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The map label for this gene is moeA [H]

Identifier: 94311379

GI number: 94311379

Start: 2654130

End: 2655416

Strand: Direct

Name: moeA [H]

Synonym: Rmet_2443

Alternate gene names: 94311379

Gene position: 2654130-2655416 (Clockwise)

Preceding gene: 94311378

Following gene: 94311380

Centisome position: 67.57

GC content: 64.72

Gene sequence:

>1287_bases
ATGCCTTCGCTTCAATCCGTCATCTCCTGCCTGTCAGACTACGACCCCTCCGCCCTGCCCGTGGCGAAGGCCAACGCCAT
CATTGGCGATGTGATCGAGCCTGTTGGCGGCATCGAACAACTGGCGATCCGCACCGCACTCGATCGCGTGCTGGCCGAGG
ATGTGATCTCGTCGATCGACGTGCCGGCGCATGACAACTCCGCGATGGACGGCTACGCGTTCAGCAGCGCGGCGCTGGCC
GACGCCGGGAGCGACGTGGTGCTTCAGGTCATCGGTACGGCCTACGCCGGCAATGCGCTTGGTAGCCCGGCAGGCCCGGG
GCAAGCCGTGCGGATCATGACCGGCGCGGTCATGCCCGACGGTTGCGATACGGTGGTGCCTCAGGAATTTGTTGAGATCC
AGGCCGGTGGCAACCAGATCCGTTTCGCGGCTGATGCCGTGCGCGCCGGCGACAACCGCCGGCTGCGTGGCGAGGATCTG
GCCAGCGGGCAGGCCGCGCTTGCTGCGGGCCGCATCCTTCAGCCAGCGGATATCGGCCTGCTGGCCTCGCTTGGTGTGGC
CGAAGTCAAAGTGCGCCGTCGCCTGCGCGTGGCCTTCTTCTCCACCGGCGACGAGCTCCGCTCGATCGGCGAGGTACTGG
ACCCGGGCTGCGTCTACGACTCGAACCGCTACACGCTGCACGGTATGCTGCGCCGTCTCAATGTCGACCTGATCGACATG
GGCGTGGTCCGGGACGACCCGGAAGCACTGGAAGCCGCGTTCCGCAGCGCTTGCGAGAATGCCGACGCGATCATCACGTC
AGGCGGCGTTTCCGTCGGAGAAGCGGACTACACCAAGCAGATCATGGCGCAACTGGGCGACGTCACCTTCTGGAAGATCG
CAATGCGCCCCGGCCGCCCGATGGCATTTGGACGCATCACGTCGAATGGCCGCGAAGCACTGTTGTTCGGCCTGCCAGGC
AATCCGGTGGCCGTGATGGTCACGTTCTACCATTTCGTGCGGGCAGCGCTGCATCGATTGATGGGTGCCAAGGTCGCCCC
ACTCCCGCTGATGCGCGTGCGCAGCGCCGGAACCATTCGCAAGAAACCGGGCCGTACCGAATACCAGCGAGGCATTCTCG
CCCCCGGTGCCGATGGCACGCTGGAAGTCCGCGTCACAGGCCAGCAGGGCTCAGGGGTGTTGCGGTCCATGAGCGAAGCC
AACTGCTTTATCGTGCTCGCGCATGAACAAGGCACCGTGGAAGCGGGGGAAAGCGTCGAAATCATGCTTTTCGACGGATT
GATCTAA

Upstream 100 bases:

>100_bases
GGTTAGACTTCCAGCCTACGCTCAAGACCTCGCCTTCCGAGTACACGCGCGCCGTCCACTGTTTCTGTTCAGACTGTCAC
GCGCGCCACCAGACTACGCC

Downstream 100 bases:

>100_bases
GCGCAGCGGTACGGCAACGTCCTGCGACGGGTGTCGTTTTTGTGCCGCATTCGGCGGCAAAAGCCGCGCCCCGCCATCCG
AATTGCCCACCCACAAGAGG

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MPSLQSVISCLSDYDPSALPVAKANAIIGDVIEPVGGIEQLAIRTALDRVLAEDVISSIDVPAHDNSAMDGYAFSSAALA
DAGSDVVLQVIGTAYAGNALGSPAGPGQAVRIMTGAVMPDGCDTVVPQEFVEIQAGGNQIRFAADAVRAGDNRRLRGEDL
ASGQAALAAGRILQPADIGLLASLGVAEVKVRRRLRVAFFSTGDELRSIGEVLDPGCVYDSNRYTLHGMLRRLNVDLIDM
GVVRDDPEALEAAFRSACENADAIITSGGVSVGEADYTKQIMAQLGDVTFWKIAMRPGRPMAFGRITSNGREALLFGLPG
NPVAVMVTFYHFVRAALHRLMGAKVAPLPLMRVRSAGTIRKKPGRTEYQRGILAPGADGTLEVRVTGQQGSGVLRSMSEA
NCFIVLAHEQGTVEAGESVEIMLFDGLI

Sequences:

>Translated_428_residues
MPSLQSVISCLSDYDPSALPVAKANAIIGDVIEPVGGIEQLAIRTALDRVLAEDVISSIDVPAHDNSAMDGYAFSSAALA
DAGSDVVLQVIGTAYAGNALGSPAGPGQAVRIMTGAVMPDGCDTVVPQEFVEIQAGGNQIRFAADAVRAGDNRRLRGEDL
ASGQAALAAGRILQPADIGLLASLGVAEVKVRRRLRVAFFSTGDELRSIGEVLDPGCVYDSNRYTLHGMLRRLNVDLIDM
GVVRDDPEALEAAFRSACENADAIITSGGVSVGEADYTKQIMAQLGDVTFWKIAMRPGRPMAFGRITSNGREALLFGLPG
NPVAVMVTFYHFVRAALHRLMGAKVAPLPLMRVRSAGTIRKKPGRTEYQRGILAPGADGTLEVRVTGQQGSGVLRSMSEA
NCFIVLAHEQGTVEAGESVEIMLFDGLI
>Mature_427_residues
PSLQSVISCLSDYDPSALPVAKANAIIGDVIEPVGGIEQLAIRTALDRVLAEDVISSIDVPAHDNSAMDGYAFSSAALAD
AGSDVVLQVIGTAYAGNALGSPAGPGQAVRIMTGAVMPDGCDTVVPQEFVEIQAGGNQIRFAADAVRAGDNRRLRGEDLA
SGQAALAAGRILQPADIGLLASLGVAEVKVRRRLRVAFFSTGDELRSIGEVLDPGCVYDSNRYTLHGMLRRLNVDLIDMG
VVRDDPEALEAAFRSACENADAIITSGGVSVGEADYTKQIMAQLGDVTFWKIAMRPGRPMAFGRITSNGREALLFGLPGN
PVAVMVTFYHFVRAALHRLMGAKVAPLPLMRVRSAGTIRKKPGRTEYQRGILAPGADGTLEVRVTGQQGSGVLRSMSEAN
CFIVLAHEQGTVEAGESVEIMLFDGLI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=423, Percent_Identity=35.2245862884161, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI66932975, Length=423, Percent_Identity=35.2245862884161, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1787049, Length=398, Percent_Identity=47.4874371859297, Blast_Score=345, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI25147659, Length=338, Percent_Identity=32.8402366863905, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17562606, Length=242, Percent_Identity=30.9917355371901, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136978, Length=398, Percent_Identity=28.391959798995, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24638841, Length=398, Percent_Identity=28.391959798995, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45104; Mature: 44973

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSLQSVISCLSDYDPSALPVAKANAIIGDVIEPVGGIEQLAIRTALDRVLAEDVISSID
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
VPAHDNSAMDGYAFSSAALADAGSDVVLQVIGTAYAGNALGSPAGPGQAVRIMTGAVMPD
CCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCC
GCDTVVPQEFVEIQAGGNQIRFAADAVRAGDNRRLRGEDLASGQAALAAGRILQPADIGL
CCCCCCCHHHHEEECCCCEEEEEHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHH
LASLGVAEVKVRRRLRVAFFSTGDELRSIGEVLDPGCVYDSNRYTLHGMLRRLNVDLIDM
HHHCCHHHHHHHHHHEEEEECCCHHHHHHHHHCCCCCEECCCCEEHHHHHHHCCCCEEEE
GVVRDDPEALEAAFRSACENADAIITSGGVSVGEADYTKQIMAQLGDVTFWKIAMRPGRP
CCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
MAFGRITSNGREALLFGLPGNPVAVMVTFYHFVRAALHRLMGAKVAPLPLMRVRSAGTIR
EEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
KKPGRTEYQRGILAPGADGTLEVRVTGQQGSGVLRSMSEANCFIVLAHEQGTVEAGESVE
CCCCCCHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCEE
IMLFDGLI
EEEECCCC
>Mature Secondary Structure 
PSLQSVISCLSDYDPSALPVAKANAIIGDVIEPVGGIEQLAIRTALDRVLAEDVISSID
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
VPAHDNSAMDGYAFSSAALADAGSDVVLQVIGTAYAGNALGSPAGPGQAVRIMTGAVMPD
CCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCC
GCDTVVPQEFVEIQAGGNQIRFAADAVRAGDNRRLRGEDLASGQAALAAGRILQPADIGL
CCCCCCCHHHHEEECCCCEEEEEHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHH
LASLGVAEVKVRRRLRVAFFSTGDELRSIGEVLDPGCVYDSNRYTLHGMLRRLNVDLIDM
HHHCCHHHHHHHHHHEEEEECCCHHHHHHHHHCCCCCEECCCCEEHHHHHHHCCCCEEEE
GVVRDDPEALEAAFRSACENADAIITSGGVSVGEADYTKQIMAQLGDVTFWKIAMRPGRP
CCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
MAFGRITSNGREALLFGLPGNPVAVMVTFYHFVRAALHRLMGAKVAPLPLMRVRSAGTIR
EEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
KKPGRTEYQRGILAPGADGTLEVRVTGQQGSGVLRSMSEANCFIVLAHEQGTVEAGESVE
CCCCCCHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCEE
IMLFDGLI
EEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]