Click here to switch to the map view.

The map label for this gene is ilvR [H]

Identifier: 94311735

GI number: 94311735

Start: 3050077

End: 3051027

Strand: Reverse

Name: ilvR [H]

Synonym: Rmet_2803

Alternate gene names: 94311735

Gene position: 3051027-3050077 (Counterclockwise)

Preceding gene: 94311737

Following gene: 94311734

Centisome position: 77.67

GC content: 66.98

Gene sequence:

>951_bases
GTGGACCTGCGCCAGCTACGTTATTTCGTCACAGTGGCCGAAGAGTTGCATTTCGGCCGCGCTGCGCGGCGGCTTGCCAT
GACACAGCCGCCGCTGTCGCAGCAGATCCAGGCACTGGAAGAGGAGATCGGCGTCCAGCTGTTCGTGCGCACGCGCCGCT
CGGTAATGCTCACGCCGGCCGGCCAGCAATGGCTGCCGGAGGTGCGCCGCGTGCTGGCCGATGCGGCTGCGTTGCCCGGG
CTGGCCCAGCGGCTCGCGCGGGGGGAGGTCGGCTCGCTGGCGCTGGCGTTCGTCAGCACGGCCGATTACGGCATCCTGCC
CGACCTTCTGCGGCATTTCCGGGCCCGGCATCCGGAAGTCCAGCTACAACTGCGCGAGGCCACCAGCGACGTCCAGCTCG
AGGCGCTGGTCGAAGGGACGATCGACGCGGGACTGGTCATCCGGCCGCAACTGACCGTGATGCCGCACGGGCTCTCCTAT
TTGCCACTGGTACGCGAACCGCTCGTGCTGGCCGTGCCCGATGGCTGGCGTCCGGCGGGGCAGGTCGATGGCGCACCACC
GCAGACCGTGGCCCTGCGCGATGCCGCGCACGAGCCGCTGATCATCTTCCCGCGCCGAAGCGCGCCAGCGTTTTATGACA
TCATTACGGGCTATTACGCGCGCGATGGGTTGACGCCGATGATTGCCCAGGAGGCGATACAGATGCAGACGATCGTCAGT
CTGGTCTCCGCCGGCATGGGGGTGGCACTAGTGCCCGCATCGCTATGCAACCTGCGCCGGACTGGGGTGTCATATCTGGC
GTTGCGCGATGCCGGGCCGGAAATCGAAACCGGTCTGGTCTGGCGTGAAGGCGCGGCTGGCGTGGCGCCTGTGCTGCGCT
CTTTCATCGATATCGCCATGGACCTCGCCGGCGCCATCGGACTGACGCAAGACAATGGCATAAAGGCCTGA

Upstream 100 bases:

>100_bases
GGGGTGGCCGTGTTGTGGTCAGAAGAATGGCGCTTGCGTTTTATCGTGTCAAATATATGATTCGACCTTTATTGAGTCGA
TAAAAATATCAAATTACCCC

Downstream 100 bases:

>100_bases
CTCCGCTATTCCGCGCTGTCCAGAATACTTACCGATACTCACTCGATCCGACATGCTCGTTCATCCCCAATTCGACCCGG
TCGCCATTCACCTCGGGCCG

Product: isoleucine biosynthesis transcriptional activator DNA-binding transcriptional regulator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MDLRQLRYFVTVAEELHFGRAARRLAMTQPPLSQQIQALEEEIGVQLFVRTRRSVMLTPAGQQWLPEVRRVLADAAALPG
LAQRLARGEVGSLALAFVSTADYGILPDLLRHFRARHPEVQLQLREATSDVQLEALVEGTIDAGLVIRPQLTVMPHGLSY
LPLVREPLVLAVPDGWRPAGQVDGAPPQTVALRDAAHEPLIIFPRRSAPAFYDIITGYYARDGLTPMIAQEAIQMQTIVS
LVSAGMGVALVPASLCNLRRTGVSYLALRDAGPEIETGLVWREGAAGVAPVLRSFIDIAMDLAGAIGLTQDNGIKA

Sequences:

>Translated_316_residues
MDLRQLRYFVTVAEELHFGRAARRLAMTQPPLSQQIQALEEEIGVQLFVRTRRSVMLTPAGQQWLPEVRRVLADAAALPG
LAQRLARGEVGSLALAFVSTADYGILPDLLRHFRARHPEVQLQLREATSDVQLEALVEGTIDAGLVIRPQLTVMPHGLSY
LPLVREPLVLAVPDGWRPAGQVDGAPPQTVALRDAAHEPLIIFPRRSAPAFYDIITGYYARDGLTPMIAQEAIQMQTIVS
LVSAGMGVALVPASLCNLRRTGVSYLALRDAGPEIETGLVWREGAAGVAPVLRSFIDIAMDLAGAIGLTQDNGIKA
>Mature_316_residues
MDLRQLRYFVTVAEELHFGRAARRLAMTQPPLSQQIQALEEEIGVQLFVRTRRSVMLTPAGQQWLPEVRRVLADAAALPG
LAQRLARGEVGSLALAFVSTADYGILPDLLRHFRARHPEVQLQLREATSDVQLEALVEGTIDAGLVIRPQLTVMPHGLSY
LPLVREPLVLAVPDGWRPAGQVDGAPPQTVALRDAAHEPLIIFPRRSAPAFYDIITGYYARDGLTPMIAQEAIQMQTIVS
LVSAGMGVALVPASLCNLRRTGVSYLALRDAGPEIETGLVWREGAAGVAPVLRSFIDIAMDLAGAIGLTQDNGIKA

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=296, Percent_Identity=40.8783783783784, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI2367136, Length=274, Percent_Identity=35.4014598540146, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788887, Length=301, Percent_Identity=32.5581395348837, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1790399, Length=287, Percent_Identity=29.616724738676, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI157672245, Length=305, Percent_Identity=30.1639344262295, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790208, Length=261, Percent_Identity=32.9501915708812, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787806, Length=292, Percent_Identity=27.0547945205479, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI145693105, Length=171, Percent_Identity=31.5789473684211, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1788748, Length=260, Percent_Identity=30, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787530, Length=259, Percent_Identity=27.7992277992278, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788297, Length=265, Percent_Identity=28.3018867924528, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87081904, Length=210, Percent_Identity=32.8571428571429, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787589, Length=141, Percent_Identity=38.2978723404255, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082132, Length=256, Percent_Identity=27.34375, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788296, Length=253, Percent_Identity=28.4584980237154, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI145693193, Length=140, Percent_Identity=34.2857142857143, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787601, Length=144, Percent_Identity=30.5555555555556, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786401, Length=164, Percent_Identity=29.8780487804878, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789173, Length=252, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786713, Length=88, Percent_Identity=42.0454545454545, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34283; Mature: 34283

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRQLRYFVTVAEELHFGRAARRLAMTQPPLSQQIQALEEEIGVQLFVRTRRSVMLTPA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEECCCEEEECCC
GQQWLPEVRRVLADAAALPGLAQRLARGEVGSLALAFVSTADYGILPDLLRHFRARHPEV
CHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCE
QLQLREATSDVQLEALVEGTIDAGLVIRPQLTVMPHGLSYLPLVREPLVLAVPDGWRPAG
EEEEECCCCCCEEHHHHHCCCCCCEEECCCEEEECCCCCCCHHHHCCEEEECCCCCCCCC
QVDGAPPQTVALRDAAHEPLIIFPRRSAPAFYDIITGYYARDGLTPMIAQEAIQMQTIVS
CCCCCCCCEEEEHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LVSAGMGVALVPASLCNLRRTGVSYLALRDAGPEIETGLVWREGAAGVAPVLRSFIDIAM
HHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHHH
DLAGAIGLTQDNGIKA
HHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDLRQLRYFVTVAEELHFGRAARRLAMTQPPLSQQIQALEEEIGVQLFVRTRRSVMLTPA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEECCCEEEECCC
GQQWLPEVRRVLADAAALPGLAQRLARGEVGSLALAFVSTADYGILPDLLRHFRARHPEV
CHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCE
QLQLREATSDVQLEALVEGTIDAGLVIRPQLTVMPHGLSYLPLVREPLVLAVPDGWRPAG
EEEEECCCCCCEEHHHHHCCCCCCEEECCCEEEECCCCCCCHHHHCCEEEECCCCCCCCC
QVDGAPPQTVALRDAAHEPLIIFPRRSAPAFYDIITGYYARDGLTPMIAQEAIQMQTIVS
CCCCCCCCEEEEHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LVSAGMGVALVPASLCNLRRTGVSYLALRDAGPEIETGLVWREGAAGVAPVLRSFIDIAM
HHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHHH
DLAGAIGLTQDNGIKA
HHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]