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The map label for this gene is lepB [H]

Identifier: 94311356

GI number: 94311356

Start: 2628817

End: 2629716

Strand: Reverse

Name: lepB [H]

Synonym: Rmet_2420

Alternate gene names: 94311356

Gene position: 2629716-2628817 (Counterclockwise)

Preceding gene: 94311357

Following gene: 94311355

Centisome position: 66.95

GC content: 57.78

Gene sequence:

>900_bases
ATGAATTTTGCACTGATACTTTTTGTGCTGGTGGTCATCACAGGCATAGCCTGGGTCGCGGACAAGCTGGTGTTCGAGCG
ACAGCGCCGGAGCGTGGCGCAACTCGCGCTGGCCGAATTCGATGCGCGTCGTAATGACATGCAGTCGATGCAGGGCGGCG
CAGACATCGATCGCTCGCGTGCGCGTCTGGCGGAAGAGAAGCTGCGCCAACCGTGGTGGCTGGAATATTCGGCGAGCTTT
TTCCCGGTGATCCTGGCGGTGTTCGTGCTGCGCTCGTTCGTGGTGGAGCCGTTCAAGATTCCGTCGGGATCGATGATCCC
CACGCTACTGATTGGCGACTTCATCCTGGTCAACAAGTACGACTACGGCATTCGTCTGCCGGTCGTGAACAAGAAGATCA
TCAGCCTCGGCGAGCCCCAGCGCGGCGATGTCATGGTGTTCCGCTATCCGCGGGACGAGTCGCTCGACTACATCAAGCGC
GTGATCGGCGTGCCGGGCGATGTGGTGCAGTACGAAAACAAGAAGCTGACGATCAATGGCAAGCCGGCCGAATACAGCCC
GCTGCCGGATTATCTCGACGAAGAACGTCTGGCGTACTCGAAGCATTTTGTCGAGCAGTTGCCGGGCGGACCCCAGCACG
GCATCCTGAATGACAATGATCGCCCCGCCTTCGTGGCCGGTGCCGATCCCGATTTTCCGTTCCGCGATAACTGCACTTAC
AATCAGCAGGGCGTGACGTGTAAAGTGCCGGAAGGTCACTATTTTGTGATGGGTGACAACCGGGATAACAGCCTGGATTC
CAGATACTGGGGGTTCGTGCCTGATCAGAATATCGTGGGCAAGGCGTTCCTGATCTGGATGAATCTGGGTAATTTCGGGC
GCGTGGGATCGTTCAAGTAA

Upstream 100 bases:

>100_bases
CGTCGAAATTCCGCAGGAGGCCTTCCTGGCGATCCTGCAGGTGGACGACAAGTAAGCGCACCCCAGCGACGACACAACAT
CGACATCACTTGAAGCCGTT

Downstream 100 bases:

>100_bases
CGCTCGTACGGTTTCACGCGGCGCAAGACACTCAAAAAAGAGGGAAGCGCAACATGGGTCAAAAGCGGTTGGGTTCACAG
GGGCGGGTTCGTTTCGATGT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MNFALILFVLVVITGIAWVADKLVFERQRRSVAQLALAEFDARRNDMQSMQGGADIDRSRARLAEEKLRQPWWLEYSASF
FPVILAVFVLRSFVVEPFKIPSGSMIPTLLIGDFILVNKYDYGIRLPVVNKKIISLGEPQRGDVMVFRYPRDESLDYIKR
VIGVPGDVVQYENKKLTINGKPAEYSPLPDYLDEERLAYSKHFVEQLPGGPQHGILNDNDRPAFVAGADPDFPFRDNCTY
NQQGVTCKVPEGHYFVMGDNRDNSLDSRYWGFVPDQNIVGKAFLIWMNLGNFGRVGSFK

Sequences:

>Translated_299_residues
MNFALILFVLVVITGIAWVADKLVFERQRRSVAQLALAEFDARRNDMQSMQGGADIDRSRARLAEEKLRQPWWLEYSASF
FPVILAVFVLRSFVVEPFKIPSGSMIPTLLIGDFILVNKYDYGIRLPVVNKKIISLGEPQRGDVMVFRYPRDESLDYIKR
VIGVPGDVVQYENKKLTINGKPAEYSPLPDYLDEERLAYSKHFVEQLPGGPQHGILNDNDRPAFVAGADPDFPFRDNCTY
NQQGVTCKVPEGHYFVMGDNRDNSLDSRYWGFVPDQNIVGKAFLIWMNLGNFGRVGSFK
>Mature_299_residues
MNFALILFVLVVITGIAWVADKLVFERQRRSVAQLALAEFDARRNDMQSMQGGADIDRSRARLAEEKLRQPWWLEYSASF
FPVILAVFVLRSFVVEPFKIPSGSMIPTLLIGDFILVNKYDYGIRLPVVNKKIISLGEPQRGDVMVFRYPRDESLDYIKR
VIGVPGDVVQYENKKLTINGKPAEYSPLPDYLDEERLAYSKHFVEQLPGGPQHGILNDNDRPAFVAGADPDFPFRDNCTY
NQQGVTCKVPEGHYFVMGDNRDNSLDSRYWGFVPDQNIVGKAFLIWMNLGNFGRVGSFK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=315, Percent_Identity=40, Blast_Score=210, Evalue=8e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 34053; Mature: 34053

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFALILFVLVVITGIAWVADKLVFERQRRSVAQLALAEFDARRNDMQSMQGGADIDRSR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ARLAEEKLRQPWWLEYSASFFPVILAVFVLRSFVVEPFKIPSGSMIPTLLIGDFILVNKY
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHCCEEEEEEC
DYGIRLPVVNKKIISLGEPQRGDVMVFRYPRDESLDYIKRVIGVPGDVVQYENKKLTING
CCCEECCCCCHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHEEECCCEEEECC
KPAEYSPLPDYLDEERLAYSKHFVEQLPGGPQHGILNDNDRPAFVAGADPDFPFRDNCTY
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
NQQGVTCKVPEGHYFVMGDNRDNSLDSRYWGFVPDQNIVGKAFLIWMNLGNFGRVGSFK
CCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNFALILFVLVVITGIAWVADKLVFERQRRSVAQLALAEFDARRNDMQSMQGGADIDRSR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ARLAEEKLRQPWWLEYSASFFPVILAVFVLRSFVVEPFKIPSGSMIPTLLIGDFILVNKY
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHCCEEEEEEC
DYGIRLPVVNKKIISLGEPQRGDVMVFRYPRDESLDYIKRVIGVPGDVVQYENKKLTING
CCCEECCCCCHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHEEECCCEEEECC
KPAEYSPLPDYLDEERLAYSKHFVEQLPGGPQHGILNDNDRPAFVAGADPDFPFRDNCTY
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
NQQGVTCKVPEGHYFVMGDNRDNSLDSRYWGFVPDQNIVGKAFLIWMNLGNFGRVGSFK
CCCCCEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]