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The map label for this gene is argH [H]

Identifier: 94311683

GI number: 94311683

Start: 2990235

End: 2991644

Strand: Direct

Name: argH [H]

Synonym: Rmet_2751

Alternate gene names: 94311683

Gene position: 2990235-2991644 (Clockwise)

Preceding gene: 94311682

Following gene: 335055628

Centisome position: 76.12

GC content: 66.6

Gene sequence:

>1410_bases
ATGACCTCCCAACTAGCCAAGAAAGGCGAAGCCTGGTCCGCCCGCTTCTCCGAACCGATGTCCGATCTGGTGAAGCGTTA
CACCGCGTCGGTCTTCTTCGACAAGCGCCTGGCGCTGTTCGACATCCAGGGCTCGCTGGCCCATGCGGCCATGCTGGCAA
AGCAGGGCATCATCGCCGAAGCCGACCGCGCCGAGATCGAGCGCGGCATGACGCAGATCCGTGGTGAGATCGAGTCCGGC
GCGTTCGAGTGGAAGCTGGACCTCGAAGACGTGCACCTGAACATCGAGGCGCGCCTGACCGCCCTCGTGGGCGACGCCGG
CAAGCGCCTGCACACGGGCCGTTCGCGTAACGACCAGGTGGCCACCGACATCCGCCTGTGGCTGCGCAGCGAGATCGACA
GCATCGTCGGCCTGCTGGGCGACCTGCGCGGCGCGCTGCTCGACCTGGCCGAGAAGAACGCCGACACGATCCTGCCCGGC
TTCACCCACCTGCAGGTGGCCCAACCGGTCACGTTCGGCCATCACCTCATGGCCTATGTGGAAATGTTTACGCGCGATGC
CGAGCGCATGGCCGATTGCCGCCGCCGCGTGAATCGCCTGCCGCTGGGTGCCGCCGCGCTGGCCGGCACCAGCTACCCGA
TCGACCGCGAGTTCGTGGCCACACAACTGGGCTTTGACGGCGTGTGCCGCAACTCGCTCGACGCCGTGTCCGACCGCGAC
TTCGCGATCGAATTCCTGGCCGCCGCATCGCTGATCATGACGCACGTCTCGCGCTTCTCTGAAGAACTAGTGATCTGGAT
GAGCCCGCGCGTCGGCTTCATCGACATCGCCGACCGCTTCTGCACCGGCAGCTCGATCATGCCGCAGAAAAAGAACCCGG
ACGTGCCCGAACTGGCCCGCGGCAAGACTGGCCGCGTGTACGGCCACCTGACCGGTCTGCTGACGCTGATGAAGGGCCAG
CCGCTGGCGTACAACAAGGACAACCAGGAAGACAAGGAGCCGCTGTTCGATACGGTCGATACCGTGGTCGATACGCTGCG
TATCTTCGCCGACATGGTGCCCGGCATCAGCGTCAAGCCGGACAACATGCGCGCCGCCGCGCTGCAGGGCTACGCCACCG
CCACCGACCTGGCCGATTACCTGGTCAAGCGCGGCCTGCCGTTCCGCGACGCGCACGAGGCCGTGGCCCACGCCGTGCGC
GCCTGCGACGACCGCCACTGCGACCTGGCCGACCTGACTGTCGAGCAACTGCGCGAAGTCTCGGGTCTGGGCGACAAGGC
CTCGCTGATTGGCGACGACGTACACAGCGTGCTGACGCTCGAAGGCTCGGTGGCATCGCGCAACCATATCGGCGGCACCG
CGCCGGATCAGGTACGCGCCGCCATCGCCGCCGCACGCAAGGCGCTGTAA

Upstream 100 bases:

>100_bases
GACTCCTCTCCCACGTGCGGGAGGGGGGAACCGGTCCGCAGCAGTTCTGCCCGCCGCTGGCGATATAATCGCCGTTTCCG
TTTTCCCGCCCTGCCCCGCC

Downstream 100 bases:

>100_bases
GTTTCGCGTAAGTCTCTGTCGTAAAAAAGCCGCTGTGCCGTCAGGCCAGCGGCTTTTTTGTTTCCCGTTTTCTCCGCCCG
GCCAAGCGCGGGAAAGGACA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTSQLAKKGEAWSARFSEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAEADRAEIERGMTQIRGEIESG
AFEWKLDLEDVHLNIEARLTALVGDAGKRLHTGRSRNDQVATDIRLWLRSEIDSIVGLLGDLRGALLDLAEKNADTILPG
FTHLQVAQPVTFGHHLMAYVEMFTRDAERMADCRRRVNRLPLGAAALAGTSYPIDREFVATQLGFDGVCRNSLDAVSDRD
FAIEFLAAASLIMTHVSRFSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVYGHLTGLLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGISVKPDNMRAAALQGYATATDLADYLVKRGLPFRDAHEAVAHAVR
ACDDRHCDLADLTVEQLREVSGLGDKASLIGDDVHSVLTLEGSVASRNHIGGTAPDQVRAAIAAARKAL

