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The map label for this gene is clpB [H]

Identifier: 94310897

GI number: 94310897

Start: 2132547

End: 2135135

Strand: Reverse

Name: clpB [H]

Synonym: Rmet_1959

Alternate gene names: 94310897

Gene position: 2135135-2132547 (Counterclockwise)

Preceding gene: 94310898

Following gene: 94310896

Centisome position: 54.36

GC content: 63.42

Gene sequence:

>2589_bases
ATGCGAATTGACAAACTGACCACCCGGTTCCAGGAAGCGCTGGCAGAAGCGCAAAGTCTGGCGCTGGGTAATGACAATCA
ATACATCGAACCCCAGCATCTGCTGCGTGCATTGCTCGCGCAGGACGATGGTGCGGCCCGCACACTGCTGTCGCGTGCTG
GCGTGAACGTGGGCGGCCTGCAGAGCGCGCTCGATGCGGCGATCCATCGCCTGCCGCAGGTTCAGGGCACGAACGAGGTC
CAGGTGGGCCGCGACCTGAACAACCTGCTGAATGCCACAGAAAAGGAAGCGATCAAGCGCAACGACCAGTTCATCGCCAG
TGAACTGTTCCTGCTCGCCGTGTCTGACGACAAGGGCGAGACGGGGCGGATCGCCCGCGAGAACGGCTTGTCGCGCAAGT
CGCTCGAGGCCGCGATCACGGCCGTGCGCGGCGGTGATACCGTCAATAGCGCCGACGCCGAGTCGCAGCGCGAGGCGCTC
AAGAAATACACGGTCGACCTGACCGAGCGAGCGCGTGCCGGCAAGCTGGACCCCGTGATTGGCCGCGACGACGAAATCCG
CCGCGCGATCCAGATCCTGCAGCGCCGCACCAAGAACAACCCCGTGCTGATCGGTGAGCCCGGCGTGGGCAAGACCGCCA
TTGTCGAAGGGCTGGCACAGCGCATCGTCAACGGCGAAGTGCCGGAGACGCTCAAAAACAAGCGCGTGCTCGTGCTCGAC
ATGGCCGGGCTGCTGGCCGGCGCCAAGTATCGCGGCGAGTTCGAGGAACGCCTGAAGGCCGTGCTCAACGACGTGGCCAA
GGACGAAGGCCAGACCATCGTCTTCATCGACGAGATTCACACGATGGTGGGCGCGGGCAAGGCCGAAGGCGCGATCGACG
CGGGCAACATGCTCAAGCCGGCGCTGGCGCGCGGCGAACTGCACTGCATCGGCGCGACCACGCTGAACGAATACCGCAAG
TACATCGAGAAGGATGCCGCGCTGGAGCGCCGCTTCCAGAAGGTGCTTGTGGATGAGCCCAGCGTCGAGGCAACGATCGC
CATTCTGCGTGGCCTGCAGGAGAAGTACGAACTGCACCACAAGGTGGAGATCACCGACCCGGCCATCGTGGCTGCGGCCG
AGCTGTCGCACCGCTACATCACCGACCGGTTCCTGCCGGACAAGGCCATCGACCTGATCGACGAGGCTGCCGCGCGGATC
AAGATGGAAATCGACTCGAAGCCCGAGGCGATGGACAAGCTTGAGCGTCGCACGATCCAGCTCAAGATCGAGCGTGAGGC
GGTCAAGAAGGAAACCGACGAGGCATCGCGCAAGCGTCTGGAACTGATCGAGCAGGAAATCATCCGGCTCGAGAAGGAAT
ACGCTGACCTGGATGAGATCTGGCGCGCCGAGAAGGGCGCCGCCCAGGGTGCGGCCGCGCTGAAGGAGGAGATCGAGAAG
ATCAAGCTCGATATCACCCGACTGCAGCGCGAAGGCAAGCTCGACAAGGTGGCTGAACTCCAGTATGGCAAGCTGCCGGA
ACTCGAGGGCAAGCTGCAGGCGGCAACCAAGGCCGAGGCCAGCGAGCAGAAGCAGCAGAACAAGCTGCTGCGCACGCAGG
TCGGCGCCGAGGAAATCGCCGAGGTCGTCAGCCGCGCCACGGGTATTCCGGTGGCCAAGATGATGCAGGGCGAGCGCGAG
AAGCTGCTCAAGATGGAAGATCGTCTGCACCAGCGTGTGGTGGGTCAGGACGAGGCCGTGCGGCTGGTGTCTGATGCGAT
CCGCCGTTCGCGTGCCGGTCTGTCGGATGAGAACAAGCCGTATGGCTCGTTCCTGTTCCTTGGGCCGACGGGCGTGGGCA
AGACCGAGTTGTGCAAGGCGCTGTCCGAGTTCCTGTTCGATTCGGAGGAACACCTGATCCGCATCGACATGAGCGAGTTC
ATGGAGAAGCACAGCGTGAGCCGGCTGATCGGCGCGCCTCCGGGCTACGTGGGCTATGACGAAGGTGGTTACCTGACCGA
GGCGGTGCGTCGCAAGCCGTACGCGGTGATCCTGCTCGACGAAGTCGAGAAGGCGCACCCGGACGTGTTCAACGTGCTGC
TGCAGGTGCTGGACGATGGTCGTCTGACCGACGGTCAGGGCCGTACCGTCGACTTCAAGAACACGGTGATCGTGATGACG
TCGAACCTGGGCTCACACATCATCCAGTCGATGGCTGGCGAACCGCAGGAGGCGGTGAAGGGCGCGGTATGGCAGGAGGT
GCGCACGCATTTCCGGCCCGAGTTCCTGAACCGGATCGACGAAGTCGTGGTGTTCCATGCGCTCGACCAGAAGAATATCG
AGTCGATCGCCAAGATTCAGCTCAAGCGCCTGCAGGTCCGTCTGGCCCGCATGGACATGACGCTGGACGTGAGCGAGCGC
GCGCTGGAGAAGATCGCCAGCGCGGGCTACGACCCGGTGTTCGGAGCCCGGCCGCTCAAGCGCGCGATCCAGCAGCAGAT
CGAGAATCCGGTGGCCAAGGCCATCCTGGAAGGCCGGTTTGCCGCGAAGGATGTCGTGCCGGTGGACTATGTGGATGGCG
AGTTCACGTTTGGGCGAATGGTGCATTGA

