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The map label for this gene is icdA [H]

Identifier: 94312661

GI number: 94312661

Start: 271791

End: 274034

Strand: Reverse

Name: icdA [H]

Synonym: Rmet_3729

Alternate gene names: 94312661

Gene position: 274034-271791 (Counterclockwise)

Preceding gene: 94312662

Following gene: 94312658

Centisome position: 10.62

GC content: 62.66

Gene sequence:

>2244_bases
ATGAGCAACCAGCAGCCAACCATCATTTACACCCTAACCGACGAAGCTCCGCTGCTGGCCACCAGTGCCTTCCTGCCCAT
CATCCGCACGTTCGCTGGCCCGGCCGGCGTGAACGTCGTGACCAGCGACATCTCGGTCGCTGGCCGTATCCTGGGCGAAT
TCCCCGAATTCCTGACCGAAGCACAGCGTGTGCCGGACAACCTGGCCGAACTGGGCAAGCTCACGCAAGACCCGGACACC
AACATCATCAAGCTGCCGAACATCAGCGCCTCGGTGTTCCAGCTCGTCAGCGCGATCAAGGAACTGCAGTCGAAGGGCTA
CAAGATCCCCGACTTCCCCGAAGATCCGAAGACCGAAGAAGAGAAGGCCATCCAGAAGCGCTACTCGAAGTGCCTGGGCA
GCGCCGTGAACCCGGTCCTGCGCGAAGGCAACTCGGACCGCCGCGCGCCTGCCGCCGTCAAGAACTACGCGCGCAAGCAC
CCGCACAGCATGGGCGAGTGGAGCATGGCCTCGCGCACGCACGTCGCCCACATGAAGCACGGCGACTTCTACCATGGCGA
GAAGTCGATCACGCTGAACGGCGCACGCGAAGTCCGCATGGAACTGCTGACCAAGAGCGGCAAGACCATCGTGCTGAAGC
CGAAGGTCGCGCTGCTGGACGGCGAAGTCATCGACAGCATGTTCATGAGCAAGAAGGCCCTGCTGGACTTCTATGAAGAC
CAGATGGAAGACGCGCGCAAGACCGGCGTCATGCTGAGCTTGCACGTGAAGGCGACGATGATGAAGGTGTCGCACCCGAT
CGTGTTCGGCCACGCCGTCAAGGTCTTCTACAAGGATGCGTTCGCCAAGCACCAGAAGCTGTTCGACGAACTGGGCGTGA
ACGTCAACAACGGCCTGGTCGACTTGTACACCAAGATCGAAACGCTGCCGGAATCGAAGCGCGAGGAAGTCATCCGCGAC
ATGCACGCCTGCCACGAACATCGCCCGGAAATGGCGATGGTAGACTCGGCCAAGGGCATCTCGAACCTGCACGCGCCGAA
CGACGTGATCGTCGACGCATCGATGCCGGCCATGATCCGTATCGGCGGCAAGATGTGGGGCGCGGACGGCCGTACGAAGG
ACACCAAGTGCCTGATTCCGGAATCGACTTTCGCCCGCATCTATCAGGAAATCATCAACTTCTGCAAGACCAACGGCGCG
TTTGATCCGGTGACGATGGGCACGGTGCCGAACGTCGGCCTGATGGCCCAGAAGGCCGAAGAGTACGGTTCGCACGACAA
GACGTTCGAGATTCCCGAAGACGGCGAAGCCCGCATCGTCGACAACGCCACCGGCGAAGTGCTGACCGCCCTGACGCAGC
AGGTTGAAGCAGGCGACATCTGGCGCATGTGCCAGGTCAAGGACGCCCCGATCCGCGACTGGGTGAAGCTGGCCGTTACG
CGCGCCCGCAATTCGGGCATGCCTGCCGTGTTCTGGCTGGACCCGTACCGTCCGCACGAGGCCGAGCTGATCAAGAAGGT
GGAAACGTACCTGAAGGACTACGACACCAACGGCCTGGACATCCAGATCATGTCGCAGGTTCGCGCCATGCGCTACACGC
TGGAACGCGTGATCCGCGGCCTGGACACCATCTCGGTGACCGGCAACATCCTGCGCGACTACCTGACCGACCTGTTCCCG
ATCATGGAACTGGGTACCAGCGCCAAGATGCTGTCGATCGTGCCGCTGATGGCAGGTGGCGGTATGTACGAAACCGGCGC
GGGCGGTTCGGCACCGAAGCACGTCGCGCAGCTGGTGGAAGAGAACCATCTGCGTTGGGACTCGCTGGGTGAATTCCTGG
CCCTGGCCGTGTCGCTGGAAGAGTTGGGCATCAAGTCCGGCAACGAACGCGCCAAGATCCTGGCCACGACGCTGGACGCC
GCCACCGGCAAGCTGCTGGACAACGCCAAGAGCCCGTCGCCGAAGACCGGCCAGCTCGACAACCGCGGCAGCCAGTTCTA
CCTGGCCATGTACTGGGCCCAGGAACTGGCCGCGCAGAAGGGCGACGCCGATCTGGCGAAGATCTTCGCGCCGCTGGCCA
AGACGCTGACGGACAACGAGTCGACCATCATCGGCGAACTCGGCGCTGTGCAGGGCAAGCCGGTGGACATCGGCGGCTAC
TACATGCCGGACGCCGCCATGCTGGAAGCCGTGATGCGCCCGAGCCAGACGCTGAACTCGGCGCTGGCGGCAGTGAAGGC
CTAA

Upstream 100 bases:

>100_bases
TTGCACCTCCGCCATGCAAAATCAGGCAAAATTCGAGTCTTGCCTCGAACCGCGACCCGGAAGAGGCATTTCCCAACCCG
AATCTGATGCGAGATAAGCG

Downstream 100 bases:

>100_bases
GTCGCGCTCGCCTCGCCGCTGGCCCGGTAGTTCTGGCTGGCGGTGGTGGTTGAAAACAGAAAAGCCCCGGAGCAGGAATG
CTCCGGGGCTTTTTCTTTGA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MSNQQPTIIYTLTDEAPLLATSAFLPIIRTFAGPAGVNVVTSDISVAGRILGEFPEFLTEAQRVPDNLAELGKLTQDPDT
NIIKLPNISASVFQLVSAIKELQSKGYKIPDFPEDPKTEEEKAIQKRYSKCLGSAVNPVLREGNSDRRAPAAVKNYARKH
PHSMGEWSMASRTHVAHMKHGDFYHGEKSITLNGAREVRMELLTKSGKTIVLKPKVALLDGEVIDSMFMSKKALLDFYED
QMEDARKTGVMLSLHVKATMMKVSHPIVFGHAVKVFYKDAFAKHQKLFDELGVNVNNGLVDLYTKIETLPESKREEVIRD
MHACHEHRPEMAMVDSAKGISNLHAPNDVIVDASMPAMIRIGGKMWGADGRTKDTKCLIPESTFARIYQEIINFCKTNGA
FDPVTMGTVPNVGLMAQKAEEYGSHDKTFEIPEDGEARIVDNATGEVLTALTQQVEAGDIWRMCQVKDAPIRDWVKLAVT
RARNSGMPAVFWLDPYRPHEAELIKKVETYLKDYDTNGLDIQIMSQVRAMRYTLERVIRGLDTISVTGNILRDYLTDLFP
IMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVAQLVEENHLRWDSLGEFLALAVSLEELGIKSGNERAKILATTLDA
ATGKLLDNAKSPSPKTGQLDNRGSQFYLAMYWAQELAAQKGDADLAKIFAPLAKTLTDNESTIIGELGAVQGKPVDIGGY
YMPDAAMLEAVMRPSQTLNSALAAVKA

Sequences:

>Translated_747_residues
MSNQQPTIIYTLTDEAPLLATSAFLPIIRTFAGPAGVNVVTSDISVAGRILGEFPEFLTEAQRVPDNLAELGKLTQDPDT
NIIKLPNISASVFQLVSAIKELQSKGYKIPDFPEDPKTEEEKAIQKRYSKCLGSAVNPVLREGNSDRRAPAAVKNYARKH
PHSMGEWSMASRTHVAHMKHGDFYHGEKSITLNGAREVRMELLTKSGKTIVLKPKVALLDGEVIDSMFMSKKALLDFYED
QMEDARKTGVMLSLHVKATMMKVSHPIVFGHAVKVFYKDAFAKHQKLFDELGVNVNNGLVDLYTKIETLPESKREEVIRD
MHACHEHRPEMAMVDSAKGISNLHAPNDVIVDASMPAMIRIGGKMWGADGRTKDTKCLIPESTFARIYQEIINFCKTNGA
FDPVTMGTVPNVGLMAQKAEEYGSHDKTFEIPEDGEARIVDNATGEVLTALTQQVEAGDIWRMCQVKDAPIRDWVKLAVT
RARNSGMPAVFWLDPYRPHEAELIKKVETYLKDYDTNGLDIQIMSQVRAMRYTLERVIRGLDTISVTGNILRDYLTDLFP
IMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVAQLVEENHLRWDSLGEFLALAVSLEELGIKSGNERAKILATTLDA
ATGKLLDNAKSPSPKTGQLDNRGSQFYLAMYWAQELAAQKGDADLAKIFAPLAKTLTDNESTIIGELGAVQGKPVDIGGY
YMPDAAMLEAVMRPSQTLNSALAAVKA
>Mature_746_residues
SNQQPTIIYTLTDEAPLLATSAFLPIIRTFAGPAGVNVVTSDISVAGRILGEFPEFLTEAQRVPDNLAELGKLTQDPDTN
IIKLPNISASVFQLVSAIKELQSKGYKIPDFPEDPKTEEEKAIQKRYSKCLGSAVNPVLREGNSDRRAPAAVKNYARKHP
HSMGEWSMASRTHVAHMKHGDFYHGEKSITLNGAREVRMELLTKSGKTIVLKPKVALLDGEVIDSMFMSKKALLDFYEDQ
MEDARKTGVMLSLHVKATMMKVSHPIVFGHAVKVFYKDAFAKHQKLFDELGVNVNNGLVDLYTKIETLPESKREEVIRDM
HACHEHRPEMAMVDSAKGISNLHAPNDVIVDASMPAMIRIGGKMWGADGRTKDTKCLIPESTFARIYQEIINFCKTNGAF
DPVTMGTVPNVGLMAQKAEEYGSHDKTFEIPEDGEARIVDNATGEVLTALTQQVEAGDIWRMCQVKDAPIRDWVKLAVTR
ARNSGMPAVFWLDPYRPHEAELIKKVETYLKDYDTNGLDIQIMSQVRAMRYTLERVIRGLDTISVTGNILRDYLTDLFPI
MELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVAQLVEENHLRWDSLGEFLALAVSLEELGIKSGNERAKILATTLDAA
TGKLLDNAKSPSPKTGQLDNRGSQFYLAMYWAQELAAQKGDADLAKIFAPLAKTLTDNESTIIGELGAVQGKPVDIGGYY
MPDAAMLEAVMRPSQTLNSALAAVKA

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 82170; Mature: 82039

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQQPTIIYTLTDEAPLLATSAFLPIIRTFAGPAGVNVVTSDISVAGRILGEFPEFLTE
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
AQRVPDNLAELGKLTQDPDTNIIKLPNISASVFQLVSAIKELQSKGYKIPDFPEDPKTEE
HHHCCHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
EKAIQKRYSKCLGSAVNPVLREGNSDRRAPAAVKNYARKHPHSMGEWSMASRTHVAHMKH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
GDFYHGEKSITLNGAREVRMELLTKSGKTIVLKPKVALLDGEVIDSMFMSKKALLDFYED
CCCCCCCCEEEECCHHHHHHHHHHCCCCEEEECCCEEECCHHHHHHHHHHHHHHHHHHHH
QMEDARKTGVMLSLHVKATMMKVSHPIVFGHAVKVFYKDAFAKHQKLFDELGVNVNNGLV
HHHHHHHCCEEEEEEHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DLYTKIETLPESKREEVIRDMHACHEHRPEMAMVDSAKGISNLHAPNDVIVDASMPAMIR
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEHHCCCCCCCCCCCCCEEEECCCCEEEE
IGGKMWGADGRTKDTKCLIPESTFARIYQEIINFCKTNGAFDPVTMGTVPNVGLMAQKAE
ECCEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHH
EYGSHDKTFEIPEDGEARIVDNATGEVLTALTQQVEAGDIWRMCQVKDAPIRDWVKLAVT
HHCCCCCEEECCCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHH
RARNSGMPAVFWLDPYRPHEAELIKKVETYLKDYDTNGLDIQIMSQVRAMRYTLERVIRG
HHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHC
LDTISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVAQLVE
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHH
ENHLRWDSLGEFLALAVSLEELGIKSGNERAKILATTLDAATGKLLDNAKSPSPKTGQLD
HCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCC
NRGSQFYLAMYWAQELAAQKGDADLAKIFAPLAKTLTDNESTIIGELGAVQGKPVDIGGY
CCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEHHCCCCCCCEECCCE
YMPDAAMLEAVMRPSQTLNSALAAVKA
ECCCHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SNQQPTIIYTLTDEAPLLATSAFLPIIRTFAGPAGVNVVTSDISVAGRILGEFPEFLTE
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
AQRVPDNLAELGKLTQDPDTNIIKLPNISASVFQLVSAIKELQSKGYKIPDFPEDPKTEE
HHHCCHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
EKAIQKRYSKCLGSAVNPVLREGNSDRRAPAAVKNYARKHPHSMGEWSMASRTHVAHMKH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
GDFYHGEKSITLNGAREVRMELLTKSGKTIVLKPKVALLDGEVIDSMFMSKKALLDFYED
CCCCCCCCEEEECCHHHHHHHHHHCCCCEEEECCCEEECCHHHHHHHHHHHHHHHHHHHH
QMEDARKTGVMLSLHVKATMMKVSHPIVFGHAVKVFYKDAFAKHQKLFDELGVNVNNGLV
HHHHHHHCCEEEEEEHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
DLYTKIETLPESKREEVIRDMHACHEHRPEMAMVDSAKGISNLHAPNDVIVDASMPAMIR
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEHHCCCCCCCCCCCCCEEEECCCCEEEE
IGGKMWGADGRTKDTKCLIPESTFARIYQEIINFCKTNGAFDPVTMGTVPNVGLMAQKAE
ECCEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHH
EYGSHDKTFEIPEDGEARIVDNATGEVLTALTQQVEAGDIWRMCQVKDAPIRDWVKLAVT
HHCCCCCEEECCCCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHH
RARNSGMPAVFWLDPYRPHEAELIKKVETYLKDYDTNGLDIQIMSQVRAMRYTLERVIRG
HHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHC
LDTISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVAQLVE
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHH
ENHLRWDSLGEFLALAVSLEELGIKSGNERAKILATTLDAATGKLLDNAKSPSPKTGQLD
HCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCC
NRGSQFYLAMYWAQELAAQKGDADLAKIFAPLAKTLTDNESTIIGELGAVQGKPVDIGGY
CCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEHHCCCCCCCEECCCE
YMPDAAMLEAVMRPSQTLNSALAAVKA
ECCCHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12005040; 4149369; 12467571 [H]