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The map label for this gene is reg1 [H]

Identifier: 94310843

GI number: 94310843

Start: 2074617

End: 2075684

Strand: Reverse

Name: reg1 [H]

Synonym: Rmet_1905

Alternate gene names: 94310843

Gene position: 2075684-2074617 (Counterclockwise)

Preceding gene: 94310844

Following gene: 94310839

Centisome position: 52.84

GC content: 65.92

Gene sequence:

>1068_bases
ATGGCGCATCGCCAACCCGTAATCGCACCGCCCGCTGCCAACATGCCCGAGCGCAAACGCCTGACTCTCAAAGACCTGGC
TGCCGAGATTGACGTCCATTACTCCACCGTCTCGCGCGTGATGAATCCGGCCACGCGGCATCTGGTGGCCGACGAGGTGG
CCGCACGCATCCTGCAGTTGGCCGAGCAGCGCGGCTTCCGGCCGAACCGGATCGCGGCCGGCCTGCGCACGCAGCGTTCC
GGACTGGTCGGCGTGGTGCTGCCCGATATTGCCAACCCGGTGTTCCCGCCGATCCTTGCTGGTATCGAATCGGTGCTGGC
GCGTGACGGCTATGTGCCGATCGTCGTCAATGCCGGCGCCGACAAGTCGCGTCAGCGGTTCGTCATCGACCAGTTGATGG
GGCGGCAGGTGGAAGGACTGGTGCTGGCCACAGCAGAGCGCGACGACCCGATCCTCGACTACTGCCTGAAGCTTTCCATC
CCGGTGGTGATGGTCAACCGGGGTGAGCCGACGGGGTGCGCATCGTGCGTGGTCAGCGATGGCTTGCTGGCGATGCAGCT
GACTGTCGATCACCTGGTGAAGCTTGGTCATCGCCGCATCGGCCATATCGCCGGACCGGAGACCACGTCCACTGGCCAGC
AGCGCCGCGAAGGCTTCCTGCAGGCGGTCAAGCGCCATCGCTTGCGCCGCGACGACTACGCGGTGGTGGAGGCCGTCAGC
TACTCCCGTGAGGCCGGACGTGAAGCCTGCGCCGAACTGTTCCAGGCATTGCCGGGCCTGACCGCGATCGCGGCCGGCAA
CGACCTCGTCGCGATGGGCTGCTATGACTATTTGCGCGAGCACGGCATCCGCTGTCCGGATGACGTATCGGTTGTCGGGC
ACAACGACATGCCGTTCGTGGATGCGCTGACCCCACCGCTGACGACGATCCGTATTGCCGTGCACGAGATGGGCGAGCAG
GCCGCTACGCTGCTGCTCAAGAAGATCGGCAAGCCGGAGGCGCCAGTGGTATCCGTCTCGCTGACGCCCGAACTCGTCGT
GCGTGGTTCGACGGCCGCGCCGCGCTAA

Upstream 100 bases:

>100_bases
TCGCGCCAGTGGTGCGGCAGTCGGGGGTGACGGCGGGGCAGTAGCCGGGGCCGCCATCTGGCAGCAAGCGGGCACGGGCG
TGCCGATCGCAGGCGCTAGA

Downstream 100 bases:

>100_bases
GCGGCTACAGCCAGCATCGGCGCATCATCAGTCTGAGTTGCCGTTAGAAGGCAATAGCTGGTAGCTACCAGCTTGGAGGT
CCCAAACGCCGTTAGCACTT

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MAHRQPVIAPPAANMPERKRLTLKDLAAEIDVHYSTVSRVMNPATRHLVADEVAARILQLAEQRGFRPNRIAAGLRTQRS
GLVGVVLPDIANPVFPPILAGIESVLARDGYVPIVVNAGADKSRQRFVIDQLMGRQVEGLVLATAERDDPILDYCLKLSI
PVVMVNRGEPTGCASCVVSDGLLAMQLTVDHLVKLGHRRIGHIAGPETTSTGQQRREGFLQAVKRHRLRRDDYAVVEAVS
YSREAGREACAELFQALPGLTAIAAGNDLVAMGCYDYLREHGIRCPDDVSVVGHNDMPFVDALTPPLTTIRIAVHEMGEQ
AATLLLKKIGKPEAPVVSVSLTPELVVRGSTAAPR

Sequences:

