Click here to switch to the map view.

The map label for this gene is yhfN [H]

Identifier: 94311511

GI number: 94311511

Start: 2799359

End: 2800768

Strand: Direct

Name: yhfN [H]

Synonym: Rmet_2575

Alternate gene names: 94311511

Gene position: 2799359-2800768 (Clockwise)

Preceding gene: 94311508

Following gene: 94311512

Centisome position: 71.27

GC content: 63.4

Gene sequence:

>1410_bases
TTGTCATTCTGGCGGTACGGCTCGATATGGAGGTCGGATAAGAGCGCCCGACGAGTTACCCAAGGGTACGGCGGGCGAAC
AATTTATAATTCTCGCATATCCGCCCCGATGGCCAGGTATGCATGCCTTCCGCCGCGCCATCGTCAACAAGGCCCACAGA
TGTTCACGCTGATCTTTCTTGCCGCACTGGTTGTCATGGTGCTGACCAAACTCTGGCTGGCCAGCCGCCAGATTCGCCAT
GTGGGCCGTCATCGCGGCGCCGTGCCGGAGCGCTTTGCCGACACCATCACATTGTCCGCCCACCAGAAGGCGGCGGACTA
CACCATCGCACGCACGCGGCTGTCGATGCTCGAGGTGCTGGCCGGCGCGGCCGTCCTGATCGGCTTCACGCTCCTGGGCG
GCCTGCACGCGCTGAACCAGCTCTGGCTGCACGTATTCGGCGGCGGTGGCTACTTCTATGGCGTCGCGCTGATCGCCAGC
GTGGTGCTGATTGGCGGGCTGATTGACCTGCCCTTCTCGCTCTACGGCCAGTTCGTGATCGAAGAGCGCTTCGGCTTCAA
CAAGATGACGTTCGGACTTTGGCTGGCGGACCTGCTCAAGATGGCCGTGGTGGCCTGCGTGCTGGGCCTGCCGCTGCTGC
TGGCCGTGCTGTGGCTGATGGACCAGGCCGGCACGTACTGGTGGGTCTGGACCTGGCTGCTGTGGATAGCGTTCAGCCTG
CTGCTGCAGGTGATCTTCCCTACCTTCATCGCCCCGCTGTTCAACAAGTTCGAACCGCTCAACGACGAAACCCTGCGCGA
GCGCATCGAGGCGCTGCTACGCAAGTGCGGCTTTGCCAGCAAGGGCCTGTTCGTGATGGATGGCAGCCGGCGCAGCGCCC
ATGGCAACGCTTATTTCACAGGCTTTGGCGCATCGAAGCGCATCGTGTTCTTCGACACCCTGCTGTCGCGGCTGGATGGC
GAGGAAGTGGAAGCGGTGCTGGCGCACGAACTGGGCCACTTCAAGCGTCGGCACGTGGCCAAGATGATGATCGTGACTTT
CGCGCTGTCGCTGGTGTTCCTGGCCCTGCTCGGCTGGCTGGCCACGCGCGAGTGGTTCTTCACCGGGCTGGGCGTGCTGC
CGAACTTCGGCAACAGCAACCACGCGCTGGCGCTGGTGCTGTTCTTCCTGACGCTGCCGGTGTTCACGTTCTTCCTGGGC
CCCCTGGCCAGCGTATCGTCCCGCAAACATGAGTTCGAGGCCGACGAATTCGCCGCGCACCAGACCAATGCTGGCCATCT
GGTCTCGGCGCTGGTCAAGCTGTACAAGGACAACGCCTCGACGCTGACCCCCGACCCGCTCTACAGCGCGTTCTACTACT
CGCATCCGCCCGCAGCCCAGCGGATCGACCGCCTGCTGGCGCACGCATGA

Upstream 100 bases:

>100_bases
GCCACTTCGATAATCCGGTCGGTGTCCGGCTGCAGGCCGGTCATTTCCATGTCCAACCAGACGAGGTTGTTTTCACTTTT
GACGGAGGATGCGGAAGGGC

Downstream 100 bases:

>100_bases
CCCGCAGCGCGCGCCATCACAACGCCGGGAAAGGCACCGGCAAGAACGACTCGAGCGAATCGGCACTGATTGTCGCGGCA
CACGGCCGGCACTATGTCGT

Product: Ste24 endopeptidase

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSFWRYGSIWRSDKSARRVTQGYGGRTIYNSRISAPMARYACLPPRHRQQGPQMFTLIFLAALVVMVLTKLWLASRQIRH
VGRHRGAVPERFADTITLSAHQKAADYTIARTRLSMLEVLAGAAVLIGFTLLGGLHALNQLWLHVFGGGGYFYGVALIAS
VVLIGGLIDLPFSLYGQFVIEERFGFNKMTFGLWLADLLKMAVVACVLGLPLLLAVLWLMDQAGTYWWVWTWLLWIAFSL
LLQVIFPTFIAPLFNKFEPLNDETLRERIEALLRKCGFASKGLFVMDGSRRSAHGNAYFTGFGASKRIVFFDTLLSRLDG
EEVEAVLAHELGHFKRRHVAKMMIVTFALSLVFLALLGWLATREWFFTGLGVLPNFGNSNHALALVLFFLTLPVFTFFLG
PLASVSSRKHEFEADEFAAHQTNAGHLVSALVKLYKDNASTLTPDPLYSAFYYSHPPAAQRIDRLLAHA

Sequences:

>Translated_469_residues
MSFWRYGSIWRSDKSARRVTQGYGGRTIYNSRISAPMARYACLPPRHRQQGPQMFTLIFLAALVVMVLTKLWLASRQIRH
VGRHRGAVPERFADTITLSAHQKAADYTIARTRLSMLEVLAGAAVLIGFTLLGGLHALNQLWLHVFGGGGYFYGVALIAS
VVLIGGLIDLPFSLYGQFVIEERFGFNKMTFGLWLADLLKMAVVACVLGLPLLLAVLWLMDQAGTYWWVWTWLLWIAFSL
LLQVIFPTFIAPLFNKFEPLNDETLRERIEALLRKCGFASKGLFVMDGSRRSAHGNAYFTGFGASKRIVFFDTLLSRLDG
EEVEAVLAHELGHFKRRHVAKMMIVTFALSLVFLALLGWLATREWFFTGLGVLPNFGNSNHALALVLFFLTLPVFTFFLG
PLASVSSRKHEFEADEFAAHQTNAGHLVSALVKLYKDNASTLTPDPLYSAFYYSHPPAAQRIDRLLAHA
>Mature_468_residues
SFWRYGSIWRSDKSARRVTQGYGGRTIYNSRISAPMARYACLPPRHRQQGPQMFTLIFLAALVVMVLTKLWLASRQIRHV
GRHRGAVPERFADTITLSAHQKAADYTIARTRLSMLEVLAGAAVLIGFTLLGGLHALNQLWLHVFGGGGYFYGVALIASV
VLIGGLIDLPFSLYGQFVIEERFGFNKMTFGLWLADLLKMAVVACVLGLPLLLAVLWLMDQAGTYWWVWTWLLWIAFSLL
LQVIFPTFIAPLFNKFEPLNDETLRERIEALLRKCGFASKGLFVMDGSRRSAHGNAYFTGFGASKRIVFFDTLLSRLDGE
EVEAVLAHELGHFKRRHVAKMMIVTFALSLVFLALLGWLATREWFFTGLGVLPNFGNSNHALALVLFFLTLPVFTFFLGP
LASVSSRKHEFEADEFAAHQTNAGHLVSALVKLYKDNASTLTPDPLYSAFYYSHPPAAQRIDRLLAHA

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=456, Percent_Identity=32.6754385964912, Blast_Score=205, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17505484, Length=423, Percent_Identity=32.6241134751773, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6322577, Length=421, Percent_Identity=33.0166270783848, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI19922414, Length=442, Percent_Identity=33.0316742081448, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI78707252, Length=422, Percent_Identity=26.0663507109005, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI78707254, Length=422, Percent_Identity=26.0663507109005, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24654305, Length=446, Percent_Identity=25.3363228699552, Blast_Score=112, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 52613; Mature: 52482

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS00196 COPPER_BLUE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFWRYGSIWRSDKSARRVTQGYGGRTIYNSRISAPMARYACLPPRHRQQGPQMFTLIFL
CCCCCCCCHHCCCHHHHHHHHCCCCCEEECCHHCCHHHHHHCCCCHHHHCCCHHHHHHHH
AALVVMVLTKLWLASRQIRHVGRHRGAVPERFADTITLSAHQKAADYTIARTRLSMLEVL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEECCHHHHHHHHHHHHHHHHHHHH
AGAAVLIGFTLLGGLHALNQLWLHVFGGGGYFYGVALIASVVLIGGLIDLPFSLYGQFVI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
EERFGFNKMTFGLWLADLLKMAVVACVLGLPLLLAVLWLMDQAGTYWWVWTWLLWIAFSL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LLQVIFPTFIAPLFNKFEPLNDETLRERIEALLRKCGFASKGLFVMDGSRRSAHGNAYFT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEE
GFGASKRIVFFDTLLSRLDGEEVEAVLAHELGHFKRRHVAKMMIVTFALSLVFLALLGWL
ECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATREWFFTGLGVLPNFGNSNHALALVLFFLTLPVFTFFLGPLASVSSRKHEFEADEFAAH
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHC
QTNAGHLVSALVKLYKDNASTLTPDPLYSAFYYSHPPAAQRIDRLLAHA
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SFWRYGSIWRSDKSARRVTQGYGGRTIYNSRISAPMARYACLPPRHRQQGPQMFTLIFL
CCCCCCCHHCCCHHHHHHHHCCCCCEEECCHHCCHHHHHHCCCCHHHHCCCHHHHHHHH
AALVVMVLTKLWLASRQIRHVGRHRGAVPERFADTITLSAHQKAADYTIARTRLSMLEVL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEECCHHHHHHHHHHHHHHHHHHHH
AGAAVLIGFTLLGGLHALNQLWLHVFGGGGYFYGVALIASVVLIGGLIDLPFSLYGQFVI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
EERFGFNKMTFGLWLADLLKMAVVACVLGLPLLLAVLWLMDQAGTYWWVWTWLLWIAFSL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LLQVIFPTFIAPLFNKFEPLNDETLRERIEALLRKCGFASKGLFVMDGSRRSAHGNAYFT
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEE
GFGASKRIVFFDTLLSRLDGEEVEAVLAHELGHFKRRHVAKMMIVTFALSLVFLALLGWL
ECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATREWFFTGLGVLPNFGNSNHALALVLFFLTLPVFTFFLGPLASVSSRKHEFEADEFAAH
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHC
QTNAGHLVSALVKLYKDNASTLTPDPLYSAFYYSHPPAAQRIDRLLAHA
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]