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The map label for this gene is merR [H]

Identifier: 94311250

GI number: 94311250

Start: 2531693

End: 2532100

Strand: Reverse

Name: merR [H]

Synonym: Rmet_2312

Alternate gene names: 94311250

Gene position: 2532100-2531693 (Counterclockwise)

Preceding gene: 94311274

Following gene: 94311240

Centisome position: 64.46

GC content: 63.48

Gene sequence:

>408_bases
ATGGAGAACGCTCAAGAGAATCTGACCATCGGGGCCTTCGCCAAGGCAGCCCGGGTCAACGTGGAGACGATCCGCTTCTA
TCAGCTCAAGGGCTTGCTACCCCAGCCGGAGCGGCCCTACGGTCGCATCCGCCGCTACGGGCAGGCGGACGTGGCGCGGG
TGAAGTTCGTGAAGTCAGCCCAGCGCCTGGGATTCAGCCTGGATGAAGTCGGCCAGCTCCTGAAACTGGAGGACGGCACC
CATTGCAGCGAGGCGGCCGAACTGGCTGCTCACCGGCTGGCCGATGTGCGCGCACGCATGGCGGACCTCACGCGGATGGA
AGAGGCCCTGTCGACGCTAGTGAGAGAGTGCAACGCGCACCATGGCAATGTTTCCTGCCCGTTGATCGCAGCTTTGCATT
GCTGCTAA

Upstream 100 bases:

>100_bases
GCGCCGCAGCCGTTCTTGGGTTCCGACATAAGGTTCTCCTTCCGGGACTTCGCTTGATGCTGTAACGTTACTTCCGTAGT
CAACTACGGAGTCAAGCGCC

Downstream 100 bases:

>100_bases
AGGGCCCACTTCGGCTCTTAGCGTACGATTTTTTTCCGTTTTCTGAGACGACCCCTGATTGGCGATGGCTTCGGTCAGCA
CGGGGCGCAGGTCAGCGCCT

Product: Mercuric resistance operon regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MENAQENLTIGAFAKAARVNVETIRFYQLKGLLPQPERPYGRIRRYGQADVARVKFVKSAQRLGFSLDEVGQLLKLEDGT
HCSEAAELAAHRLADVRARMADLTRMEEALSTLVRECNAHHGNVSCPLIAALHCC

Sequences:

>Translated_135_residues
MENAQENLTIGAFAKAARVNVETIRFYQLKGLLPQPERPYGRIRRYGQADVARVKFVKSAQRLGFSLDEVGQLLKLEDGT
HCSEAAELAAHRLADVRARMADLTRMEEALSTLVRECNAHHGNVSCPLIAALHCC
>Mature_135_residues
MENAQENLTIGAFAKAARVNVETIRFYQLKGLLPQPERPYGRIRRYGQADVARVKFVKSAQRLGFSLDEVGQLLKLEDGT
HCSEAAELAAHRLADVRARMADLTRMEEALSTLVRECNAHHGNVSCPLIAALHCC

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=127, Percent_Identity=36.2204724409449, Blast_Score=82, Evalue=1e-17,
Organism=Escherichia coli, GI1786695, Length=130, Percent_Identity=26.9230769230769, Blast_Score=60, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14989; Mature: 14989

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENAQENLTIGAFAKAARVNVETIRFYQLKGLLPQPERPYGRIRRYGQADVARVKFVKSA
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
QRLGFSLDEVGQLLKLEDGTHCSEAAELAAHRLADVRARMADLTRMEEALSTLVRECNAH
HHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HGNVSCPLIAALHCC
CCCCCHHHHHHHHCC
>Mature Secondary Structure
MENAQENLTIGAFAKAARVNVETIRFYQLKGLLPQPERPYGRIRRYGQADVARVKFVKSA
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
QRLGFSLDEVGQLLKLEDGTHCSEAAELAAHRLADVRARMADLTRMEEALSTLVRECNAH
HHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HGNVSCPLIAALHCC
CCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2666393 [H]