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The map label for this gene is hutH [H]

Identifier: 94311787

GI number: 94311787

Start: 3104066

End: 3105634

Strand: Reverse

Name: hutH [H]

Synonym: Rmet_2855

Alternate gene names: 94311787

Gene position: 3105634-3104066 (Counterclockwise)

Preceding gene: 94311788

Following gene: 94311786

Centisome position: 79.06

GC content: 68.32

Gene sequence:

>1569_bases
ATGACGATGACCCAAGATTCCCGACCGCTCCTGACGCTGAACCCCGGCCACGTGTCGCTGGATGACCTGCGCCGCATCCA
TCGTGGCGAAGTGCGACTGGCGATGGCGGAGTCGGCGTGGGCCGGCGTGCGTGCCGCGCAGGCCACCGTGCAGGACATCA
TCGACGCCGACGCGGTGGTCTATGGCATCAATACCGGCTTCGGCAAGCTTGCCCAGTCGCGCATCGCGCACGACAAGCTC
GCCGAACTGCAACGCAATCTGGTGCTCTCGCACAGCGTGGGTACGGGCTCCGACCTGTCCGTCGATACCGTGCGGCTGAT
CCTGGCCATCAAGGCTGTCAGCCTCGCGCGTGGGCATTCGGGCGTGCGCCCCGAACTGATCGAAGCGCTGCTGGCGCTGG
CCAACCACGGCGTGACGCCGTGCATCCCCGCCAAGGGCTCGGTCGGCGCATCGGGCGATCTGGCGCCGCTGGCCCATATG
TCCTGCACGCTGATCGGCGTGGGCGATGTGTATGTCGACGGCCAGCGCGTGCCGGCTGCGCAGGGTCTGGTCCATGCGGG
GCTCGCCGCCTTCACGCTGGGCCCGAAGGAAGGTCTGGCGCTGCTCAACGGCACGCAGGTTTCCACCGCTCTGGCCCTGG
CCGGCCTGTTCGCCGCGGAGGACGCCTTCGCGGCCGGACTGGTGGCGGGCGCGCTGTCGCTCGAAGCGATCAAGGGATCG
GTCAAGCCGTTCGATGCTCGCATTCACGCGGCACGCGGCCAGGCGGGCCAGATCGCCGTGGCCGGCGCGGCACGCGCGAT
GCTTGATGGCAGCGAGATCGTCGACTCGCACAAGATGTGCGGCCGGGTGCAGGACCCGTACTCGATCCGCTGCCAGCCGC
AGGTGATGGGCGCGTGCCTGGACAACCTGACCCATGCCGCCCGCATCCTGCGCATCGAAGCCAACGCGGCATCCGACAAT
CCGCTGGTGTTCTCCGAACAGGGTGATGTGGTCTCCGGCGGCAACTTCCACGCGGAGTCGGTGGCCTTTGCCGCCGACAT
CATCGCACTGGCGATCGCCGAGATCGGCGCAATCTCGGAACGCCGCCTTGCGCTGCTGCTCGACACCGGCCTGTCGGGCC
TGCCGCCGTTCCTGGTGCGCGATGGCGGCCTGAACTCCGGATTCATGATCGCGCAGGTCACGGCCGCGGCGTTGGCGTCC
GAGAACAAGTCGCTGGCCCATCCGTCCAGCGTGGACAGCCTGCCCACTTCGGCCAACCAGGAGGACCATGTGTCGATGGC
CACCTACGGCGCGCGCCGCCTGGGCGAGATGGCGGCCAACACCGCTGTGATCGTCGGCATCGAGGCGATGGCCGCCGCGC
AGGGTATCGAATTTCATCGACCGCTCAAGTCGTCGCCGCTGGTGGAGCAGGAACTGGCGCGTATCCGCGCGCGCGTGGCG
TTCGTCGAAGCCGATCGCTATCTCGCGCCGGACATCGAGGCCATGAAGCAGTGGGTGGTTCAAGGCGATGCGGGCGCGGG
CTGGCCTGACGCCGTGCGGGAGATCTTGCCGACGAACGTCGGCGCATGA

