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The map label for this gene is mutL [H]

Identifier: 94311840

GI number: 94311840

Start: 3161819

End: 3163786

Strand: Direct

Name: mutL [H]

Synonym: Rmet_2908

Alternate gene names: 94311840

Gene position: 3161819-3163786 (Clockwise)

Preceding gene: 94311838

Following gene: 94311841

Centisome position: 80.49

GC content: 66.92

Gene sequence:

>1968_bases
ATGCCTGCCGAAGCCGACCGTACCCATCCTCGCACCGCCCAACCCAACCGCCCCATTCGCCCGCTGCCGGACCAGCTGAT
CAGCCAGATCGCCGCCGGTGAAGTGGTGGAACGGCCCGCGTCGGTCGTCAAGGAACTGCTCGAGAACGCACTCGACGCCG
GCGCCACGCAACTGGGTATCCGGCTCGAGGAAGGCGGCGTGAGACGCATCGTCATCACCGACAACGGCTGCGGCATCCCC
GCCGACGAACTACCCGTCGCGCTGATGCGCCACGCCACCAGCAAGATCGCCTCGCTGGACGAACTCGAATCGGTCCTGAC
ACTGGGCTTCCGCGGCGAGGCGCTGGCCTCGATTGCCTCGGTCTCCCATCTCGTGCTGACCAGCCGCACGGCCACCGCCA
CGCACGCCACCCAGATCAGCGCGGACACCGGCCATCTGCAACCCGCTTCAGGCGGAGTTGGCACGATGATCGACGTGCAG
CACCTGTACTTCAACACGCCAGCCCGTAGAAAGTTCCTGAAATCGGAACAAACCGAGCTGGGGCATTGCCTGGAGATGAT
CCGCCGCGCCGCGCTGGCACGGCCCGACGTCACGATTTCGGTGCATCACAACGGCAAGCCGCTGGAGCACTGGAATGCCG
GCGACGTGGCCACGCGCACGGCGCAGGTGCTCGGCAGCGACTTCGCACGCGCCCGCCTGCCGCTCGACGAACAGGCCGAC
GCGCTGCACCTCTATGGCTTTGCCGGGCTACCCACTGCATCGCGAGGCCGGCCTGACCAGCAGTATTTCTTCGTCAATGG
CCGTTTCGTGCGCGACAAGCTGCTCAACCATGCCGTGCGCAGCGCCTATCAGGACGTGCTGCATGGGGACCGATTCCCAT
CGTATGTGATCTGCCTGGACCTGCCGCCCGAACTGGTCGACGTGAACGTTCACCCGTCCAAGATCGAGGTTCGCTTCCGC
GAATCGCGTGCGGTGCACCAGTTCGTCTATCACGCAGTGCAGCGATGCCTTGCACGCCAGGCCGGCGAGCAAGGCGACAG
CCTGCATTCGGAGATCGCCGATGAGGCAGGACGGCCTTCGATGCCTGCGGCCCGCCCAGTCGGCGCGCCGGGTGCGCCGG
GAGCCGCGCCGCAGTGGGTCAATTATTCGGCAGGCCGCCAGACCGAGCTTGGTATCGCACAGCCGCGCCAAGCCTATCTG
GGCATGGTCCGCGACGCCGCCGGGCAAGGTAGCGCGCGGCCCTGGCAACCGTCGCCGCAGCCGCCCGCATGGCTGGCCGA
CGCACAGGCGGCACGCGCAGACGAACCGCCGGGCCTGCTCGACCGATTACCGCAGCAACCGCTGCAGCCTTCCACCCTGC
CCGCGGCAGGCGAAGGCGACGATGATCATCCGCTCGGTTACGCAGTGGCGCAGTTGCACGGCATCTATGTGCTAGCGCAG
AACGCCCGGGGGCTGGTGCTGGTCGATATGCACGCGGCGCACGAGCGCATCCTGTACGAACAGATCAAGACCGCCCTTGA
GGCGCGCGAACTGGCGGTGCAGCCGCTACTGATTCCGGTCACGCTGCCGGCCAGTCCGGTGGAAATCGGCGCGGCCGAAG
AACACCAGGAAACGCTGCAACTGCTCGGCTTCGACATCAAGCCCGTATCCCCCACGACGCTCGCCGTGCGCGCGATTCCC
GCGCTGCTCAAGCAGGCCGATACCGAAGCCTTGGCACGCGACGTGCTGCGCGACCTGCAGGCCTACGGAGGCTCGCGCGT
GCTGGCCGAGCGCCAGAATGAATTGCTGGCCACGTTGGCTTGCCACAGCGCCGTGCGCGCCAATCGCAAGCTGACCGTAG
AAGAGATGAACGCCTTGCTGCGCCAGATGGAGCAGACCGAGCGCGCCGACCAGTGCAACCACGGCCGCCCGACATGGGTG
CAGTTGACGGTTGCGGAACTCGACCGCCTGTTCCTGCGCGGCCAGTAA

