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The map label for this gene is cueR [H]

Identifier: 94313017

GI number: 94313017

Start: 659290

End: 659703

Strand: Reverse

Name: cueR [H]

Synonym: Rmet_4090

Alternate gene names: 94313017

Gene position: 659703-659290 (Counterclockwise)

Preceding gene: 94313019

Following gene: 94313016

Centisome position: 25.57

GC content: 64.98

Gene sequence:

>414_bases
ATGAAGATTGGAGAACTGGCACGCCTGAGCGGCGTGGCCGCCTCGCGCATTCGGTTCTACGAGGCAAGCGGTCTGCTCCA
GCCGGCACAGCGGCAGGCCAATGGCTACCGTGAGTACGCCCCGGAAACGCTGACACGGCTAGAAATCATCCTGCGGGCCC
AGAACGCCGGCTTCTCGCTCGACGAAATCCGCGCCATCCTTCCGACCCGTCTCAATGACTGGCCGCGCGAAAAACTGATC
GAGGTATTGCGGCGCAAGGCCGGCGAGATCGAATTGTTGGAACAGCGGCTGGCTGGCACCCGGCGCGACCTGCTCGCGCT
CGCCCACGACATCGAGAACCTTGCCGACGACGAAGACTGCTCGGGACACGCGCGGCACGTGCTGGGGCAGATGGATCAGC
GCTCCGGGCGCTGA

Upstream 100 bases:

>100_bases
TTCATGGCTGGGGTTCGCAGGCATTTGCGCATTGCGTTGACGACTGCGTAACCCTAAGCTTAAAGTCAACTTTAATGTCA
AGTCCCCTGGAACACTGCAG

Downstream 100 bases:

>100_bases
TTCATGCAGTTTCATTCGCCGGTTACGCCAATTACGCCGATTACGCCGGGCATATCCCGTGCGTAGCCCGGCGATGCTGG
ACCAAAGTCCCCTACCCGAT

Product: putative MerR/CueR family transcriptional regulator domain-containing protein

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MKIGELARLSGVAASRIRFYEASGLLQPAQRQANGYREYAPETLTRLEIILRAQNAGFSLDEIRAILPTRLNDWPREKLI
EVLRRKAGEIELLEQRLAGTRRDLLALAHDIENLADDEDCSGHARHVLGQMDQRSGR

Sequences:

>Translated_137_residues
MKIGELARLSGVAASRIRFYEASGLLQPAQRQANGYREYAPETLTRLEIILRAQNAGFSLDEIRAILPTRLNDWPREKLI
EVLRRKAGEIELLEQRLAGTRRDLLALAHDIENLADDEDCSGHARHVLGQMDQRSGR
>Mature_137_residues
MKIGELARLSGVAASRIRFYEASGLLQPAQRQANGYREYAPETLTRLEIILRAQNAGFSLDEIRAILPTRLNDWPREKLI
EVLRRKAGEIELLEQRLAGTRRDLLALAHDIENLADDEDCSGHARHVLGQMDQRSGR

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=138, Percent_Identity=36.231884057971, Blast_Score=70, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15516; Mature: 15516

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGELARLSGVAASRIRFYEASGLLQPAQRQANGYREYAPETLTRLEIILRAQNAGFSL
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCH
DEIRAILPTRLNDWPREKLIEVLRRKAGEIELLEQRLAGTRRDLLALAHDIENLADDEDC
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
SGHARHVLGQMDQRSGR
CHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIGELARLSGVAASRIRFYEASGLLQPAQRQANGYREYAPETLTRLEIILRAQNAGFSL
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCH
DEIRAILPTRLNDWPREKLIEVLRRKAGEIELLEQRLAGTRRDLLALAHDIENLADDEDC
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
SGHARHVLGQMDQRSGR
CHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796; 12147073 [H]