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The map label for this gene is pccB [H]

Identifier: 94310661

GI number: 94310661

Start: 1863369

End: 1864988

Strand: Direct

Name: pccB [H]

Synonym: Rmet_1721

Alternate gene names: 94310661

Gene position: 1863369-1864988 (Clockwise)

Preceding gene: 94310659

Following gene: 94310662

Centisome position: 47.44

GC content: 66.73

Gene sequence:

>1620_bases
ATGATCACCATCGATACCCGGATTGATTCCACCTCGGATACCTTTGCCACGCAGCGTGCTGGCATGCAGGCGCTGACAGA
CCGGCTGCGCGCGCTGGAACAGCGAGCCGTCGACGCCTCGTCGCGTGCTCGCTCAAGCTTTCAGAAACGCGGGGCGCTGC
TGCCGCGCGAGCGAGTTGCCTGTCTGCTCGACCCCGGCGCGCCATTCCTGCCGCTGGCCACGCTTGCGGGATATGGGCTG
GACGATCCGAATCCCGATACGTCGATTCCCGGCGGCTCGCTGGTGGCTGGAATCGGCTTTGTGTGCGGCGTGCGCTGCAT
GGTGCTGGCCACGGATTCAGGCATCGACGCCGGCGCCATGACCGAGGCCGGCAACCTGAAGCTGATGCGCTGTCAGGACA
TCGCGCTGGAGAACCGGTTGCCGCTGATCCATCTCGTGGAGTCGGCCGGCGCAAACCTGCGCAAGTACAGGGTCGAAAAA
TTCGTGCGAGGCGGCACGATCTTCTACAACCTGGCGCGGCTCTCGGCAGCGGGGCTACCGGTCATTACGGTGGTCCACGG
CTCGTCCACGGCCGGCGGGGCGTACATGCCGGGCCTGTCCGATTACGTCGTGATGGTCCGCAAGCGTGCCCGCGCCTTCC
TGGCCGGCCCGCCACTGCTCAAAGCCGCCACCGGCGAGATTGCCACCGACGAAGAACTGGGTGGCGCGGATCTACACGCC
ACCGTCAGCGGTCTGGCCGAGTATCTGGCCGAGGACGACGAGCACGCCATTGCCACGGCACGGGACATCGTCGCCAGCCT
TGACTGGCCCCGTGTGGATCAGACGCCGCCACGGCCGGCACGGGCGCCGAAGCTCCCCGCGGCCGAGCTCGAAGGTGTCA
TGACCCTGGATCACAAGCGTCCGGTCGATATGCGCGAGGTTATCGCCAGGCTGGTGGATGACTCCGCCTGGCTGCCGTTC
AAGCCCGACTACGGACCGGGCACCGTCTGCGGTCATGCCCGCATCGAAGGCCATGCCGTCGGCTTTATCGCCAACAATGG
CCCGATCGATCCGGCTGGCGCCACCAAGGCCGCGCAGTTTATTCAGGCCTGCAACCAGTCCGGCACACCGATCGTGTTTC
TGCAGAACACCACGGGCTTCATCGTCGGCAAGGCATCGGAGGAGGCCGGCATGATCAAGCACGGCTCGAAGATGATTCAG
GCGCTCTCCAACTCCACCGTCCCACATGTCACGCTGTACTGCGGCGCGAGCTTCGGCGCCGGCAATTTCGGCATGTGCGG
CCGTGGCTTCCATCCGCGCTTCTGCTTCTCGTGGCCCAACGCGCGAACGGCCGTCATGGGCGGAGAGCAGGCTGCGATGA
CACTCGAAATCGTGGCCCGCCAGCAGGCCGCGCGCAAGGGCGTGCCCGTGGACGAGGCGGCGCTGGCCGCGCAGACCGCC
GAGATCGTCGCCAACTTCGAGCGTCAGGGCAGCGCGTTCGTCACCAGCGGGTTGCTGCTGGACGATGGTGTGATCGACCC
ACGCGACACGCGCGCGGTGCTGGCCTTTGTGCTGGCCACAGCGCGAGAAGCCGCCGCCCGCACGCCCCGCGCGATGCAGT
TCGGCGTTGCGCGTTTCTGA

Upstream 100 bases:

>100_bases
CGTTGTGGTTGTCCAGCGGTGAAGGGTGGATTGCAATGGATTCACTTCGTACAACCCGTCACGCCAACACGCGCCATCGG
ACGCCAGCCGGTCTCCCACC

Downstream 100 bases:

>100_bases
CGCTTCCGACGCTTCCAACGCTTTCGCGCCTCATCAGATCTGAACAAACAAGGTACCCCGGAGACACAGATGCTTTATAC
CCAGGACCACCGCAGCATCA

Product: Propionyl-CoA carboxylase beta chain

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MITIDTRIDSTSDTFATQRAGMQALTDRLRALEQRAVDASSRARSSFQKRGALLPRERVACLLDPGAPFLPLATLAGYGL
DDPNPDTSIPGGSLVAGIGFVCGVRCMVLATDSGIDAGAMTEAGNLKLMRCQDIALENRLPLIHLVESAGANLRKYRVEK
FVRGGTIFYNLARLSAAGLPVITVVHGSSTAGGAYMPGLSDYVVMVRKRARAFLAGPPLLKAATGEIATDEELGGADLHA
TVSGLAEYLAEDDEHAIATARDIVASLDWPRVDQTPPRPARAPKLPAAELEGVMTLDHKRPVDMREVIARLVDDSAWLPF
KPDYGPGTVCGHARIEGHAVGFIANNGPIDPAGATKAAQFIQACNQSGTPIVFLQNTTGFIVGKASEEAGMIKHGSKMIQ
ALSNSTVPHVTLYCGASFGAGNFGMCGRGFHPRFCFSWPNARTAVMGGEQAAMTLEIVARQQAARKGVPVDEAALAAQTA
EIVANFERQGSAFVTSGLLLDDGVIDPRDTRAVLAFVLATAREAAARTPRAMQFGVARF

Sequences:

>Translated_539_residues
MITIDTRIDSTSDTFATQRAGMQALTDRLRALEQRAVDASSRARSSFQKRGALLPRERVACLLDPGAPFLPLATLAGYGL
DDPNPDTSIPGGSLVAGIGFVCGVRCMVLATDSGIDAGAMTEAGNLKLMRCQDIALENRLPLIHLVESAGANLRKYRVEK
FVRGGTIFYNLARLSAAGLPVITVVHGSSTAGGAYMPGLSDYVVMVRKRARAFLAGPPLLKAATGEIATDEELGGADLHA
TVSGLAEYLAEDDEHAIATARDIVASLDWPRVDQTPPRPARAPKLPAAELEGVMTLDHKRPVDMREVIARLVDDSAWLPF
KPDYGPGTVCGHARIEGHAVGFIANNGPIDPAGATKAAQFIQACNQSGTPIVFLQNTTGFIVGKASEEAGMIKHGSKMIQ
ALSNSTVPHVTLYCGASFGAGNFGMCGRGFHPRFCFSWPNARTAVMGGEQAAMTLEIVARQQAARKGVPVDEAALAAQTA
EIVANFERQGSAFVTSGLLLDDGVIDPRDTRAVLAFVLATAREAAARTPRAMQFGVARF
>Mature_539_residues
MITIDTRIDSTSDTFATQRAGMQALTDRLRALEQRAVDASSRARSSFQKRGALLPRERVACLLDPGAPFLPLATLAGYGL
DDPNPDTSIPGGSLVAGIGFVCGVRCMVLATDSGIDAGAMTEAGNLKLMRCQDIALENRLPLIHLVESAGANLRKYRVEK
FVRGGTIFYNLARLSAAGLPVITVVHGSSTAGGAYMPGLSDYVVMVRKRARAFLAGPPLLKAATGEIATDEELGGADLHA
TVSGLAEYLAEDDEHAIATARDIVASLDWPRVDQTPPRPARAPKLPAAELEGVMTLDHKRPVDMREVIARLVDDSAWLPF
KPDYGPGTVCGHARIEGHAVGFIANNGPIDPAGATKAAQFIQACNQSGTPIVFLQNTTGFIVGKASEEAGMIKHGSKMIQ
ALSNSTVPHVTLYCGASFGAGNFGMCGRGFHPRFCFSWPNARTAVMGGEQAAMTLEIVARQQAARKGVPVDEAALAAQTA
EIVANFERQGSAFVTSGLLLDDGVIDPRDTRAVLAFVLATAREAAARTPRAMQFGVARF

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=542, Percent_Identity=43.3579335793358, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI119943100, Length=493, Percent_Identity=30.8316430020284, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI295821216, Length=513, Percent_Identity=29.8245614035088, Blast_Score=199, Evalue=8e-51,
Organism=Homo sapiens, GI310133460, Length=147, Percent_Identity=39.4557823129252, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17552936, Length=541, Percent_Identity=41.5896487985213, Blast_Score=415, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI25147362, Length=436, Percent_Identity=30.2752293577982, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25147359, Length=436, Percent_Identity=30.2752293577982, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24586065, Length=557, Percent_Identity=41.4721723518851, Blast_Score=427, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57008; Mature: 57008

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIDTRIDSTSDTFATQRAGMQALTDRLRALEQRAVDASSRARSSFQKRGALLPRERVA
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHEE
CLLDPGAPFLPLATLAGYGLDDPNPDTSIPGGSLVAGIGFVCGVRCMVLATDSGIDAGAM
EEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCC
TEAGNLKLMRCQDIALENRLPLIHLVESAGANLRKYRVEKFVRGGTIFYNLARLSAAGLP
CCCCCEEEEEEHHHHHHCCCCCEEEHHHCCCHHHHHHHHHHHCCCHHEEEHHHHHCCCCC
VITVVHGSSTAGGAYMPGLSDYVVMVRKRARAFLAGPPLLKAATGEIATDEELGGADLHA
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCHHHH
TVSGLAEYLAEDDEHAIATARDIVASLDWPRVDQTPPRPARAPKLPAAELEGVMTLDHKR
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCEEEECCCC
PVDMREVIARLVDDSAWLPFKPDYGPGTVCGHARIEGHAVGFIANNGPIDPAGATKAAQF
CCCHHHHHHHHHCCCCCCCCCCCCCCCCEECCEEECCEEEEEEECCCCCCCCCHHHHHHH
IQACNQSGTPIVFLQNTTGFIVGKASEEAGMIKHGSKMIQALSNSTVPHVTLYCGASFGA
HHHHCCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
GNFGMCGRGFHPRFCFSWPNARTAVMGGEQAAMTLEIVARQQAARKGVPVDEAALAAQTA
CCCCCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
EIVANFERQGSAFVTSGLLLDDGVIDPRDTRAVLAFVLATAREAAARTPRAMQFGVARF
HHHHHHHHCCCEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
>Mature Secondary Structure
MITIDTRIDSTSDTFATQRAGMQALTDRLRALEQRAVDASSRARSSFQKRGALLPRERVA
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHEE
CLLDPGAPFLPLATLAGYGLDDPNPDTSIPGGSLVAGIGFVCGVRCMVLATDSGIDAGAM
EEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCC
TEAGNLKLMRCQDIALENRLPLIHLVESAGANLRKYRVEKFVRGGTIFYNLARLSAAGLP
CCCCCEEEEEEHHHHHHCCCCCEEEHHHCCCHHHHHHHHHHHCCCHHEEEHHHHHCCCCC
VITVVHGSSTAGGAYMPGLSDYVVMVRKRARAFLAGPPLLKAATGEIATDEELGGADLHA
EEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCHHHH
TVSGLAEYLAEDDEHAIATARDIVASLDWPRVDQTPPRPARAPKLPAAELEGVMTLDHKR
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCEEEECCCC
PVDMREVIARLVDDSAWLPFKPDYGPGTVCGHARIEGHAVGFIANNGPIDPAGATKAAQF
CCCHHHHHHHHHCCCCCCCCCCCCCCCCEECCEEECCEEEEEEECCCCCCCCCHHHHHHH
IQACNQSGTPIVFLQNTTGFIVGKASEEAGMIKHGSKMIQALSNSTVPHVTLYCGASFGA
HHHHCCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
GNFGMCGRGFHPRFCFSWPNARTAVMGGEQAAMTLEIVARQQAARKGVPVDEAALAAQTA
CCCCCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
EIVANFERQGSAFVTSGLLLDDGVIDPRDTRAVLAFVLATAREAAARTPRAMQFGVARF
HHHHHHHHCCCEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]