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The map label for this gene is proC [H]

Identifier: 94311870

GI number: 94311870

Start: 3192912

End: 3193733

Strand: Direct

Name: proC [H]

Synonym: Rmet_2938

Alternate gene names: 94311870

Gene position: 3192912-3193733 (Clockwise)

Preceding gene: 94311869

Following gene: 94311875

Centisome position: 81.28

GC content: 68.49

Gene sequence:

>822_bases
ATGCTCGACTCCCTTACTTTCGGCTTCCTCGGCGGCGGCAATATGGCCTCGGCCCTGATCGGTGGCCTGGTAGCCCGTGG
CGTGCCAGCCAACGCGATTCGCGTGGTCGATCCGTTCGAAGACGCCCGCCAACGCCTGGCCACGACGCTTGGCGTACAGA
CACTGGCTGCACCGGACGCCGCGTTTGGCGCCAGCAACGTGATCGTGCTGGCGGTCAAGCCGCAGCAGTTCAAGGACGCC
GTGGGCGCCCTGGCTCCACAGTTGAAGAACAGCCTGATCATCAGCGTGGCGGCTGGCATCCGGCTTCAGGACATGCAGCG
CTGGCTGGGCACCAACCGCCTTGTCCGCGCGATGCCCAATACGCCCGCGCTGGCCGGCATGGGGATGACCGGACTGGCCG
CCGCCCCGGGTCTGTCCGACGAAGACCGCGCCATCGCCAAGGCCGTGGCCGAGGCCGTCGGCCAGTGCGTGTGGGTCGAG
GGCGACGACCAGATCGACGCCGTGACGGCGATTTCCGGCAGCGGCCCGGCCTACGTGTTCTATTTCGTCGAGGCGATGGA
GCGTGCCGCCATCGAGATGGGTCTGTCCGCCGAGCAGGGTCGCAAGCTGGCCGTCGAAACGTTCCGCGGGGCCGCCGCGC
TGGCAGCGGAGTCGTCCGAACCAGTATCGACGCTGCGTGAGCGTGTCACCTCGAAAGGCGGCACGACCTATGCCGCGCTG
ACCTCGATGGACGCCAGCGGCATCCAGGACGCCTTCGTTCGCGCCATGCTGGCCGCCGCCGCGCGGGGCCGCGAGATGGG
AGCGGAGTTCGGGAAGGACTAA

Upstream 100 bases:

>100_bases
GGCGCGCGAGGCTGACGGCACCCGTCGCTTCACACCCTCCCCGCTCAACAGATTCATCAACGCCAGCCGACATGCGTCGT
GCCGGCAGACAGGAACCATG

Downstream 100 bases:

>100_bases
GAAAAAACCGGGGCCTGGCCCCGGTTTCTTACTTCAGCAGATACGCCACGAACGTCCCGGCGAACACGCAGGCACCCAGC
CAGTTGTTGTGCCGGAAGGC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MLDSLTFGFLGGGNMASALIGGLVARGVPANAIRVVDPFEDARQRLATTLGVQTLAAPDAAFGASNVIVLAVKPQQFKDA
VGALAPQLKNSLIISVAAGIRLQDMQRWLGTNRLVRAMPNTPALAGMGMTGLAAAPGLSDEDRAIAKAVAEAVGQCVWVE
GDDQIDAVTAISGSGPAYVFYFVEAMERAAIEMGLSAEQGRKLAVETFRGAAALAAESSEPVSTLRERVTSKGGTTYAAL
TSMDASGIQDAFVRAMLAAAARGREMGAEFGKD

Sequences:

>Translated_273_residues
MLDSLTFGFLGGGNMASALIGGLVARGVPANAIRVVDPFEDARQRLATTLGVQTLAAPDAAFGASNVIVLAVKPQQFKDA
VGALAPQLKNSLIISVAAGIRLQDMQRWLGTNRLVRAMPNTPALAGMGMTGLAAAPGLSDEDRAIAKAVAEAVGQCVWVE
GDDQIDAVTAISGSGPAYVFYFVEAMERAAIEMGLSAEQGRKLAVETFRGAAALAAESSEPVSTLRERVTSKGGTTYAAL
TSMDASGIQDAFVRAMLAAAARGREMGAEFGKD
>Mature_273_residues
MLDSLTFGFLGGGNMASALIGGLVARGVPANAIRVVDPFEDARQRLATTLGVQTLAAPDAAFGASNVIVLAVKPQQFKDA
VGALAPQLKNSLIISVAAGIRLQDMQRWLGTNRLVRAMPNTPALAGMGMTGLAAAPGLSDEDRAIAKAVAEAVGQCVWVE
GDDQIDAVTAISGSGPAYVFYFVEAMERAAIEMGLSAEQGRKLAVETFRGAAALAAESSEPVSTLRERVTSKGGTTYAAL
TSMDASGIQDAFVRAMLAAAARGREMGAEFGKD

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=273, Percent_Identity=31.1355311355311, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI24797097, Length=273, Percent_Identity=31.1355311355311, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI21361454, Length=275, Percent_Identity=30.9090909090909, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI198041662, Length=262, Percent_Identity=29.0076335877863, Blast_Score=109, Evalue=3e-24,
Organism=Escherichia coli, GI1786585, Length=263, Percent_Identity=34.2205323193916, Blast_Score=137, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=31.8352059925094, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17540664, Length=290, Percent_Identity=27.9310344827586, Blast_Score=103, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6320861, Length=236, Percent_Identity=25.4237288135593, Blast_Score=96, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21358587, Length=266, Percent_Identity=34.9624060150376, Blast_Score=144, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=28.7272727272727, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=35.5029585798817, Blast_Score=97, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28149; Mature: 28149

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSLTFGFLGGGNMASALIGGLVARGVPANAIRVVDPFEDARQRLATTLGVQTLAAPDA
CCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCH
AFGASNVIVLAVKPQQFKDAVGALAPQLKNSLIISVAAGIRLQDMQRWLGTNRLVRAMPN
HCCCCCEEEEEECCHHHHHHHHHHHHHHHCCEEEEHCCCCCHHHHHHHHCCCHHHHCCCC
TPALAGMGMTGLAAAPGLSDEDRAIAKAVAEAVGQCVWVEGDDQIDAVTAISGSGPAYVF
CCCHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCEEEEEEECCCCCEEEH
YFVEAMERAAIEMGLSAEQGRKLAVETFRGAAALAAESSEPVSTLRERVTSKGGTTYAAL
HHHHHHHHHHHHHCCCHHHCCEEHHHHHHCHHHHHCCCCCHHHHHHHHHHCCCCCEEEEE
TSMDASGIQDAFVRAMLAAAARGREMGAEFGKD
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDSLTFGFLGGGNMASALIGGLVARGVPANAIRVVDPFEDARQRLATTLGVQTLAAPDA
CCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCH
AFGASNVIVLAVKPQQFKDAVGALAPQLKNSLIISVAAGIRLQDMQRWLGTNRLVRAMPN
HCCCCCEEEEEECCHHHHHHHHHHHHHHHCCEEEEHCCCCCHHHHHHHHCCCHHHHCCCC
TPALAGMGMTGLAAAPGLSDEDRAIAKAVAEAVGQCVWVEGDDQIDAVTAISGSGPAYVF
CCCHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCEEEEEEECCCCCEEEH
YFVEAMERAAIEMGLSAEQGRKLAVETFRGAAALAAESSEPVSTLRERVTSKGGTTYAAL
HHHHHHHHHHHHHCCCHHHCCEEHHHHHHCHHHHHCCCCCHHHHHHHHHHCCCCCEEEEE
TSMDASGIQDAFVRAMLAAAARGREMGAEFGKD
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]