Sequences:

>Translated_469_residues
MTSQLAKKGEAWSARFSEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAEADRAEIERGMTQIRGEIESG
AFEWKLDLEDVHLNIEARLTALVGDAGKRLHTGRSRNDQVATDIRLWLRSEIDSIVGLLGDLRGALLDLAEKNADTILPG
FTHLQVAQPVTFGHHLMAYVEMFTRDAERMADCRRRVNRLPLGAAALAGTSYPIDREFVATQLGFDGVCRNSLDAVSDRD
FAIEFLAAASLIMTHVSRFSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVYGHLTGLLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGISVKPDNMRAAALQGYATATDLADYLVKRGLPFRDAHEAVAHAVR
ACDDRHCDLADLTVEQLREVSGLGDKASLIGDDVHSVLTLEGSVASRNHIGGTAPDQVRAAIAAARKAL
>Mature_468_residues
TSQLAKKGEAWSARFSEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAEADRAEIERGMTQIRGEIESGA
FEWKLDLEDVHLNIEARLTALVGDAGKRLHTGRSRNDQVATDIRLWLRSEIDSIVGLLGDLRGALLDLAEKNADTILPGF
THLQVAQPVTFGHHLMAYVEMFTRDAERMADCRRRVNRLPLGAAALAGTSYPIDREFVATQLGFDGVCRNSLDAVSDRDF
AIEFLAAASLIMTHVSRFSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVYGHLTGLLTLMKGQP
LAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGISVKPDNMRAAALQGYATATDLADYLVKRGLPFRDAHEAVAHAVRA
CDDRHCDLADLTVEQLREVSGLGDKASLIGDDVHSVLTLEGSVASRNHIGGTAPDQVRAAIAAARKAL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=464, Percent_Identity=40.301724137931, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI68303542, Length=464, Percent_Identity=40.301724137931, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI68303547, Length=464, Percent_Identity=37.9310344827586, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI68303549, Length=464, Percent_Identity=37.7155172413793, Blast_Score=325, Evalue=7e-89,
Organism=Escherichia coli, GI1790398, Length=459, Percent_Identity=45.5337690631808, Blast_Score=405, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321806, Length=450, Percent_Identity=42.4444444444444, Blast_Score=352, Evalue=1e-97,
Organism=Drosophila melanogaster, GI221473854, Length=457, Percent_Identity=38.2932166301969, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI78706858, Length=457, Percent_Identity=38.2932166301969, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51367; Mature: 51236

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQLAKKGEAWSARFSEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAE
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCC
ADRAEIERGMTQIRGEIESGAFEWKLDLEDVHLNIEARLTALVGDAGKRLHTGRSRNDQV
CHHHHHHHHHHHHHHHHCCCCEEEEEEHHHEEEEHHHHHHHHHHCCHHHHCCCCCCCCHH
ATDIRLWLRSEIDSIVGLLGDLRGALLDLAEKNADTILPGFTHLQVAQPVTFGHHLMAYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
EMFTRDAERMADCRRRVNRLPLGAAALAGTSYPIDREFVATQLGFDGVCRNSLDAVSDRD
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHCCCCHHHHCCHHHCCCCH
FAIEFLAAASLIMTHVSRFSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVYGHLTGLLTLMKGQPLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGISVKP
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DNMRAAALQGYATATDLADYLVKRGLPFRDAHEAVAHAVRACDDRHCDLADLTVEQLREV
CCCHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
SGLGDKASLIGDDVHSVLTLEGSVASRNHIGGTAPDQVRAAIAAARKAL
HCCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSQLAKKGEAWSARFSEPMSDLVKRYTASVFFDKRLALFDIQGSLAHAAMLAKQGIIAE
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCC
ADRAEIERGMTQIRGEIESGAFEWKLDLEDVHLNIEARLTALVGDAGKRLHTGRSRNDQV
CHHHHHHHHHHHHHHHHCCCCEEEEEEHHHEEEEHHHHHHHHHHCCHHHHCCCCCCCCHH
ATDIRLWLRSEIDSIVGLLGDLRGALLDLAEKNADTILPGFTHLQVAQPVTFGHHLMAYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
EMFTRDAERMADCRRRVNRLPLGAAALAGTSYPIDREFVATQLGFDGVCRNSLDAVSDRD
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHCCCCHHHHCCHHHCCCCH
FAIEFLAAASLIMTHVSRFSEELVIWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVYGHLTGLLTLMKGQPLAYNKDNQEDKEPLFDTVDTVVDTLRIFADMVPGISVKP
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DNMRAAALQGYATATDLADYLVKRGLPFRDAHEAVAHAVRACDDRHCDLADLTVEQLREV
CCCHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
SGLGDKASLIGDDVHSVLTLEGSVASRNHIGGTAPDQVRAAIAAARKAL
HCCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA