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The map label for this gene is yoeA [H]

Identifier: 94312890

GI number: 94312890

Start: 522170

End: 523648

Strand: Direct

Name: yoeA [H]

Synonym: Rmet_3962

Alternate gene names: 94312890

Gene position: 522170-523648 (Clockwise)

Preceding gene: 94312888

Following gene: 94312891

Centisome position: 20.24

GC content: 63.15

Gene sequence:

>1479_bases
ATGAAGCCTGACGCCAGACTGACCACCGGCCCGATCGGCCGCACGCTGCTGATGTTCTCGCTGCCGGTGCTTGGCAGCAA
CATCCTGCAGTCGCTCAACGCCTCGATCAATTCGGTCTGGGTCGGCCGATACCTTGGTGAGGCGGCGCTCACGGCCACGT
CGAACGCCAACATCATTCTGTTTTTCCTGCTCGGCGTGGTGTTCGGGATCAGCATGGCCAATACGATCATGATCGGCCAG
GCAGTCGGCGGGCGTGACATCGAAGAGGCGCGACGCGTGGTGGGCACCAGCACCACGTTCTTCGTCGGTCTGTCGGTGCT
GGCCGCCGTGCTGGGCTTTGTCTTCACGCCGCATATCCTGGCCGCGATGCATACGCCGGACGATGCCACGCCGCTGGCCA
TCATCTACCTGCGCATCATCTTCATCGCGCTGCCGTTCATGTACTTCTACAACTTCGTGATGATGACGCTGCGCGGCGCC
GGTGACTCGCGCACGCCGTTCTACTTCATGTTGCTGTCGGTGGTGCTGGACGTCGTGCTGAATCCCGTGCTGATCTTCGG
GGTAGGCCCGATTCCCCCGCTCGGCATCGCGGGCTCGGCGCTCGCCACGCTGATTGCGCAACTGACCAGCCTGGCGGCGA
TGATCGGGTTGCTGTACCGGCGCCGGCACTTCCTGCTGCTGCACCGGGAGCAACTTGCGCTGCTCCGGCCGGACATGGCT
ATCCTGCGCGCGCTGGTGATGAAGGGGCTGCCGATGGGCCTGCAGATGGTGGTGATCTCGTCGTCGGCCATCGTGATGAT
GTCGCTGGTCAATACGTACGGCTCGCGGACGACCGCGGCCTACGGTGTGGCATCGCAGCTCTGGACCTATGTGCAGATGC
CGGCTCTGGCTGTTGGCGCCAGTGTGTCATCGATGGTTGCGCAGAACGTAGGGGCGGGATTGTGGGTGCGTGTGGCGCGT
GTCACGCAGGTTGGCATGCTCTTCAACATGTTGATGACCGGCGCGCTGGTGGCGCTGGTCTATGTATTCAATCGTCACTC
GCTTGGTCTGTTCCTGGGGGAGGACAGCGTCGCGATCGAGATTGCTCAGCACATCAACAACGTGGTGCTGTGGTCGTTCA
TCCTGTTCGGCTTCACCATTGTCGTGTTCGGCGCCGTGCGCGCCACGGGCGCCGTCATGGCGCCGCTGGTCATTCTGTTC
GTGTCGATGTGGCTGATCCGGCTGCCGTTCGCGTGGCTGCTCGGCCCGCACATCGGCGCCGAATCGATCTGGTGGAGCTT
CCCGCTCGGCTCGGTGGTGTCGGTGCTGCTTTCGTTTGGCTACTACCGATATGGCAATTGGCGCCGCAGCCATATCCTGC
CGGTCGCGCCACATCCGGAAGCGGTGGGGAATGCACCCGATACCAGCATGGGTGTGCCATGCGAGGATGCCGATGCGGGC
GCGGAAGCCGATGAGGGAGTCGCACGACAACCTTCCTAA

Upstream 100 bases:

>100_bases
GCGACGGTCATGTGCACGGCGGCTGGCATGGTGCCCAGCCAGGGACTAGACTGACACGTTCGCAACCCTCGCACTGCTGC
GGTGCGGAAAACCTGTCCCA

Downstream 100 bases:

>100_bases
TGCATCCAGACAGGTTTCTGAATGTATGGATGAGAGACATTTGATCGCGTCGCTTACGCACCGCCCGGCGGTGTAAGCAA
GTCGAAAGCTGCGCGGCATC

Product: multi antimicrobial extrusion protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MKPDARLTTGPIGRTLLMFSLPVLGSNILQSLNASINSVWVGRYLGEAALTATSNANIILFFLLGVVFGISMANTIMIGQ
AVGGRDIEEARRVVGTSTTFFVGLSVLAAVLGFVFTPHILAAMHTPDDATPLAIIYLRIIFIALPFMYFYNFVMMTLRGA
GDSRTPFYFMLLSVVLDVVLNPVLIFGVGPIPPLGIAGSALATLIAQLTSLAAMIGLLYRRRHFLLLHREQLALLRPDMA
ILRALVMKGLPMGLQMVVISSSAIVMMSLVNTYGSRTTAAYGVASQLWTYVQMPALAVGASVSSMVAQNVGAGLWVRVAR
VTQVGMLFNMLMTGALVALVYVFNRHSLGLFLGEDSVAIEIAQHINNVVLWSFILFGFTIVVFGAVRATGAVMAPLVILF
VSMWLIRLPFAWLLGPHIGAESIWWSFPLGSVVSVLLSFGYYRYGNWRRSHILPVAPHPEAVGNAPDTSMGVPCEDADAG
AEADEGVARQPS

