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The map label for this gene is alsR [H]

Identifier: 94310838

GI number: 94310838

Start: 2069485

End: 2070387

Strand: Direct

Name: alsR [H]

Synonym: Rmet_1900

Alternate gene names: 94310838

Gene position: 2069485-2070387 (Clockwise)

Preceding gene: 335055562

Following gene: 94310840

Centisome position: 52.68

GC content: 59.14

Gene sequence:

>903_bases
ATGGAACTGAGGCATCTGCGCTATTTCGCGTGCGTTGGCGAGGCGGAGCACTTCGGGAGAGCAGCGAAGCTACTCAAAAT
CGCGCAGCCAGCGCTTTCGCGGCAGATCCAGGATCTGGAAGCGGAGTTGGGCGTCGCGCTCTTCGATCGCTTGCCGCGCG
GGGTACGGCTAAATGCTGTGGGACGCTCATTTCTCGACGACGCTCGTCGTATTCTGCGCGAGGTGAATGAGGCGAAGCTT
CGGGTGGAGCGGATCGCCGCCGGTCAAACCGGAACGCTGCGAGTGGGATTCGGTGAAACCCAAGCGTGGCATGGTGCCGT
ACCTGACTCGCTGCGCGCGTTTCGTGAACAGCACCCGACTGTGGAACTTGAACTCCATGCCATGGCTTCCAGTCGTCAGG
TTGATGCGGTCAGCTCGGGAAACCTGGACGCAGGATTCATCTTCAGCTTGACAAAGCCGCCTTCGGAGTTCGCGCATCGA
AAGGTCGCCCGGCACAAGCTGGTGCTGGCCGCGCCGAAGGATCATCCCATCATGTCGCTCGACAGCGTGCGATTGCGCGA
ACTCCGCGATGTTCCCTTTATCTGGTTCCATCGATGGGTCTATCCACGCTTCCATGATCGCTTAATCCGCGCGTGCCTTC
GCGACGGGGCTCTGGCGCCACAAATTGTTCAGCAGGTCACAGATCACGCGACGATGCTGAGCTTGGTATCTTGTCGCCTC
GGTGTCGCCTTCGTCAGCGAGGCGACGCGGTGGCAGTGCCCGGCGGGAGTGGCCCTTCGCCCTGTCGACGACTTGAACTT
TTCGTTACCGTTCTATTTGATCTGGAAGAAAAACAATTCCTCGACACTACTGCGTGAGTTTCTGGAGAACGTCTGGACGG
TAACCAATGCGCGTGATAGCTGA

Upstream 100 bases:

>100_bases
CGCCATCGTTTTGCCCACGCCGGACGTTTCGAGTTTAGATAGCCTCATCCGATGCGTCCAAGACCTACTATTTATCTGTC
CGATACTCTTGAGGCATGAA

Downstream 100 bases:

>100_bases
CGGCAGCGTCTTGTGACCGCGATTAGCGAGAATTGCCGCCACCTCGAAGCTGTCGGATGTCTCAGAAGGGTCGCTATACA
ACGTTCGCGCGTCCAACAGC

Product: transcriptional regulator, LysR family

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MELRHLRYFACVGEAEHFGRAAKLLKIAQPALSRQIQDLEAELGVALFDRLPRGVRLNAVGRSFLDDARRILREVNEAKL
RVERIAAGQTGTLRVGFGETQAWHGAVPDSLRAFREQHPTVELELHAMASSRQVDAVSSGNLDAGFIFSLTKPPSEFAHR
KVARHKLVLAAPKDHPIMSLDSVRLRELRDVPFIWFHRWVYPRFHDRLIRACLRDGALAPQIVQQVTDHATMLSLVSCRL
GVAFVSEATRWQCPAGVALRPVDDLNFSLPFYLIWKKNNSSTLLREFLENVWTVTNARDS

Sequences:

>Translated_300_residues
MELRHLRYFACVGEAEHFGRAAKLLKIAQPALSRQIQDLEAELGVALFDRLPRGVRLNAVGRSFLDDARRILREVNEAKL
RVERIAAGQTGTLRVGFGETQAWHGAVPDSLRAFREQHPTVELELHAMASSRQVDAVSSGNLDAGFIFSLTKPPSEFAHR
KVARHKLVLAAPKDHPIMSLDSVRLRELRDVPFIWFHRWVYPRFHDRLIRACLRDGALAPQIVQQVTDHATMLSLVSCRL
GVAFVSEATRWQCPAGVALRPVDDLNFSLPFYLIWKKNNSSTLLREFLENVWTVTNARDS
>Mature_300_residues
MELRHLRYFACVGEAEHFGRAAKLLKIAQPALSRQIQDLEAELGVALFDRLPRGVRLNAVGRSFLDDARRILREVNEAKL
RVERIAAGQTGTLRVGFGETQAWHGAVPDSLRAFREQHPTVELELHAMASSRQVDAVSSGNLDAGFIFSLTKPPSEFAHR
KVARHKLVLAAPKDHPIMSLDSVRLRELRDVPFIWFHRWVYPRFHDRLIRACLRDGALAPQIVQQVTDHATMLSLVSCRL
GVAFVSEATRWQCPAGVALRPVDDLNFSLPFYLIWKKNNSSTLLREFLENVWTVTNARDS

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=282, Percent_Identity=35.8156028368794, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI2367136, Length=287, Percent_Identity=29.9651567944251, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1788887, Length=288, Percent_Identity=32.9861111111111, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI157672245, Length=233, Percent_Identity=30.4721030042918, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788297, Length=257, Percent_Identity=27.6264591439689, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790208, Length=258, Percent_Identity=29.0697674418605, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790399, Length=188, Percent_Identity=31.3829787234043, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI145693105, Length=243, Percent_Identity=26.7489711934156, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI87081904, Length=214, Percent_Identity=28.5046728971963, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787530, Length=266, Percent_Identity=26.6917293233083, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787601, Length=292, Percent_Identity=24.3150684931507, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788296, Length=234, Percent_Identity=29.0598290598291, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787806, Length=296, Percent_Identity=26.0135135135135, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788748, Length=243, Percent_Identity=23.0452674897119, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693193, Length=139, Percent_Identity=31.6546762589928, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788481, Length=198, Percent_Identity=26.2626262626263, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33974; Mature: 33974

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHLRYFACVGEAEHFGRAAKLLKIAQPALSRQIQDLEAELGVALFDRLPRGVRLNAV
CCCHHEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
GRSFLDDARRILREVNEAKLRVERIAAGQTGTLRVGFGETQAWHGAVPDSLRAFREQHPT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCC
VELELHAMASSRQVDAVSSGNLDAGFIFSLTKPPSEFAHRKVARHKLVLAAPKDHPIMSL
EEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHEEEEECCCCCCCCCH
DSVRLRELRDVPFIWFHRWVYPRFHDRLIRACLRDGALAPQIVQQVTDHATMLSLVSCRL
HHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
GVAFVSEATRWQCPAGVALRPVDDLNFSLPFYLIWKKNNSSTLLREFLENVWTVTNARDS
HHHHHHHCCCCCCCCCCEECCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MELRHLRYFACVGEAEHFGRAAKLLKIAQPALSRQIQDLEAELGVALFDRLPRGVRLNAV
CCCHHEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
GRSFLDDARRILREVNEAKLRVERIAAGQTGTLRVGFGETQAWHGAVPDSLRAFREQHPT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCC
VELELHAMASSRQVDAVSSGNLDAGFIFSLTKPPSEFAHRKVARHKLVLAAPKDHPIMSL
EEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHEEEEECCCCCCCCCH
DSVRLRELRDVPFIWFHRWVYPRFHDRLIRACLRDGALAPQIVQQVTDHATMLSLVSCRL
HHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
GVAFVSEATRWQCPAGVALRPVDDLNFSLPFYLIWKKNNSSTLLREFLENVWTVTNARDS
HHHHHHHCCCCCCCCCCEECCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]