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The map label for this gene is pan [H]

Identifier: 94311278

GI number: 94311278

Start: 2557226

End: 2558140

Strand: Reverse

Name: pan [H]

Synonym: Rmet_2342

Alternate gene names: 94311278

Gene position: 2558140-2557226 (Counterclockwise)

Preceding gene: 94311279

Following gene: 335055595

Centisome position: 65.12

GC content: 59.13

Gene sequence:

>915_bases
ATGACCAAGAATCCTTCATCAGACGCCACTTTGCCGAAAGGCATCCATCGAAGCTGGAAGCTGCCGGATAAGTCGCTGGG
TGACTTGTGGGATTCGATCGTGATGGACGAAGCCATCAAAAAACAGTTGCTGTCACAAGCGATCGTCAACTTCACGGTGC
GCCCCAAGGTGGAGCGCACGGTACTCCCCCTGCACGGCGTGATCTTGTTGGTCGGCCCGCCGGGGACTGGGAAGACCTCC
TTGGCACGGGGCTTGGCGCATCGTGTGGCCGAATCTTTTTCTTCTGCGAAGTTTCGATTGCTGGAAGTGGAGCCTCACAC
GCTGACGAGCTCTGCAATGGGAAAGACTCAACGCGCCGTGGCAGACCTGTTCTCGCAATCGATCGCAGAATCCGCAGCGG
CGGGCCCGACGATCGTCCTTCTGGACGAGGTCGAAACGCTTGCGGCTGATCGAGCGAAGCTCAGCCTGGAAGCCAACCCG
GTTGATGTGCACCGGGCCACCGACGCGGTGTTGGTGCAGTTGGACATGTTGGCCGAACGCAACCCGCATCTGCTGTTCGT
GGCCACCAGCAACTTCCCACAGGCCGTCGACAGTGCCTTCCTATCTCGTTGCGACATGGTGATGGAGGTGCCACTGCCCG
GCAAGGATGCCTGCAAGCAGATCCTAGTGGACTGCCTGAATGGCCTGGCAAAGACATTTCCGGGGATTGGCAAGCTTTCC
TCGGCTCACCAGTTCGACGCGTGCGCTGGCGAGTGCGTCGGATTGGATGGTCGGGCCATTCGCAAGGTCGTAGCCAACGC
CCTCGCGGCCGACCCGCAAGTGGCTATCGATCCGAACAAGCTTTCCGTAGAGCACTTGCGCAGTGCGATACGACAGGCAA
AGCAAATGCGCCTTCAAGGAGGGAAGCAAAAATGA

Upstream 100 bases:

>100_bases
TGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTATCGCACCATTCTC
TGACCCGCCGAGAGCCACGG

Downstream 100 bases:

>100_bases
CCACCGTTGTCAGCCGGACGTTTCGCAGCTCGCCGCACCGCGATGCGTTGCAGACATGGGATGCCATTGTCGAACTGCTC
ACTCAGGGCAAGGACGGCAC

Product: putative AAA ATPase, central region

Products: NA

Alternate protein names: PAN; Proteasomal ATPase; Proteasome regulatory ATPase; Proteasome regulatory particle [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTKNPSSDATLPKGIHRSWKLPDKSLGDLWDSIVMDEAIKKQLLSQAIVNFTVRPKVERTVLPLHGVILLVGPPGTGKTS
LARGLAHRVAESFSSAKFRLLEVEPHTLTSSAMGKTQRAVADLFSQSIAESAAAGPTIVLLDEVETLAADRAKLSLEANP
VDVHRATDAVLVQLDMLAERNPHLLFVATSNFPQAVDSAFLSRCDMVMEVPLPGKDACKQILVDCLNGLAKTFPGIGKLS
SAHQFDACAGECVGLDGRAIRKVVANALAADPQVAIDPNKLSVEHLRSAIRQAKQMRLQGGKQK

Sequences:

>Translated_304_residues
MTKNPSSDATLPKGIHRSWKLPDKSLGDLWDSIVMDEAIKKQLLSQAIVNFTVRPKVERTVLPLHGVILLVGPPGTGKTS
LARGLAHRVAESFSSAKFRLLEVEPHTLTSSAMGKTQRAVADLFSQSIAESAAAGPTIVLLDEVETLAADRAKLSLEANP
VDVHRATDAVLVQLDMLAERNPHLLFVATSNFPQAVDSAFLSRCDMVMEVPLPGKDACKQILVDCLNGLAKTFPGIGKLS
SAHQFDACAGECVGLDGRAIRKVVANALAADPQVAIDPNKLSVEHLRSAIRQAKQMRLQGGKQK
>Mature_303_residues
TKNPSSDATLPKGIHRSWKLPDKSLGDLWDSIVMDEAIKKQLLSQAIVNFTVRPKVERTVLPLHGVILLVGPPGTGKTSL
ARGLAHRVAESFSSAKFRLLEVEPHTLTSSAMGKTQRAVADLFSQSIAESAAAGPTIVLLDEVETLAADRAKLSLEANPV
DVHRATDAVLVQLDMLAERNPHLLFVATSNFPQAVDSAFLSRCDMVMEVPLPGKDACKQILVDCLNGLAKTFPGIGKLSS
AHQFDACAGECVGLDGRAIRKVVANALAADPQVAIDPNKLSVEHLRSAIRQAKQMRLQGGKQK

Specific function: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereb

COG id: COG0464

COG function: function code O; ATPases of the AAA+ class

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AAA ATPase family [H]

Homologues:

Organism=Homo sapiens, GI11321607, Length=289, Percent_Identity=31.1418685121107, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI261337161, Length=165, Percent_Identity=35.1515151515151, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI226371754, Length=240, Percent_Identity=30, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI14149767, Length=284, Percent_Identity=28.169014084507, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI62177112, Length=284, Percent_Identity=28.169014084507, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI31742536, Length=199, Percent_Identity=28.1407035175879, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI112789543, Length=199, Percent_Identity=28.1407035175879, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI7019569, Length=193, Percent_Identity=27.979274611399, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI5901990, Length=207, Percent_Identity=28.9855072463768, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI17865802, Length=151, Percent_Identity=31.1258278145695, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI157671927, Length=197, Percent_Identity=29.9492385786802, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17533043, Length=291, Percent_Identity=29.553264604811, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI86561515, Length=207, Percent_Identity=27.536231884058, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17508053, Length=196, Percent_Identity=32.1428571428571, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25146157, Length=239, Percent_Identity=26.3598326359833, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25144281, Length=157, Percent_Identity=31.8471337579618, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25144278, Length=157, Percent_Identity=31.8471337579618, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17541226, Length=254, Percent_Identity=25.1968503937008, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17541224, Length=254, Percent_Identity=25.1968503937008, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17508421, Length=220, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI32563584, Length=220, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI9755327, Length=230, Percent_Identity=30, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320077, Length=205, Percent_Identity=31.219512195122, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325431, Length=186, Percent_Identity=31.1827956989247, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320887, Length=212, Percent_Identity=29.2452830188679, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573181, Length=298, Percent_Identity=32.8859060402685, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24581396, Length=221, Percent_Identity=32.1266968325792, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644145, Length=186, Percent_Identity=29.5698924731183, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281360136, Length=203, Percent_Identity=30.0492610837438, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24644411, Length=203, Percent_Identity=30.0492610837438, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281360146, Length=203, Percent_Identity=30.0492610837438, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281360138, Length=203, Percent_Identity=30.0492610837438, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281360144, Length=203, Percent_Identity=30.0492610837438, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281360140, Length=203, Percent_Identity=30.0492610837438, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281360142, Length=203, Percent_Identity=30.0492610837438, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21357333, Length=203, Percent_Identity=30.0492610837438, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28571849, Length=200, Percent_Identity=30, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28571847, Length=200, Percent_Identity=30, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI19921202, Length=158, Percent_Identity=29.746835443038, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005937
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR003960 [H]

Pfam domain/function: PF00004 AAA [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 32601; Mature: 32470

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNPSSDATLPKGIHRSWKLPDKSLGDLWDSIVMDEAIKKQLLSQAIVNFTVRPKVERT
CCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHE
VLPLHGVILLVGPPGTGKTSLARGLAHRVAESFSSAKFRLLEVEPHTLTSSAMGKTQRAV
EECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHH
ADLFSQSIAESAAAGPTIVLLDEVETLAADRAKLSLEANPVDVHRATDAVLVQLDMLAER
HHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCC
NPHLLFVATSNFPQAVDSAFLSRCDMVMEVPLPGKDACKQILVDCLNGLAKTFPGIGKLS
CCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
SAHQFDACAGECVGLDGRAIRKVVANALAADPQVAIDPNKLSVEHLRSAIRQAKQMRLQG
CCHHHHHCCCCEECCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCC
GKQK
CCCC
>Mature Secondary Structure 
TKNPSSDATLPKGIHRSWKLPDKSLGDLWDSIVMDEAIKKQLLSQAIVNFTVRPKVERT
CCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHE
VLPLHGVILLVGPPGTGKTSLARGLAHRVAESFSSAKFRLLEVEPHTLTSSAMGKTQRAV
EECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHH
ADLFSQSIAESAAAGPTIVLLDEVETLAADRAKLSLEANPVDVHRATDAVLVQLDMLAER
HHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCC
NPHLLFVATSNFPQAVDSAFLSRCDMVMEVPLPGKDACKQILVDCLNGLAKTFPGIGKLS
CCCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
SAHQFDACAGECVGLDGRAIRKVVANALAADPQVAIDPNKLSVEHLRSAIRQAKQMRLQG
CCHHHHHCCCCEECCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHCC
GKQK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]