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The map label for this gene is fur

Identifier: 94311908

GI number: 94311908

Start: 3235281

End: 3235712

Strand: Direct

Name: fur

Synonym: Rmet_2976

Alternate gene names: 94311908

Gene position: 3235281-3235712 (Clockwise)

Preceding gene: 94311898

Following gene: 94311910

Centisome position: 82.36

GC content: 57.64

Gene sequence:

>432_bases
ATGCCGAGTCCGGCGGACCTCAAAAATATCGGCCTCAAGGCGACCGTCCCCCGCCTGAAGATCCTTGAGATCTTCCAGAC
CAGCGAACAGCGCCATCTAAGCGCGGAAGATGTCTATCGCATCCTGCTCAACGAGCATATGGATATCGGCCTCGCCACGG
TCTATCGCGTTCTCACGCAGTTCGAACAGGCTGGCCTGCTCTCGCGGAACAACTTCGAGTCGGGCAAGGCGATTTTCGAA
CTGAACGAAGGCAAGCACCACGATCACCTGGTGTGCCTGGATTGCGGGCGCGTCGAGGAATTTTTCGATGCTGATATCGA
ACAGCGGCAACAGAGCATCGCCCGCGAGCGCGGCTTTGCACTACAGGAACATGCCCTGTCGCTCTATGGCAACTGCACCA
AGGACGATTGCCCCCACAGACCGAGACGATAA

Upstream 100 bases:

>100_bases
CGGAGAGCGGCGTGTACGCGTCATGGCACCGGGGCGACATTTGCCGCCAAAACCCTTATGATTCAACTATCCAGACATTG
TACTCTAGGGAGTCACGCCC

Downstream 100 bases:

>100_bases
CCCCGCTGCGGTACCCGCCCAGCAGCAGGCAATAAAAAACCGGCGCCAAGGCGCCGGTTTTTTATTGGGTCGACACAGCG
TTATTCCTGCGTCAGATCCT

Product: DNA-binding transcriptional dual regulator of siderophore biosynthesis and transport

Products: NA

Alternate protein names: Ferric uptake regulator

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MPSPADLKNIGLKATVPRLKILEIFQTSEQRHLSAEDVYRILLNEHMDIGLATVYRVLTQFEQAGLLSRNNFESGKAIFE
LNEGKHHDHLVCLDCGRVEEFFDADIEQRQQSIARERGFALQEHALSLYGNCTKDDCPHRPRR

Sequences:

>Translated_143_residues
MPSPADLKNIGLKATVPRLKILEIFQTSEQRHLSAEDVYRILLNEHMDIGLATVYRVLTQFEQAGLLSRNNFESGKAIFE
LNEGKHHDHLVCLDCGRVEEFFDADIEQRQQSIARERGFALQEHALSLYGNCTKDDCPHRPRR
>Mature_142_residues
PSPADLKNIGLKATVPRLKILEIFQTSEQRHLSAEDVYRILLNEHMDIGLATVYRVLTQFEQAGLLSRNNFESGKAIFEL
NEGKHHDHLVCLDCGRVEEFFDADIEQRQQSIARERGFALQEHALSLYGNCTKDDCPHRPRR

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulator for biosynthesis of the siderophore alcaligin E

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family

Homologues:

Organism=Escherichia coli, GI1786899, Length=131, Percent_Identity=56.4885496183206, Blast_Score=160, Evalue=3e-41,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): FUR_RALME (O30330)

Other databases:

- EMBL:   AJ001224
- EMBL:   CP000352
- RefSeq:   YP_585118.1
- ProteinModelPortal:   O30330
- SMR:   O30330
- STRING:   O30330
- GeneID:   4039804
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_2976
- eggNOG:   COG0735
- HOGENOM:   HBG731501
- OMA:   GEVIEFF
- PhylomeDB:   O30330
- ProtClustDB:   CLSK897440
- BioCyc:   RMET266264:RMET_2976-MONOMER
- GO:   GO:0005737
- InterPro:   IPR002481
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10

Pfam domain/function: PF01475 FUR

EC number: NA

Molecular weight: Translated: 16432; Mature: 16301

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSPADLKNIGLKATVPRLKILEIFQTSEQRHLSAEDVYRILLNEHMDIGLATVYRVLTQ
CCCCCCHHHCCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
FEQAGLLSRNNFESGKAIFELNEGKHHDHLVCLDCGRVEEFFDADIEQRQQSIARERGFA
HHHHCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHHHCCH
LQEHALSLYGNCTKDDCPHRPRR
HHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSPADLKNIGLKATVPRLKILEIFQTSEQRHLSAEDVYRILLNEHMDIGLATVYRVLTQ
CCCCCHHHCCCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
FEQAGLLSRNNFESGKAIFELNEGKHHDHLVCLDCGRVEEFFDADIEQRQQSIARERGFA
HHHHCCCCCCCCCCCCEEEEECCCCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHHHCCH
LQEHALSLYGNCTKDDCPHRPRR
HHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA