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The map label for this gene is yhcA [H]

Identifier: 94312554

GI number: 94312554

Start: 157587

End: 159164

Strand: Reverse

Name: yhcA [H]

Synonym: Rmet_3622

Alternate gene names: 94312554

Gene position: 159164-157587 (Counterclockwise)

Preceding gene: 94312555

Following gene: 291481479

Centisome position: 6.17

GC content: 64.01

Gene sequence:

>1578_bases
GTGACCGCGCAGGCAGACCCGTGGCATCGGCTGCGCGCCCGCATGAGGTGGCTGCGCCTGCTCAGCCACCAGCAGCGGCA
GACGTTGCTCATGATCTTGCTGGGCCTGGCTACAGGCGTCGAGTTTCTCGAGAACATCATGTTCGTGTTCGCGTCGAGCC
ATATCATCGGCGGGATCGACGCGGACCCGCGCAGCTTCGCGCTGGTCCAGGCCGCCTATGCCGTCGGGAGCATGCTGATG
ATCCTGACGCAGCATTGGCTCGCGCGGCGATTCGGATATCGCTACTACCTGACCGGGTCACTCCTGCTGTTCATGGCGGG
CACGCTCGCGGCCGCTACCAGCACCGGACTGACGCAAATGGTGGGCGCCCGCTTCGTGCAGGGCGTTGGCGGCGGCGCGC
TGTTCACGAGCTGCCGGATCCTGGTGAACATGATGTTCAGCCAGACCGACCGGGTGCGGGCTTCGCGCATCTTCATGCTT
GGCATCTTCAGCGCTTCGGCGCTGGGCCCCGCCTTCGCCGCGGAGCTGGTCGATCGAGGCGTCTGGCAGGACGTCTTCTA
TGGCGTGCTGCCGTTTGCGGCACTTGCCACGATAGGCGCCTGGCTGTTGCTCCCGGACGCGGAAGCCCGCGATGACGTGG
AAGGACCCGGGCTCGGTCCACTGCTGCTGTTCGGGGTCGCGATCGTCGCACTGCAGGCAACGTTGACGGAAGCCCGTTTC
GACGTGTTCTCGCATCCGATACGCATTGCGCTGATCGCCGCGCTCGCGCTGACGCTGCTAACTGTCTTTCTGTGGCAGCA
GTGGCACCACGAAAAGCCCGTGTTGCACCTGCGTGCGCTGTACCAGCCCGTCTTCCTGACCGGCCTGGCCATGTACTTCG
TCTATTACATGATCAGCAACCTCGCCGCCTATGTGTTCCCGATCTACGCGGAGCAAGCGCTGCGGTTTCCGCTTGCCACC
ACCGGCTGGCTGAACACGTTCGCCGCGACGATCAGTCTGGTCGGCATCTGGGTGTACCAGCGCGTGGCGCGCAAGCTGAA
ACACAAGAAGCCGCTGATGACGACGGGGTTGCTGCTGATGGCTGGGGCGATGACGTGGTTCTCCTTCATGCCGCCAGACG
TCGGCCCCCCAGCGCTCATCGTCGGGCTGATCGGCAAGGGGCTCTTCGGCGTGATGGTCATCATTCCGATCGCGGGCCTG
ACATTCGGCTCACTGGCCGGCGATGACTTCGCGCATGGGTATCGCAGCAAGAACCTGATTCGCCAGATCGCCAGTTCGTT
TGCATCGGCGCTAGGTGCTGTCCTGCTGCAGAACCGGCAGTTCGCAGTGCATACGAGCCTGGTGCACGCCCTGGGGCAGC
GGCCAGCCGAAACGGAGCAATGGATGCATACCGTGCAGGCTGCGCTGGTAGCACGCGGATTCGAGCCGGGCCAGGCCCAT
GCAGGTGCGCTCGCACAACTTGCTGCCCTGGTGGATCAACAGGCGCGGTTGATTGCCTGCGAGGATCTCTATCGATTGAT
TGCCGTGCTAGCCATGGCGGCTGCGGTCTTCATGCTAGTACAGCGTCGGCTCGACTAG

Upstream 100 bases:

>100_bases
CCGAAGCTTGGGCCCCCATCGGCAAGACCGGTCTGGCAGCCGTCACGCGCGATCTCGGTCGGCTACATCAGCATCTGGCT
GCGCTGGGAGCAAACGCATC

Downstream 100 bases:

>100_bases
TCAGGGAATGTGCCTTGCTTAGGCAGGAAAGGCGGGAGGGGTACTGCGTTTGCGCTGGCGACAGCGCGGCAATGGCGGCG
GATCGCCATCACATCGATCA

Product: major facilitator superfamily transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MTAQADPWHRLRARMRWLRLLSHQQRQTLLMILLGLATGVEFLENIMFVFASSHIIGGIDADPRSFALVQAAYAVGSMLM
ILTQHWLARRFGYRYYLTGSLLLFMAGTLAAATSTGLTQMVGARFVQGVGGGALFTSCRILVNMMFSQTDRVRASRIFML
GIFSASALGPAFAAELVDRGVWQDVFYGVLPFAALATIGAWLLLPDAEARDDVEGPGLGPLLLFGVAIVALQATLTEARF
DVFSHPIRIALIAALALTLLTVFLWQQWHHEKPVLHLRALYQPVFLTGLAMYFVYYMISNLAAYVFPIYAEQALRFPLAT
TGWLNTFAATISLVGIWVYQRVARKLKHKKPLMTTGLLLMAGAMTWFSFMPPDVGPPALIVGLIGKGLFGVMVIIPIAGL
TFGSLAGDDFAHGYRSKNLIRQIASSFASALGAVLLQNRQFAVHTSLVHALGQRPAETEQWMHTVQAALVARGFEPGQAH
AGALAQLAALVDQQARLIACEDLYRLIAVLAMAAAVFMLVQRRLD

Sequences:

>Translated_525_residues
MTAQADPWHRLRARMRWLRLLSHQQRQTLLMILLGLATGVEFLENIMFVFASSHIIGGIDADPRSFALVQAAYAVGSMLM
ILTQHWLARRFGYRYYLTGSLLLFMAGTLAAATSTGLTQMVGARFVQGVGGGALFTSCRILVNMMFSQTDRVRASRIFML
GIFSASALGPAFAAELVDRGVWQDVFYGVLPFAALATIGAWLLLPDAEARDDVEGPGLGPLLLFGVAIVALQATLTEARF
DVFSHPIRIALIAALALTLLTVFLWQQWHHEKPVLHLRALYQPVFLTGLAMYFVYYMISNLAAYVFPIYAEQALRFPLAT
TGWLNTFAATISLVGIWVYQRVARKLKHKKPLMTTGLLLMAGAMTWFSFMPPDVGPPALIVGLIGKGLFGVMVIIPIAGL
TFGSLAGDDFAHGYRSKNLIRQIASSFASALGAVLLQNRQFAVHTSLVHALGQRPAETEQWMHTVQAALVARGFEPGQAH
AGALAQLAALVDQQARLIACEDLYRLIAVLAMAAAVFMLVQRRLD
>Mature_524_residues
TAQADPWHRLRARMRWLRLLSHQQRQTLLMILLGLATGVEFLENIMFVFASSHIIGGIDADPRSFALVQAAYAVGSMLMI
LTQHWLARRFGYRYYLTGSLLLFMAGTLAAATSTGLTQMVGARFVQGVGGGALFTSCRILVNMMFSQTDRVRASRIFMLG
IFSASALGPAFAAELVDRGVWQDVFYGVLPFAALATIGAWLLLPDAEARDDVEGPGLGPLLLFGVAIVALQATLTEARFD
VFSHPIRIALIAALALTLLTVFLWQQWHHEKPVLHLRALYQPVFLTGLAMYFVYYMISNLAAYVFPIYAEQALRFPLATT
GWLNTFAATISLVGIWVYQRVARKLKHKKPLMTTGLLLMAGAMTWFSFMPPDVGPPALIVGLIGKGLFGVMVIIPIAGLT
FGSLAGDDFAHGYRSKNLIRQIASSFASALGAVLLQNRQFAVHTSLVHALGQRPAETEQWMHTVQAALVARGFEPGQAHA
GALAQLAALVDQQARLIACEDLYRLIAVLAMAAAVFMLVQRRLD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=489, Percent_Identity=22.0858895705521, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081983, Length=311, Percent_Identity=26.0450160771704, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790195, Length=379, Percent_Identity=22.6912928759894, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789042, Length=439, Percent_Identity=21.6400911161731, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 57509; Mature: 57378

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQADPWHRLRARMRWLRLLSHQQRQTLLMILLGLATGVEFLENIMFVFASSHIIGGID
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ADPRSFALVQAAYAVGSMLMILTQHWLARRFGYRYYLTGSLLLFMAGTLAAATSTGLTQM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
VGARFVQGVGGGALFTSCRILVNMMFSQTDRVRASRIFMLGIFSASALGPAFAAELVDRG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VWQDVFYGVLPFAALATIGAWLLLPDAEARDDVEGPGLGPLLLFGVAIVALQATLTEARF
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DVFSHPIRIALIAALALTLLTVFLWQQWHHEKPVLHLRALYQPVFLTGLAMYFVYYMISN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAYVFPIYAEQALRFPLATTGWLNTFAATISLVGIWVYQRVARKLKHKKPLMTTGLLLM
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AGAMTWFSFMPPDVGPPALIVGLIGKGLFGVMVIIPIAGLTFGSLAGDDFAHGYRSKNLI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RQIASSFASALGAVLLQNRQFAVHTSLVHALGQRPAETEQWMHTVQAALVARGFEPGQAH
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
AGALAQLAALVDQQARLIACEDLYRLIAVLAMAAAVFMLVQRRLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAQADPWHRLRARMRWLRLLSHQQRQTLLMILLGLATGVEFLENIMFVFASSHIIGGID
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]