Sequences:

>Translated_492_residues
MKPDARLTTGPIGRTLLMFSLPVLGSNILQSLNASINSVWVGRYLGEAALTATSNANIILFFLLGVVFGISMANTIMIGQ
AVGGRDIEEARRVVGTSTTFFVGLSVLAAVLGFVFTPHILAAMHTPDDATPLAIIYLRIIFIALPFMYFYNFVMMTLRGA
GDSRTPFYFMLLSVVLDVVLNPVLIFGVGPIPPLGIAGSALATLIAQLTSLAAMIGLLYRRRHFLLLHREQLALLRPDMA
ILRALVMKGLPMGLQMVVISSSAIVMMSLVNTYGSRTTAAYGVASQLWTYVQMPALAVGASVSSMVAQNVGAGLWVRVAR
VTQVGMLFNMLMTGALVALVYVFNRHSLGLFLGEDSVAIEIAQHINNVVLWSFILFGFTIVVFGAVRATGAVMAPLVILF
VSMWLIRLPFAWLLGPHIGAESIWWSFPLGSVVSVLLSFGYYRYGNWRRSHILPVAPHPEAVGNAPDTSMGVPCEDADAG
AEADEGVARQPS
>Mature_492_residues
MKPDARLTTGPIGRTLLMFSLPVLGSNILQSLNASINSVWVGRYLGEAALTATSNANIILFFLLGVVFGISMANTIMIGQ
AVGGRDIEEARRVVGTSTTFFVGLSVLAAVLGFVFTPHILAAMHTPDDATPLAIIYLRIIFIALPFMYFYNFVMMTLRGA
GDSRTPFYFMLLSVVLDVVLNPVLIFGVGPIPPLGIAGSALATLIAQLTSLAAMIGLLYRRRHFLLLHREQLALLRPDMA
ILRALVMKGLPMGLQMVVISSSAIVMMSLVNTYGSRTTAAYGVASQLWTYVQMPALAVGASVSSMVAQNVGAGLWVRVAR
VTQVGMLFNMLMTGALVALVYVFNRHSLGLFLGEDSVAIEIAQHINNVVLWSFILFGFTIVVFGAVRATGAVMAPLVILF
VSMWLIRLPFAWLLGPHIGAESIWWSFPLGSVVSVLLSFGYYRYGNWRRSHILPVAPHPEAVGNAPDTSMGVPCEDADAG
AEADEGVARQPS

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 53025; Mature: 53025

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDARLTTGPIGRTLLMFSLPVLGSNILQSLNASINSVWVGRYLGEAALTATSNANIIL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCCHH
FFLLGVVFGISMANTIMIGQAVGGRDIEEARRVVGTSTTFFVGLSVLAAVLGFVFTPHIL
HHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AAMHTPDDATPLAIIYLRIIFIALPFMYFYNFVMMTLRGAGDSRTPFYFMLLSVVLDVVL
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
NPVLIFGVGPIPPLGIAGSALATLIAQLTSLAAMIGLLYRRRHFLLLHREQLALLRPDMA
CCHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ILRALVMKGLPMGLQMVVISSSAIVMMSLVNTYGSRTTAAYGVASQLWTYVQMPALAVGA
HHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
SVSSMVAQNVGAGLWVRVARVTQVGMLFNMLMTGALVALVYVFNRHSLGLFLGEDSVAIE
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHH
IAQHINNVVLWSFILFGFTIVVFGAVRATGAVMAPLVILFVSMWLIRLPFAWLLGPHIGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ESIWWSFPLGSVVSVLLSFGYYRYGNWRRSHILPVAPHPEAVGNAPDTSMGVPCEDADAG
CHHEECCCHHHHHHHHHHHCHHHCCCCCCCCEEECCCCCHHCCCCCCCCCCCCCCCCCCC
AEADEGVARQPS
CCCCCCCCCCCC
>Mature Secondary Structure
MKPDARLTTGPIGRTLLMFSLPVLGSNILQSLNASINSVWVGRYLGEAALTATSNANIIL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCCHH
FFLLGVVFGISMANTIMIGQAVGGRDIEEARRVVGTSTTFFVGLSVLAAVLGFVFTPHIL
HHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AAMHTPDDATPLAIIYLRIIFIALPFMYFYNFVMMTLRGAGDSRTPFYFMLLSVVLDVVL
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
NPVLIFGVGPIPPLGIAGSALATLIAQLTSLAAMIGLLYRRRHFLLLHREQLALLRPDMA
CCHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ILRALVMKGLPMGLQMVVISSSAIVMMSLVNTYGSRTTAAYGVASQLWTYVQMPALAVGA
HHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
SVSSMVAQNVGAGLWVRVARVTQVGMLFNMLMTGALVALVYVFNRHSLGLFLGEDSVAIE
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHH
IAQHINNVVLWSFILFGFTIVVFGAVRATGAVMAPLVILFVSMWLIRLPFAWLLGPHIGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ESIWWSFPLGSVVSVLLSFGYYRYGNWRRSHILPVAPHPEAVGNAPDTSMGVPCEDADAG
CHHEECCCHHHHHHHHHHHCHHHCCCCCCCCEEECCCCCHHCCCCCCCCCCCCCCCCCCC
AEADEGVARQPS
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]