Upstream 100 bases:

>100_bases
CACATCATACAAGAGCGCCCGGTTTGATCCGTCACCTGGCGCCCGGAAAAGTGCCCGGACTGTGCCGAATTCGTGTCCTC
GCGCACGTATAATCGCCCAC

Downstream 100 bases:

>100_bases
TCTCCCCAGCTTCAAGATGTCCGTACAGTCCCACCCGCCCGTCGTCTGCCTGCTCGGCCCCACCGCATCGGGCAAGACGG
CGGCCGCGCTCGAACTGGCC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 655; Mature: 654

Protein sequence:

>655_residues
MPAEADRTHPRTAQPNRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGATQLGIRLEEGGVRRIVITDNGCGIP
ADELPVALMRHATSKIASLDELESVLTLGFRGEALASIASVSHLVLTSRTATATHATQISADTGHLQPASGGVGTMIDVQ
HLYFNTPARRKFLKSEQTELGHCLEMIRRAALARPDVTISVHHNGKPLEHWNAGDVATRTAQVLGSDFARARLPLDEQAD
ALHLYGFAGLPTASRGRPDQQYFFVNGRFVRDKLLNHAVRSAYQDVLHGDRFPSYVICLDLPPELVDVNVHPSKIEVRFR
ESRAVHQFVYHAVQRCLARQAGEQGDSLHSEIADEAGRPSMPAARPVGAPGAPGAAPQWVNYSAGRQTELGIAQPRQAYL
GMVRDAAGQGSARPWQPSPQPPAWLADAQAARADEPPGLLDRLPQQPLQPSTLPAAGEGDDDHPLGYAVAQLHGIYVLAQ
NARGLVLVDMHAAHERILYEQIKTALEARELAVQPLLIPVTLPASPVEIGAAEEHQETLQLLGFDIKPVSPTTLAVRAIP
ALLKQADTEALARDVLRDLQAYGGSRVLAERQNELLATLACHSAVRANRKLTVEEMNALLRQMEQTERADQCNHGRPTWV
QLTVAELDRLFLRGQ

Sequences:

>Translated_655_residues
MPAEADRTHPRTAQPNRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGATQLGIRLEEGGVRRIVITDNGCGIP
ADELPVALMRHATSKIASLDELESVLTLGFRGEALASIASVSHLVLTSRTATATHATQISADTGHLQPASGGVGTMIDVQ
HLYFNTPARRKFLKSEQTELGHCLEMIRRAALARPDVTISVHHNGKPLEHWNAGDVATRTAQVLGSDFARARLPLDEQAD
ALHLYGFAGLPTASRGRPDQQYFFVNGRFVRDKLLNHAVRSAYQDVLHGDRFPSYVICLDLPPELVDVNVHPSKIEVRFR
ESRAVHQFVYHAVQRCLARQAGEQGDSLHSEIADEAGRPSMPAARPVGAPGAPGAAPQWVNYSAGRQTELGIAQPRQAYL
GMVRDAAGQGSARPWQPSPQPPAWLADAQAARADEPPGLLDRLPQQPLQPSTLPAAGEGDDDHPLGYAVAQLHGIYVLAQ
NARGLVLVDMHAAHERILYEQIKTALEARELAVQPLLIPVTLPASPVEIGAAEEHQETLQLLGFDIKPVSPTTLAVRAIP
ALLKQADTEALARDVLRDLQAYGGSRVLAERQNELLATLACHSAVRANRKLTVEEMNALLRQMEQTERADQCNHGRPTWV
QLTVAELDRLFLRGQ
>Mature_654_residues
PAEADRTHPRTAQPNRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGATQLGIRLEEGGVRRIVITDNGCGIPA
DELPVALMRHATSKIASLDELESVLTLGFRGEALASIASVSHLVLTSRTATATHATQISADTGHLQPASGGVGTMIDVQH
LYFNTPARRKFLKSEQTELGHCLEMIRRAALARPDVTISVHHNGKPLEHWNAGDVATRTAQVLGSDFARARLPLDEQADA
LHLYGFAGLPTASRGRPDQQYFFVNGRFVRDKLLNHAVRSAYQDVLHGDRFPSYVICLDLPPELVDVNVHPSKIEVRFRE
SRAVHQFVYHAVQRCLARQAGEQGDSLHSEIADEAGRPSMPAARPVGAPGAPGAAPQWVNYSAGRQTELGIAQPRQAYLG
MVRDAAGQGSARPWQPSPQPPAWLADAQAARADEPPGLLDRLPQQPLQPSTLPAAGEGDDDHPLGYAVAQLHGIYVLAQN
ARGLVLVDMHAAHERILYEQIKTALEARELAVQPLLIPVTLPASPVEIGAAEEHQETLQLLGFDIKPVSPTTLAVRAIPA
LLKQADTEALARDVLRDLQAYGGSRVLAERQNELLATLACHSAVRANRKLTVEEMNALLRQMEQTERADQCNHGRPTWVQ
LTVAELDRLFLRGQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=329, Percent_Identity=33.7386018237082, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI4505911, Length=327, Percent_Identity=30.5810397553517, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI189458898, Length=327, Percent_Identity=30.5810397553517, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI189458896, Length=317, Percent_Identity=31.8611987381703, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI4505913, Length=351, Percent_Identity=28.7749287749288, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI310128478, Length=351, Percent_Identity=28.7749287749288, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=28.936170212766, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=27.1186440677966, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI91992160, Length=267, Percent_Identity=26.5917602996255, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI91992162, Length=267, Percent_Identity=26.5917602996255, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1790612, Length=588, Percent_Identity=40.1360544217687, Blast_Score=344, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI71991825, Length=331, Percent_Identity=33.8368580060423, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17562796, Length=375, Percent_Identity=25.8666666666667, Blast_Score=131, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=314, Percent_Identity=34.0764331210191, Blast_Score=168, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324247, Length=343, Percent_Identity=27.9883381924198, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323063, Length=374, Percent_Identity=22.9946524064171, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136968, Length=310, Percent_Identity=33.5483870967742, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=25.7703081232493, Blast_Score=102, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71197; Mature: 71065

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAEADRTHPRTAQPNRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGATQLGI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCE
RLEEGGVRRIVITDNGCGIPADELPVALMRHATSKIASLDELESVLTLGFRGEALASIAS
EEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VSHLVLTSRTATATHATQISADTGHLQPASGGVGTMIDVQHLYFNTPARRKFLKSEQTEL
HHHHHHCCCCCCHHHHEEECCCCCCCCCCCCCCCCEEEEHHHHCCCHHHHHHHHHHHHHH
GHCLEMIRRAALARPDVTISVHHNGKPLEHWNAGDVATRTAQVLGSDFARARLPLDEQAD
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
ALHLYGFAGLPTASRGRPDQQYFFVNGRFVRDKLLNHAVRSAYQDVLHGDRFPSYVICLD
EEEEEEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
LPPELVDVNVHPSKIEVRFRESRAVHQFVYHAVQRCLARQAGEQGDSLHSEIADEAGRPS
CCCCCEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
MPAARPVGAPGAPGAAPQWVNYSAGRQTELGIAQPRQAYLGMVRDAAGQGSARPWQPSPQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
PPAWLADAQAARADEPPGLLDRLPQQPLQPSTLPAAGEGDDDHPLGYAVAQLHGIYVLAQ
CCCHHCCCHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEEEE
NARGLVLVDMHAAHERILYEQIKTALEARELAVQPLLIPVTLPASPVEIGAAEEHQETLQ
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHH
LLGFDIKPVSPTTLAVRAIPALLKQADTEALARDVLRDLQAYGGSRVLAERQNELLATLA
HHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
CHSAVRANRKLTVEEMNALLRQMEQTERADQCNHGRPTWVQLTVAELDRLFLRGQ
HHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
PAEADRTHPRTAQPNRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGATQLGI
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCE
RLEEGGVRRIVITDNGCGIPADELPVALMRHATSKIASLDELESVLTLGFRGEALASIAS
EEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VSHLVLTSRTATATHATQISADTGHLQPASGGVGTMIDVQHLYFNTPARRKFLKSEQTEL
HHHHHHCCCCCCHHHHEEECCCCCCCCCCCCCCCCEEEEHHHHCCCHHHHHHHHHHHHHH
GHCLEMIRRAALARPDVTISVHHNGKPLEHWNAGDVATRTAQVLGSDFARARLPLDEQAD
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
ALHLYGFAGLPTASRGRPDQQYFFVNGRFVRDKLLNHAVRSAYQDVLHGDRFPSYVICLD
EEEEEEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
LPPELVDVNVHPSKIEVRFRESRAVHQFVYHAVQRCLARQAGEQGDSLHSEIADEAGRPS
CCCCCEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
MPAARPVGAPGAPGAAPQWVNYSAGRQTELGIAQPRQAYLGMVRDAAGQGSARPWQPSPQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
PPAWLADAQAARADEPPGLLDRLPQQPLQPSTLPAAGEGDDDHPLGYAVAQLHGIYVLAQ
CCCHHCCCHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEEEE
NARGLVLVDMHAAHERILYEQIKTALEARELAVQPLLIPVTLPASPVEIGAAEEHQETLQ
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHH
LLGFDIKPVSPTTLAVRAIPALLKQADTEALARDVLRDLQAYGGSRVLAERQNELLATLA
HHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
CHSAVRANRKLTVEEMNALLRQMEQTERADQCNHGRPTWVQLTVAELDRLFLRGQ
HHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]