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The map label for this gene is pgi

Identifier: 94310817

GI number: 94310817

Start: 2041066

End: 2042691

Strand: Direct

Name: pgi

Synonym: Rmet_1879

Alternate gene names: 94310817

Gene position: 2041066-2042691 (Clockwise)

Preceding gene: 335055555

Following gene: 94310819

Centisome position: 51.96

GC content: 65.01

Gene sequence:

>1626_bases
ATGCCGACTGACCTCCAAGCCTGGAACGCCCTTCGCCAACACCATGACGTCGTCCGCGAGACGCCGATGCAGCAGTGGTT
CGCCGAAGCCGGGGCTGCCCAACGGGTCGATGCCTTCTCGCTGGAAGCCTCTGGCCTGTATCTGGATTACTCGAAGAACC
GCATCACCGGCGAGACCCTTGCGCTGCTGATGAAGCTTGCCGAGGAAGCCGGCGTGCCGGCGCGCCGCGACGCCATGTTC
GCTGGCGAACATATCAACGCCACCGAAGATCGTGCCGCGTTGCACGTCGCGCTACGCGCCCTGCCCGACGCGCCGTTCAA
GGTCGACGGCGCATCGGTCATGCCCGCCATCCACGATGTACTCCGCCGGATGCGCGAGTTTGCCGGCCGCGTGCGCAGTG
GCGTTTGGACCGGCTCCACGGGCCAGGGGATCACCGACATTGTCAACATCGGCATCGGCGGCTCTGACCTGGGCCCGCGC
ATGGTATGCCGCGCCCTGGCGCATCTGGCCGACCCGCGCGGACCGCGTGTGCACTTCGTTTCGAATGTGGATGGCACCGA
GCTTGCCGAAACGCTCCAGCGCCTGGATCCAGCACGCACGCTAGCGATCGTCTGTTCGAAGACGTTCACCACGCTCGAAA
CCATGGCCAACGCCTGCAGCATGCGGGACTGGTTCCTGCGCCACGGCGTGGCCGAGAATCAGCTCGCGCGGCACTTCGTC
GCCGTGTCGACCAATCGCGACGCGGTGGTCGATTTCGGCATCGACCCGAACAACATGTTCGAGTTCTGGGATTGGATCGG
TGGCCGGTTCTCGCTGTGGTCGTCGGTCGGCCTGTCGATTGCGCTGGCCGTCGGCTTCGACGCCTTCGAGGACCTGCTGC
TCGGGGCCCGCGCGATGGACGATCATTTCCGCACTGCACCGCTCGCCCAAAACATGCCGGTGGTGATGGCGATGCTGGGC
ATCTGGTATCGCAATTTCCACGACATGCCGACGAGCTGCATGGCGCCCTATTCGACCTCGCTCGAACTGTTTCCGGCGTT
CCTCCAGCAACTCGAGATGGAGAGCAACGGCAAGTCGGTCCAGCTCGATGGCCGTCCGGTGGACGCGGATACCGCGCCAG
TGGTCTGGGGCACGGCTGGCACCAACGGCCAGCACGCCTACTTCCAGATGATCCACCAGGGCTCACAGATCGTGCCGGTC
GATTTCGTCGCGCCGCTGGTGCCGCCGCGCGAACTGCCGGGACATCACGTCAAGCTGCTGGCCAACTGCTTTGCACAGGC
CGAGGCATTGATGCGCGGACGCAGTGCGGAAGAACTCCAAGCGGCCGGCGTCGACGCAGCACGCATTCCGCATATGGTGT
TCGAGGGCAACCGCCCCAGCAACATGCTGCTGATGGAAAACCTGACGCCGCACGTGCTGGGCGCGCTGATCGCGCTCTAT
GAGCACCGCACCTTCGTGCAGGGCATCGTCTGGAACATCAATTCGTTCGATCAGTGGGGCGTGGAGCTCGGCAAGATCCT
GGCGCGCCCGATCGAGGCCGAACTCAGTGGCAATGCCACGGAAGCCCACGATGCATCGACCGCCGCGCTGATCGCGCGGG
CACGCCGCTCACTGGCGCGCAGTTAA

Upstream 100 bases:

>100_bases
TTTTGCTGCCACTTCCGGAATTTGCGATCACATTCTGACGATATACTTGCTGGCGCCTGCCTCGTGCGGGCGTTCGTGCC
CGATTTCCCCCCAAGAACGA

Downstream 100 bases:

>100_bases
CCCCGTCGACACCGCTCAGACGCCCACATCCATGAACTCATCGCTGGCTACACGGCCAGCCTCGATCGTCAGGATGCGGC
CGCATCGCGCCGCCACCGAA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MPTDLQAWNALRQHHDVVRETPMQQWFAEAGAAQRVDAFSLEASGLYLDYSKNRITGETLALLMKLAEEAGVPARRDAMF
AGEHINATEDRAALHVALRALPDAPFKVDGASVMPAIHDVLRRMREFAGRVRSGVWTGSTGQGITDIVNIGIGGSDLGPR
MVCRALAHLADPRGPRVHFVSNVDGTELAETLQRLDPARTLAIVCSKTFTTLETMANACSMRDWFLRHGVAENQLARHFV
AVSTNRDAVVDFGIDPNNMFEFWDWIGGRFSLWSSVGLSIALAVGFDAFEDLLLGARAMDDHFRTAPLAQNMPVVMAMLG
IWYRNFHDMPTSCMAPYSTSLELFPAFLQQLEMESNGKSVQLDGRPVDADTAPVVWGTAGTNGQHAYFQMIHQGSQIVPV
DFVAPLVPPRELPGHHVKLLANCFAQAEALMRGRSAEELQAAGVDAARIPHMVFEGNRPSNMLLMENLTPHVLGALIALY
EHRTFVQGIVWNINSFDQWGVELGKILARPIEAELSGNATEAHDASTAALIARARRSLARS

Sequences:

>Translated_541_residues
MPTDLQAWNALRQHHDVVRETPMQQWFAEAGAAQRVDAFSLEASGLYLDYSKNRITGETLALLMKLAEEAGVPARRDAMF
AGEHINATEDRAALHVALRALPDAPFKVDGASVMPAIHDVLRRMREFAGRVRSGVWTGSTGQGITDIVNIGIGGSDLGPR
MVCRALAHLADPRGPRVHFVSNVDGTELAETLQRLDPARTLAIVCSKTFTTLETMANACSMRDWFLRHGVAENQLARHFV
AVSTNRDAVVDFGIDPNNMFEFWDWIGGRFSLWSSVGLSIALAVGFDAFEDLLLGARAMDDHFRTAPLAQNMPVVMAMLG
IWYRNFHDMPTSCMAPYSTSLELFPAFLQQLEMESNGKSVQLDGRPVDADTAPVVWGTAGTNGQHAYFQMIHQGSQIVPV
DFVAPLVPPRELPGHHVKLLANCFAQAEALMRGRSAEELQAAGVDAARIPHMVFEGNRPSNMLLMENLTPHVLGALIALY
EHRTFVQGIVWNINSFDQWGVELGKILARPIEAELSGNATEAHDASTAALIARARRSLARS
>Mature_540_residues
PTDLQAWNALRQHHDVVRETPMQQWFAEAGAAQRVDAFSLEASGLYLDYSKNRITGETLALLMKLAEEAGVPARRDAMFA
GEHINATEDRAALHVALRALPDAPFKVDGASVMPAIHDVLRRMREFAGRVRSGVWTGSTGQGITDIVNIGIGGSDLGPRM
VCRALAHLADPRGPRVHFVSNVDGTELAETLQRLDPARTLAIVCSKTFTTLETMANACSMRDWFLRHGVAENQLARHFVA
VSTNRDAVVDFGIDPNNMFEFWDWIGGRFSLWSSVGLSIALAVGFDAFEDLLLGARAMDDHFRTAPLAQNMPVVMAMLGI
WYRNFHDMPTSCMAPYSTSLELFPAFLQQLEMESNGKSVQLDGRPVDADTAPVVWGTAGTNGQHAYFQMIHQGSQIVPVD
FVAPLVPPRELPGHHVKLLANCFAQAEALMRGRSAEELQAAGVDAARIPHMVFEGNRPSNMLLMENLTPHVLGALIALYE
HRTFVQGIVWNINSFDQWGVELGKILARPIEAELSGNATEAHDASTAALIARARRSLARS

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=535, Percent_Identity=53.6448598130841, Blast_Score=563, Evalue=1e-160,
Organism=Homo sapiens, GI296080693, Length=535, Percent_Identity=49.7196261682243, Blast_Score=502, Evalue=1e-142,
Organism=Escherichia coli, GI1790457, Length=544, Percent_Identity=51.8382352941177, Blast_Score=562, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI71996708, Length=501, Percent_Identity=52.2954091816367, Blast_Score=539, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI71996703, Length=510, Percent_Identity=51.5686274509804, Blast_Score=538, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6319673, Length=546, Percent_Identity=48.7179487179487, Blast_Score=537, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24651916, Length=542, Percent_Identity=50.3690036900369, Blast_Score=542, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24651914, Length=542, Percent_Identity=50.3690036900369, Blast_Score=542, Evalue=1e-154,
Organism=Drosophila melanogaster, GI17737445, Length=542, Percent_Identity=50.3690036900369, Blast_Score=542, Evalue=1e-154,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_RALME (Q1LM68)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_584027.1
- ProteinModelPortal:   Q1LM68
- SMR:   Q1LM68
- STRING:   Q1LM68
- GeneID:   4038681
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_1879
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- PhylomeDB:   Q1LM68
- ProtClustDB:   PRK00179
- BioCyc:   RMET266264:RMET_1879-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59349; Mature: 59218

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3; PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: ACT_SITE 354-354 ACT_SITE 385-385 ACT_SITE 505-505

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTDLQAWNALRQHHDVVRETPMQQWFAEAGAAQRVDAFSLEASGLYLDYSKNRITGETL
CCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHCCHHEEEECCCEEEECCCCCCCHHHH
ALLMKLAEEAGVPARRDAMFAGEHINATEDRAALHVALRALPDAPFKVDGASVMPAIHDV
HHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHH
LRRMREFAGRVRSGVWTGSTGQGITDIVNIGIGGSDLGPRMVCRALAHLADPRGPRVHFV
HHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEE
SNVDGTELAETLQRLDPARTLAIVCSKTFTTLETMANACSMRDWFLRHGVAENQLARHFV
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHE
AVSTNRDAVVDFGIDPNNMFEFWDWIGGRFSLWSSVGLSIALAVGFDAFEDLLLGARAMD
EEECCCCEEEECCCCCCHHHHHHHHCCCHHHHHHHHCHHEEEHHCHHHHHHHHHHHHHHH
DHFRTAPLAQNMPVVMAMLGIWYRNFHDMPTSCMAPYSTSLELFPAFLQQLEMESNGKSV
HHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHCCCCCEE
QLDGRPVDADTAPVVWGTAGTNGQHAYFQMIHQGSQIVPVDFVAPLVPPRELPGHHVKLL
EECCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEHHHHHCCCCCCCCCCHHHHHH
ANCFAQAEALMRGRSAEELQAAGVDAARIPHMVFEGNRPSNMLLMENLTPHVLGALIALY
HHHHHHHHHHHCCCCHHHHHHCCCCHHHCCHHEECCCCCCCEEEECCCCHHHHHHHHHHH
EHRTFVQGIVWNINSFDQWGVELGKILARPIEAELSGNATEAHDASTAALIARARRSLAR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
S
C
>Mature Secondary Structure 
PTDLQAWNALRQHHDVVRETPMQQWFAEAGAAQRVDAFSLEASGLYLDYSKNRITGETL
CCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHCCHHEEEECCCEEEECCCCCCCHHHH
ALLMKLAEEAGVPARRDAMFAGEHINATEDRAALHVALRALPDAPFKVDGASVMPAIHDV
HHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHH
LRRMREFAGRVRSGVWTGSTGQGITDIVNIGIGGSDLGPRMVCRALAHLADPRGPRVHFV
HHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEE
SNVDGTELAETLQRLDPARTLAIVCSKTFTTLETMANACSMRDWFLRHGVAENQLARHFV
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHE
AVSTNRDAVVDFGIDPNNMFEFWDWIGGRFSLWSSVGLSIALAVGFDAFEDLLLGARAMD
EEECCCCEEEECCCCCCHHHHHHHHCCCHHHHHHHHCHHEEEHHCHHHHHHHHHHHHHHH
DHFRTAPLAQNMPVVMAMLGIWYRNFHDMPTSCMAPYSTSLELFPAFLQQLEMESNGKSV
HHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHCCCCCEE
QLDGRPVDADTAPVVWGTAGTNGQHAYFQMIHQGSQIVPVDFVAPLVPPRELPGHHVKLL
EECCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEHHHHHCCCCCCCCCCHHHHHH
ANCFAQAEALMRGRSAEELQAAGVDAARIPHMVFEGNRPSNMLLMENLTPHVLGALIALY
HHHHHHHHHHHCCCCHHHHHHCCCCHHHCCHHEECCCCCCCEEEECCCCHHHHHHHHHHH
EHRTFVQGIVWNINSFDQWGVELGKILARPIEAELSGNATEAHDASTAALIARARRSLAR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA