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The map label for this gene is ivd [H]

Identifier: 94311466

GI number: 94311466

Start: 2751791

End: 2752927

Strand: Reverse

Name: ivd [H]

Synonym: Rmet_2530

Alternate gene names: 94311466

Gene position: 2752927-2751791 (Counterclockwise)

Preceding gene: 94311470

Following gene: 94311465

Centisome position: 70.08

GC content: 63.76

Gene sequence:

>1137_bases
GTGGAAGTCGTTCGCAGTGTCTATCGTGAAGATCATGAGCAGTTCCGCACCACCGTGCGCCGTTTCCTGGAGCGCGAATG
CGTACCGCGCCAGGAACAATGGCTGGCCGACGGCATCGTCGACCGCGAAACCTGGCTCAAGGCCGGGCGCGAAGGGCTTC
TTTGCACGGCACTGCCGACCGAGTATGGCGGCGGCGGTGGCGACTTCGGCCACGCGGCCATCATCGCCGAGGAAATGGCC
TATGCCGGTGTCAGCGTGTCGTTCGGGCTGCACTCGGATATCGTGGCGCCCTACATTGCCCGCTTGGGCACGGAGGAACA
GAAGCAGCGCTGGCTGCCCGACATCTGCGCGGGCAAGACCATCCTCGCCGTTGCCATCACCGAGCCGGGAGGCGGCTCGG
ACGTCAAGGCCTGCCGGACTACGGCGGTGCGCGACGGCGACGAATGGGTCATCAATGGCAGCAAGACCTTCATCAGCAAC
GGCTTCTGCTCGGACATGGTGATGGTGGTCTGCAAGACCGACCCCGCGGCCGGCGCCAGGGGCGTGAGCCTGATCCTGGT
CGAGACCAACCGAGAAGGCTTCCGCCGCGGCCGCAAGCTGCACAAGGTGGGCATGCACTCGCAGGATACCGCCGAGCTGT
TCTTCGACAACGTGCGCGTGCCGGCGGGCAACCTGCTGGGCGAAGTGAACAAGGGCTTTGGCTACCTGATGCACGACCTG
GCACAGGAGCGGTTCATCATCGCTGTGACGGCTGCCGCCAAGATCGAACGCCTGCTGGAACAGACCATCGAGTATGTGAA
GGACCGCAAGGCCTTTGGCGGCACCGTCTGGGACTTCCAGAACACCAAGTTCAAGCTGGCCGATGTCAAGGCCAATGCCG
TGGCGCTGCGCACCATGGTGGACTACTACCTGGGCGAGCACATGCGCCGCCGGCTGTCGGGCGAAGAAGCCGCCATTGCC
AAGCTGCACGCCACCGAAGTGCAGTGGAAATGCATTGACGACATGGTCCAGCTGCATGGCGGCTACGGCTACATGCTCGA
GTATCCGATCGCCCGCGCCTTTGTCGACATGCGCGTGGCGCGCGTCTACGGCGGGTCCAATGAAGTGATGCGCGACATCA
TCACGCGCAAGATGTAA

Upstream 100 bases:

>100_bases
GGGGGGGTGGTGGGGCTCGCGGCGCATCATCCGTTCACCGAGAGCCGGCCGGATCGTTTGACCTGCCGGCTACGCCAATA
CCTGACAGGGAGGAGACGTC

Downstream 100 bases:

>100_bases
CTACAACGATTTCAGCGAGGAGACAACAGCGATGTCCAAGCATGTGGTGGTAGCCGGGGTCGGCATGATCCCGTTCAAGA
AACCGGGTCAGAGCGATTCC

Product: isovaleryl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MEVVRSVYREDHEQFRTTVRRFLERECVPRQEQWLADGIVDRETWLKAGREGLLCTALPTEYGGGGGDFGHAAIIAEEMA
YAGVSVSFGLHSDIVAPYIARLGTEEQKQRWLPDICAGKTILAVAITEPGGGSDVKACRTTAVRDGDEWVINGSKTFISN
GFCSDMVMVVCKTDPAAGARGVSLILVETNREGFRRGRKLHKVGMHSQDTAELFFDNVRVPAGNLLGEVNKGFGYLMHDL
AQERFIIAVTAAAKIERLLEQTIEYVKDRKAFGGTVWDFQNTKFKLADVKANAVALRTMVDYYLGEHMRRRLSGEEAAIA
KLHATEVQWKCIDDMVQLHGGYGYMLEYPIARAFVDMRVARVYGGSNEVMRDIITRKM

Sequences:

>Translated_378_residues
MEVVRSVYREDHEQFRTTVRRFLERECVPRQEQWLADGIVDRETWLKAGREGLLCTALPTEYGGGGGDFGHAAIIAEEMA
YAGVSVSFGLHSDIVAPYIARLGTEEQKQRWLPDICAGKTILAVAITEPGGGSDVKACRTTAVRDGDEWVINGSKTFISN
GFCSDMVMVVCKTDPAAGARGVSLILVETNREGFRRGRKLHKVGMHSQDTAELFFDNVRVPAGNLLGEVNKGFGYLMHDL
AQERFIIAVTAAAKIERLLEQTIEYVKDRKAFGGTVWDFQNTKFKLADVKANAVALRTMVDYYLGEHMRRRLSGEEAAIA
KLHATEVQWKCIDDMVQLHGGYGYMLEYPIARAFVDMRVARVYGGSNEVMRDIITRKM
>Mature_378_residues
MEVVRSVYREDHEQFRTTVRRFLERECVPRQEQWLADGIVDRETWLKAGREGLLCTALPTEYGGGGGDFGHAAIIAEEMA
YAGVSVSFGLHSDIVAPYIARLGTEEQKQRWLPDICAGKTILAVAITEPGGGSDVKACRTTAVRDGDEWVINGSKTFISN
GFCSDMVMVVCKTDPAAGARGVSLILVETNREGFRRGRKLHKVGMHSQDTAELFFDNVRVPAGNLLGEVNKGFGYLMHDL
AQERFIIAVTAAAKIERLLEQTIEYVKDRKAFGGTVWDFQNTKFKLADVKANAVALRTMVDYYLGEHMRRRLSGEEAAIA
KLHATEVQWKCIDDMVQLHGGYGYMLEYPIARAFVDMRVARVYGGSNEVMRDIITRKM

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=378, Percent_Identity=48.4126984126984, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI226958412, Length=373, Percent_Identity=32.9758713136729, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI226958414, Length=339, Percent_Identity=33.3333333333333, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4557233, Length=367, Percent_Identity=32.9700272479564, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI4557235, Length=389, Percent_Identity=33.4190231362468, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI76496475, Length=389, Percent_Identity=33.4190231362468, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI7656849, Length=372, Percent_Identity=31.4516129032258, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4501859, Length=379, Percent_Identity=27.7044854881267, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI21361497, Length=369, Percent_Identity=31.1653116531165, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4557231, Length=374, Percent_Identity=28.6096256684492, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI187960098, Length=374, Percent_Identity=28.6096256684492, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI211971008, Length=350, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI48976061, Length=350, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI4503943, Length=381, Percent_Identity=24.6719160104987, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI38505218, Length=382, Percent_Identity=25.6544502617801, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=24.8633879781421, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI87081958, Length=347, Percent_Identity=29.1066282420749, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786223, Length=318, Percent_Identity=26.1006289308176, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17538396, Length=368, Percent_Identity=32.8804347826087, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=32.6259946949602, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17551932, Length=379, Percent_Identity=32.4538258575198, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=32.6145552560647, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=32.2666666666667, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17570075, Length=373, Percent_Identity=30.8310991957105, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17569725, Length=376, Percent_Identity=30.0531914893617, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17506239, Length=329, Percent_Identity=32.2188449848024, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71985184, Length=334, Percent_Identity=34.7305389221557, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17534899, Length=374, Percent_Identity=29.9465240641711, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=37.0503597122302, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI32563615, Length=225, Percent_Identity=35.5555555555556, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=30.03663003663, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71985192, Length=283, Percent_Identity=33.5689045936396, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17534353, Length=385, Percent_Identity=25.974025974026, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17562446, Length=291, Percent_Identity=29.2096219931272, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17531909, Length=242, Percent_Identity=25.6198347107438, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=32.8, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24660351, Length=374, Percent_Identity=31.283422459893, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI21356377, Length=373, Percent_Identity=29.7587131367292, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI281363737, Length=351, Percent_Identity=31.0541310541311, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=28.0323450134771, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24646207, Length=368, Percent_Identity=31.7934782608696, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=26.246719160105, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24652780, Length=300, Percent_Identity=23.3333333333333, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42200; Mature: 42200

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVVRSVYREDHEQFRTTVRRFLERECVPRQEQWLADGIVDRETWLKAGREGLLCTALPT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHCCCCCEEEEECCC
EYGGGGGDFGHAAIIAEEMAYAGVSVSFGLHSDIVAPYIARLGTEEQKQRWLPDICAGKT
CCCCCCCCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCHHHHHHCCCHHHCCCE
ILAVAITEPGGGSDVKACRTTAVRDGDEWVINGSKTFISNGFCSDMVMVVCKTDPAAGAR
EEEEEEECCCCCCCHHHHHHHHCCCCCCEEECCCHHEECCCCCCCEEEEEECCCCCCCCC
GVSLILVETNREGFRRGRKLHKVGMHSQDTAELFFDNVRVPAGNLLGEVNKGFGYLMHDL
CEEEEEEECCCHHHHHCHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AQERFIIAVTAAAKIERLLEQTIEYVKDRKAFGGTVWDFQNTKFKLADVKANAVALRTMV
HHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCHHHHHHHHH
DYYLGEHMRRRLSGEEAAIAKLHATEVQWKCIDDMVQLHGGYGYMLEYPIARAFVDMRVA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHH
RVYGGSNEVMRDIITRKM
HHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MEVVRSVYREDHEQFRTTVRRFLERECVPRQEQWLADGIVDRETWLKAGREGLLCTALPT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHCCCCCEEEEECCC
EYGGGGGDFGHAAIIAEEMAYAGVSVSFGLHSDIVAPYIARLGTEEQKQRWLPDICAGKT
CCCCCCCCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCHHHHHHCCCHHHCCCE
ILAVAITEPGGGSDVKACRTTAVRDGDEWVINGSKTFISNGFCSDMVMVVCKTDPAAGAR
EEEEEEECCCCCCCHHHHHHHHCCCCCCEEECCCHHEECCCCCCCEEEEEECCCCCCCCC
GVSLILVETNREGFRRGRKLHKVGMHSQDTAELFFDNVRVPAGNLLGEVNKGFGYLMHDL
CEEEEEEECCCHHHHHCHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AQERFIIAVTAAAKIERLLEQTIEYVKDRKAFGGTVWDFQNTKFKLADVKANAVALRTMV
HHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCHHHHHHHHH
DYYLGEHMRRRLSGEEAAIAKLHATEVQWKCIDDMVQLHGGYGYMLEYPIARAFVDMRVA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHH
RVYGGSNEVMRDIITRKM
HHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]