>Translated_355_residues
MAHRQPVIAPPAANMPERKRLTLKDLAAEIDVHYSTVSRVMNPATRHLVADEVAARILQLAEQRGFRPNRIAAGLRTQRS
GLVGVVLPDIANPVFPPILAGIESVLARDGYVPIVVNAGADKSRQRFVIDQLMGRQVEGLVLATAERDDPILDYCLKLSI
PVVMVNRGEPTGCASCVVSDGLLAMQLTVDHLVKLGHRRIGHIAGPETTSTGQQRREGFLQAVKRHRLRRDDYAVVEAVS
YSREAGREACAELFQALPGLTAIAAGNDLVAMGCYDYLREHGIRCPDDVSVVGHNDMPFVDALTPPLTTIRIAVHEMGEQ
AATLLLKKIGKPEAPVVSVSLTPELVVRGSTAAPR
>Mature_354_residues
AHRQPVIAPPAANMPERKRLTLKDLAAEIDVHYSTVSRVMNPATRHLVADEVAARILQLAEQRGFRPNRIAAGLRTQRSG
LVGVVLPDIANPVFPPILAGIESVLARDGYVPIVVNAGADKSRQRFVIDQLMGRQVEGLVLATAERDDPILDYCLKLSIP
VVMVNRGEPTGCASCVVSDGLLAMQLTVDHLVKLGHRRIGHIAGPETTSTGQQRREGFLQAVKRHRLRRDDYAVVEAVSY
SREAGREACAELFQALPGLTAIAAGNDLVAMGCYDYLREHGIRCPDDVSVVGHNDMPFVDALTPPLTTIRIAVHEMGEQA
ATLLLKKIGKPEAPVVSVSLTPELVVRGSTAAPR

Specific function: Transcription repressor involved in control of expression of alpha-amylase and chitinase genes and of actinorhodin production [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=334, Percent_Identity=29.940119760479, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1790194, Length=331, Percent_Identity=29.0030211480363, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1787948, Length=334, Percent_Identity=28.7425149700599, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788474, Length=334, Percent_Identity=27.8443113772455, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789202, Length=333, Percent_Identity=28.2282282282282, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787906, Length=331, Percent_Identity=26.5861027190332, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790715, Length=339, Percent_Identity=25.3687315634218, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1786540, Length=351, Percent_Identity=28.7749287749288, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1787580, Length=331, Percent_Identity=25.6797583081571, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI48994940, Length=339, Percent_Identity=25.6637168141593, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1789068, Length=303, Percent_Identity=24.0924092409241, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790689, Length=331, Percent_Identity=24.773413897281, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786268, Length=320, Percent_Identity=21.5625, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789456, Length=337, Percent_Identity=24.6290801186944, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38430; Mature: 38299

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHRQPVIAPPAANMPERKRLTLKDLAAEIDVHYSTVSRVMNPATRHLVADEVAARILQL
CCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AEQRGFRPNRIAAGLRTQRSGLVGVVLPDIANPVFPPILAGIESVLARDGYVPIVVNAGA
HHHCCCCCHHHHHHHHHHCCCEEEEECCHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCC
DKSRQRFVIDQLMGRQVEGLVLATAERDDPILDYCLKLSIPVVMVNRGEPTGCASCVVSD
CCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHC
GLLAMQLTVDHLVKLGHRRIGHIAGPETTSTGQQRREGFLQAVKRHRLRRDDYAVVEAVS
CHHEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YSREAGREACAELFQALPGLTAIAAGNDLVAMGCYDYLREHGIRCPDDVSVVGHNDMPFV
HHHHHHHHHHHHHHHHCCCCEEEECCCCEEEHHHHHHHHHCCCCCCCCCEEECCCCCCCH
DALTPPLTTIRIAVHEMGEQAATLLLKKIGKPEAPVVSVSLTPELVVRGSTAAPR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEECCCCCCC
>Mature Secondary Structure 
AHRQPVIAPPAANMPERKRLTLKDLAAEIDVHYSTVSRVMNPATRHLVADEVAARILQL
CCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AEQRGFRPNRIAAGLRTQRSGLVGVVLPDIANPVFPPILAGIESVLARDGYVPIVVNAGA
HHHCCCCCHHHHHHHHHHCCCEEEEECCHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCC
DKSRQRFVIDQLMGRQVEGLVLATAERDDPILDYCLKLSIPVVMVNRGEPTGCASCVVSD
CCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHC
GLLAMQLTVDHLVKLGHRRIGHIAGPETTSTGQQRREGFLQAVKRHRLRRDDYAVVEAVS
CHHEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YSREAGREACAELFQALPGLTAIAAGNDLVAMGCYDYLREHGIRCPDDVSVVGHNDMPFV
HHHHHHHHHHHHHHHHCCCCEEEECCCCEEEHHHHHHHHHCCCCCCCCCEEECCCCCCCH
DALTPPLTTIRIAVHEMGEQAATLLLKKIGKPEAPVVSVSLTPELVVRGSTAAPR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9335287 [H]