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The map label for this gene is uvrD [H]

Identifier: 94311565

GI number: 94311565

Start: 2862070

End: 2864433

Strand: Reverse

Name: uvrD [H]

Synonym: Rmet_2629

Alternate gene names: 94311565

Gene position: 2864433-2862070 (Counterclockwise)

Preceding gene: 94311568

Following gene: 94311560

Centisome position: 72.92

GC content: 64.09

Gene sequence:

>2364_bases
ATGTCCAGTCTGCTCGCCAATCTCAACGCTGAACAACTCGCCGCCGTCACATTACCTGACGAGCCGGCCCTGATCCTGGC
CGGTGCGGGCAGTGGCAAGACCCGTGTGCTGACCACGCGGATCGCGTGGCTGATCCAGAACGGCCGTGTGTCCCCGGCCG
GCATCCTGGCGGTGACCTTCACGAACAAGGCCGCCAAGGAGATGCAGACCCGGCTGTCGTCGATGTTGCCGATCAACACC
CGGGGCATGTGGATCGGCACGTTCCATGGCCTCTGCAACCGGATGCTGCGTGCGCATTTCCGTGACGCCGGCTTGCCCCA
GACATTTGCCATCCTGGACTCCCAGGACCAGCTTTCGGCGATCAAGCGGCTGCTCAAGGGGCTGAATGTCGACGACGAAA
AGTACCCACCCAAGAATCTCCAGTACTTCATCAACAACGCCAAGGAGCAGGGCCTGCGCCCGGCCGACGTCGAAGCCAAT
GACGATTTCAATCGTCGCTTCGTCGACCTGTACGCGGCCTACGACGAGCAGTGCCAGCGCGAGGGCGTGGTCGACTTCGC
CGAACTGTTGCTGCGCTGCTACGAACTGCTGCGTTACAACGACGCGATCCGCCAGCACTACCAGCACCGTTTCCGCCATG
TGCTCGTCGACGAGTTCCAGGACACCAACGTGCTGCAGTACCAGTGGCTCAAGCTGCTTGCCGGCTACGGCTCGGGCAAT
GCCGCGGCAGTGTTCGCCGTGGGCGACGATGACCAGAGCATCTACGCGTTCCGTGGCGCCAACGTCGGCAATATGCGCGA
CTTCGAGCAGGAATTCCGCGTTCGCCACCTGATCAAGCTCGAGCAGAACTACCGCTCGCACGGGCATATTCTCGATTCGG
CCAACCACCTGATCTCGCACAATGCGCGCCGACTGGGCAAGAACCTGCGCACCGACGCCGGGCACGGCGAGCCGGTGCGC
GTGTTCCAGGCAGGTTCGGACGGCCAGGAAGCCTCGTGGATCGTCGAGGAAATCCGCGACCAGATCGCGCAGGGCATGTC
GCGCTCGGAGATCGCGATCCTCTATCGCAGCAATGCGCAGTCGCGGGTCATCGAACACGCGCTGTTCTCGTCGGGTATCC
CGTACCGGGTGTACGGCGGCCTGCGCTTCTTCGAGCGCGCCGAAGTGAAGCACGCGCTGGCCTACCTGCAGTTGATCGAG
AACCCTCGCAATGACGCCGCATTCGGGCGGGTGGTCAATTTCCCCACGCGCGGCATCGGCGCGAAGTCGCTCGAAGTGCT
GCAGGACGCAGCGCGGCAGTACAACTGTTCACTGGCCGAAGCCGTGGCCTACGTGCCTGGCAAGGCCGGCAGCTCGTTGG
GCGCCTTTATCCGGCTGATCGAGCAGATGCGTGCCGAGACCAGCCGGATGACGCTGGCGCAAACGGTCGAGTACGTGACC
AACACCAGCGGCCTGATGACGCATTACCAGACCGAGAAGGAAGGCCAGGACCGCATCGAGAACTTGCAGGAACTGGTGAC
GGCCGCGCAGGCATTCGTGGTCGAGGAAGGCTACGGGCTCGAGGCGCTGGGCCGCATGCTGCCGGCGAACCGCGATGCCA
TGCCGGCGCTGGCGCAGGGCGAACAGGACCAGCAGGTGCTGGACCCCGAACAGTTGCCGGTGGTGATGACGCCGCTGGTG
GCGTTCCTGACCCATGCATCACTGGAGGCGGGGGACAACCAGGCGCAGGCCGGCCAGGATGCGGTGCAAATGATGACCGT
GCACGCGGCCAAGGGGCTCGAGTTCAATGTGGTGTTTATCACCGGGCTCGAGGAAGGCCTGTTCCCGCACGAGAACAGCG
CGATGGAAGCCGACGGTCTGGAGGAAGAACGCCGCCTGATGTATGTGGCCATCACGCGCGCGCGGGCACGGCTCTATCTG
TCGTTCGCCCAAAGCCGCGTGCTGCACGGCCAGATGCGCTATCACGTGCGGTCGCGCTTCTTCGAGGAGCTTCCCGAGGC
TTCGCTGAAGTGGATCACTCCGCAGGGCCAGGCCTATGGTGCCTATGGCTCAGGTAGCGGACGCCAGTCATCTGAGCGCG
AAAGCGCTTGGGGCCGTGACTGGTTCAAGCGTGCCGAGGACGTGCCCTATACCGGCGTCAAGCCGACCGGCGGCATGGAC
ACCGGCAAGAACTACGCCGAAGAGAAGCGCGCCGCGGCCACTGGATTCCGCGTGGGCCAGAGCGTGTTCCACAACAAGTT
CGGGGAAGGCAAGATCAAGGCGCTGGAAGGCGAGGGCGCCGATGCGCGCGCGAACATCGACTTCAAGCGTCACGGCACCA
AGTGGCTGGCGCTGTCGGTGGCGAAGCTGGACGCGATTGATTGA

Upstream 100 bases:

>100_bases
GCGCCGGAAGGTGGTCCGGGCGAGTGGATGCTGTCGTTGCTGCCAGGACGCGACGGGGGCCATCGGTATAATTGCGGCCT
ATCCTTCCGGCCCCGCTCCG

Downstream 100 bases:

>100_bases
GGAGGGGATTTTCTCCCCACTTCCGCATATGGAAGCGGGGAGAAAAGAGGGTCAGGACTGCGCTACGCTATCGTTTGCCG
TCTCACCCGGCGGCGCGATG

Product: DNA-dependent ATPase I and helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 787; Mature: 786

Protein sequence:

>787_residues
MSSLLANLNAEQLAAVTLPDEPALILAGAGSGKTRVLTTRIAWLIQNGRVSPAGILAVTFTNKAAKEMQTRLSSMLPINT
RGMWIGTFHGLCNRMLRAHFRDAGLPQTFAILDSQDQLSAIKRLLKGLNVDDEKYPPKNLQYFINNAKEQGLRPADVEAN
DDFNRRFVDLYAAYDEQCQREGVVDFAELLLRCYELLRYNDAIRQHYQHRFRHVLVDEFQDTNVLQYQWLKLLAGYGSGN
AAAVFAVGDDDQSIYAFRGANVGNMRDFEQEFRVRHLIKLEQNYRSHGHILDSANHLISHNARRLGKNLRTDAGHGEPVR
VFQAGSDGQEASWIVEEIRDQIAQGMSRSEIAILYRSNAQSRVIEHALFSSGIPYRVYGGLRFFERAEVKHALAYLQLIE
NPRNDAAFGRVVNFPTRGIGAKSLEVLQDAARQYNCSLAEAVAYVPGKAGSSLGAFIRLIEQMRAETSRMTLAQTVEYVT
NTSGLMTHYQTEKEGQDRIENLQELVTAAQAFVVEEGYGLEALGRMLPANRDAMPALAQGEQDQQVLDPEQLPVVMTPLV
AFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFNVVFITGLEEGLFPHENSAMEADGLEEERRLMYVAITRARARLYL
SFAQSRVLHGQMRYHVRSRFFEELPEASLKWITPQGQAYGAYGSGSGRQSSERESAWGRDWFKRAEDVPYTGVKPTGGMD
TGKNYAEEKRAAATGFRVGQSVFHNKFGEGKIKALEGEGADARANIDFKRHGTKWLALSVAKLDAID

Sequences:

>Translated_787_residues
MSSLLANLNAEQLAAVTLPDEPALILAGAGSGKTRVLTTRIAWLIQNGRVSPAGILAVTFTNKAAKEMQTRLSSMLPINT
RGMWIGTFHGLCNRMLRAHFRDAGLPQTFAILDSQDQLSAIKRLLKGLNVDDEKYPPKNLQYFINNAKEQGLRPADVEAN
DDFNRRFVDLYAAYDEQCQREGVVDFAELLLRCYELLRYNDAIRQHYQHRFRHVLVDEFQDTNVLQYQWLKLLAGYGSGN
AAAVFAVGDDDQSIYAFRGANVGNMRDFEQEFRVRHLIKLEQNYRSHGHILDSANHLISHNARRLGKNLRTDAGHGEPVR
VFQAGSDGQEASWIVEEIRDQIAQGMSRSEIAILYRSNAQSRVIEHALFSSGIPYRVYGGLRFFERAEVKHALAYLQLIE
NPRNDAAFGRVVNFPTRGIGAKSLEVLQDAARQYNCSLAEAVAYVPGKAGSSLGAFIRLIEQMRAETSRMTLAQTVEYVT
NTSGLMTHYQTEKEGQDRIENLQELVTAAQAFVVEEGYGLEALGRMLPANRDAMPALAQGEQDQQVLDPEQLPVVMTPLV
AFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFNVVFITGLEEGLFPHENSAMEADGLEEERRLMYVAITRARARLYL
SFAQSRVLHGQMRYHVRSRFFEELPEASLKWITPQGQAYGAYGSGSGRQSSERESAWGRDWFKRAEDVPYTGVKPTGGMD
TGKNYAEEKRAAATGFRVGQSVFHNKFGEGKIKALEGEGADARANIDFKRHGTKWLALSVAKLDAID
>Mature_786_residues
SSLLANLNAEQLAAVTLPDEPALILAGAGSGKTRVLTTRIAWLIQNGRVSPAGILAVTFTNKAAKEMQTRLSSMLPINTR
GMWIGTFHGLCNRMLRAHFRDAGLPQTFAILDSQDQLSAIKRLLKGLNVDDEKYPPKNLQYFINNAKEQGLRPADVEAND
DFNRRFVDLYAAYDEQCQREGVVDFAELLLRCYELLRYNDAIRQHYQHRFRHVLVDEFQDTNVLQYQWLKLLAGYGSGNA
AAVFAVGDDDQSIYAFRGANVGNMRDFEQEFRVRHLIKLEQNYRSHGHILDSANHLISHNARRLGKNLRTDAGHGEPVRV
FQAGSDGQEASWIVEEIRDQIAQGMSRSEIAILYRSNAQSRVIEHALFSSGIPYRVYGGLRFFERAEVKHALAYLQLIEN
PRNDAAFGRVVNFPTRGIGAKSLEVLQDAARQYNCSLAEAVAYVPGKAGSSLGAFIRLIEQMRAETSRMTLAQTVEYVTN
TSGLMTHYQTEKEGQDRIENLQELVTAAQAFVVEEGYGLEALGRMLPANRDAMPALAQGEQDQQVLDPEQLPVVMTPLVA
FLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFNVVFITGLEEGLFPHENSAMEADGLEEERRLMYVAITRARARLYLS
FAQSRVLHGQMRYHVRSRFFEELPEASLKWITPQGQAYGAYGSGSGRQSSERESAWGRDWFKRAEDVPYTGVKPTGGMDT
GKNYAEEKRAAATGFRVGQSVFHNKFGEGKIKALEGEGADARANIDFKRHGTKWLALSVAKLDAID

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=795, Percent_Identity=44.2767295597484, Blast_Score=637, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=678, Percent_Identity=35.8407079646018, Blast_Score=364, Evalue=1e-101,
Organism=Escherichia coli, GI1787196, Length=343, Percent_Identity=30.0291545189504, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789183, Length=526, Percent_Identity=23.7642585551331, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322369, Length=751, Percent_Identity=28.2290279627164, Blast_Score=226, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6324477, Length=697, Percent_Identity=23.3859397417504, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 87791; Mature: 87660

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLLANLNAEQLAAVTLPDEPALILAGAGSGKTRVLTTRIAWLIQNGRVSPAGILAVTF
CCCHHHCCCHHHEEEEECCCCCEEEEEECCCCCCEEHHHHHHHHHHCCCCCCCEEEEEEE
TNKAAKEMQTRLSSMLPINTRGMWIGTFHGLCNRMLRAHFRDAGLPQTFAILDSQDQLSA
CCHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
IKRLLKGLNVDDEKYPPKNLQYFINNAKEQGLRPADVEANDDFNRRFVDLYAAYDEQCQR
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EGVVDFAELLLRCYELLRYNDAIRQHYQHRFRHVLVDEFQDTNVLQYQWLKLLAGYGSGN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
AAAVFAVGDDDQSIYAFRGANVGNMRDFEQEFRVRHLIKLEQNYRSHGHILDSANHLISH
EEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
NARRLGKNLRTDAGHGEPVRVFQAGSDGQEASWIVEEIRDQIAQGMSRSEIAILYRSNAQ
HHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCH
SRVIEHALFSSGIPYRVYGGLRFFERAEVKHALAYLQLIENPRNDAAFGRVVNFPTRGIG
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEECCCCCCCC
AKSLEVLQDAARQYNCSLAEAVAYVPGKAGSSLGAFIRLIEQMRAETSRMTLAQTVEYVT
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTSGLMTHYQTEKEGQDRIENLQELVTAAQAFVVEEGYGLEALGRMLPANRDAMPALAQG
CCCHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHCC
EQDQQVLDPEQLPVVMTPLVAFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFNVVFI
CCCCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEE
TGLEEGLFPHENSAMEADGLEEERRLMYVAITRARARLYLSFAQSRVLHGQMRYHVRSRF
ECCCCCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEELPEASLKWITPQGQAYGAYGSGSGRQSSERESAWGRDWFKRAEDVPYTGVKPTGGMD
HHHCCCCCEEEECCCCCEEECCCCCCCCCCCHHHHHCCHHHHHHCCCCCCCCCCCCCCCC
TGKNYAEEKRAAATGFRVGQSVFHNKFGEGKIKALEGEGADARANIDFKRHGTKWLALSV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEECCCHHHCCCEEEEEEE
AKLDAID
HHHCCCC
>Mature Secondary Structure 
SSLLANLNAEQLAAVTLPDEPALILAGAGSGKTRVLTTRIAWLIQNGRVSPAGILAVTF
CCHHHCCCHHHEEEEECCCCCEEEEEECCCCCCEEHHHHHHHHHHCCCCCCCEEEEEEE
TNKAAKEMQTRLSSMLPINTRGMWIGTFHGLCNRMLRAHFRDAGLPQTFAILDSQDQLSA
CCHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
IKRLLKGLNVDDEKYPPKNLQYFINNAKEQGLRPADVEANDDFNRRFVDLYAAYDEQCQR
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EGVVDFAELLLRCYELLRYNDAIRQHYQHRFRHVLVDEFQDTNVLQYQWLKLLAGYGSGN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
AAAVFAVGDDDQSIYAFRGANVGNMRDFEQEFRVRHLIKLEQNYRSHGHILDSANHLISH
EEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
NARRLGKNLRTDAGHGEPVRVFQAGSDGQEASWIVEEIRDQIAQGMSRSEIAILYRSNAQ
HHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCH
SRVIEHALFSSGIPYRVYGGLRFFERAEVKHALAYLQLIENPRNDAAFGRVVNFPTRGIG
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEECCCCCCCC
AKSLEVLQDAARQYNCSLAEAVAYVPGKAGSSLGAFIRLIEQMRAETSRMTLAQTVEYVT
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTSGLMTHYQTEKEGQDRIENLQELVTAAQAFVVEEGYGLEALGRMLPANRDAMPALAQG
CCCHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHCC
EQDQQVLDPEQLPVVMTPLVAFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFNVVFI
CCCCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEE
TGLEEGLFPHENSAMEADGLEEERRLMYVAITRARARLYLSFAQSRVLHGQMRYHVRSRF
ECCCCCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEELPEASLKWITPQGQAYGAYGSGSGRQSSERESAWGRDWFKRAEDVPYTGVKPTGGMD
HHHCCCCCEEEECCCCCEEECCCCCCCCCCCHHHHHCCHHHHHHCCCCCCCCCCCCCCCC
TGKNYAEEKRAAATGFRVGQSVFHNKFGEGKIKALEGEGADARANIDFKRHGTKWLALSV
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEECCCHHHCCCEEEEEEE
AKLDAID
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]