387, Length=197, Percent_Identity=31.4720812182741, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI116007234, Length=198, Percent_Identity=33.8383838383838, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI116007232, Length=187, Percent_Identity=32.620320855615, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24584752, Length=240, Percent_Identity=27.9166666666667, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640442, Length=212, Percent_Identity=30.6603773584906, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24663911, Length=199, Percent_Identity=31.1557788944724, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281364892, Length=173, Percent_Identity=30.0578034682081, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21356301, Length=225, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24641388, Length=198, Percent_Identity=32.3232323232323, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 30628; Mature: 30628

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSKVALVTGASSGIGEATALKLLAQGYTVYAAARRVERMRSQADAGVHVLAMDVTDDAV
CCCCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHH
MRAGIEEIIAKSGRLDVLVNNAGYGAYGAIEDVPLDEARAQFDVNVFGAVRLIQLALPHM
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHEECHHHHHHHHHHHHHHHHH
RAQRSGTIVNITSMGGKIHTPMGAWYHGTKFALEAISDCLRMEVEPFGIDVVVIEPGGIK
HHHCCCCEEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
TEWAGIAAENLLKVSGTGSYAPQASAMAKLMINEANGNRQSPPQLIAETIAKAVNAARPK
CHHHHHHHHHEEEECCCCCCCCHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCC
TRYAVGFGARPMILMRRLLSDRAFDSLMRMAARMPRSAQRRSCGAAS
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCC
>Mature Secondary Structure
MHSKVALVTGASSGIGEATALKLLAQGYTVYAAARRVERMRSQADAGVHVLAMDVTDDAV
CCCCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHH
MRAGIEEIIAKSGRLDVLVNNAGYGAYGAIEDVPLDEARAQFDVNVFGAVRLIQLALPHM
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHEECHHHHHHHHHHHHHHHHH
RAQRSGTIVNITSMGGKIHTPMGAWYHGTKFALEAISDCLRMEVEPFGIDVVVIEPGGIK
HHHCCCCEEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
TEWAGIAAENLLKVSGTGSYAPQASAMAKLMINEANGNRQSPPQLIAETIAKAVNAARPK
CHHHHHHHHHEEEECCCCCCCCHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCC
TRYAVGFGARPMILMRRLLSDRAFDSLMRMAARMPRSAQRRSCGAAS
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9139899; 9252185 [H]