Upstream 100 bases:

>100_bases
TTCGGAAGTAACGTGTCCGGCTGGGCATATGTGGCGGCAGCCGATGCCGCCGCGGGCCTCGCATCAGGACACACTTTCCT
AGAGAGAGAGAGGGCTCCTA

Downstream 100 bases:

>100_bases
GACGCGCCGGCTGCATCGGCCGATCTCCAGCCCGGGCAGTCTGGCCGGGTTGAGCAAGGGACCTCTGCGGAGGTCCCTTT
TTTTCGCCACAATGGTGGCT

Product: ATP-dependent Clp protease, ATP-binding subunit ClpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 862; Mature: 862

Protein sequence:

>862_residues
MRIDKLTTRFQEALAEAQSLALGNDNQYIEPQHLLRALLAQDDGAARTLLSRAGVNVGGLQSALDAAIHRLPQVQGTNEV
QVGRDLNNLLNATEKEAIKRNDQFIASELFLLAVSDDKGETGRIARENGLSRKSLEAAITAVRGGDTVNSADAESQREAL
KKYTVDLTERARAGKLDPVIGRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPETLKNKRVLVLD
MAGLLAGAKYRGEFEERLKAVLNDVAKDEGQTIVFIDEIHTMVGAGKAEGAIDAGNMLKPALARGELHCIGATTLNEYRK
YIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHHKVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARI
KMEIDSKPEAMDKLERRTIQLKIEREAVKKETDEASRKRLELIEQEIIRLEKEYADLDEIWRAEKGAAQGAAALKEEIEK
IKLDITRLQREGKLDKVAELQYGKLPELEGKLQAATKAEASEQKQQNKLLRTQVGAEEIAEVVSRATGIPVAKMMQGERE
KLLKMEDRLHQRVVGQDEAVRLVSDAIRRSRAGLSDENKPYGSFLFLGPTGVGKTELCKALSEFLFDSEEHLIRIDMSEF
MEKHSVSRLIGAPPGYVGYDEGGYLTEAVRRKPYAVILLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVMT
SNLGSHIIQSMAGEPQEAVKGAVWQEVRTHFRPEFLNRIDEVVVFHALDQKNIESIAKIQLKRLQVRLARMDMTLDVSER
ALEKIASAGYDPVFGARPLKRAIQQQIENPVAKAILEGRFAAKDVVPVDYVDGEFTFGRMVH