Upstream 100 bases:

>100_bases
CTGAGGCCAGCAACAGCTGGTCATCGGGCTTATTTTTCGACTAACCTGTATAGACAGGCCCATACAAGGTCTTTATCCAA
GACCGACAAGCAAGCAGAGA

Downstream 100 bases:

>100_bases
GCTTCGTGAACCGCTAGTCCATTCTCCATTCTCCATTCGAGCAGCCTTCATCCATCCCGGGACCGACCATGAACGCCAAC
GAACACCAATTCACCCAGAC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MTMTQDSRPLLTLNPGHVSLDDLRRIHRGEVRLAMAESAWAGVRAAQATVQDIIDADAVVYGINTGFGKLAQSRIAHDKL
AELQRNLVLSHSVGTGSDLSVDTVRLILAIKAVSLARGHSGVRPELIEALLALANHGVTPCIPAKGSVGASGDLAPLAHM
SCTLIGVGDVYVDGQRVPAAQGLVHAGLAAFTLGPKEGLALLNGTQVSTALALAGLFAAEDAFAAGLVAGALSLEAIKGS
VKPFDARIHAARGQAGQIAVAGAARAMLDGSEIVDSHKMCGRVQDPYSIRCQPQVMGACLDNLTHAARILRIEANAASDN
PLVFSEQGDVVSGGNFHAESVAFAADIIALAIAEIGAISERRLALLLDTGLSGLPPFLVRDGGLNSGFMIAQVTAAALAS
ENKSLAHPSSVDSLPTSANQEDHVSMATYGARRLGEMAANTAVIVGIEAMAAAQGIEFHRPLKSSPLVEQELARIRARVA
FVEADRYLAPDIEAMKQWVVQGDAGAGWPDAVREILPTNVGA

Sequences:

>Translated_522_residues
MTMTQDSRPLLTLNPGHVSLDDLRRIHRGEVRLAMAESAWAGVRAAQATVQDIIDADAVVYGINTGFGKLAQSRIAHDKL
AELQRNLVLSHSVGTGSDLSVDTVRLILAIKAVSLARGHSGVRPELIEALLALANHGVTPCIPAKGSVGASGDLAPLAHM
SCTLIGVGDVYVDGQRVPAAQGLVHAGLAAFTLGPKEGLALLNGTQVSTALALAGLFAAEDAFAAGLVAGALSLEAIKGS
VKPFDARIHAARGQAGQIAVAGAARAMLDGSEIVDSHKMCGRVQDPYSIRCQPQVMGACLDNLTHAARILRIEANAASDN
PLVFSEQGDVVSGGNFHAESVAFAADIIALAIAEIGAISERRLALLLDTGLSGLPPFLVRDGGLNSGFMIAQVTAAALAS
ENKSLAHPSSVDSLPTSANQEDHVSMATYGARRLGEMAANTAVIVGIEAMAAAQGIEFHRPLKSSPLVEQELARIRARVA
FVEADRYLAPDIEAMKQWVVQGDAGAGWPDAVREILPTNVGA
>Mature_521_residues
TMTQDSRPLLTLNPGHVSLDDLRRIHRGEVRLAMAESAWAGVRAAQATVQDIIDADAVVYGINTGFGKLAQSRIAHDKLA
ELQRNLVLSHSVGTGSDLSVDTVRLILAIKAVSLARGHSGVRPELIEALLALANHGVTPCIPAKGSVGASGDLAPLAHMS
CTLIGVGDVYVDGQRVPAAQGLVHAGLAAFTLGPKEGLALLNGTQVSTALALAGLFAAEDAFAAGLVAGALSLEAIKGSV
KPFDARIHAARGQAGQIAVAGAARAMLDGSEIVDSHKMCGRVQDPYSIRCQPQVMGACLDNLTHAARILRIEANAASDNP
LVFSEQGDVVSGGNFHAESVAFAADIIALAIAEIGAISERRLALLLDTGLSGLPPFLVRDGGLNSGFMIAQVTAAALASE
NKSLAHPSSVDSLPTSANQEDHVSMATYGARRLGEMAANTAVIVGIEAMAAAQGIEFHRPLKSSPLVEQELARIRARVAF
VEADRYLAPDIEAMKQWVVQGDAGAGWPDAVREILPTNVGA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=502, Percent_Identity=44.2231075697211, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17567831, Length=535, Percent_Identity=39.2523364485981, Blast_Score=363, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54122; Mature: 53991

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMTQDSRPLLTLNPGHVSLDDLRRIHRGEVRLAMAESAWAGVRAAQATVQDIIDADAVV
CCCCCCCCCEEEECCCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEE
YGINTGFGKLAQSRIAHDKLAELQRNLVLSHSVGTGSDLSVDTVRLILAIKAVSLARGHS
EECCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCC
GVRPELIEALLALANHGVTPCIPAKGSVGASGDLAPLAHMSCTLIGVGDVYVDGQRVPAA
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCEEEEEEECCEEECCCCCCHH
QGLVHAGLAAFTLGPKEGLALLNGTQVSTALALAGLFAAEDAFAAGLVAGALSLEAIKGS
HHHHHHCHHHEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VKPFDARIHAARGQAGQIAVAGAARAMLDGSEIVDSHKMCGRVQDPYSIRCQPQVMGACL
CCCHHHEEEECCCCCCCEEEECHHHHHCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHH
DNLTHAARILRIEANAASDNPLVFSEQGDVVSGGNFHAESVAFAADIIALAIAEIGAISE
HHHHHHEEEEEEECCCCCCCCEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
RRLALLLDTGLSGLPPFLVRDGGLNSGFMIAQVTAAALASENKSLAHPSSVDSLPTSANQ
CCEEEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
EDHVSMATYGARRLGEMAANTAVIVGIEAMAAAQGIEFHRPLKSSPLVEQELARIRARVA
CCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
FVEADRYLAPDIEAMKQWVVQGDAGAGWPDAVREILPTNVGA
EEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
TMTQDSRPLLTLNPGHVSLDDLRRIHRGEVRLAMAESAWAGVRAAQATVQDIIDADAVV
CCCCCCCCEEEECCCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEE
YGINTGFGKLAQSRIAHDKLAELQRNLVLSHSVGTGSDLSVDTVRLILAIKAVSLARGHS
EECCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCC
GVRPELIEALLALANHGVTPCIPAKGSVGASGDLAPLAHMSCTLIGVGDVYVDGQRVPAA
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCEEEEEEECCEEECCCCCCHH
QGLVHAGLAAFTLGPKEGLALLNGTQVSTALALAGLFAAEDAFAAGLVAGALSLEAIKGS
HHHHHHCHHHEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VKPFDARIHAARGQAGQIAVAGAARAMLDGSEIVDSHKMCGRVQDPYSIRCQPQVMGACL
CCCHHHEEEECCCCCCCEEEECHHHHHCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHH
DNLTHAARILRIEANAASDNPLVFSEQGDVVSGGNFHAESVAFAADIIALAIAEIGAISE
HHHHHHEEEEEEECCCCCCCCEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
RRLALLLDTGLSGLPPFLVRDGGLNSGFMIAQVTAAALASENKSLAHPSSVDSLPTSANQ
CCEEEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
EDHVSMATYGARRLGEMAANTAVIVGIEAMAAAQGIEFHRPLKSSPLVEQELARIRARVA
CCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
FVEADRYLAPDIEAMKQWVVQGDAGAGWPDAVREILPTNVGA
EEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA