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The map label for this gene is degP [H]

Identifier: 94312552

GI number: 94312552

Start: 155450

End: 156913

Strand: Direct

Name: degP [H]

Synonym: Rmet_3620

Alternate gene names: 94312552

Gene position: 155450-156913 (Clockwise)

Preceding gene: 94312549

Following gene: 94312553

Centisome position: 6.02

GC content: 62.57

Gene sequence:

>1464_bases
ATGATTCGTCAGACTCTCGCCCGCTCTGCTGTCGGTGTCGCTGCCTTGGCTGCCCTTGCCGGCGGCTACGCGTATCTGCA
GAAGGATGCGATCACCCCGGGATACGCCGCACAGACCCCGGTCACCGCAAGCGCAGGACCGATTGCAGTCGCCACGCCAA
CGGATTTCTCGAGCATCGTGGATCAATATGGCCCAGCCGTCGTGAACATCAGCGTGACCGCGCGCGCCCAGCGTACTTCG
GCACAAGTGCCGCAGGGCGTCGATCCGGATGACCCGCTGTTCCAGTTCTTCAAGCGATTCGGCCCGCAGTTCCAGGGGCC
GCAGAATGCGCAGCCGCAGCTGGTGCGTGGACTAGGCTCGGGATTCATCGTTAGCCAGGACGGTCTGATCCTGACGAATG
CGCACGTGGTCGACAACGCTACCGAAGTCACGGTGAAGCTCACAGACCGCCGCGAGTTCAAGGCCAAGGTGTTAGGCAGC
GATCCGCAGACTGACATCGCGGTGATTCGCATCGATGCAAAGAATCTCCCCACGGTCCGGCTGGGCGACCCGTCGAAAAC
CCGCGTTGGCGAGCCGGTGCTCGCCATTGGGTCCCCGTACGGCTTCGAGAACACGGTCACTGCCGGTATCGTCAGTGCCA
AATCGCGTTCGCTGCCCGATGACACCTACGTGCCGTTCATCCAGACCGACGTTGCGGTGAATCCCGGCAATTCCGGCGGT
CCGCTGTTTAATCAGCGCGGCGAAGTGATCGGCATCAACTCGCAGATCTACAGCCAGACTGGTGGCTATCAGGGCCTCTC
GTTTGCCATCCCGATCAACGTAGCGACCAAGGTCGAGGAGCAACTCGTAGCCCATGGCAAGGTCACGCGCGGCCGTCTCG
GTATCTCGGTTCAGGAAGTGAACCAGGCGCTTGCGCAGTCGTTCAACTTGCCGAAGCCTGCGGGTGCGCTGGTTAATTCG
GTGGAACCGGACAGCCCCGCGGCGAAAGGTGGTGTGAAGGCTGGCGACGTGATCGTGCAGCTCGGCGATGACGTCATCGA
TCATTCCGGTGATCTGCCCGAGCATGTGGCCGACCTCAAGCCGGGCACTGAGACGAAGCTCAAGGTCATCCGCAAGGGGC
AACCGATGACGCTGACGGTCCAGGTCGGGGCGGTGAAGGAAGACGCCCTGGCTCAGAAGGGTAACGGTGGTCAGGACGGC
GGACGCCTGGGTCTTGCGGTTCGTCAGCTGACGCCTGCGGAGAAGCGCGACAGTGGCATAGACGGCGGCCTCGTGGTCGA
AGACGTGACGGGACCCGCTGCGCGAGTAGGTATCCAGCCGGGCGATGTCATTCTCTCACTGAACGGCACGCCGATCTCTT
CCGCCGAGCAACTGCGAACGCTGGTGTCCAAGTCTGGCAAGCAGGTGGCACTGCTGGTACAGCGTGACGATGCGCGGATT
TTCATCCCGCTCGACCTCGGCTGA

Upstream 100 bases:

>100_bases
ATCTGGTTCTTTAAGTCTGGCTTAAGTGTGGCTGCTTACCATGATTCCGTCGCGCCAAGAAAACCGTCGGCGCTATGGAC
CATCGAGAAAGGAAAGCACC

Downstream 100 bases:

>100_bases
GCGAGTGCGAGGAAGTGGTTTACGGTCCTCGCAACACGTATACGGGACGTATACCGTAAACGGGTATACGTCCCGCAAAC
CCTTGCCAGAAGCGGATTTC

Product: multifunctional enzyme (serine-type endopeptidase / oxidoreductase) (degP / mucD-like)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MIRQTLARSAVGVAALAALAGGYAYLQKDAITPGYAAQTPVTASAGPIAVATPTDFSSIVDQYGPAVVNISVTARAQRTS
AQVPQGVDPDDPLFQFFKRFGPQFQGPQNAQPQLVRGLGSGFIVSQDGLILTNAHVVDNATEVTVKLTDRREFKAKVLGS
DPQTDIAVIRIDAKNLPTVRLGDPSKTRVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSGG
PLFNQRGEVIGINSQIYSQTGGYQGLSFAIPINVATKVEEQLVAHGKVTRGRLGISVQEVNQALAQSFNLPKPAGALVNS
VEPDSPAAKGGVKAGDVIVQLGDDVIDHSGDLPEHVADLKPGTETKLKVIRKGQPMTLTVQVGAVKEDALAQKGNGGQDG
GRLGLAVRQLTPAEKRDSGIDGGLVVEDVTGPAARVGIQPGDVILSLNGTPISSAEQLRTLVSKSGKQVALLVQRDDARI
FIPLDLG

Sequences:

>Translated_487_residues
MIRQTLARSAVGVAALAALAGGYAYLQKDAITPGYAAQTPVTASAGPIAVATPTDFSSIVDQYGPAVVNISVTARAQRTS
AQVPQGVDPDDPLFQFFKRFGPQFQGPQNAQPQLVRGLGSGFIVSQDGLILTNAHVVDNATEVTVKLTDRREFKAKVLGS
DPQTDIAVIRIDAKNLPTVRLGDPSKTRVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSGG
PLFNQRGEVIGINSQIYSQTGGYQGLSFAIPINVATKVEEQLVAHGKVTRGRLGISVQEVNQALAQSFNLPKPAGALVNS
VEPDSPAAKGGVKAGDVIVQLGDDVIDHSGDLPEHVADLKPGTETKLKVIRKGQPMTLTVQVGAVKEDALAQKGNGGQDG
GRLGLAVRQLTPAEKRDSGIDGGLVVEDVTGPAARVGIQPGDVILSLNGTPISSAEQLRTLVSKSGKQVALLVQRDDARI
FIPLDLG
>Mature_487_residues
MIRQTLARSAVGVAALAALAGGYAYLQKDAITPGYAAQTPVTASAGPIAVATPTDFSSIVDQYGPAVVNISVTARAQRTS
AQVPQGVDPDDPLFQFFKRFGPQFQGPQNAQPQLVRGLGSGFIVSQDGLILTNAHVVDNATEVTVKLTDRREFKAKVLGS
DPQTDIAVIRIDAKNLPTVRLGDPSKTRVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSGG
PLFNQRGEVIGINSQIYSQTGGYQGLSFAIPINVATKVEEQLVAHGKVTRGRLGISVQEVNQALAQSFNLPKPAGALVNS
VEPDSPAAKGGVKAGDVIVQLGDDVIDHSGDLPEHVADLKPGTETKLKVIRKGQPMTLTVQVGAVKEDALAQKGNGGQDG
GRLGLAVRQLTPAEKRDSGIDGGLVVEDVTGPAARVGIQPGDVILSLNGTPISSAEQLRTLVSKSGKQVALLVQRDDARI
FIPLDLG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=275, Percent_Identity=38.9090909090909, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI7019477, Length=285, Percent_Identity=38.2456140350877, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI22129776, Length=264, Percent_Identity=36.7424242424242, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI24308541, Length=250, Percent_Identity=37.2, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1786356, Length=470, Percent_Identity=35.9574468085106, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI1789629, Length=494, Percent_Identity=34.0080971659919, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789630, Length=280, Percent_Identity=38.2142857142857, Blast_Score=183, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24646839, Length=262, Percent_Identity=38.1679389312977, Blast_Score=152, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50756; Mature: 50756

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRQTLARSAVGVAALAALAGGYAYLQKDAITPGYAAQTPVTASAGPIAVATPTDFSSIV
CCHHHHHHHHHHHHHHHHHHCCHHEEHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHH
DQYGPAVVNISVTARAQRTSAQVPQGVDPDDPLFQFFKRFGPQFQGPQNAQPQLVRGLGS
HHHCCEEEEEEEEEECCHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHCCC
GFIVSQDGLILTNAHVVDNATEVTVKLTDRREFKAKVLGSDPQTDIAVIRIDAKNLPTVR
CEEEECCCEEEEECEEECCCEEEEEEEECCCCEEHEECCCCCCCCEEEEEEECCCCCEEE
LGDPSKTRVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSGG
ECCCCCCCCCCCEEEECCCCCCCCCHHHHEEECCCCCCCCCCCCCEEEEEEEECCCCCCC
PLFNQRGEVIGINSQIYSQTGGYQGLSFAIPINVATKVEEQLVAHGKVTRGRLGISVQEV
CCCCCCCCEEEECHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCHHHH
NQALAQSFNLPKPAGALVNSVEPDSPAAKGGVKAGDVIVQLGDDVIDHSGDLPEHVADLK
HHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEECCHHHHCCCCCHHHHHHCC
PGTETKLKVIRKGQPMTLTVQVGAVKEDALAQKGNGGQDGGRLGLAVRQLTPAEKRDSGI
CCCCHHHHHEECCCCEEEEEEECCCCHHHHHHCCCCCCCCCEEEEEEECCCCCHHHCCCC
DGGLVVEDVTGPAARVGIQPGDVILSLNGTPISSAEQLRTLVSKSGKQVALLVQRDDARI
CCCEEEEECCCCHHEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEECCCEE
FIPLDLG
EEEECCC
>Mature Secondary Structure
MIRQTLARSAVGVAALAALAGGYAYLQKDAITPGYAAQTPVTASAGPIAVATPTDFSSIV
CCHHHHHHHHHHHHHHHHHHCCHHEEHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHH
DQYGPAVVNISVTARAQRTSAQVPQGVDPDDPLFQFFKRFGPQFQGPQNAQPQLVRGLGS
HHHCCEEEEEEEEEECCHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHCCC
GFIVSQDGLILTNAHVVDNATEVTVKLTDRREFKAKVLGSDPQTDIAVIRIDAKNLPTVR
CEEEECCCEEEEECEEECCCEEEEEEEECCCCEEHEECCCCCCCCEEEEEEECCCCCEEE
LGDPSKTRVGEPVLAIGSPYGFENTVTAGIVSAKSRSLPDDTYVPFIQTDVAVNPGNSGG
ECCCCCCCCCCCEEEECCCCCCCCCHHHHEEECCCCCCCCCCCCCEEEEEEEECCCCCCC
PLFNQRGEVIGINSQIYSQTGGYQGLSFAIPINVATKVEEQLVAHGKVTRGRLGISVQEV
CCCCCCCCEEEECHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCHHHH
NQALAQSFNLPKPAGALVNSVEPDSPAAKGGVKAGDVIVQLGDDVIDHSGDLPEHVADLK
HHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEECCHHHHCCCCCHHHHHHCC
PGTETKLKVIRKGQPMTLTVQVGAVKEDALAQKGNGGQDGGRLGLAVRQLTPAEKRDSGI
CCCCHHHHHEECCCCEEEEEEECCCCHHHHHHCCCCCCCCCEEEEEEECCCCCHHHCCCC
DGGLVVEDVTGPAARVGIQPGDVILSLNGTPISSAEQLRTLVSKSGKQVALLVQRDDARI
CCCEEEEECCCCHHEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEECCCEE
FIPLDLG
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]