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The map label for this gene is hemE

Identifier: 94312422

GI number: 94312422

Start: 3781514

End: 3782617

Strand: Reverse

Name: hemE

Synonym: Rmet_3491

Alternate gene names: 94312422

Gene position: 3782617-3781514 (Counterclockwise)

Preceding gene: 94312423

Following gene: 335055671

Centisome position: 96.3

GC content: 65.85

Gene sequence:

>1104_bases
ATGACCGCATTGCAGAACGACACCTTCCTGCGGGCGCTGCGCCGGCAACCCACTGAATACACACCCCTCTGGCTCATGCG
CCAGGCGGGTCGCTACCTGCCCGAGTACAACGCCACGCGCGCGCGCGCCGGCAGCTTCCTCGGCCTGGCCAAGAACCCGG
CCTACGCCACCGAGGTGACGCTGCAGCCGCTCGACCGCTACCCGCTCGACGCCGCGATCCTCTTCTCGGACATCCTCACC
GTACCCGATGCGATGGGCCTCGGCCTGTCGTTCGCGCAGGGCGAGGGCCCGCGTTTTGCGCATCCGTTGCGCACGGAAGC
CGACGTGGCCAAGCTCGCGGTGCCGGACATGGCGTCGCTGCAATACGTGTTCGATGCGGTCAGCGAAATCCGCAAGGCGC
TGGTGCAGGACGGCCGTCAGCGTGTGCCGCTGATCGGTTTCTCGGGCAGCCCGTGGACGCTGGCCTGCTATATGGTCGAA
GGTGGTGGCTCGGACGACTTCCGCACCGTCAAGGCGATGATGTACGCCCGGCCCGACCTGATGCATCGCATTCTCGACAT
CAATGCTACCGCCGTGTCCGCGTACCTCAACGCGCAGATCGAAGCCGGGGCCCAGGCCGTGATGGTTTTCGACACCTGGG
GCGGCGCGCTGGCGGATGGCATGTATCAGGCCTTCTCGCTAGCGTACATGCGCAAGGTACTTCAGGGCCTCAAGCGCGAG
CACGACGGCCAGCAGATCCCAGTGATCGTATTCACCAAGGGCGGCGGCATCTGGCTCGAGGAAATCGCCGGGATCGGCCC
GGATGCGATCGGGCTCGACTGGACCGTGAACCTGGCGAAAGCTCGCCGTCGGACCGAAGGCCGCGTGGCACTGCAAGGCA
ATATCGACCCGACCGTGCTGTTCGCGTCCGAATCGGCCATCCGCGAACAGGTACGGGGCGTGCTCGACTCTTACGCATCC
GCCGGTGGCAGCGATGGACACGTCTTCAACCTCGGCCACGGCATTTCGCAGTTCACGCCGCCCGAGAACGTTTCGGTCCT
GGTTGACGAAGTGCACAACCATAGCCGCAAGCTGCGCGCCGGGCAGGTTGCAGCGGCCGTCTGA

Upstream 100 bases:

>100_bases
GCTGAGGCCCGATCCAGCGCAAGCATTCGTGTGGATATCACTCGCCATAGGGCTTGCGGGTGCGGGCATCCCTTAGAATG
TCGGTCTCACGAGGATGACC

Downstream 100 bases:

>100_bases
AACAGGCGTTTTCCCCGCGGCGCAGCGATTCGTCGACCCGACTGCGCCGCTGTGTCGCAGTCGTCGCTATCGATAAGCTG
TCAAGTAAACTATTTGCGTT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MTALQNDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKNPAYATEVTLQPLDRYPLDAAILFSDILT
VPDAMGLGLSFAQGEGPRFAHPLRTEADVAKLAVPDMASLQYVFDAVSEIRKALVQDGRQRVPLIGFSGSPWTLACYMVE
GGGSDDFRTVKAMMYARPDLMHRILDINATAVSAYLNAQIEAGAQAVMVFDTWGGALADGMYQAFSLAYMRKVLQGLKRE
HDGQQIPVIVFTKGGGIWLEEIAGIGPDAIGLDWTVNLAKARRRTEGRVALQGNIDPTVLFASESAIREQVRGVLDSYAS
AGGSDGHVFNLGHGISQFTPPENVSVLVDEVHNHSRKLRAGQVAAAV

Sequences:

>Translated_367_residues
MTALQNDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKNPAYATEVTLQPLDRYPLDAAILFSDILT
VPDAMGLGLSFAQGEGPRFAHPLRTEADVAKLAVPDMASLQYVFDAVSEIRKALVQDGRQRVPLIGFSGSPWTLACYMVE
GGGSDDFRTVKAMMYARPDLMHRILDINATAVSAYLNAQIEAGAQAVMVFDTWGGALADGMYQAFSLAYMRKVLQGLKRE
HDGQQIPVIVFTKGGGIWLEEIAGIGPDAIGLDWTVNLAKARRRTEGRVALQGNIDPTVLFASESAIREQVRGVLDSYAS
AGGSDGHVFNLGHGISQFTPPENVSVLVDEVHNHSRKLRAGQVAAAV
>Mature_366_residues
TALQNDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKNPAYATEVTLQPLDRYPLDAAILFSDILTV
PDAMGLGLSFAQGEGPRFAHPLRTEADVAKLAVPDMASLQYVFDAVSEIRKALVQDGRQRVPLIGFSGSPWTLACYMVEG
GGSDDFRTVKAMMYARPDLMHRILDINATAVSAYLNAQIEAGAQAVMVFDTWGGALADGMYQAFSLAYMRKVLQGLKREH
DGQQIPVIVFTKGGGIWLEEIAGIGPDAIGLDWTVNLAKARRRTEGRVALQGNIDPTVLFASESAIREQVRGVLDSYASA
GGSDGHVFNLGHGISQFTPPENVSVLVDEVHNHSRKLRAGQVAAAV

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=361, Percent_Identity=46.5373961218837, Blast_Score=313, Evalue=2e-85,
Organism=Escherichia coli, GI2367337, Length=358, Percent_Identity=60.8938547486033, Blast_Score=434, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6320252, Length=364, Percent_Identity=38.1868131868132, Blast_Score=258, Evalue=9e-70,
Organism=Drosophila melanogaster, GI221330099, Length=356, Percent_Identity=37.9213483146067, Blast_Score=246, Evalue=1e-65,
Organism=Drosophila melanogaster, GI19921920, Length=356, Percent_Identity=37.9213483146067, Blast_Score=246, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_RALME (Q1LHL3)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_585632.1
- ProteinModelPortal:   Q1LHL3
- SMR:   Q1LHL3
- STRING:   Q1LHL3
- GeneID:   4040339
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_3491
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q1LHL3
- ProtClustDB:   PRK00115
- BioCyc:   RMET266264:RMET_3491-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39923; Mature: 39792

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 77-77 BINDING 157-157 BINDING 212-212 BINDING 333-333

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALQNDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKNPAYATEVT
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEEECCCCCEEEEEE
LQPLDRYPLDAAILFSDILTVPDAMGLGLSFAQGEGPRFAHPLRTEADVAKLAVPDMASL
ECCCCCCCCHHHHHHHHHHHCCCHHCCCCEECCCCCCCCCCCCCCCHHHHHHCCCCHHHH
QYVFDAVSEIRKALVQDGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKAMMYARPDL
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHCHHH
MHRILDINATAVSAYLNAQIEAGAQAVMVFDTWGGALADGMYQAFSLAYMRKVLQGLKRE
HHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HDGQQIPVIVFTKGGGIWLEEIAGIGPDAIGLDWTVNLAKARRRTEGRVALQGNIDPTVL
CCCCCCCEEEEECCCCEEHHHHCCCCCCCCCCCEEEEHHHHHHCCCCCEEEECCCCCEEE
FASESAIREQVRGVLDSYASAGGSDGHVFNLGHGISQFTPPENVSVLVDEVHNHSRKLRA
EECHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GQVAAAV
CCHHHCC
>Mature Secondary Structure 
TALQNDTFLRALRRQPTEYTPLWLMRQAGRYLPEYNATRARAGSFLGLAKNPAYATEVT
CCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCEEEECCCCCEEEEEE
LQPLDRYPLDAAILFSDILTVPDAMGLGLSFAQGEGPRFAHPLRTEADVAKLAVPDMASL
ECCCCCCCCHHHHHHHHHHHCCCHHCCCCEECCCCCCCCCCCCCCCHHHHHHCCCCHHHH
QYVFDAVSEIRKALVQDGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKAMMYARPDL
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHCHHH
MHRILDINATAVSAYLNAQIEAGAQAVMVFDTWGGALADGMYQAFSLAYMRKVLQGLKRE
HHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HDGQQIPVIVFTKGGGIWLEEIAGIGPDAIGLDWTVNLAKARRRTEGRVALQGNIDPTVL
CCCCCCCEEEEECCCCEEHHHHCCCCCCCCCCCEEEEHHHHHHCCCCCEEEECCCCCEEE
FASESAIREQVRGVLDSYASAGGSDGHVFNLGHGISQFTPPENVSVLVDEVHNHSRKLRA
EECHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GQVAAAV
CCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA