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The map label for this gene is fabG [C]

Identifier: 94312830

GI number: 94312830

Start: 447394

End: 448446

Strand: Direct

Name: fabG [C]

Synonym: Rmet_3902

Alternate gene names: 94312830

Gene position: 447394-448446 (Clockwise)

Preceding gene: 94312828

Following gene: 94312832

Centisome position: 17.34

GC content: 63.25

Gene sequence:

>1053_bases
ATGGCTTCGGCGGGCACGAAGCCCACTTTTGTGATTCATGAATTCCAAAGTTTCGGCCGCCAATTTATCGTATCCAGCTC
TGCAATAAAACGGGCAGGCTTCCCTGTCCGTGCAGACAGCAAGCCAATGGAGGATACGATGAGCGGAATGATGGAAGGCA
AGGTAGTGGTGGTAACGGGCGCCGGTGGCGGTATCGGACGAGGCATTGCCCTGGGCATGGCGGCGGCTGGCGCTCGTGTG
GTGGTCAATGACCTGGGCGTGTCGATGAGCGGCGAAGGCGGCGATGCCGGCCCCGCGCAGCGCGTGGTCGAGGAAATCCG
CGCGGCCGGCGGCCAGGCCGTGGCCAATACCGATTCCGTTTCGACCTGGGCTGGCGGCAACGCCATCGTGCAATGCGCGC
TCGACACCTTCGGTCGCATCGACGCTGTGGTCAACAACGCCGGCAACCTGCGCGATCGCATGTTTTTCAAGATGAACGAG
GAAGAATGGCGCTCGGTGATCGACGTGCACCTGCACGGCACCTTCTTCGTCAGCCGTGCGGCAGCCAACTATTTCAAGGA
TCAGGAGAGCGGCGCCTACGTCAACATGACGTCGACGTCGGGGCTGATCGGCAACCTGGGTCAGGCTAACTACTCCGCGG
CCAAGCTGGGCATCGCCGCGCTGTCCAAATCGATCGCGCTGGACATGGCCCGTTTCAATGTGCGCTCGAATTGCATCGCG
CCGTTCGCCTGGAGCCGCATGACCAGCTCGATCCCGGCCGAGACGCCTGCGGAGAAGGAGCGCGTGGCCCGCCTGCAGAA
GATGGAAGCCGGCAAGATCGCTCCGGTGGCCGTGTTCCTGGCCAGCGACGCGGCCAAGGACGTGAATGCCCAGATCTTCG
CGGTGCGTGCCAACGAGATCATGCTGATGAGCCAGTCGCGCCCGGTGCGCTCGGTCCATACCGGCGAAGGCTGGACGCCG
GAAACCGTCGCGGAGATCGCCATGCCCGCAATGCGTGGCAGCTTCTTCAAGCTCGACCGCTCGCCCGACGTCATCAACTG
GGACCCGATCTGA

Upstream 100 bases:

>100_bases
GGCCGCGGGCAGCGAGAGAAAGCTGCGCTCGGCCGCGCGTGTGATGTTCTCTGTTTCTCCCACGTTCAGAAACAGCCGCA
GGTCGGTCAGGTCGTAGTGC

Downstream 100 bases:

>100_bases
CCGAGTCCCGAGGCCGGCCTGGATCGAATTCAGGCTGAACCCGAGGCCGGCCCGCCTTCCGCTTTCCGTTGATGCTGCAT
TGCAGCGCGACGCGTCCATA

Product: putative short-chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MASAGTKPTFVIHEFQSFGRQFIVSSSAIKRAGFPVRADSKPMEDTMSGMMEGKVVVVTGAGGGIGRGIALGMAAAGARV
VVNDLGVSMSGEGGDAGPAQRVVEEIRAAGGQAVANTDSVSTWAGGNAIVQCALDTFGRIDAVVNNAGNLRDRMFFKMNE
EEWRSVIDVHLHGTFFVSRAAANYFKDQESGAYVNMTSTSGLIGNLGQANYSAAKLGIAALSKSIALDMARFNVRSNCIA
PFAWSRMTSSIPAETPAEKERVARLQKMEAGKIAPVAVFLASDAAKDVNAQIFAVRANEIMLMSQSRPVRSVHTGEGWTP
ETVAEIAMPAMRGSFFKLDRSPDVINWDPI

Sequences:

>Translated_350_residues
MASAGTKPTFVIHEFQSFGRQFIVSSSAIKRAGFPVRADSKPMEDTMSGMMEGKVVVVTGAGGGIGRGIALGMAAAGARV
VVNDLGVSMSGEGGDAGPAQRVVEEIRAAGGQAVANTDSVSTWAGGNAIVQCALDTFGRIDAVVNNAGNLRDRMFFKMNE
EEWRSVIDVHLHGTFFVSRAAANYFKDQESGAYVNMTSTSGLIGNLGQANYSAAKLGIAALSKSIALDMARFNVRSNCIA
PFAWSRMTSSIPAETPAEKERVARLQKMEAGKIAPVAVFLASDAAKDVNAQIFAVRANEIMLMSQSRPVRSVHTGEGWTP
ETVAEIAMPAMRGSFFKLDRSPDVINWDPI
>Mature_349_residues
ASAGTKPTFVIHEFQSFGRQFIVSSSAIKRAGFPVRADSKPMEDTMSGMMEGKVVVVTGAGGGIGRGIALGMAAAGARVV
VNDLGVSMSGEGGDAGPAQRVVEEIRAAGGQAVANTDSVSTWAGGNAIVQCALDTFGRIDAVVNNAGNLRDRMFFKMNEE
EWRSVIDVHLHGTFFVSRAAANYFKDQESGAYVNMTSTSGLIGNLGQANYSAAKLGIAALSKSIALDMARFNVRSNCIAP
FAWSRMTSSIPAETPAEKERVARLQKMEAGKIAPVAVFLASDAAKDVNAQIFAVRANEIMLMSQSRPVRSVHTGEGWTPE
TVAEIAMPAMRGSFFKLDRSPDVINWDPI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=275, Percent_Identity=43.6363636363636, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI15277342, Length=253, Percent_Identity=29.6442687747036, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI40254992, Length=228, Percent_Identity=30.2631578947368, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=26.0536398467433, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI59889578, Length=180, Percent_Identity=29.4444444444444, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI4758504, Length=217, Percent_Identity=29.9539170506912, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI31542939, Length=215, Percent_Identity=28.8372093023256, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI32483357, Length=260, Percent_Identity=25.3846153846154, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI209862901, Length=203, Percent_Identity=29.064039408867, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI19923983, Length=203, Percent_Identity=29.064039408867, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI83715985, Length=194, Percent_Identity=30.4123711340206, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=259, Percent_Identity=33.5907335907336, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=31.8897637795276, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1790717, Length=257, Percent_Identity=29.9610894941634, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=30.6451612903226, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=27.0916334661355, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082100, Length=249, Percent_Identity=29.718875502008, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=27.4131274131274, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786812, Length=255, Percent_Identity=27.843137254902, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=29.5546558704453, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787526, Length=267, Percent_Identity=23.9700374531835, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789057, Length=185, Percent_Identity=29.1891891891892, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=238, Percent_Identity=42.436974789916, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI25147288, Length=258, Percent_Identity=34.1085271317829, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=31.9066147859922, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17564282, Length=214, Percent_Identity=27.1028037383178, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=255, Percent_Identity=27.843137254902, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17538182, Length=220, Percent_Identity=31.3636363636364, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193203115, Length=228, Percent_Identity=24.1228070175439, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=191, Percent_Identity=25.6544502617801, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=199, Percent_Identity=30.1507537688442, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=197, Percent_Identity=28.4263959390863, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71997099, Length=204, Percent_Identity=28.4313725490196, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=189, Percent_Identity=27.5132275132275, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=179, Percent_Identity=26.8156424581006, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=24.3137254901961, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=253, Percent_Identity=25.6916996047431, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=248, Percent_Identity=45.1612903225806, Blast_Score=204, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6324126, Length=252, Percent_Identity=27.3809523809524, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI18859837, Length=241, Percent_Identity=43.9834024896266, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24639444, Length=246, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI17737361, Length=216, Percent_Identity=30.0925925925926, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI23397609, Length=191, Percent_Identity=31.9371727748691, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24640492, Length=205, Percent_Identity=25.8536585365854, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281364892, Length=211, Percent_Identity=26.0663507109005, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24644339, Length=190, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24643142, Length=191, Percent_Identity=27.2251308900524, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357041, Length=192, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 37119; Mature: 36987

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASAGTKPTFVIHEFQSFGRQFIVSSSAIKRAGFPVRADSKPMEDTMSGMMEGKVVVVTG
CCCCCCCCEEEEHHHHHHHHHEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEC
AGGGIGRGIALGMAAAGARVVVNDLGVSMSGEGGDAGPAQRVVEEIRAAGGQAVANTDSV
CCCCCCHHHHHHHHHCCCEEEEEECCCEECCCCCCCCHHHHHHHHHHHCCCCEEECCCCC
STWAGGNAIVQCALDTFGRIDAVVNNAGNLRDRMFFKMNEEEWRSVIDVHLHGTFFVSRA
CCCCCCHHEEEEHHHHHHHHHHHHCCCCCCCHHEEEEECHHHHHCEEEEEECHHHHHHHH
AANYFKDQESGAYVNMTSTSGLIGNLGQANYSAAKLGIAALSKSIALDMARFNVRSNCIA
HHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PFAWSRMTSSIPAETPAEKERVARLQKMEAGKIAPVAVFLASDAAKDVNAQIFAVRANEI
CHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCEE
MLMSQSRPVRSVHTGEGWTPETVAEIAMPAMRGSFFKLDRSPDVINWDPI
EEEECCCCCCEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure 
ASAGTKPTFVIHEFQSFGRQFIVSSSAIKRAGFPVRADSKPMEDTMSGMMEGKVVVVTG
CCCCCCCEEEEHHHHHHHHHEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEC
AGGGIGRGIALGMAAAGARVVVNDLGVSMSGEGGDAGPAQRVVEEIRAAGGQAVANTDSV
CCCCCCHHHHHHHHHCCCEEEEEECCCEECCCCCCCCHHHHHHHHHHHCCCCEEECCCCC
STWAGGNAIVQCALDTFGRIDAVVNNAGNLRDRMFFKMNEEEWRSVIDVHLHGTFFVSRA
CCCCCCHHEEEEHHHHHHHHHHHHCCCCCCCHHEEEEECHHHHHCEEEEEECHHHHHHHH
AANYFKDQESGAYVNMTSTSGLIGNLGQANYSAAKLGIAALSKSIALDMARFNVRSNCIA
HHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PFAWSRMTSSIPAETPAEKERVARLQKMEAGKIAPVAVFLASDAAKDVNAQIFAVRANEI
CHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCEE
MLMSQSRPVRSVHTGEGWTPETVAEIAMPAMRGSFFKLDRSPDVINWDPI
EEEECCCCCCEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]