Sequences:

>Translated_862_residues
MRIDKLTTRFQEALAEAQSLALGNDNQYIEPQHLLRALLAQDDGAARTLLSRAGVNVGGLQSALDAAIHRLPQVQGTNEV
QVGRDLNNLLNATEKEAIKRNDQFIASELFLLAVSDDKGETGRIARENGLSRKSLEAAITAVRGGDTVNSADAESQREAL
KKYTVDLTERARAGKLDPVIGRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPETLKNKRVLVLD
MAGLLAGAKYRGEFEERLKAVLNDVAKDEGQTIVFIDEIHTMVGAGKAEGAIDAGNMLKPALARGELHCIGATTLNEYRK
YIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHHKVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARI
KMEIDSKPEAMDKLERRTIQLKIEREAVKKETDEASRKRLELIEQEIIRLEKEYADLDEIWRAEKGAAQGAAALKEEIEK
IKLDITRLQREGKLDKVAELQYGKLPELEGKLQAATKAEASEQKQQNKLLRTQVGAEEIAEVVSRATGIPVAKMMQGERE
KLLKMEDRLHQRVVGQDEAVRLVSDAIRRSRAGLSDENKPYGSFLFLGPTGVGKTELCKALSEFLFDSEEHLIRIDMSEF
MEKHSVSRLIGAPPGYVGYDEGGYLTEAVRRKPYAVILLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVMT
SNLGSHIIQSMAGEPQEAVKGAVWQEVRTHFRPEFLNRIDEVVVFHALDQKNIESIAKIQLKRLQVRLARMDMTLDVSER
ALEKIASAGYDPVFGARPLKRAIQQQIENPVAKAILEGRFAAKDVVPVDYVDGEFTFGRMVH
>Mature_862_residues
MRIDKLTTRFQEALAEAQSLALGNDNQYIEPQHLLRALLAQDDGAARTLLSRAGVNVGGLQSALDAAIHRLPQVQGTNEV
QVGRDLNNLLNATEKEAIKRNDQFIASELFLLAVSDDKGETGRIARENGLSRKSLEAAITAVRGGDTVNSADAESQREAL
KKYTVDLTERARAGKLDPVIGRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPETLKNKRVLVLD
MAGLLAGAKYRGEFEERLKAVLNDVAKDEGQTIVFIDEIHTMVGAGKAEGAIDAGNMLKPALARGELHCIGATTLNEYRK
YIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHHKVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARI
KMEIDSKPEAMDKLERRTIQLKIEREAVKKETDEASRKRLELIEQEIIRLEKEYADLDEIWRAEKGAAQGAAALKEEIEK
IKLDITRLQREGKLDKVAELQYGKLPELEGKLQAATKAEASEQKQQNKLLRTQVGAEEIAEVVSRATGIPVAKMMQGERE
KLLKMEDRLHQRVVGQDEAVRLVSDAIRRSRAGLSDENKPYGSFLFLGPTGVGKTELCKALSEFLFDSEEHLIRIDMSEF
MEKHSVSRLIGAPPGYVGYDEGGYLTEAVRRKPYAVILLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVMT
SNLGSHIIQSMAGEPQEAVKGAVWQEVRTHFRPEFLNRIDEVVVFHALDQKNIESIAKIQLKRLQVRLARMDMTLDVSER
ALEKIASAGYDPVFGARPLKRAIQQQIENPVAKAILEGRFAAKDVVPVDYVDGEFTFGRMVH

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=303, Percent_Identity=37.2937293729373, Blast_Score=202, Evalue=9e-52,
Organism=Escherichia coli, GI1788943, Length=848, Percent_Identity=66.3915094339623, Blast_Score=1142, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=399, Percent_Identity=41.3533834586466, Blast_Score=286, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6320464, Length=702, Percent_Identity=52.8490028490028, Blast_Score=743, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=858, Percent_Identity=42.3076923076923, Blast_Score=661, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 95944; Mature: 95944

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIDKLTTRFQEALAEAQSLALGNDNQYIEPQHLLRALLAQDDGAARTLLSRAGVNVGGL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCHH
QSALDAAIHRLPQVQGTNEVQVGRDLNNLLNATEKEAIKRNDQFIASELFLLAVSDDKGE
HHHHHHHHHHCCCCCCCCCEECCCHHHHHHCHHHHHHHHHCHHHHHEEEEEEEEECCCCC
TGRIARENGLSRKSLEAAITAVRGGDTVNSADAESQREALKKYTVDLTERARAGKLDPVI
CCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPETLKNKRVLVLD
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCCEEEEE
MAGLLAGAKYRGEFEERLKAVLNDVAKDEGQTIVFIDEIHTMVGAGKAEGAIDAGNMLKP
HHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHH
ALARGELHCIGATTLNEYRKYIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHH
HHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARIKMEIDSKPEAMDKLERRTIQ
EEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHEE
LKIEREAVKKETDEASRKRLELIEQEIIRLEKEYADLDEIWRAEKGAAQGAAALKEEIEK
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHH
IKLDITRLQREGKLDKVAELQYGKLPELEGKLQAATKAEASEQKQQNKLLRTQVGAEEIA
HHHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
EVVSRATGIPVAKMMQGEREKLLKMEDRLHQRVVGQDEAVRLVSDAIRRSRAGLSDENKP
HHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
YGSFLFLGPTGVGKTELCKALSEFLFDSEEHLIRIDMSEFMEKHSVSRLIGAPPGYVGYD
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCC
EGGYLTEAVRRKPYAVILLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVMT
CCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEE
SNLGSHIIQSMAGEPQEAVKGAVWQEVRTHFRPEFLNRIDEVVVFHALDQKNIESIAKIQ
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHH
LKRLQVRLARMDMTLDVSERALEKIASAGYDPVFGARPLKRAIQQQIENPVAKAILEGRF
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCH
AAKDVVPVDYVDGEFTFGRMVH
HHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRIDKLTTRFQEALAEAQSLALGNDNQYIEPQHLLRALLAQDDGAARTLLSRAGVNVGGL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCHH
QSALDAAIHRLPQVQGTNEVQVGRDLNNLLNATEKEAIKRNDQFIASELFLLAVSDDKGE
HHHHHHHHHHCCCCCCCCCEECCCHHHHHHCHHHHHHHHHCHHHHHEEEEEEEEECCCCC
TGRIARENGLSRKSLEAAITAVRGGDTVNSADAESQREALKKYTVDLTERARAGKLDPVI
CCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPETLKNKRVLVLD
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCCEEEEE
MAGLLAGAKYRGEFEERLKAVLNDVAKDEGQTIVFIDEIHTMVGAGKAEGAIDAGNMLKP
HHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHH
ALARGELHCIGATTLNEYRKYIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELHH
HHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KVEITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARIKMEIDSKPEAMDKLERRTIQ
EEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHEE
LKIEREAVKKETDEASRKRLELIEQEIIRLEKEYADLDEIWRAEKGAAQGAAALKEEIEK
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHH
IKLDITRLQREGKLDKVAELQYGKLPELEGKLQAATKAEASEQKQQNKLLRTQVGAEEIA
HHHHHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
EVVSRATGIPVAKMMQGEREKLLKMEDRLHQRVVGQDEAVRLVSDAIRRSRAGLSDENKP
HHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
YGSFLFLGPTGVGKTELCKALSEFLFDSEEHLIRIDMSEFMEKHSVSRLIGAPPGYVGYD
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCC
EGGYLTEAVRRKPYAVILLDEVEKAHPDVFNVLLQVLDDGRLTDGQGRTVDFKNTVIVMT
CCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEE
SNLGSHIIQSMAGEPQEAVKGAVWQEVRTHFRPEFLNRIDEVVVFHALDQKNIESIAKIQ
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHH
LKRLQVRLARMDMTLDVSERALEKIASAGYDPVFGARPLKRAIQQQIENPVAKAILEGRF
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCH
AAKDVVPVDYVDGEFTFGRMVH
HHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]