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The map label for this gene is lldP [H]

Identifier: 94311451

GI number: 94311451

Start: 2729992

End: 2731668

Strand: Direct

Name: lldP [H]

Synonym: Rmet_2515

Alternate gene names: 94311451

Gene position: 2729992-2731668 (Clockwise)

Preceding gene: 335055602

Following gene: 94311452

Centisome position: 69.5

GC content: 64.28

Gene sequence:

>1677_bases
GTGTGGAGTCAAGTGTATGACCCGCTCGGCAGTATGGCGTTGTCCACTATTGCCGCCGCGGTTCCGGTTGTCGTGCTGCT
CGCAGCGCTGGCGTTCTTTCACATGCAGGCCCACCTGGCGGCCGGGCTGGCGCTGGTCGTCGGCGTCGTCGTGGCGTCAT
TCGTGTTCGGAATGCCTCCGGAAATGGCTGGCAAAGCCGCCGGGCTCGGCATCATCTCCGGCTTGTTCCCGATTGGCTGG
ATCGTCCTCAACATCATCTTCCTGCACCGGCTGACCACGATAAACGGGTCATTCAAGGTGTTGCAGAACTCGATCTCGGG
CGTCACCGAAGATCGCCGCCTGCAGCTCCTGCTGGTGGCATTCAGCTTTGGCGCGTTCTTCGAAGGCGCGGCCGGCTTCG
GCACGCCCGTGGCCGTGACCGGCGCCATCCTGATCGGCCTGGGCTTCTCACCGCTGGCCGCATCGGGCCTGGCGCTGATC
GCCAACACCGCGCCGGTGGCATTCGGCGCGCTCGGCGCGCCGATCATCGGCCTGTCCTCGGTGACCGGCATCGACCAGGT
GCAACTCTCCGCGATGATCGGCCGCCAGTTGCCGTTCTTCTCGGTGCTGGTGCCGTTCTGGCTGATCTGGGCGTTCGCGG
GCTTCCGCGGCATGCTGGCGATCTGGCCGGCGATCCTGGTGGCCGGCGTCAGCTTCGCGGTGCCGCAGTTCCTGGTGTCG
AACTTCCACGGCCCGTGGCTGGTGGACGTGATTTCGGCGCTGGTCTCGATGGGCTGCCTGACCGCCTTCCTGAAAATCTG
GCATCCGAAGGAAATCTGGACCTCGACGCGCATCCTGGGCCGTCACGACGATTCCAAGGTCGACAATGCCGAAGCCCTCG
AAGCCGATGCCAAGGCCAACGCCGCATCGGCCAACATCTCGGTGATCAAGGCGTGGATGCCGTGGGTGATCCTGACCGTC
TTCGTGTTCGTCTGGGGCATCCCCGAGTTCAAGAAGCTGATGGACGGCGTCTGGCAATGGAAGTTCGCCATCCCGGGTCT
GGACAAGGCGGTGCTCAAGGGCCCGCCCGTGGTGGCGAAGCAAATCGCCGAGCCGGCCGTGTTCGCGTTCAACGTGCTGT
CGATGGCGGGTACCGGCATTCTGGTGTCGGCCCTCGTTGGCGGCCTGCTGATGGGCTATTCGATCCCGCGCCTGATCAAG
GAGTACTTCGAGACGATCAAGCTCGTGCGCTACTCGCTGTTGACGATCTGCGCGATGTTCGGCATCGGCTACCTGACCCG
CTACTCGGGGCTGGACGCCACGCTGGGTCTGGCTTTCGCGCAGACCGGCGTGCTCTACCCGCTGTTCGGCACGATGCTGG
GCTGGCTGGGTGTGGCGCTCACCGGTTCGGACACCGCATCGAACGTGCTGTTCGGCGGCCTGCAGAAGACCACGGCGGAA
CAGCTTGGCCTGTCTCCGACCCTGATGGCCGCGGCCAACAGCTCGGGCGGCGTGATGGGCAAGATGATCGATGCACAGTC
GATCGTGGTGGCTTCCACCGCCACCAAGTGGTATGGCCACGAAGGCGAGATTCTGCGCTACGTGTTCTTCCACTCGATCG
CGCTGGCGCTGATGGTCGGTATCTTCGTGACGCTGCAGGCGTACGTGCATCCGTTCACGCTGATGGTGATCCACTGA

Upstream 100 bases:

>100_bases
CTCCCAGGGGCGCTATCGTCGCTTGAACGGGCATTTGCATTCCGGCAGCCCAGGCCCGTCAGAGGCAAGCTGTCGTTTCA
TTCCAGAGGAGGATTCAATC

Downstream 100 bases:

>100_bases
TCCACCAGCCATCATCCGCTGCAGTCTTCAAGCCCCGCCCTCGAGCGGGGCTTTTTCATGGGCGTATCATGATCGGCTCA
CCCGGCAGACATGACGAGGA

Product: glycolate transporter

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MWSQVYDPLGSMALSTIAAAVPVVVLLAALAFFHMQAHLAAGLALVVGVVVASFVFGMPPEMAGKAAGLGIISGLFPIGW
IVLNIIFLHRLTTINGSFKVLQNSISGVTEDRRLQLLLVAFSFGAFFEGAAGFGTPVAVTGAILIGLGFSPLAASGLALI
ANTAPVAFGALGAPIIGLSSVTGIDQVQLSAMIGRQLPFFSVLVPFWLIWAFAGFRGMLAIWPAILVAGVSFAVPQFLVS
NFHGPWLVDVISALVSMGCLTAFLKIWHPKEIWTSTRILGRHDDSKVDNAEALEADAKANAASANISVIKAWMPWVILTV
FVFVWGIPEFKKLMDGVWQWKFAIPGLDKAVLKGPPVVAKQIAEPAVFAFNVLSMAGTGILVSALVGGLLMGYSIPRLIK
EYFETIKLVRYSLLTICAMFGIGYLTRYSGLDATLGLAFAQTGVLYPLFGTMLGWLGVALTGSDTASNVLFGGLQKTTAE
QLGLSPTLMAAANSSGGVMGKMIDAQSIVVASTATKWYGHEGEILRYVFFHSIALALMVGIFVTLQAYVHPFTLMVIH

Sequences:

>Translated_558_residues
MWSQVYDPLGSMALSTIAAAVPVVVLLAALAFFHMQAHLAAGLALVVGVVVASFVFGMPPEMAGKAAGLGIISGLFPIGW
IVLNIIFLHRLTTINGSFKVLQNSISGVTEDRRLQLLLVAFSFGAFFEGAAGFGTPVAVTGAILIGLGFSPLAASGLALI
ANTAPVAFGALGAPIIGLSSVTGIDQVQLSAMIGRQLPFFSVLVPFWLIWAFAGFRGMLAIWPAILVAGVSFAVPQFLVS
NFHGPWLVDVISALVSMGCLTAFLKIWHPKEIWTSTRILGRHDDSKVDNAEALEADAKANAASANISVIKAWMPWVILTV
FVFVWGIPEFKKLMDGVWQWKFAIPGLDKAVLKGPPVVAKQIAEPAVFAFNVLSMAGTGILVSALVGGLLMGYSIPRLIK
EYFETIKLVRYSLLTICAMFGIGYLTRYSGLDATLGLAFAQTGVLYPLFGTMLGWLGVALTGSDTASNVLFGGLQKTTAE
QLGLSPTLMAAANSSGGVMGKMIDAQSIVVASTATKWYGHEGEILRYVFFHSIALALMVGIFVTLQAYVHPFTLMVIH
>Mature_558_residues
MWSQVYDPLGSMALSTIAAAVPVVVLLAALAFFHMQAHLAAGLALVVGVVVASFVFGMPPEMAGKAAGLGIISGLFPIGW
IVLNIIFLHRLTTINGSFKVLQNSISGVTEDRRLQLLLVAFSFGAFFEGAAGFGTPVAVTGAILIGLGFSPLAASGLALI
ANTAPVAFGALGAPIIGLSSVTGIDQVQLSAMIGRQLPFFSVLVPFWLIWAFAGFRGMLAIWPAILVAGVSFAVPQFLVS
NFHGPWLVDVISALVSMGCLTAFLKIWHPKEIWTSTRILGRHDDSKVDNAEALEADAKANAASANISVIKAWMPWVILTV
FVFVWGIPEFKKLMDGVWQWKFAIPGLDKAVLKGPPVVAKQIAEPAVFAFNVLSMAGTGILVSALVGGLLMGYSIPRLIK
EYFETIKLVRYSLLTICAMFGIGYLTRYSGLDATLGLAFAQTGVLYPLFGTMLGWLGVALTGSDTASNVLFGGLQKTTAE
QLGLSPTLMAAANSSGGVMGKMIDAQSIVVASTATKWYGHEGEILRYVFFHSIALALMVGIFVTLQAYVHPFTLMVIH

Specific function: Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=562, Percent_Identity=47.3309608540925, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1790031, Length=554, Percent_Identity=42.4187725631769, Blast_Score=412, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 59189; Mature: 59189

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCEEEEEEC
>Mature Secondary Structure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HHHHHHHHHCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 11283302; 11785976 [H]