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The map label for this gene is recQ [H]

Identifier: 94312259

GI number: 94312259

Start: 3592027

End: 3593919

Strand: Reverse

Name: recQ [H]

Synonym: Rmet_3328

Alternate gene names: 94312259

Gene position: 3593919-3592027 (Counterclockwise)

Preceding gene: 94312261

Following gene: 94312258

Centisome position: 91.49

GC content: 64.03

Gene sequence:

>1893_bases
GTGGTATGGTTACGCCTTTCCTGGCTTTCCGAATCCCGCTGTCCCATGTCGCGCGCCCTGGCGATCCTCAAAGAAGTCTT
CGGCTACCACGCATTCCGCGGCCGGCAGGGCGAGATCATCGACCACGTGGCCGAAGGCGGTGATTGCCTGGTGCTGATGC
CGACCGGTGGCGGCAAGTCGCTCTGCTACCAGATTCCCGCGCTGCTCCGGCAGCAGGCAGGCCACGGCGTGGGTATCGTC
GTATCGCCACTGATCGCGCTGATGCAGGATCAGGTCGCCGCACTGACGGAGGCGGGGGTTCGCGCCGCGGTGCTCAACTC
GACGCTGAGCAGCAGCGAGGCATCGGCAGTCGAGCGGGACCTGCTGGCGGGGCGGCTGGATATCCTCTATGTGGCGCCGG
AGCGGCTGATGACGCCGCGGTTCCTCGATCTGCTCGAGCGGACACGCGTGGGTCTCTTTGCGATTGACGAAGCGCATTGC
GTATCGCAATGGGGACATGACTTCCGGCCCGAGTACATCCAGCTGTCGGTCCTGCACGAGCGCTTTCCGCGTGTTCCGCG
TATCGCCTTGACGGCCACGGCCGATGCACTGACGCGCCAGGAGATTGTCGAGCGTCTGGCGCTGGACGAGGCGAGCGTCT
TCATCTCAAGCTTCGACCGCCCCAATATCCGCTATCGGATCATCGAAAAGGACAACGCCCGGCAGCAGTTGCTCGCGTTC
ATCAAGGCAGAGCACATGAACGCGACTGGCGGGCACGACAGCGGCATTGTCTACTGCCTGTCGCGCAAGAAGGTCGAGGA
TACCGCAGCGTGGCTGTCCAGCCACGGCATCAACGCGCTGGGCTATCACGCCGGCATGGACTCCCAGATTCGCCAGACGC
ACCAGGCCCGATTCCGCGAGGAAGAAGGGATCGTGATGGTAGCCACCATCGCTTTCGGCATGGGTATCGACAAGCCGGAC
GTACGCTTTGTGGCGCACCTGGACCTGCCCAAGAGCATGGAAGGGTACTACCAGGAAACCGGACGCGCGGGACGCGACGG
CCTGCCCGCCAATGCATGGATGGCATACGGGCTGGGCGACGTGGTGCAGCAGAAACGCATGATCGACGAGTCGGAAGCGG
ACGAGGCGCACAAGCGCGTCTCGTCGTCCAAGCTCGATGCCTTGCTGGGTTTGTGTGAAACCGCTGGCTGCCGGCGTGTG
CGCATCCTGGCGTATTTCGACGAGACGGCCGAGCCTTGTGGAAATTGCGATACCTGCCTGGAGCCACCTTCCACATGGGA
TGGGACACGCGAGGCCCAGATGGCGCTGTCGTGTGTCTACCGTATCGCGCAGGCGAGCCGCGTCTATTTTGGCGCCACAC
ATCTGATCGACGTGCTGCGTGGCAATGCCAACGAGAAGATCCGGCAATGGGGGCATGACAAGGTGTCGACGTTCGGCATC
GGCAAGGATCGCTCGGTATCCGAATGGCACGCGATCTTCCGTCAGTTGATCGCGCACGGGCTTCTGGTCATCGATCACGG
TGGACACGGAGCGTTGCTGCTAGGCGATTCGGCGCGTGCCGTGCTCAAGGGTGAGGAATTGATCACCCTGCGCCGCCAGG
TCAGCAAGCCGGGCAAGTCCGGCGACCGTGGCGCGCGCGGGGCGCGGATCGACCATACGGCGACGATGGATGCCGACATG
CTGGCCAACTGGGAAGCGCTGCGCGGCTGGCGGACCACCACGGCGCGCGAGCATGGCGTGCCCGCCTATGTGATCTTCCA
TGACGCCACGCTGGCGGAACTGGCGCGCAGCGCACCCGAGTCGCTCGATGAGCTGGCGGAAGTGCCCGGAATCGGTGCGT
CGAAACTCGAACGCTACGGCGAGGAAATCCTCGAAATCCTGCGCGCGGTCTGA

Upstream 100 bases:

>100_bases
GCAAGGTGAGCCGGGATGCGTCGGATTGGGGCAACGCGGTTGTCGGCCGTTGAAGTCTTCACGACATTGACACGGACACA
TACAGGTGAGCCGGGCCTTA

Downstream 100 bases:

>100_bases
GCGTGAGGGCGCCCGGGGGATCTTCGGGTATACCGCTTGACCATTGCAAGCCGGCCTGCTAGAGTGCCAGATTCGAGTTT
TTGGCTTTGGATTTCGCTCG

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MVWLRLSWLSESRCPMSRALAILKEVFGYHAFRGRQGEIIDHVAEGGDCLVLMPTGGGKSLCYQIPALLRQQAGHGVGIV
VSPLIALMQDQVAALTEAGVRAAVLNSTLSSSEASAVERDLLAGRLDILYVAPERLMTPRFLDLLERTRVGLFAIDEAHC
VSQWGHDFRPEYIQLSVLHERFPRVPRIALTATADALTRQEIVERLALDEASVFISSFDRPNIRYRIIEKDNARQQLLAF
IKAEHMNATGGHDSGIVYCLSRKKVEDTAAWLSSHGINALGYHAGMDSQIRQTHQARFREEEGIVMVATIAFGMGIDKPD
VRFVAHLDLPKSMEGYYQETGRAGRDGLPANAWMAYGLGDVVQQKRMIDESEADEAHKRVSSSKLDALLGLCETAGCRRV
RILAYFDETAEPCGNCDTCLEPPSTWDGTREAQMALSCVYRIAQASRVYFGATHLIDVLRGNANEKIRQWGHDKVSTFGI
GKDRSVSEWHAIFRQLIAHGLLVIDHGGHGALLLGDSARAVLKGEELITLRRQVSKPGKSGDRGARGARIDHTATMDADM
LANWEALRGWRTTTAREHGVPAYVIFHDATLAELARSAPESLDELAEVPGIGASKLERYGEEILEILRAV

Sequences:

>Translated_630_residues
MVWLRLSWLSESRCPMSRALAILKEVFGYHAFRGRQGEIIDHVAEGGDCLVLMPTGGGKSLCYQIPALLRQQAGHGVGIV
VSPLIALMQDQVAALTEAGVRAAVLNSTLSSSEASAVERDLLAGRLDILYVAPERLMTPRFLDLLERTRVGLFAIDEAHC
VSQWGHDFRPEYIQLSVLHERFPRVPRIALTATADALTRQEIVERLALDEASVFISSFDRPNIRYRIIEKDNARQQLLAF
IKAEHMNATGGHDSGIVYCLSRKKVEDTAAWLSSHGINALGYHAGMDSQIRQTHQARFREEEGIVMVATIAFGMGIDKPD
VRFVAHLDLPKSMEGYYQETGRAGRDGLPANAWMAYGLGDVVQQKRMIDESEADEAHKRVSSSKLDALLGLCETAGCRRV
RILAYFDETAEPCGNCDTCLEPPSTWDGTREAQMALSCVYRIAQASRVYFGATHLIDVLRGNANEKIRQWGHDKVSTFGI
GKDRSVSEWHAIFRQLIAHGLLVIDHGGHGALLLGDSARAVLKGEELITLRRQVSKPGKSGDRGARGARIDHTATMDADM
LANWEALRGWRTTTAREHGVPAYVIFHDATLAELARSAPESLDELAEVPGIGASKLERYGEEILEILRAV
>Mature_630_residues
MVWLRLSWLSESRCPMSRALAILKEVFGYHAFRGRQGEIIDHVAEGGDCLVLMPTGGGKSLCYQIPALLRQQAGHGVGIV
VSPLIALMQDQVAALTEAGVRAAVLNSTLSSSEASAVERDLLAGRLDILYVAPERLMTPRFLDLLERTRVGLFAIDEAHC
VSQWGHDFRPEYIQLSVLHERFPRVPRIALTATADALTRQEIVERLALDEASVFISSFDRPNIRYRIIEKDNARQQLLAF
IKAEHMNATGGHDSGIVYCLSRKKVEDTAAWLSSHGINALGYHAGMDSQIRQTHQARFREEEGIVMVATIAFGMGIDKPD
VRFVAHLDLPKSMEGYYQETGRAGRDGLPANAWMAYGLGDVVQQKRMIDESEADEAHKRVSSSKLDALLGLCETAGCRRV
RILAYFDETAEPCGNCDTCLEPPSTWDGTREAQMALSCVYRIAQASRVYFGATHLIDVLRGNANEKIRQWGHDKVSTFGI
GKDRSVSEWHAIFRQLIAHGLLVIDHGGHGALLLGDSARAVLKGEELITLRRQVSKPGKSGDRGARGARIDHTATMDADM
LANWEALRGWRTTTAREHGVPAYVIFHDATLAELARSAPESLDELAEVPGIGASKLERYGEEILEILRAV

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=648, Percent_Identity=35.1851851851852, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI14591902, Length=409, Percent_Identity=38.6308068459658, Blast_Score=295, Evalue=1e-79,
Organism=Homo sapiens, GI14591904, Length=409, Percent_Identity=38.6308068459658, Blast_Score=295, Evalue=1e-79,
Organism=Homo sapiens, GI148612816, Length=432, Percent_Identity=39.8148148148148, Blast_Score=282, Evalue=6e-76,
Organism=Homo sapiens, GI51242947, Length=405, Percent_Identity=40, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI51242943, Length=405, Percent_Identity=40, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI110735439, Length=519, Percent_Identity=34.6820809248555, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI169218196, Length=519, Percent_Identity=34.6820809248555, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI284005309, Length=344, Percent_Identity=37.7906976744186, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI148613856, Length=355, Percent_Identity=24.2253521126761, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI38201710, Length=355, Percent_Identity=24.2253521126761, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI4758138, Length=345, Percent_Identity=24.6376811594203, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI48994977, Length=616, Percent_Identity=46.7532467532467, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1788930, Length=316, Percent_Identity=25.3164556962025, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87082221, Length=350, Percent_Identity=22.5714285714286, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25145561, Length=657, Percent_Identity=33.4855403348554, Blast_Score=325, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI71987997, Length=416, Percent_Identity=40.8653846153846, Blast_Score=297, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71987993, Length=416, Percent_Identity=40.8653846153846, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI32564293, Length=689, Percent_Identity=30.6240928882438, Blast_Score=286, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17552866, Length=447, Percent_Identity=36.4653243847875, Blast_Score=259, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17537549, Length=339, Percent_Identity=22.7138643067847, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17555296, Length=346, Percent_Identity=26.5895953757225, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=536, Percent_Identity=36.0074626865672, Blast_Score=342, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6321360, Length=334, Percent_Identity=22.1556886227545, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646066, Length=641, Percent_Identity=35.8814352574103, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24664226, Length=449, Percent_Identity=36.9710467706013, Blast_Score=262, Evalue=6e-70,
Organism=Drosophila melanogaster, GI62472181, Length=450, Percent_Identity=36.8888888888889, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24664230, Length=450, Percent_Identity=36.8888888888889, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI21358123, Length=355, Percent_Identity=36.056338028169, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI28574962, Length=329, Percent_Identity=26.4437689969605, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24644479, Length=362, Percent_Identity=20.9944751381215, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281361218, Length=362, Percent_Identity=20.9944751381215, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24644481, Length=362, Percent_Identity=20.9944751381215, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24644487, Length=362, Percent_Identity=21.5469613259669, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45551833, Length=362, Percent_Identity=21.5469613259669, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24644485, Length=362, Percent_Identity=21.5469613259669, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24644483, Length=362, Percent_Identity=20.9944751381215, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI18857967, Length=379, Percent_Identity=23.7467018469657, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 69520; Mature: 69520

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS50967 HRDC ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVWLRLSWLSESRCPMSRALAILKEVFGYHAFRGRQGEIIDHVAEGGDCLVLMPTGGGKS
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCH
LCYQIPALLRQQAGHGVGIVVSPLIALMQDQVAALTEAGVRAAVLNSTLSSSEASAVERD
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LLAGRLDILYVAPERLMTPRFLDLLERTRVGLFAIDEAHCVSQWGHDFRPEYIQLSVLHE
HHHCCEEEEEECHHHHCCHHHHHHHHHHCCCEEEECHHHHHHHCCCCCCCCHHHHHHHHH
RFPRVPRIALTATADALTRQEIVERLALDEASVFISSFDRPNIRYRIIEKDNARQQLLAF
HCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHH
IKAEHMNATGGHDSGIVYCLSRKKVEDTAAWLSSHGINALGYHAGMDSQIRQTHQARFRE
HHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHC
EEGIVMVATIAFGMGIDKPDVRFVAHLDLPKSMEGYYQETGRAGRDGLPANAWMAYGLGD
CCCEEEEEEEHHHCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHCHHH
VVQQKRMIDESEADEAHKRVSSSKLDALLGLCETAGCRRVRILAYFDETAEPCGNCDTCL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCC
EPPSTWDGTREAQMALSCVYRIAQASRVYFGATHLIDVLRGNANEKIRQWGHDKVSTFGI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEECC
GKDRSVSEWHAIFRQLIAHGLLVIDHGGHGALLLGDSARAVLKGEELITLRRQVSKPGKS
CCCCCHHHHHHHHHHHHHCCEEEEEECCCEEEEECCCCCHHHCCHHHHHHHHHHCCCCCC
GDRGARGARIDHTATMDADMLANWEALRGWRTTTAREHGVPAYVIFHDATLAELARSAPE
CCCCCCCCCCCCCCCCCHHHHHCHHHHCCCCCCCHHHCCCCEEEEEECCHHHHHHHHCHH
SLDELAEVPGIGASKLERYGEEILEILRAV
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVWLRLSWLSESRCPMSRALAILKEVFGYHAFRGRQGEIIDHVAEGGDCLVLMPTGGGKS
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCH
LCYQIPALLRQQAGHGVGIVVSPLIALMQDQVAALTEAGVRAAVLNSTLSSSEASAVERD
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LLAGRLDILYVAPERLMTPRFLDLLERTRVGLFAIDEAHCVSQWGHDFRPEYIQLSVLHE
HHHCCEEEEEECHHHHCCHHHHHHHHHHCCCEEEECHHHHHHHCCCCCCCCHHHHHHHHH
RFPRVPRIALTATADALTRQEIVERLALDEASVFISSFDRPNIRYRIIEKDNARQQLLAF
HCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHH
IKAEHMNATGGHDSGIVYCLSRKKVEDTAAWLSSHGINALGYHAGMDSQIRQTHQARFRE
HHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHC
EEGIVMVATIAFGMGIDKPDVRFVAHLDLPKSMEGYYQETGRAGRDGLPANAWMAYGLGD
CCCEEEEEEEHHHCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHCHHH
VVQQKRMIDESEADEAHKRVSSSKLDALLGLCETAGCRRVRILAYFDETAEPCGNCDTCL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCC
EPPSTWDGTREAQMALSCVYRIAQASRVYFGATHLIDVLRGNANEKIRQWGHDKVSTFGI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEECC
GKDRSVSEWHAIFRQLIAHGLLVIDHGGHGALLLGDSARAVLKGEELITLRRQVSKPGKS
CCCCCHHHHHHHHHHHHHCCEEEEEECCCEEEEECCCCCHHHCCHHHHHHHHHHCCCCCC
GDRGARGARIDHTATMDADMLANWEALRGWRTTTAREHGVPAYVIFHDATLAELARSAPE
CCCCCCCCCCCCCCCCCHHHHHCHHHHCCCCCCCHHHCCCCEEEEEECCHHHHHHHHCHH
SLDELAEVPGIGASKLERYGEEILEILRAV
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]